Kyushu University Academic Staff Educational and Research Activities Database
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shigehiro ohdo Last modified date:2017.08.26



Graduate School
Undergraduate School
Other Organization
Administration Post
Dean of the Faculty of Pharmaceutical Sciences
Dean of the Graduate School of Pharmaceutical Sciences
Dean of the School of Pharmaceutical Sciences


E-Mail
Homepage
http://yakuzai.phar.kyushu-u.ac.jp
The study on the individualization of pharmacotherapy has been carried out aiming at further improvement of pharmacotherapy. However, intraindividual variability as well as interindividual variability should be considered to aim at further improvement of rational pharmacotherapy. Because many drugs vary in potency and/or toxicity associated with the rhythmicity of biochemical, physiological and behavioral processes. One approach to increasing the efficiency of pharmacotherapy is the administration of drugs at times at which they are most effective and/or best tolerated. The application of biological rhythm to pharmacotherapy may be accomplished by the appropriate timing of conventionally formulated tabletes and capsules, and the special drug delivery system to synchronize drug concentrations to rhythms in disease activity. In all living organisms, circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN). Clock genes are the genes that control the circadian rhythms in physiology and behavior. The knowledge of clock genes may be important for the clinical practice. Therefore, we aim at the development of new chronotherapy based on the following strategy: to monitor a rhythmic marker for selecting dosing time, to overcome the alteration of the clock function, a new concept of adverse effects, by devising a dosing schedule and to produce new rhythmicity by manipulating the conditions of living organs by using rhythmic administration of altered feeding schedules or several drugs. .
Phone
092-642-6610
Fax
092-642-6614
Academic Degree
Doctor of philosophy
Field of Specialization
pharmaceutics, chronopharmacology
Outline Activities
The study on the individualization of pharmacotherapy has been carried out aiming at further improvement of pharmacotherapy. However, intraindividual variability as well as interindividual variability should be considered to aim at further improvement of rational pharmacotherapy. Because many drugs vary in potency and/or toxicity associated with the rhythmicity of biochemical, physiological and behavioral processes. One approach to increasing the efficiency of pharmacotherapy is the administration of drugs at times at which they are most effective and/or best tolerated. The application of biological rhythm to pharmacotherapy may be accomplished by the appropriate timing of conventionally formulated tabletes and capsules, and the special drug delivery system to synchronize drug concentrations to rhythms in disease activity. In all living organisms, circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN). Clock genes are the genes that control the circadian rhythms in physiology and behavior. The knowledge of clock genes may be important for the clinical practice. Therefore, we aim at the development of new chronotherapy based on the following strategy: to monitor a rhythmic marker for selecting dosing time, to overcome the alteration of the clock function, a new concept of adverse effects, by devising a dosing schedule and to produce new rhythmicity by manipulating the conditions of living organs by using rhythmic administration of altered feeding schedules or several drugs.
Research
Research Interests
  • Development of new chronotherapy based on molecular clock
    keyword : circadian rhythm, clock gene, chronopharmacology, chronopharmaceutics
    1990.08~2016.03The study on the individualization of pharmacotherapy has been carried out aiming at further improvement of pharmacotherapy. However, intraindividual variability as well as interindividual variability should be considered to aim at further improvement of rational pharmacotherapy. Because many drugs vary in potency and/or toxicity associated with the rhythmicity of biochemical, physiological and behavioral processes. One approach to increasing the efficiency of pharmacotherapy is the administration of drugs at times at which they are most effective and/or best tolerated. The application of biological rhythm to pharmacotherapy may be accomplished by the appropriate timing of conventionally formulated tabletes and capsules, and the special drug delivery system to synchronize drug concentrations to rhythms in disease activity. In all living organisms, circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN). Clock genes are the genes that control the circadian rhythms in physiology and behavior. The knowledge of clock genes may be important for the clinical practice. Therefore, we aim at the development of new chronotherapy based on the following strategy: to monitor a rhythmic marker for selecting dosing time, to overcome the alteration of the clock function, a new concept of adverse effects, by devising a dosing schedule and to produce new rhythmicity by manipulating the conditions of living organs by using rhythmic administration of altered feeding schedules or several drugs..
Academic Activities
Other Research Activities
  • 2001.03.
Educational
Other Educational Activities
  • 2010.04.
  • 2006.09.
  • 2006.05.
  • 2005.09.