Kyushu University [MAYUMI ONO (Professor) Faculty of Pharmaceutical Sciences, ]

Department of Chemo-Pharmaceutical Sciences
Graduate School of Pharmaceutical Sciences

Department of Physiological Sciences
Graduate School of Medical Sciences

Department of Medicine
School of Medicine

Ph.D

Cell biology , Mechanism of Tumor Angiogenesis

Research Interests

Identification of biomarkers that predict therapeutic efficacy of molecular targeting drugs
keyword : Molecular targeting agents, gefitinib, erlotinib, EGFR
2002.04.
Molecular mechanism of tumor angiogenesis and development of therapeutic strategy
keyword : tumor angiogenesis, cancer
1992.04.

Academic Activities

Reports

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Papers

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1.	Fujii, T., Yokoyama, G., Takahashi, H., Toh, U., Kage, M., Ono, M., Shirouzu, K., and Kuwano, M.,Preclinical and Clinical Studies of Novel Breast Cancer Drugs Targeting Molecules Involved in Protein Kinase C Signaling, the Putative Metastasis-Suppressor Gene Cap43and the Y-box Binding Protein-1,Current Medicinal Chemistry,15, 528-537,2008.01.
2.	Maruyama, Y., Oie, S., Ono, M., Jimi, A., Kawahara, A., Yokoyama, T., Kage, M., Aoyagi, S., Kinoshita, H. and Kuwano, M.,Low expression of the metastasis-suppressor gene Cap43 is associated with poor prognosis in pancreatic cancer.,Cancer Res.,2006.01.
3.	Ueda, S., Basaki, Y., Yoshie, M., Ogawa, K., Sakisaka, S., Kuwano, M. and Ono, M.,PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib.,Cancer Res.,2006.01.
4.	Fotovati., A., Fujii, T., Yamaguchi, M., Kage, M., Shirouzu, K., Oie, S., Basaki, Y., Ono, M., Yamana, H. and Kuwano, M.,17-beta-Estradiol Induces Downregulation of Cap43/NDRG1/Drg-1, a Putative Differentiation-related and Metastasis Suppressor Gene, in Human Breast Cancer Cells. Clinic.,Clinic. Cancer Res.,2006.01.
5.	Fujisaki, Y., Kawamura, K., Wang, WF., Ishiwata, K., Yamamoto, F., Kuwano, T., Ono, M. and Maeda, M.,Radiosynthesis and in vivo evaluation of 11C-labeled 1,5-dairylpyrazole derivatives for mapping cyclooxygenases.,Nuclea Med.,19: 617-625,2005.01.
6.	Nakamura, H., Takamori, S., Fujii, T., Ono, M., Yamana, H., Kuwano, M. and Shirouzu, K.,Cooperative cell-growth inhibition by combination treatment with ZD1839 (Iressa) and trastuzumab (Herceptin) in non-small-cell lung cancer.,Cancer Lett.,230: 33-46,2005.01.
7.	Taron, M., Ichinose, Y., Rosell, R., Mok, T., Massuti, B., Zamora, L., Mate, J. L., Manegold, C., Ono, M., Queralt, C., Jahan, T., Sanchez, J. J., Sanchez-Ronco, M., Hsue, V., Jablons, D., Sanchez, J. M. And Maron, T.,Activating mutation in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas.,Clin. Cancer Res.,11: 5878-5885,2005.01.
8.	Nakao, S., Kuwano, T., Tsutsumi- Miyahara, C., Ueda, S., Hamano, S., Sonoda, K., Saijo, Y., Nukiwa, T., Ishibashi, T., Kuwano, M., Ono, M.,Infiltration of COX2-expressing macrophage is prerequisite for IL-1beta-induced neovascularization and tumor growth.,J. Clin. Invest.,115: 2979-2991,2005.01.
9.	Sanda, T., Kuwano, T., Nakao, S., Iida, S., Ishida, T., Komatsu, H., Shudo, K., Kuwano, M., Ono, M. and Ueda, R.,Anti-myeloma effects of a novel synthetic retinoid Am80 (Tamibarotene) through inhibition of angiogenesis.,Leukemia,19: 901-909,2005.01.
10.	Hirata, A., Ueda, S., Miyagawa, M., Naito, S., Fujii, T., Kuwano, M and Ono, M.,HER2 Overexpression Increases Sensitivity to Gefitinib, an EGF receptor tyrosine kinase inhibitor through inhibition of HER2/ HER3 heterodimer formation in lung cancer cells.,Cancer Res,65:4253-4260,2005.01.
11.	Hirata, A., Uehara, H., Izumi, K., Naito, S., Kuwano, M. and Ono, M.,Direct inhibition of EGF receptor activation in vascular endothelial cells by gefitinib (‘Iresse’, ZD1839).,Cancer Science,95: 614-618,2004.01.
12.	Ono, M., Hirata, A., Kometani, T., Miyagawa, M., Ueda, S., Kinoshita, H., Fujii, T. and Kuwano, M.,Sensitivity to gefitinib (Iressa: ZD1839) in non-small cell lung cancer cell lines correlated with dependence on the EGF receptor/ ERK1/2 and EGF receptor/ ARK pathway for proliferation.,Mol. Cancer Ther.,3: 465-472,2004.01.
13.	Kuwano, T., Nakao, S., Yamamoto, H., Tsuneyoshi, M., Yamamoto, T., Kuwano, M. and Ono, M.,Cyclooxygenase 2 is a key enzyme for inflammatory cytokinase induced angiogenesis.,FASEB J.,18: 300-310,2004.01.
14.	Jeong, S. J., Higuchi, R., Ono, M., Kuwano, M., Kim, Y. C. And Miyamoto, T.,Cis-hinokiresinol, a norlignan from Anemarrhena asphodeloides, inhibits angiogenic response in vitro and in vivo.,Biol. Pharm. Bull.,26: 1721-1724,2003.01.
15.	Jeong, S. J., Inagaki, M., Higuchi, R., Miyamoto, T., Ono, M., Kuwano, M. and Van, Soest RW.,1, 3-dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis.,Chem. Pharm. Bull.,51: 731-733,2003.01.
16.	Masuda, K., Ono, M., Okamoto, M., Morikawa, W., Otsubo, M., Migita, T., Tsuneyoshi, M., Okuda, H., Shuin, T., Naito, S. and Kuwano, M.,Down-regulation of cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells.,Int. J. Cancer,105:803-810,2003.01.
17.	Nakao, S., Kuwano, T., Ishibashi, T., Kuwano, M. and Ono, M.,Synergistic effect of TNF-alpha in soluble vascular cell adhesion molecule-1-induced angiogenesis through a4 integrins.,J. Immunol.,170:5704-5711,2003.01.
18.	Kuwano, M., Uchiumi, T., Hayakawa, H., Ono, M., Wada, M., Izumi, H. and Kohno, K.,The Basic and Clinical Implication of ABC transporters, YB-1 and Angiogenesis in Human Malignancies.,Cancer Science.,94: 9-14,2003.01.
19.	Jeong, S. J., Higuchi, R., Miyamoto, T., Ono, M., Kuwano, M. and Mawatari, S. F.,Bryoanthrathiophene, a New Antiangiogenic Constituent from the Bryozoan Watersipora subtorquata (d'Orbigny,1852).,J. Nat. Prod.,65: 1344-1345,2002.01.
20.	Jeong, S., Itokawa, T., Shibuya, M., Kuwano, M., Ono, M., Higuchi, R and Miyamoto, T.,Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway.,Cancer Lett.,187: 129-133,2002.01.
21.	Uchimiya, H., Furukawa, T., Okamoto, M., Nakajima, Y., Matsushita, S., Ikeda, R., Gotanda, T., Haraguchi, M., Sumizawa, T., Ono, M., Kuwano M., Kanzaki, T. and Akiyama, S.,Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose.,Cancer Res.,62: 2834-2839,2002.01.
22.	Itokawa, T., Nokihara, H., Nishioka, Y., Sone, S., Iwamoto, Y., Yamada, Y., Cherrington, J., McMahon, G., Shibuya, M., Kuwano, M. and Ono, M.,Antiangiogenic Effect by SU5416 Is Partly Attributable to Inhibition of Flt-1 Receptor Signaling.,Mol.Cancer.Ther.,1: 295-302,2002.01.
23.	Hirata, A., Ogawa, S., Kometani, T., Kuwano, T., Naito, S., Kuwano, M. and Ono, M.,ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase.,Cancer Res.,62: 2554-2560,2002.01.
24.	Okamoto, M., Ono, M., Uchiumi, T., Ueno, H., Kohno, K., Sugimachi, K. and Kuwano, M.,Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor beta in human cancer cells - transcriptional activation and messenger RNA stabilization.,Biochim. Biophys Acta.,1574: 24-34,2002.01.
25.	Nishie, A., Masuda, K., Otsubo, M., Migita, T., Tsuneyoshi, M., Kohno, K., Shuin, T., Naito, S., Ono, M., and Kuwano, M.,High expression of the cap43 gene in infiltrating macrophages of human renal cell carcinomas.,Clin. Cancer Res.,7: 2145-2151,2001.01.
26.	Kuwano, M., Fukushi, J., Okamoto, M., Nishie, A., Goto, H., Ishibashi, T. and Ono, M.,Anigiogenesis factors.,Int. Med.,40: 565-572,2001.01.
27.	Goto, H., Kohno, K., Sone, S., Akiyama, S., Kuwano, M. and Ono, M.,Gamma interferon-dependent induction of thymidine phosphorylase/platelet derived endothelial growth factor through gamma-activated sequence-like element in human macrophages.,Cancer Res.,61: 469-473,2001.01.
28.	Iguchi, H., Ono, M., Matsushima, K. and Kuwano, M.,Overproduction of IL-8 results in suppression of bone metastasis by lung cancer cells in vivo.,Int. J. Oncol.,17: 329-333,2000.01.
29.	Morikawa, W., Yamamoto, K., Ishikawa, S., Takemoto, S., Ono, M., Fukushi, J., Naito, S., Nozaki, C., Iwanaga, S. and Kuwano, M.,Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells.,J. Biol.Chem.,275: 38912-38920,2000.01.
30.	Fukushi, J., Ono, M., Morikawa, W., Iwamoto,,The activity of soluble VCAM-1 in angiogenesis stimulated by IL-4 and IL-13.,J. Immunol.,165: 2818-2823,2000.01.
31.	Torisu, H-I., Furue, M., Kuwano, M. and Ono, M.,Co-expression of thymidine phosphorylase and heme oxygenase-1 in macrophages in human malignant vertical growth melanomas.,Jpn. J. Cancer Res.,91: 906-910,2000.01.
32.	Torisu, H., Ono, M., Kiryu, H., Furue, M., Ohmoto, Y., Nakayama, J., Nisioka, Y., Sone, S. and Kuwano, M.,Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNF-alpha and IL-1beta,Int. J. Cancer,85: 182-188,2000.01.
33.	Ogawa, S., Yoshida, S., Ono, M., Onoue, H., Ito, Y., Ishibashi, T., Inomata, H. and Kuwano, M.,Induction of macrophage inflammatory protein-1alpha and vascular endothelial growth factor during inflammatory neovascularization in the mouse cornea.,Angiogenesis,3: 327-334,1999.01.
34.	Kawabe, T., Chen, Z., Wada, M., Uchiumi, T., Ono, M., Akiyama, S. and Kuwano, M.,Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter(cMOAT/MRP2),FEBS Lett.,456: 327-331,1999.01.
35.	Nishie, A., Ono, M., Shono T., Fukushi, J., Otsubo, M., Onoue, H., Ito, Y., Inamura, T., Ikezaki, K., Fukui, M., Iwaki, T., and Kuwano, M.,Macrophage infiltration and heme oxygenase-1 expression correlate with angiogenesis in human gliomas.,Clin Cancer Res.,5: 1107-1113,1999.01.
36.	Ono, M., Torisu, H., Fukushi, J., Nishie, A. and Kuwano, M.,Biological implications of macrophage infiltration in human tumor angiogenesis.,Cancer Chemother Pharmacol.,43(suppl): s69-s71,1999.01.
37.	Shono, T., Motoyama, M., Tatsumi, K., Ulbrich, N., Iwamoto, Y., Kuwano, M. and Ono, M.,A new synthetic matrix metalloproteinase inhibitor modulates both angiogenesis and urokinase type plasminogen activator activity.,Angiogenesis,2: 319-329,1998.01.
38.	Goto, D., Izumi, H., Ono, M., Okamoto, T., Kohno, K. and Kuwano, M.,Tubular morphogenesis by genotoxic therapeutic agents that induce NF-kB activation in human vascular endothelial cells.,Angiogenesis,2:345-356,1998.01.
39.	Fukushi, J., Morisaki, T., Shono, T., Nishie, T., Torisu, H., Ono, M. and Kuwano, M.,Novel biological functions of interleukin-4: Formation of tube-like structures by vascular endothelial cells in vitro and angiogenesis in vivo.,Biochem. Biophys. Res. Commun.,250: 444-448,1998.01.
40.	Kawahara, N., Ono, M., Taguchi, K., Okamoto, M., Shimada, M., Takenaka, K., Hayashi, K., Mosher, D.F., Sugimach, K., Tsuneyoshi, M. and Kuwano, M.,Enhanced expression of thrombospondin-1 and hypovascularity in human cholangiocarcinoma,Hepatology,28: 1512-1517,1998.01.

Presentations

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Membership in Academic Society

The japanese society for morecular cell biology of macrophages

Educational Activities

Graduate school & under graduate school : tumor biology

Professional and Outreach Activities

Attending at lecture meetings at the Oita Prefectural Hospital to give a presentation on molecular targeted drugs once or twice a year.

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