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Ryuichi Tatsumi Last modified date:2017.05.16

Associate Professor / Animal & Mairne Bioresource Sciences
Department of Bioresource Sciences
Faculty of Agriculture


Graduate School
Undergraduate School


E-Mail
Homepage
http://www.agr.kyushu-u.ac.jp/biosci-biotech/chikusan/
Brief sketch of research faculty, projects and activities .
Phone
092-642-2950
Fax
092-642-2951
Academic Degree
Ph.D.
Field of Specialization
Muscle Cell Biology, Muscle and Meat Biochemistry, Mechanobiology
Outline Activities
Outline of research:
1) Molecular mechanism of meat tenderlization during postmortem aging of meat.
Giant myofibrillar proteins connectin (also called titin, 3000 kDa) and nebulin (800 kDa) have been shown to split into subfragments through the binding of calcium ions to their filamentous molecules, beeing responsible for meat tenderlization during postmortem aging.

2) Gene expression analysis of giant myofibrillar proteins during neonatal myogenesis.
Giant myofibrillar proteins connectin and nebulin were evaluated for their gene expression during neonatal myogenesis. In this precess, we have found a new lipoprotein having a chain weight of 500 kDa, and reported its characterization and localization in skeletal muscle tissue.

3) Molecular mechanism of postnatal muscle growth and regeneration.
Satellite cells, resident myogenic stem cells found between the basement membrane and the sarcolemma, are normally quiescent most of the time in adult skeketal muscle. When muscle is injured, overused or mechanically stretched, these cells are activated to enter the cell cycle, divide, differentiate and fuse with muscle fibers to repair damaged regions and to enhance hypertrophy of muscle fibers. We have shown that hepatocyte growth factor (HGF) is present in extracellular matrix of uninjured adult muscle and that HGF can activate quiescent satellite cells through its rapid release from the extracellular association and its subsequent presentation to the c-met receptor (Tatsumi et al. 1998, Dev. Biol.; 2001, Exp. Cell Res). HGF release was dependent on calcium-calmodulin formation and nitric oxide (NO) production by NO syntase in response to mechanical perturbation of muscle (Tatsumi et al. 2002, Mol. Biol. Cell) . According to these findinds, we have proposed a activation cascade to translate mechanical changes in muscle tissue into chemical signals that can activate satellite cells.

Education:
Seminars and lectures in Bioscience and Biotechnology at undergraduate and graduate levels.

Others:
a member of Kyushu University Research Core "Food Safety and Healthy Life (Research Head: Prof. Imaizumi, K.)" (Oct. 2004-).
Research
Research Interests
  • Molecular mechanisms for satellite cell activation entry into the cell cycle
    keyword : muscle hypertrophy, regeneration, HGF, satellite cells, activation, NO radical, NOS, calmodulin, calcium ions, proteoglycan, MMP, myofiber, skeletal muscle
    1996.02Research Title: Molecular Mechanism of Mechanical Perturbation-induced Activation of Skeletal Muscle Satellite Cells..
  • Molecular mechanisms for satellite cell quiescence
    keyword : muscle hypertrophy, regeneration, satellite cells, activation, quiescence, myostatin (GDF8), proteoglycan, myofiber, skeletal muscle, meat
    2003.09Research Title: Molecular Mechanism of Muscle Satellite Cell Quiescence and its application to Skeletal Muscle Hypertrophy and Regeneration..
  • Possible Changes in Muscle Fiber Types by Functional Food Ingredients.
    keyword : fiber types, satellite cells, myotubes, beef extract, polyphenol
    2005.04Research Title: Possible Changes in Muscle Fiber Types by Functional Food Ingredients..
  • New role of muscle satellite cells: implication in regenerative motoneuritogenesis
    keyword : muscle hypertrophy, regeneration, satellite cells, neurochemorepellent, myofiber, skeletal muscle, ALS
    2007.04Research Title: Molecular Mechanism of Motor Neuron Network Formation in Skeletal Muscle..
Current and Past Project
  • Research Title: Possible Local Communocation between Myogenic Stem Cells and Motoneuron Terminals.
    Abstract: Regenerative coordination and remodeling of the intramuscular motoneuron network and neuromuscular connections are critical for restoring skeletal muscle function and physiological properties. The regulatory mechanisms of such coordination remain unclear, although both attractive and repulsive axon guidance molecules may be involved in the signaling pathway. Recent our studies highlight a heretofore unexplored and active role for satellite cells as a key source of neural secreted chemorepellent Sema3A expression triggered by HGF, hence suggesting that regenerative activity toward motor innervation may importantly reside in satellite cells and could be a crucial contributor during postnatal myogenesis (Tatsumi et al. 2009, American Journal of Physiology-Cell Physiology 297, C238-C252, selected for the Editorial Focus.)
  • Research Title: Molecular Mechanism of Muscle Satellite Cell Quiescence.
    Abstract: Skeletal muscle regeneration and work-induced hypertrophy rely on molecular events responsible for activation and quiescence of resident myogenic stem cells, satellite cells. Recent studies demonstrated that hepatocyte growth factor (HGF) triggers activation and entry into the cell cycle in response to mechanical perturbation, and that subsequent expression of myostatin may signal a return to cell quiescence. However, mechanisms responsible for coordinating expression of myostatin after an appropriate time-lag following activation and proliferation are not clear. Our recent publications demonstrated that HGF could induce satellite cell quiescence by stimulating myostatin expression. The HGF concentration required (over 10-50 ng/ml), however, is much higher than that for activation. Considering that HGF is produced by satellite cells and spleen and liver cells in response to muscle damage, local concentrations of HGF bathing satellite cells may reach a threshold sufficient to induce myostatin expression. This time-lag may delay action of the quiescence signaling program in proliferating satellite cells during initial phases of muscle regeneration followed by induction of quiescence in a subset of cells during later phases (Yamada et al. 2010. American Journal of Physiology-Cell Physiology 298, C465–C476, selected for the Editorial Focus).
  • Research Title: Molecular Mechanism of Mechanical Perturbation-Induced Activation of Muscle Satellite Cells.
    Abstract: In undamaged postnatal muscle fibers with normal contraction and relaxation activities, quiescent satellite cells of resident myogenic stem cells are interposed between the overlying external lamina and the sarcolemma of a subjacent mature muscle fiber. When muscle is injured, exercised, overused or mechanically stretched, these cells are activated to enter the cell proliferation cycle, divide, differentiate, and fuse with the adjacent muscle fiber, and are responsible for regeneration and work-induced hypertrophy of muscle fibers. Therefore, a mechanism must exist to translate mechanical changes in muscle tissue into chemical signals that can activate satellite cells. Recent studies of satellite cells or single muscle fibers in culture and in vivo demonstrated the essential role of hepatocyte growth factor (HGF) and nitric oxide (NO) radical in the activation pathway. These experiments have also reported that mechanically stretching satellite cells or living skeletal muscles triggers the activation by rapid release of HGF from its extracellular tethering and the subsequent presentation to the receptor c-met. HGF release has been shown to rely on calcium-calmodulin formation and NO radical production in satellite cells and/or muscle fibers in response to the mechanical perturbation, and depend on the subsequent up-regulation of matrix metalloproteinase (MMP) activity. These results indicate that the activation mechanism is a cascade of events including calcium ion influx, calcium-calmodulin formation, NO synthase activation, NO radical production, MMP activation, HGF release and binding to c-met. Better understanding of ‘mechano-biology’ on the satellite cell activation is essential for designing procedures that could enhance muscle growth and repair activities in meat-animal agriculture and also in neuromuscular disease and aging of human (Tatsumi & Allen 2008, Animal Science Journal 79, 279-290, invited review; Tasumi 2010, Animal Science Journal 81, 11-20, invited review).
Academic Activities
Reports
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5. Tatsumi, R. (2007) Improvement of Age-Related Sarcopenia by Functional Food Ingredients., The Research Reports of the Uehara Memorial Foundation, 21, 92-94..
6. Tatsumi, R. and Ikeuchi, Y. (2005) More shine to Meat Production: a Programmed Cascade for Muscle Satellite Cell Activation and Quiescence. Proceedings of Japanese Society for Animal Nutrition and Metabolism, 49(1), 1-19..
7. Tatsumi, R. (2001) Molecular Mechanism of Muscle Satellite Cell Activation., Shokuniku-no-Kagaku 42 (2), 123-133..
8. Tatsumi, R. (1997) Activation of Muscle Stem Cells, Kagaku-to-Seibutsu 35(4), 295-297..
Papers
1. Wataru Mizunoya, Shinpei Okamoto, Hideo Miyahara, Mariko Akahoshi, Takahiro SUZUKI, Mai-Khoi Q. Do, Hideaki Ohtsubo, Yusuke Komiya, Mulan Qahar, Toshiaki Waga, Koichi Nakazato, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi Tatsumi, Fast-to-slow shift of muscle fiber-type composition by dietary apple polyphenols in rats: Impact of the low-dose supplementation, Animal Science Journal, 88, 3, 10.1111/asj.12655, 2017.04.
2. Judy E. Anderson, Mai-Khoi Q. Do, N. Daneshvar, Takahiro SUZUKI, J. Dort, Wataru Mizunoya, Ryuichi Tatsumi, The role of semaphorin 3A in myogenic regeneration and the formation of functional neuromuscular junctions on new fibers, Biological Reviews, 10.1111/brv.12286, 2017.04.
3. Hideaki Ohtsubo, Yusuke Sato, Takahiro SUZUKI, Wataru Mizunoya, Mako Nakamura, Ryuichi Tatsumi, Yoshihide Ikeuchi, Data supporting possible implication of APOBEC2 in self-renewal functions of myogenic stem satellite cells: toward understanding the negative regulation of myoblast differentiation, Data in Brief, 10.1016/j.dib.2017.03.051, 2017.04.
4. Hideaki Ohtsubo, Yusuke Sato, Takahiro SUZUKI, Wataru Mizunoya, Mako Nakamura, Ryuichi Tatsumi, Yoshihide Ikeuchi, APOBEC2 negatively regulates myoblast differentiation in muscle regeneration, International Journal of Biochemistry and Cell Biology , 85, 10.1016/j.biocel.2017.02.005, 2017.03.
5. Mai-Khoi Q. Do, Naomi Shimizu, Takahiro Suzuki, Hideaki Ohtsubo, Wataru Mizunoya, Mako Nakamura, Shoko Sawano, Mitsuhiro Furuse, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi Tatsumi, Transmembrane proteoglycans syndecan-2, 4, receptor candidates for the impact of HGF and FGF2 on semaphorin 3A expression in early-differentiated myoblasts, Physiological Reports, 3, 9, e12553, 2015.09.
6. Wataru Mizunoya, Hideo Miyahara, Shinpei Okamoto, Mariko Akahoshi, Takahiro Suzuki, Mai-Khoi Q. Do, Hideaki Ohtsubo, Yusuke Komiya, Mu Lan, Toshiaki Waga, Akira Iwata, Koichi Nakazato, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi Tatsumi, Improvement of endurance based on muscle fiber-type composition by treatment with dietary apple polyphenols in rats, PLoS ONE, 10, 7, e0134303, 2015.07.
7. Shoko Sawano, Takahiro Suzuki, Mai-Khoi Q. Do, Hideaki Ohtsubo, Wataru Mizunoya, Yoshihide Ikeuchi, Ryuichi Tatsumi, Supplementary immunocytochemistry of hepatocyte growth factor production in activated macrophages early in muscle regeneration, Animal Science Journal, 85, 12, 2014.12.
8. Shohei Sakaguchi, Jun-ichi Shono, Takahiro Suzuki, Shoko Sawano, Judy E. Anderson, Mai-Khoi Q. Do, Hideaki Ohtsubo, Wataru Mizunoya, Mako Nakamura, Mitsuhiro Furuse, Yoshihide Ikeuchi, Ryuichi Tatsumi, Anti-inflammatory macrophages implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression, Animal Science Congress 2014 of the Asian-Australian Association of Animal Production Societies (AAAP) Grha Sabha Pramana, Universitas Gadjah Mada (UGM), Yogyakarta, Indonesia (November 10-14, 2014), 2014.11.
9. Tatsumi, R.,* Sakaguchi, S.,* Shono, J.,* Suzuki, T.,* Sawano, S., Anderson, J.E., Do, M.-K.Q., Ohtsubo, H., Mizunoya, W., Nakamura, M., Furuse, M., and Ikeuchi, Y. (*equal contributors), M2 macrophages may implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression, 2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells” Steamboat Springs, CO, USA (July 20-25, 2014), 2014.07.
10. Suzuki, T., Ohya, Y., Ojima, K., Mizunoya, W., Sawano, S., Ohtsubo, H., Nishimatsu, S., Anderson, J. E., Do, M.-K. Q., Nakamura, M., Furuse, M., Ikeuchi, Y., Nohno, T., and Tatsumi, R., Sema3A secreted from satellite cells promotes slow-twitch fiber generation, 2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells” Steamboat Springs, CO, USA (July 20-25, 2014), 2014.07.
11. Ryuichi Tatsumi, Investigating muscle regeneration: The secret of Sema3A, International Innovation, 139, 2014.06.
12. Shohei Sakaguchi, Jun-ichi Shono, Takahiro Suzuki, Shoko Sawano, Judy E. Anderson, Mai-Khoi Q. Do, Hideaki Ohtsubo, Wataru Mizunoya, Yusuke Sato, Mako Nakamura, Mitsuhiro Furuse, Koji Yamada, Yoshihide Ikeuchi, Ryuichi A Tatsumi, Implication of anti-inflammatory macrophages in regenerative moto-neuritogenesis: promotion of myoblast migration and neural chemorepellent semaphorin 3A expression in injured muscle, International Journal of Biochemistry and Cell Biology, 54, 2014.06.
13. Jun-ichi Shono, Shohei Sakaguchi, Takahiro Suzuki, Mai-Khoi Q. Do, Wataru Mizunoya, Mako Nakamura, Yusuke Sato, Mitsuhiro Furuse, Koji Yamada, Yoshihide Ikeuchi, Ryuichi A Tatsumi, Preliminary Time-Course Study of Antiinflammatory Macrophage Infiltration in Crush-Injured Skeletal Muscle, Animal Science Journal, 84, 11, 2013.11.
14. Takahiro Suzuki, Koichi Ojima, Mai-Khoi Q. Do, Minako Hara, Wataru Mizunoya, Mako Nakamura, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi Tatsumi, Semaphorin 3A secreted from myogenic stem cells promotes slow-twitch muscle fiber generation, 2013 EMBO Workshop on “Semaphorin Function and Mechanism in Action”, Cemay-la-Ville, France (October 29-31, 2013), 2013.10.
15. Ryuichi Tatsumi, Judy E. Anderson, Ronald E. Allen, Muscle regeneration dynamics mediated by resident myogenic stem cells: a possible implication in moto-neuritogenesis and fiber-type regulation, Tucson Symposium 2013 on “The Biology of Muscle Growth and Repair”, 2013.09.
16. Yusuke Sato, Mai-Khoi Q. Do, Takahiro Suzuki, Hideaki Ohtsubo, Wataru Mizunoya, Mako Nakamura, Mitsuhiro Furuse, Yoshihide Ikeuchi, Ryuichi A Tatsumi, Satellite Cells Produce Neural Chemorepellent Semaphorin 3A upon Muscle Injury, Animal Science Journal, 84, Listed on ScienceAlerts.com, 2013.02.
17. Takahiro Suzuk, Mai-Khoi Q. Do, Yusuke Sato, Koichi Ojima, Minako Hara, Wataru Mizunoya, Mako Nakamura, Mitsuhiro Furuse, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi A Tatsumi, Comparative Analysis of Semaphorin 3A in Soleus and EDL Muscle Satellite Cells In Vitro toward Understanding Its Role in Modulating Myogenin Expression, International Journal of Biochemistry and Cell Biology, 45, 2, 476-482, Listed on ScienceAlerts.com, 2013.02.
18. Mai-Khoi Q. Do, Takahiro Suzuki, Borjigin Gerelt, Yusuke Sato, Wataru Mizunoya, Mako Nakamura, Yoshihide Ikeuchi, Judy E. Anderson, and Ryuichi Tatsumi, Time-Coordinated Prevalence of Extracellular HGF, FGF2 and TGF-β3 in Crush-Injured Skeletal Muscle, Animal Science Journal, 83, 712-717, 2012.10.
19. Tatsumi, R.,* Hara, M.,* Tabata, K.,* Suzuki, T., Do, M.-K. Q., Mizunoya, W., Nakamura, M., Ikeuchi, Y., Anderson, J. E., and Allen, R. E. (*equal contributors), Mechano-Sensing Calcium-Influx Machinery that Instigates Skeletal Muscle Satellite Cell Activation, 2012 FASEB Science Research Conference on “Skeletal Muscle Satellite & Stem Cells", Lucca, Italy, 2012.08.
20. Suzuki, T., Ojima, K., Do, M.Q., Hara, M., Mizunoya, W., Nakamura, M., Ikeuchi, Y., Anderson, J.E. and Tatsumi, R., Semaphorin 3A regulates the early differentiation of satellite cells, 2012 FASEB Science Research Conference on “Skeletal Muscle Satellite & Stem Cells", Lucca, Italy, 2012.08.
21. Do, M.Q., Shimizu, N., Suzuki, T., Mizunoya, W., Nakamura, M., Ikeuchi, Y., Anderson, J.E. and Tatsumi, R., Heparan/chondroitin sulfate chains may mediate HGF/FGF2-induced up-regulation of neural chemorepellent Sema3A in satellite cell cultures, 2012 FASEB Science Research Conference on “Skeletal Muscle Satellite & Stem Cells", Lucca, Italy, 2012.08.
22. Komiya, Y., Mizunoya, W., Anderson, J.E., Goto, T., Takahashi, N., Kawada, T., Sato, Y., Nakamura, M., Tatsumi, R., and Ikeuchi, Y., Change of skeletal muscle fiber types by n-3 poly unsaturated fatty acid, 2012 FASEB Science Research Conference on “Skeletal Muscle Satellite & Stem Cells", Lucca, Italy, 2012.08.
23. Minako Hara, Kuniko Tabata, Takahiro Suzuki, Mai-Khoi Q. Do, Wataru Mizunoya, Mako Nakamura, Shotaro Nishimura, Shoji Tabata, Yoshihide Ikeuchi, Kenji Sunagawa, Judy E. Anderson, Ronald E. Allen, and Ryuichi Tatsumi, Calcium Influx through a Possible Coupling of Cation Channels Impacts Skeletal Muscle Satellite Cell Activation in Response to Mechanical Stretch, American Journal of Physiology-Cell Physiology, 2012年3月26日掲載受理、セットで先行公開, 2012.03.
24. Do, M.-K. Q., Sato, Y., Shimizu, N., Suzuki, T., Shono, J.-I., Mizunoya, W., Nakamura, M., Ikeuchi, Y., Anderson, J. E., and Tatsumi, R., Growth Factor Regulation of Neural Chemorepellent Sema3A Expression in Satellite Cell Cultures, American Journal of Physiology-Cell Physiology, 301, C1270-C1279, Listed on the March edition of Global Medical Discovery Series, 2011.11.
25. Tatsumi, R., Mizunoya, W., Ikeuchi, Y., Hattori, A., Anderson, J. E., and Allen, R. E., Mechano-Biology of Resident Myogenic Stem Cells: Implication in Postnatal Myogenesis and Intramuscular Motoneuritogenesis, Animal Science Congress 2010 of the Asian-Australian Association of Animal Production Societies (AAAP), National Pingtung University of Science and Technology (NPUST), Pingtung, Taiwan , 2010.08.
26. Tatsumi, R.,* Do, M.-K. Q.,* Shimizu, N.,* Sankoda, Y.,* Anderson, J. E., Sato, Y., Suzuki, T., Mizunoya, W., Ikeuchi, Y., and Allen, R. E. (*equal contributors), Possible Implication of Satellite Cells in Regenerative Motoneuritogenesis: HGF and FGF2 Upregulate Neural Chemorepellent Sema3A Expression, Theme 3: Tissue Mechanics, Track 3.6 Muscle Mechanics and Motor Control, at the 6th World Congress on Biomechanics (WCB) 2010, in conjunction with the 14th International Conference on Biomedical Engineering (ICBME) 2010 and the 5th Asian Pacific Conference on Biomechanics (APBiomech) 2010, Suntec Convention and Exhibition Center, Singapore , 2010.08.
27. Tatsumi, R., Anderson, J. E. and Allen, R. E.., Mechano-Biology on Stretch-Induced Activation of Resident Myogenic Stem Cells, Symposium on “Muscle Injury” section at the 6th World Congress on Biomechanics (WCB) 2010, in conjunction with the 14th International Conference on Biomedical Engineering (ICBME) 2010 and the 5th Asian Pacific Conference on Biomechanics (APBiomech) 2010, Suntec Convention and Exhibition Center, Singapore , 2010.08.
28. Do, M.-K. Q.,* Shimizu, N.,* Sato, Y., Suzuki, T., Tatsumi, R., Mizunoya, W., Ikeuchi, Y., Anderson, J. E., and Allen, R. E. (*equal contributors), Possible Implication of Satellite Cells in Regenerative Motoneuritogenesis: Temporal Coordination of HGF/FGF-2/TGF-beta may Regulate Neural Chemorepellent Sema3A expression, 2010 FASEB Summer Research Conference on “Skeletal Muscle Satellite & Stem Cells", Carefree, AZ, US, 2010.07.
29. Suzuki, T., Takaishi, H., Sakata, T., Do, M. Q., Hara, M., Sato, A., Mizunoya, W., Nishimura, T, Hattori, A., Ikeuchi, Y., and Tatsumi, R., In Vitro Measurement of Postnatal Changes in Proliferating Satellite Cell Frequency during Rat Muscle Growth, Animal Science Journal, 81, 2, 245-251, 2010.04.
30. Sato, Y., Probst, H. C., Tatsumi, R., Ikeuchi, Y., Neuberger, M. S., and Rada, C., Deficiency in APOBEC2 Leads to a Shift in Muscle Fiber Type, Diminished Body Mass and Myopathy, Journal of Biological Chemistry, 285, 7111-7118 , 2010.03.
31. Yamada, M., Tatsumi, R., Yamanouchi, K., Hosoyama, T., Shiratsuchi, S., Sato, A., Mizunoya, W., Ikeuchi, Y., Furuse, M., and Allen, R. E. , High Concentrations of HGF Inhibit Skeletal Muscle Satellite Cell Proliferation In Vitro By Inducing Expression of Myostatin: A Possible Mechanism for Re-Establishing Satellite Cell Quiescence In Vivo. , American Journal of Physiology-Cell Physiology, 298, C465–C476 , Editorial Focusに選定, 2010.03.
32. Ryuichi A Tatsumi, Mechano-Biology of Skeletal Muscle Hypertrophy and Regeneration: Possible Mechanism of Stretch-Induced Activation of Resident Myogenic Stem Cells, Animal Science Journal, 81, 11-20, invited review, 2010.01.
33. Ryuichi Tatsumi, Yoriko Sankoda, Judy E. Anderson, Yusuke Sato, Wataru Mizunoya, Naomi Shimizu, Takahiro Suzuki, Michiko Yamada, Robert P. Rhoads, Jr., Yoshihide Ikeuchi, and Ronald E. Allen, Possible Implication of Satellite Cells in Regenerative Motoneuritogenesis: HGF Up-Regulates Neural Chemorepellent Sema3A during Myogenic Differentiation, American Journal of Physiology-Cell Physiology, 297, C238-C252, Editorial Focusに選定, 2009.08.
34. Sato, Y., Shimizu, M., Mizunoya, W., Wariishi, H., Tatsumi, R., Buchman, V. L., and Ikeuchi, Y. , Differential Expression of Sarcoplasmic and Myofibrillar Proteins of Rat Soleus Muscle during Denervation Atrophy, Bioscience, Biotechnology and Biochemistry, 73, 1748-1756, 2009年度BBB論文賞を受賞, 2009.06.
35. Sato, Y., Shimizu, M., Mizunoya, W., Tatsumi, R., Probst, H., Rada, C., Neuberger, M. S., and Ikeuchi, Y., Skeletal Muscle Fiber Type Change and Myopathy in APOBEC-2 KO Mouse, A Joint meeting of Frontiers in Myogenesis and Skeletal Muscle Satellite and Stem Cells, 2009.05.
36. Yamada, M., Tatsumi, R., Mizunoya, W., Ikeuchi, Y., and Allen, R. E., HGF Induces Myostatin Expression and the Subsequent Satellite Cell Quiescence in a Neuropilin-1 Dependent Manner, A Joint meeting of Frontiers in Myogenesis and Skeletal Muscle Satellite and Stem Cells, 2009.05.
37. Tatsumi, R., Sankoda, Y., Anderson, J. E., Sato, Y., Mizunoya, W., Shimizu, N., Suzuki, T., Yamada, M., Rhoads, R. P., Jr., Ikeuchi, Y., and Allen, R. E. , A Possible Role for Satellite Cells in Regenerative Motoneurogenesis: HGF Up-Regulates Neural Chemorepellent Sema3A Expression, A Joint meeting of Frontiers in Myogenesis and Skeletal Muscle Satellite and Stem Cells, 2009.05.
38. Tatsumi, R., Wuollet, A. L., Tabata, K., Nishimura, S., Tabata, S., Mizunoya, W., Ikeuchi, Y., and Allen, R. E., A Role for Calcium-Calmodulin in Regulating Nitric Oxide Production during Skeletal Muscle Satellite Cell Activation, American Journal of Physiology-Cell Physiology, 296, C922-C929, 2009.03.
39. Yamada, M., Shiratsuchi, S.-I., Tatsumi, R., Mizunoya, W., Ikeuchi, Y., and Allen, R. E., A Receptor Neuropilin-1 Mediates HGF-Induced Muscle Satellite Cell Quiescence, The American Society for Cell Biology 48th Annual Meeting, 2008.12.
40. Yamada, M., Sankoda, Y., Tatsumi, R., Mizunoya, W., Ikeuchi, Y., Sunagawa, K., and Allen, R. E., Matrix Metalloproteinase-2 Mediates Stretch-Induced Activation of Skeletal Muscle Satellite Cells in A Nitric Oxide Dependent Manner, International Journal of Biochemistry and Cell Biology, 40, 2183-2191., 2008.07.
41. Tatsumi, R. and Allen, R.E., Mechano-Biology of Resident Myogenic Stem Cells: Molecular Mechanism of Stretch-Induced Activation of Satellite Cells., Animal Science Journal, 79, 279-290; invited review, 2008.05.
42. Yamada, M., Sankoda, Y., Tatsumi, R., Mizunoya, W., Ikeuchi, Y., and Allen, R. E., Matrix Metalloproteinase-2 Is Involved In Mechanical Stretch-Induced Activation of Skeletal Muscle Satellite Cells., 2007 FASEB Summer Research Conference on “Skeletal Muscle Satellite & Stem Cells, 2007.07.
43. Sato, Y., Shimizu, M., Mizunoya, W., Wariishi, H., Tatsumi, R., and Ikeuchi, Y. , Differential Expression of Sarcoplasmic and Myofibrillar Proteins of Rat Soleus Muscle during Denervation Atrophy., Adult Skeletal Muscle Symposium: Growth, Function and Motility , 2007.06.
44. Mizunoya, Y., Okamoto, S., Wakamatsu, J.-I., Sonoda, Y., Sekiguchi, T., Waga, T., Tatsumi, R., and Ikeuchi, Y. , Food Components Do Affect Skeletal Muscle Mass and Fiber Types: Effects of Beef Extract and Apple Polyphenol. , Adult Skeletal Muscle Symposium: Growth, Function and Motility , 2007.06.
45. Tatsumi, R., Yamada, M., Katsuki, Y., Okamoto, S., Ishizaki, J., Muzunoya, W., Ikeuchi, Y., Hattori, A., Shimokawa, H., and Allen, R. E., Low-pH Preparation of Skeletal Muscle Satellite Cells Can be Used to Study Activation In Vitro., International Journal of Biochemistry and Cell Biology, 38, 1678-1685, 2006.08.
46. Tatsumi, R., Liu, X., Pulido, A., Morales, M., Sakata, T., Dail, S., Hattori, A., Ikeuchi, Y., and Allen, R. E., Satellite Cell Activation in Stretched Skeletal Muscle and The Role of Nitric Oxide and Hepatocyte Growth Factor., American Journal of Physiology-Cell Physiology, 290, 1487-1494, 2006.06.
47. Yamada, M., Tatsumi, R., Kikuiri, T., Okamoto, S., Nonoshita, S., Mizunoya, W., Ikeuchi, Y., Shimokawa, H., Sunagawa, K., and Allen, R. E., Matrix Metalloproteinases are Involved in Mechanical Stretch-Induced Activation of Skeletal Muscle Satellite Cells., Muscle & Nerve, 34, 313-319, 2006.04.
48. Sakata, T., Tatsumi, R., Yamada, M., Shiratsuchi, S., Okamoto, S., Mizunoya, W., Hattori, A., and Ikeuchi, Y., Preliminary Experiments on Mechanical Stretch-Induced Activation of Skeletal Muscle Satellite Cells In Vivo., Animal Science Journal, 77, 518-525, 2006.04.
49. Yamada, M., Tatsumi, R., Okamoto, S., Nonoshita, S., Mizunoya, W., Ikeuchi, Y., and Allen, R. E., Mechanical Stretch-Induced Activation of Skeletal Muscle Satellite Cells Requires Matrix Metalloproteinase Activity., FRONTIERS IN MYOGENESIS, the meeting of the Society for Muscle Biology, 2006.04.
50. Ryuichi Tatsumi, Keitaro Yamanouchi, Toru Hosoyama, Sei-ichi Shiratsuchi, Michiko Yamada, Jun-ichiro Wakamatsu, Wataru Mizunoya, Yoshihide Ikeuchi, and Ronald E. Allen, A Possible Mechanism of Muscle Satellite Cell Quiescence: HGF Induces Myostatin Expression and Secretion., FASEB Summer Research Conference 2005, 4rd International Conference on Skeletal Muscle & Stem Cells, 2005.06.
51. Tatsumi, R. and Allen, R.E., Active Hepatocyte Growth Factor Is Present in Skeletal Muscle Extracellular Matrix, Muscle & Nerve, 30, 5, 30, 654-658, 2004.11.
52. Mendias, C., Tatsumi, R., and Allen, R.E., Role of Cyclooxygenase-1 and -2 in Satellite Cell Proliferation, Differentiatio, and Fusion, Muscle & Nerve, 30, 4, 30, 497-500, 2004.10.
53. Tatsumi, R., Mitsuhashi, K., Ashida, K., Haruno, A., Hattori, A., Ikeuchi, Y., and Allen, R.E., Comparative Analysis of Mechanical Stretch-Induced Activation Activity of Back and Leg Muscle Satellite Cells In Vitro, Animal Science Journal, 75, 345-351, 2004.08.
54. Tatsumi, R. and Allen, R.E., Satellite Cell Activation in Response to Muscle Stretch and Damage, FASEB Summer Research Conference 2003, 3rd International Conference on Muscle Satellite & Stem Cells, 2003.07.
55. Allen, R.E. and Tatsumi, R., Satellite Cell Activation in Response to Muscle Damage, Molecular Biology of Muscle Development and Regeneration, 2003.05.
56. Tatsumi, R., Hattori, A., Ikeuchi, Y., Anderson, J. E., and Allen, R. E., Release of Hepatocyte Growth Factor from Mechanical Stretched Skeletal Muscle Satellite Cells and the Role of pH and Nitric Oxide, Molecular Biology of the Cell, 13, 8, 13, 2909-2918, 2002.12.
57. Tatsumi, R., Hattori, A., Allen, R. E., Ikeuchi Y., and Ito, T., Mechanical Stretch-Induced Activation of Skeletal Muscle Satellite Cells Is Dependent on Nitric Oxide Production, Animal Science Journal, 73, 235-239, 2002.12.
58. Tatsumi, R., Maeda, K., Hattori, A., and Takahashi, K., Calcium Binding to an Elastic Portion of Connectin/Titin Filaments, Journal of Muscle Research and Cell Motility, 22, 149-162, 2001.12.
59. Tatsumi, R., Sheehan, S. M., Iwasaki, H., Hattori, A., and Allen, R. E., Mechanical Stretch Induces Activation of Skeletal Muscle Satellite Cells In Vitro, Experimental Cell Research, 267, 107-114, 2001.12.
60. Tatsumi, R., Sakata, T., Sheehan, S.M., Hattori, A., and Allen, R.E., Mechanical Stretch-Induced Activation of Skeletal Muscle Satellite Cells: the Possible Role of HGF in the Mechanism, FASEB Summer Research Conference 2000, 2nd International Conference on Muscle Satellite & Stem Cells, 2001.07.
61. Sheehan, S. M., Tatsumi, R., Temm-Grove, C.J., and Allen, R. E., HGF is an Autocrine Growth Factor for Skeletal Muscle Satellite Cells In Vitro, Muscle & Nerve, 23, 239-245, 2000.12.
62. Tatsumi, R., Sheehan, S.M., Iwasaki, H., Hattori, A., and Allen, R.E., Mechanical Stretch Induces Activation of Skeletal Muscle Satellite Cells In Vitro., 2000 Keystone Symposia on the Molecular Biology of Muscle Development and Disease, 2000.05.
63. Tatsumi, R., Anderson, J. E., Nevoret, C. J., Halevy, O., and Allen, R. E., HGF/SF is Present in Normal Adult Skeletal Muscle and Is Capable of Activating Satellite Cells, Developmental Biology, 194, 114-128., 1998.12.
64. Allen, R.E. and Tatsumi, R., Satellite Cell Activation and the Role of Hepatocyte Growth Factor/Scatter Factor, Post-natal Myogenesis: Satellite Cells In Action, 1998.08.
65. Tatsumi, R., Shimada, K., and Hattori, A., Fluorescence Detection of Calcium-Binding Proteins with Quinoline Ca-Indicator Quin2, Analytical Biochemistry, 254, 126-131, 1997.01.
Presentations
1. 鈴木貴弘, 西松伸一郎, 寺田久美子, 片瀬直樹, 濃野 勉, 水野谷 航, 池内 義秀, 辰巳 隆一, 筋幹細胞特異的 Sema3A cKO マウスの解析, 第119回日本畜産学会大会, 2015.03.29.
2. ド マイコイ, 水野谷 航, 尾嶋孝一, 中村 真子, 池内 義秀, 辰巳 隆一, Sema3A ligand secreted from satellite cells promotes aneural nAChR clustering, 第119回日本畜産学会大会, 2015.03.29.
3. Shohei Sakaguchi, Junichi Shono, Takahiro Suzuki, Shoko Sawano, Judy E. Anderson, Mai-Khoi Q. Do, Hideaki Ohtsubo, Wataru Mizunoya, Mako Nakamura, Mitsuhiro Furuse, Yoshihide Ikeuchi, Ryuichi Tatsumi, Anti-inflammatory macrophages implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression., Animal Science Congress 2014 of the Asian-Australian Association of Animal Production Societies (AAAP), 2014.11.14.
4. Ryuichi Tatsumi, Judy E. Andeson, Ronald E. Allen, Muscle regeneration dynamics: satellite cells may do more., A Meeting-of-Minds Muscle Symposium, 2014.09.09.
5. Ryuichi Tatsumi, Shohei Sakaguchi, Junichi Shono, Takahiro Suzuki, Shoko Sawano, Judy E. Anderson, Mai-Khoi Q. Do, Hideaki Ohtsubo, Wataru Mizunoya, Mako Nakamura, Mitsuhiro Furuse, Yoshihide Ikeuchi, M2 macrophages may implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression., 2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells”, 2014.07.23.
6. Takahiro Suzuki, Yuki Ohya, Koichi Ojima, Wataru Mizunoya, Shoko Sawano, Hideaki Ohtsubo, Shinichiro Nishimatsu, Judy E. Anderson, Mai-Khoi Q. Do, Mako Nakamura, Mitsuhiro Furuse, Yoshihide Ikeuchi, Tsutomu Nohno, Ryuichi Tatsumi, Sema3A secreted from satellite cells promotes slow-twitch fiber generation., 2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells”, 2014.07.22.
7. Takahiro Suzuki, Koichi Ojima, Mai-Khoi Q. Do, Minako Hara, Wataru Mizunoya, Mako Nakamura, Yoshihide Ikeuchi, Judy E. Andeson, Ryuichi Tatsumi, Semaphorin 3A secreted from myogenic stem cells promotes slow-twitch muscle fiber generation, 2013 EMBO Workshop on“Semaphorin Function and Mechanism in Action”, 2013.10.30.
8. Ryuichi Tatsumi, Judy E. Andeson, Ronald E. Allen, Muscle regeneration dynamics mediated by resident myogenic stem cells: a possible implication in moto-neuritogenesis and fiber-type regulation, Tucson Symposium 2013 on "The Biology of Muscle Growth and Repair", 2013.09.27.
9. Muscle regeneration dynamics mediated by resident myogenic stem cells
Authored by Ryuichi Tatsumi, Kyushu Univ., Fukuoka, JAPAN

Skeletal muscle regeneration and work-induced hypertrophy are initiated by mechanical insult or other perturbation and one of the earliest events is triggering the activation (re-entry to cell cycle from G0) of quiescent resident myogenic stem cells, satellite cells. Recent studies of satellite cells in culture and in vivo addressed the possible dual-roles of hepatocyte growth factor (HGF) in the stretch-induced activation and the re-establishing quiescence. In the proposed scenario, the time-coordinated increase in extracellular HGF is a key modulator for the two contrary pathways having low and high thresholds to impact activation and the counterpart quiescence of satellite cells, respectively. Moreover, the role of HGF in muscle repair may not be restricted to myogenesis; we demonstrated that HGF up-regulates expression of secreted axon-guidance molecule semaphorin 3A (Sema3A) in satellite cells at early-differentiation phase in primary cultures and in vivo. The results encourage a possible implication of satellite cells in the spatiotemporal regulation of extracellular Sema3A concentrations, which potentially mediates restoration or remodeling of nerve-muscle connections in muscle regeneration in synchrony with recovery of muscle-fiber integrity and types (fast and slow). Overall our results highlight the “programmed mechano-biology dynamics” that successful muscle regeneration, comprised of satellite cell-driving myogenesis and intramuscular moto-neuritogenesis, may be a programmed sequence of events that respond to a mechanical perturbation in a synchronous, HGF-dependent and time-coordinated manner..
10. Programmed mechano-biology of resident myogenic stem cells
Authored by Ryuichi Tatsumi, Kyushu Univ., Fukuoka, JAPAN

Skeletal muscle regeneration and work-induced hypertrophy are initiated by mechanical insult or other perturbation and one of the earliest events is triggering the activation (re-entry to cell cycle from G0) of quiescent resident myogenic stem cells, satellite cells. Recent studies of satellite cells in culture and in vivo addressed the possible dual-roles of hepatocyte growth factor (HGF) in the stretch-induced activation and the re-establishing quiescence. In the proposed scenario, the time-coordinated increase in extracellular HGF is a key modulator for the two contrary pathways having low and high thresholds to impact activation and the counterpart quiescence of satellite cells, respectively. Moreover, the role of HGF in muscle repair may not be restricted to myogenesis; we demonstrated that HGF up-regulates expression of secreted axon-guidance molecule semaphorin 3A (Sema3A) in satellite cells at early-differentiation phase in primary cultures and in vivo. The results encourage a possible implication of satellite cells in the spatiotemporal regulation of extracellular Sema3A concentrations, which potentially mediates restoration or remodeling of nerve-muscle connections in muscle regeneration in synchrony with recovery of muscle-fiber integrity. Overall our results highlight the “programmed mechano-biology” that successful muscle regeneration, comprised of satellite cell-driving myogenesis and intramuscular moto-neuritogenesis, may be a programmed sequence of events that respond to a mechanical perturbation in a synchronous, HGF-dependent and time-coordinated manner..
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14. Do, Mai-Khoi Q., Sato, Y., Sankoda, Y., Shimizu, N., Suzuki, T., Mizunoya, W., Nakamura, M., Ikeuchi, Y., Judy E. Anderson, Ronald E. Allen (2011) Possible implication of myogenic stem cells in regenerative motoneuritogenesis through axon guidance molecule Sema3A expression and secretion, Group Meeting 2011 on Translational Research for Muscular Dystrophy (Dec. 1-2, 2011, Tokyo).
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15. Tatsumi, R. (2011) Possible implication of myogenic stem cells in regenerative motoneuritogenesis, The 26th Annual Research Meeting of the Japanese Orthopaedic Association (Oct. 20, 21th, 2011, Maebashi, Gunma)..
16. Ryuichi Tatsumi, Mechanobiology on muscle hypertrophy and regeneration: HGF/NO-dependent cascade model of satellite cell activation and quiescence mechanism. Lecture at the Graduate School of Veterinary Science, Hokkaido University, Feb. 1st., 2007..
17. Tatsumi R. (2006) Mechanobiology of Skeletal Muscle Satellite Cells., the 10th Annual Symposium on Animal Life Sciences., invited talk.
18. Tatsumi R. (2006) Myostatin Expression in Myogenic Stem cells., Symposium of the 106th Annual Meeting of Japan Society of Animal Science., invited talk.
19. Okamoto, S., Wakamatsu, J.-I., Mizunoya, W., Waga, T., Tatsumi, R., Ikeuchi, Y. (2006) Effects of Apple-Polyphenol Intake on Rat Skeletal Muscle and Lipid Metabolism., the 106th Annual Meeting of Japan Society of Animal Science..
20. Ryuichi Tatsumi, Keitaro Yamanouchi, Toru Hosoyama, Sei-ichi Shiratsuchi, Michiko Yamada, Jun-Ichiro Wakamatsu, Wataru Mizunoya, Yoshihide Ikeuchi, and Ronald E. Allen, A Possible Programmed Mechanism of Muscle Satellite Cell Quiescence: The cell Activator HGF Induces Myostatin Expression and Secretion., FASEB Summer Research Conference 2005, 4rd International Conference on Skeletal Muscle & Stem Cells, Omni Tucson Golf Resort & Spa, Tucson, AZ, US (June 11-16, 2005).
21. Tatsumi, R., Ikeuchi, Y. (2005) More Shine to Meat Production: A Programmed Cascade Model for Muscle Satellite Cell Activation and Quiescence., the Annual Spring Meeting 2005 of Japanese Society for Animal Nutrition and Metabolism..
22. Tatsumi, R., Yamanouchi, K., Hosoyama, T., Ikeuchi, Y. (2005) Activation Factor HGF Induces Satellite Cell Quiescence In Vitro., the 104th Annual Meeting of Japan Society of Animal Science..
23. Tatsumi, R., Ikeuchi, Y., and Hattori, A. (2004) Molecular Mechanism of Muscle Satellite Cell Activation: Mechanical Perturbation triggers Nitric Oxide-Dependent Cascade., the 137th Annual Meeting of Japanese Society of Veterinary Science..
24. Ryuichi Tatsumi and Ronald E. Allen, Satellite Cell Activation in Response to Muscle Stretch and Damage., FASEB Summer Research Conference 2003, 3rd International Conference on Muscle Satellite & Stem Cells, Omni Tucson Golf Resort & Spa, Tucson, AZ, US (July 26-30, 2003), invited speak..
25. Ronald E. Allen and Ryuichi Tatsumi, Satellite Cell Activation in Response to Muscle Damage., Molecular Biology of Muscle Development and Regeneration,
The Banff Centre, Alberta, Canada (May 30-June 4, 2003), invited speak..
26. Takehiro Ogawa, Toshiya Hayashi, Kazumasa Nodake, Shohei Shiraishi, Sunao Mori, Ryuichi Tatsumi,, Yoshihide Ikeuchi and Tatsumi Ito, A Novel Muscle Cell Growth Factor, S-Myotrophin, Promotes the Expression of Fast Myosin in Myotubes Developed from C2C12 Cells., 48th International Congress of Meat Science and Technology, Rome, Italy (August 25-30, 2002)..
27. Ryuichi Tatsumi, Tomowa Sakata, Shannon M. Sheehan, Akihito Hattori and Ronald E. Allen, Mechanical Stretch-Induced Activation of Skeletal Muscle Satellite Cells: the Possible Role of HGF in the Mechanism., FASEB Summer Research Conference 2000, 2nd International Conference on Muscle Satellite & Stem Cells,
Omni Tucson Golf Resort & Spa, Tucson, AZ, US (July 14-19, 2001)..
28. Ryuichi Tatsumi, Shannon M. Sheehan, Hiroyuki Iwasaki, Akihito Hattori and Ronald E. Allen, Mechanical Stretch Induces Activation of Skeletal Muscle Satellite Cells In Vitro., 2000 Keystone Symposia on the Molecular Biology of Muscle Development and Disease, Asilomar, CA, US (May 21-26, 2000)..
29. Yukiko Ito, Ryuichi Tatsumi, Takanori Nishimura and Akihito Hattori,
Solubilization of Myofibrillar Proteins of Chicken Skeletal Muscle in Water., 45th International Congress of Meat Science and Technology, Yokohama, Japan (August 1-6, 1999)..
30. Ryuichi Tatsumi, Kenji Maeda and Koui Takahashi, (1999) Calcium-Induced Splitting of Connectin/Titin Filaments: Localization and Characterization of Calcium-Binding Sites., 45th International Congress of Meat Science and Technology, Yokohama, Japan (August 1-6, 1999)..
31. Ronald. E. Allen and Ryuichi Tatsumi, Satellite Cell Activation and the Role of Hepatocyte Growth Factor/Scatter Factor., Post-natal Myogenesis: Satellite Cells in Action, Boston, US (August 13-16, 1998)., invited speak..
32. Ronald. E. Allen, Ryuichi Tatsumi, and Shannon M. Sheehan, HGF is the Activating Factor in Crushed Muscle Extract and Is an Autocrine Growth Factor for Satellite Cells., 1997 Keystone Symposia on Molecular and Cellular Biology, Molecular Biology of Muscle Development, Aspen, CO, US (April 1-6, 1997)..
Other Research Activities
  • 2008.12.
  • 2009.03.
  • 2014.03.
  • 2012.01.
  • 2012.01.
  • 2007.05.
  • 2008.03.
  • 2009.03.
  • 2011.01.
  • 2008.04.
  • 2009.08, Selected for the Editorial Focus..
  • 2010.03, Selected for the Editorial Focus.
    The 50 Most-Frequently Read Articles in Am. J. Physiol. Cell Physiol. during March 2010 (the 39th position), during April 2010 (the 32nd position).
  • 2010.04.
  • 2011.04.
  • 2010.03, Awarded for the BBB Excellent Paper Award 2009 (March 27th, 2010, at Tokyo, Japan).
Membership in Academic Society
  • Japan Muscle Society (JMS)
  • Japanese Society of Animal Science (JSAS)
  • West Japan Society of Animal Science(WJSAS)
  • Japan Society for Meat Science and Technology (JSMST)
  • Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA)
  • West Japan Society for Bioscience, Biotechnology, and Agrochemistry (WJSBBA)
  • Japanese Society for Animal Nutrition and Metabolism
  • The American Society for Cell Biology (ASCB)
  • The American Physiological Society (APS)
Awards
  • ASJ Excellent Paper Award 2013
    Tatsumi, R.
    Mechano-Biology of Skeletal Muscle Hypertrophy and Regeneration: Possible Mechanism of Stretch-Induced Activation of Resident Myogenic Stem Cells.
    Animal Science Journal 81, 11-20 (2010), Invited Review Article
  • ASJ Excellent Paper Award 2011
    Tatsumi, R. and Allen, R. E.
    Mechano-Biology of Resident Myogenic Stem Cells: Molecular Mechanism of Stretch-Induced Activation of Satellite Cells.
    Animal Science Journal 79, 279-290 (2008), Invited Review Article
  • BBB Excellent Paper Award 2009
    Sato, Y., Shimizu, M., Mizunoya, W., Wariishi, H., Tatsumi, R., Buchman, V. L., and Ikeuchi, Y.
    Differential Expression of Sarcoplasmic and Myofibrillar Proteins of Rat Soleus Muscle during Denervation Atrophy.
    Bioscience, Biotechnology and Biochemistry 73, 1748-1756 (2009).
  • R. Tatsumi (2008) Award presented by Japanese Society of Animal Science,
    Research Titile: Mechano-biology on the postnatal muscle hypertrophy and regeneration, March 2008.
Educational
Other Educational Activities
  • 2005.09.
  • 2006.03.
  • 2006.03, Kyushu University Foundation Grant 2006 to aid international congress fee, “Mechanical stretch-induced activation of skeletal muscle satellite cells requires matrix metalloproteinase (MMP) activity”; student name: M.Yamada (master course)..
  • 2006.04.
  • 2007.04.
  • 2007.05.
  • 2007.09.
  • 2008.04, Competitive Research Grant 2008 from Kyushu University Foundation to support student research activity, “Role of myogenic stem cells in postnatal motor neuron network formation”; student name: Y. Sankoda (master course)..
  • 2008.04.
  • 2008.04.
  • 2008.07.
  • 2009.04.
  • 2009.04.
  • 2009.05.
  • 2010.04, Competitive Research Grant 2010 from Kyushu University Foundation to support student research activity, “Regulation of postnatal motoneuritogenesis by myogenic stem cells”; student name: T. Suzuki (master course)..
  • 2010.06, Competitive Research Grant of Academic Challenge 2010 from Kyushu University Venture Business Laboratory, “Evaluation of calcium ion influx mechanism in satellite cell activation cascade”; student name: M. Hara (master course)..
  • 2010.08, Grant in Aid 2010-2011 for Research Activity Start-Up from Japan Society for the Promotion of Science (JSPS, No. 22880025), Y.Sato, Research Fellow (post-doctoral)..
  • 2010.09, Competitive Research Grant 2010 from Kyushu University Foundation to support student research activity, “Cross-talk between myogenic stem cells and macrophages during muscle hypertrophy and regeneration”; student name: J.-I. Syono (master course)..
  • 2010.04.
  • 2011.04.
Social
Professional and Outreach Activities
Research Collaboration with
1. Ito-hamu Co. (1999, 2000, 2001)
2. Meiji Kenko-hamu Co. (2000, 2001)
3. Katayama Co. (2001)
4. Asahi Beer Co. (2005, 2006).