Kyushu University Academic Staff Educational and Research Activities Database
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Takeshi Uchiumi Last modified date:2016.08.19

Associate Professor / Department of Clinical Chemistry and Laboratory Medicine
Department of Basic Medicine
Faculty of Medical Sciences


Graduate School
Undergraduate School


E-Mail
Phone
092-642-5750
Fax
092-642-5772
Academic Degree
Medical Doctor 
Field of Specialization
Biochemistry, Molecular Biology、Clinical chemistry、Clinical Chemistry and Laboratory Medicine
Research
Research Interests
  • Mitochondria and cancer
    keyword : mitochondria
    2016.05~2016.05.
  • Functional analysis of mitochondrial protein p32
    keyword : p32 , mitochondria , translation
    2010.05~2018.05.
  • Cross talk between cytoplasm and mitochndria translation
    keyword : mitochondria translation
    2008.05~2012.05.
  • Mitochondria related gene and Cancer
    keyword : Mitochondria , tumor, translation, replication, siRNA
    2007.06~2010.05.
  • Multifunction of YB-1 gene response to stress- cross-talk to translation, transcription and repair
    keyword : YB-1, translation, transcription, repair
    1998.04~2008.03.
Academic Activities
Papers
1. 内海 健, Mutation and functional analysis of ABCC2/multidrug resistance protein 2 in a Japanese patient with Dubin-Johnson syndrome., Hepatol. Research, 43, 2013.02.
2. Fukuda, T., Ashizuka, M., Nakamura, T., Shibahara,K., Maeda, K., Izumi, I., Kohno, K., Kuwano, M.,and Uchiumi,T.,, Characterization of 5'untranslated region of YB-1 mRNA and plausible regulation of translation., Nucleic Acid Res, 2004.01.
3. Kohno K, Izumi H, Uchiumi T, Ashizuka M, and Kuwano M, The pleiotropic functions of the Y-box-binding protein, YB-1, Bioessays, 25, 7, 25: 691-698, 2003.01.
4. Kuwano, M., Uchiumi, T., Hayakawa, H., Ono, M., Wada, M., Izumi, H., and Kohno, K, The basic and clinical implications of ABC transporters, Y-box-binding protein-1 (YB-1) and angiogenesis-related factors in human malignancies., Cancer Sci, 94, 1, 94: 9-14, 2003.01.
5. Hashimoto K.,Uchiumi T., Konno T., Ebihara T., Nakamura T., Wada M., Sakisaka S., Maniwa F., Amachi T., Ueda K., and Kuwano M., Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome., Hepatology, 36, 5, 36:1236-1245, 2002.01.
6. Ashizuka, M., Fukuda, T., Nakamura, T., Shirasuna, K., Iwai, K., Izumi, H., Kohno, K., Kuwano, M., and Uchiumi, T., Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2., Mol Cell Biol, 22, 18, 22: 6375-6383, 2002.01.
7. Inokuchi, A., Hinoshita, E., Wada, M., Iwamoto, Y., Kohno, K., Kuwano, M. and Uchiumi, T., Enhanced expression of Human Multidrug resistance protein 3 by bile salt in human enterocytes: a transcriptional control of plausible bile acid transporter., J. Biol. Chem., 276, 50, 276: 46822-46829, 2001.01.
8. Hinoshita, E., Taguchi, K., Inokuchi, A., Uchiumi, T., Kinukawa, N., Shimada, M., Tsuneyoshi, M., Sugimachi, K. and Kuwano, M., Decreased expression of an ATP-binding cassette transporter, MRP2, in human livers with hepatitis C virus infection., J. Hepatology, 35, 6, 35,765-773, 2001.01.
9. Haga, S., Hinoshita, E., Ikezaki, K., Fukui, M., Scheffer, G. L., Uchiumi, T. and Kuwano, M., Involvement of the multidrug resistance protein 3 in drug sensitivity and its expression in human glioma., Jpn. J. Cancer Res, 92, 2, 92: 211-219, 2001.01.
10. Hinoshita, E., Uchiumi, T., Taguchi, K., Kinukawa, N., Tsuneyoshi, M., Maehara, Y., Sugimachi, K. and Kuwano, M., Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas., Clin Cancer Res, 6, 6, 6:2401-2407, 2000.01.
11. Tanaka,T., Uchiumi,T., Hinoshita,E., Inokuchi,A., Toh,S., Wada,M., Takano,H., Kohno,K., and Kuwano,M., The human multispecific resistance protein2 gene : functional characterization of 5'-flanking region and expression in hepatic cells., Hepatology, 30: 1507-1512, 1999.01.
12. Kawabe, T., Chen, Z., Wada, M., Uchiumi, T., Ono, M., Akiyama, S. and Kuwano, M., Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)., FEBS Lett., 456, 2, 456: 327-331, 1999.01.
13. Uchiumi, T., Hinoshita, E., Haga, S., Nakamura, T., Tanaka, T., Toh, S., Furukawa, M., Kawabe, T., Wada, M., Kagotani, K., Okumura, K., Kohno, K., Akiyama, S. and Kuwano, M., Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport., Biochem. Biophys. Res. Commun, 252, 1, 252: 103-110, 1998.01.
14. Uchiumi, T., Longo, D. and Ferris, D, Cell cycle regulation of PLK promoter., J. Bio. Chem, 272,9166-9174, 1997.01.
Presentations
1. 内海 健, KANG DONGCHON, 八木美佳子, Cardiomyocyte Specific Deletion of p32/C1qbp Causes Mitochondrial Cardiomyopathy, EuroMit, 2014.06.16.
2. 内海 健, p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA binding ability, ミトコンドリア学会, 2013.11.06.
Membership in Academic Society
  • American Association of Cancer Research
  • Japanease Cancer Association