Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Takeshi Uchiumi Last modified date:2016.08.19

Associate Professor / Department of Clinical Chemistry and Laboratory Medicine / Department of Basic Medicine / Faculty of Medical Sciences

1. Shiota M, Akira Yokomizo, Takeshi Uchiumi, Seiji Naito, Crosstalk between epithelial-mesenchymal transition and castration resistance mediated by Twist1/AR signaling in prostate cancer, ENDOCRINE-RELATED CANCER, 22, 6, 889-900, 2015.12.
2. Shiota M, Akira Yokomizo, Takeshi Uchiumi, Seiji Naito, SRD5A gene polymorphism in Japanese men predicts prognosis of metastatic prostate cancer with androgen-deprivation therapy, EUROPEAN JOURNAL OF CANCER, 51, 14, 1962-1969, 2015.09.
3. Kuniyuki Nakamura, Ago T, Takeshi Uchiumi, Kitazono T, A CADASIL-Like Case with a Novel Noncysteine Mutation of the NOTCH3 Gene and Granular Deposits in the Renal Arterioles, Case Rep Neurol Med, 2015.03.
4. Rie Amamoto, Takeshi Uchiumi, Mikako Yagi, Keisuke Monji, Song, Yoshinao Oda, Shiota M, Akira Yokomizo, Seiji Naito, Dongchon Kang, The Expression of Ubiquitous Mitochondrial Creatine Kinase Is Downregulated as Prostate Cancer Progression, JOURNAL OF CANCER, 7, 1, 50-59.
5. Itsumi, M., Shiota, M., Yokomizo, A, Takeshi Uchiumi, PMA induces androgen receptor downregulation and cellular apoptosis in prostate cancer cells, 53, 1, 2014.05.
6. Masaki Shiota, Akira Yokomizo, Takeshi Uchiumi, Seiji Naito, Inhibition of RSK/YB-1 signaling enhances the anti-cancer effect of enzalutamide in prostate cancer, 74, 9, 2014.04.
7. Aihara, M, Jin, X, Kurihara, Y, Yoshida, Y., Yuichi Matsushima, Takeshi Uchiumi, Dongchon Kang, Kanki, T., Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast, 127, 2014.05.
8. Fang J, 内海 健, 康東天, Dihydroorotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction., Bioscience report, 33, 2013.03.
9. 内海 健, Mutation and functional analysis of ABCC2/multidrug resistance protein 2 in a Japanese patient with Dubin-Johnson syndrome., Hepatol. Research, 43, 2013.02.
10. 神吉智久, 内海 健, Casein kinase 2 is essential for mitophagy, EMBO Reports, 14, 2013.10.
11. Mikako Yagi, 内海 健, 康 東天, P32/gC1qR is indispensable for fetal development and mitochondrial translation: Importance of its RNA-binding ability, Nucleic Acid Reserch, 40, 2012.10.
12. Matsumoto S, Uchiumi T, Saito T, Yagi M, Takazaki S, Kanki T, Kang D, Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins., Mitochondrion, 12, 391-398, 2012.03.
13. Matsumoto S, Uchiumi T, Tanamachi H, Saito T, Yagi M, Takazaki S, Kanki T, Kang D., Ribonucleoprotein Y-box binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA, Biochem J, 2012.05.
14. Uchiumi T, Kang D., The role of TFAM-associated proteins in mitochondrial RNA metabolism., Biochim Biophys Acta., 2011.08.
15. Aoki Y, Kanki T, Hirota Y, Kurihara Y, Saigusa T, Uchiumi T, Kang D, Phosphorylation of Serine 114 on Atg32 mediates mitophagy., Mol Biol Cell, 22, 3206-17, 2011.08.
16. Fotovati A, Abu-Ali S, Wang PS, Deleyrolle LP, Lee C, Triscott J, Chen JY, Franciosi S, Nakamura Y, Sugita Y, Uchiumi T, Kuwano M, Leavitt BR, Singh SK, Jury A, Jones C, Wakimoto H, Reynolds BA, Pallen CJ, Dunn SE., YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth., Cancer Res, 71, 5569-78, 2011.08.
17. Shiota M, Takeuchi A, Song Y, Yokomizo A, Kashiwagi E, Uchiumi T, Kuroiwa K, Tatsugami K, Fujimoto N, Oda Y, Naito S., Y-box binding protein-1 promotes castration-resistant prostate cancer growth via androgen receptor expression. , Endocr Relat Cancer., 18, 505-17, 2011.05.
18. Shiota M, Yokomizo A, Kashiwagi E, Takeuchi A, Fujimoto N, Uchiumi T, Naito S. , Peroxiredoxin 2 in the nucleus and cytoplasm distinctly regulates androgen receptor activity in prostate cancer cells., Free Radic Biol Med, 51, 78-87, 2011.05.
19. Amamoto R, Yagi M, Song Y, Oda Y, Tsuneyoshi M, Naito S, Yokomizo A, Kuroiwa K, Tokunaga S, Kato S, Hiura H, Samori T, Kang D, Uchiumi T. , Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter PSA relapse time after radical prostatectomy., Cancer Science, 2011.03.
20. Twist1 and Y-box-binding protein-1 promote malignant potential in bladder cancer cells., Twist1 and Y-box-binding protein-1 promote malignant potential in bladder cancer cells., BJU Int, 2010.09.
21. Shiota M, Eto M, Yokomizo A, Tada Y, Takeuchi A, Itsumi M, Tatsugami K, Uchiumi T, Naito S, Sensitivity of doxorubicin-resistant cells to sorafenib: possible role for inhibition of eukaryotic initiation factor-2alpha phosphorylation, Int J Oncol, 37, 509-517, 2010.07.
22. Shiota M, Song Y, Yokomizo A, Kiyoshima K, Tada Y, Uchino H, Uchiumi T, Inokuchi J, Oda Y, Kuroiwa K, Tatsugami K, Naito S, Foxo3a suppression of urothelial cancer invasiveness through Twist1, Y-box-binding protein 1, and E-cadherin regulation, Clin. Cancer Res, 16, 5654-5663, 2010.07.
23. Izumi H, Wakasugi T, Shimajiri S, Tanimoto A, Sasaguri Y, Kashiwagi E, Yasuniwa Y, Akiyama M, Han B, Wu Y, Uchiumi T, Arao T, Nishio K, Yamazaki R, Kohno K, Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes, Cancer Science, 101, 2538-2545, 2010.09.
24. Shiota M, Yokomizo A, Tada Y, Uchiumi T, Inokuchi J, Tatsugami K, Kuroiwa K, Yamamoto K, Seki N, Naito S., P300/CBP-associated factor regulates Y-box binding protein-1 expression and promotes cancer cell growth, cancer invasion and drug resistance., Cancer Science, 101, 1797-1806, 2010.07.
25. Shiota, M. Eto, M. Yokomizo, A. Tada, Y. Takeuchi, A. Masubuchi, D. Inokuchi, J. Tatsugami, K. Kuroiwa, K. Uchiumi, T. Seki, N. Naito, S., Sorafenib with doxorubicin augments cytotoxicity to renal cell cancer through PERK inhibition, Int J Oncol, 36, 6, 1521-31, 2010.06.
26. Shiota, M. Song, Y. Yokomizo, A. Tada, Y. Kuroiwa, K. Eto, M. Oda, Y. Inokuchi, J. Uchiumi, T. Fujimoto, N. Seki, N. Naito, S., Human heterochromatin protein 1 isoform HP1{beta} enhances androgen receptor activity and is implicated in prostate cancer growth, Endocr Relat Cancer, 2010.05.
27. Shiota, M. Yokomizo, A. Kashiwagi, E. Tada, Y. Inokuchi, J. Tatsugami, K. Kuroiwa, K. Uchiumi, T. Seki, N. Naito, S., Foxo3a expression and acetylation regulate cancer cell growth and sensitivity to cisplatin, Cancer Sci, 2010.05.
28. Shiota, M. Yokomizo, A. Masubuchi, D. Tada, Y. Inokuchi, J. Eto, M. Uchiumi, T. Fujimoto, N. Naito, S., Tip60 promotes prostate cancer cell proliferation by translocation of androgen receptor into the nucleus, Prostate, 70, 5, 540-54, 2010.04.
29. Shiota, M. Yokomizo, A. Tada, Y. Inokuchi, J. Kashiwagi, E. Masubuchi, D. Eto, M. Uchiumi, T. Naito, S., Castration resistance of prostate cancer cells caused by castration-induced oxidative stress through Twist1 and androgen receptor overexpression, Oncogene, 29, 2, 237-50, 2010.01.
30. Shiota, M. Yokomizo, A. Tada, Y. Inokuchi, J. Tatsugami, K. Kuroiwa, K. Uchiumi, T. Fujimoto, N. Seki, N. Naito, S., Peroxisome proliferator-activated receptor gamma coactivator-1alpha interacts with the androgen receptor (AR) and promotes prostate cancer cell growth by activating the AR, Mol Endocrinol, 2010.05.
31. Fukuoh, A. Ohgaki, K. Hatae, H. Kuraoka, I. Aoki, Y. Uchiumi, T. Jacobs, H. T.Kang, D., DNA conformation-dependent activities of human mitochondrial RNA polymerase, Genes Cells, 14, 8, 1029-42, 2009.08.
32. Uchiumi, T. Ohgaki, K. Yagi, M. Aoki, Y. Sakai, A. Matsumoto, S. Kang, D., ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation, Nucleic Acids Res, 2010.05.
33. Uramoto H, Uchiumi T, Izumi H, Kohno K, Oyama T, Sugio K, and Yasumoto K, A new mechanism for primary resistance to gefitinib in lung adenocarcinoma: the role of a novel G796A mutation in exon 20 of EGFR, Anticancer Res,, 27, 2297-2303, 2007.10.
34. Momii Y, Izumi H, Shiota M, Onistuka T, Abe T, Kobayasi H, Miyamoto N, Uchiumi T, and Kohno K, p73gamma transactivates the p21 promoter through preferential interaction with the p300/CBP-associated factor in human prostate cancer cells., Oncology Report, 18, 411-416, 2007.10.
35. Niina I, Uchiumi T, Izumi H,Torigoe T, Wakasugi T, Igarashi T, Miyamoto N, Onitsuka T, Shiota M, Okayasu R, Chijiiwa K, and Kohno K, DNA topoisomerase inhibitor, etoposide, enhances GC-box-dependent promoter activity via Sp1 phosphorylation, Cancer Science, 2007.10.
36. Wakasugi,T., Izumi,H., Uchiumi,T., Suzuki,H., Arao,T., Nishio,K. and Kohno,K, ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes., Oncogene, 26: 5194-5203, 2007.09.
37. Igarashi,T., Izumi,H., Uchiumi,T., Nishio,K., Arao,T., Uramoto,H., Sugio,K., Yasumoto,K., Sasaguri,Y., Wang,KY., Otsuji,Y. and Kohno,K., Clock/ATF4 transcription system regulates multidrug resistance in human cancer cell line., Oncogene, 26, 4749-4760, 2007.06.
38. Uchiumi,T., Fotovati,A., Sasaguri,T., Shibahara,K., Shimada,T., Fukuda,T., Nakamura,T., Izumi,H., Tsuzuki,T., Kuwano,M. and Kohno,K, YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation. , J. Biol.Chem, 281: 40440-40449, 2006.11.
39. Yamashita,F., Ohtani,H., Koyabu,N., Ushigome,F., Satoh,H., Murakami,H., Uchiumi,T., Nakamura,T., Kuwano,M., Tsujimoto,M. and Sawada,Y., Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4. , J. Pharm. Pharmacol., 2006.06.
40. Kohno,K., Matsuki,Y., Tanimoto,A., Izumi,H., Uchiumi,T., Kohno,K., Shimajiri,S. and Sasaguri,Y., Expression of Y-box-binding protein dbpC/contrin, a potentially new cancer/testis antigen., Br. J. Cancer, 94: 710-716, 2006.05.
41. Yoshida,T., Izumi,H., Uchiumi,T., Sasaguri,Y., Tanimoto,A., Matsumoto,T., Naito,S. and Kohno,K., Expression and cellular localization of dbpC/Contrin in germ cell tumor cell lines., Biochim. Biophys. Acta, 1759: 80-88, 2006.03.
42. Oda,Y., Saito,T., Tateishi,N., Ohishi,Y., Tamiya,S.,Yamamoto,H.,Yokoyama,R., Uchiumi,T., Iwamoto,Y., Kuwano,M. and Tsuneyoshi,M, ATP-binding cassette superfamily transporter gene expression in human soft tissue sarcoma., Int. J. Cancer, 114, 6, 2005.11.
43. Sata,R., Ohtani,H., Tsujimoto,M., Murakami,H., Koyabu,N., Nakamura,T., Uchiumi,T., Kuwano,M., Nagata,H., Tsukimori,K., Nakano,H. and Sawada,Y, Functional analysis of organic cation transporter 3 expressed in human placenta. , J. Pharmacol. Exp. Ther., 315, 2, 2005.10.
44. Pulaski,L., Kania,K., Ratajewski,M., Uchiumi,T., Kuwano,M. and Bartosz,G. , Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids. , J. Steroid Biochem. Mol. Biol., 96, 3-4, 96: 229-234, 2005.08.
45. Yasen,M., Kajino,K., Kano,S., Tobita,H., Yamamoto,J., Uchiumi,T., Kon,S., Maeda,M., Obulhasim,G., Arii,S. and Hino,O., The up-regulation of Y-box binding proteins (DNA binding protein A and Y-box binding protein-1) as prognostic markers of hepatocellular carcinoma., Clin. Cancer Res, 11: 7354-7361, 2005.07.
46. Pulaski,L., Szemraj,J., Uchiumi,T., Kuwano,M. and Bartosz,G., Transcriptional upregulation of the human MRP2 gene expression by serine/threonine protein kinase inhibitors., J. Biol. Regul. Homeost. Agents, 19, 3-4, 19: 113-119, 2005.05.
47. Honda,Y., Ushigome,F., Koyabu,N., Morimoto,S., Shoyama,Y., Uchiumi,T., Kuwano,M., Ohtani H. and Sawada Y., Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux., Br. J. Pharmacol., 143, 7, 143: 856-864, 2004.11.
48. Shibahara,K., Uchiumi,T., Fukuda,T., Kura,S., Tominaga,Y., Maehara,Y., Kohno,K., Nakabeppu,Y., Tsuzuki,T. and Kuwano,M., Targeted disruption of one allele of the Y-box binding protein-1 (YB-1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C, Cancer Sci., 95, 4, 95: 348-353, 2004.07.
49. Hisaeda,K., Inokuchi,A., Nakamura,T., Iwamoto,Y., Kohno,K., Kuwano,M. and Uchiumi,T. , Interleukin-1ß represses MRP2 gene expression through inactivation of interferon regulatory factor 3 in HepG2 cells., Hepatology, 39, 6, 39: 1574-1582, 2004.04.
50. Fukuda, T., Ashizuka, M., Nakamura, T., Shibahara,K., Maeda, K., Izumi, I., Kohno, K., Kuwano, M.,and Uchiumi,T.,, Characterization of 5'untranslated region of YB-1 mRNA and plausible regulation of translation., Nucleic Acid Res, 2004.01.
51. Kohno K, Izumi H, Uchiumi T, Ashizuka M, and Kuwano M, The pleiotropic functions of the Y-box-binding protein, YB-1, Bioessays, 25, 7, 25: 691-698, 2003.01.
52. Nagashige M, Ushigome F, Koyabu N, Hirata K, Kawabuchi M, Hirakawa T, Satoh, Basal membrane localization of MRP1 in human placental trophoblast., Placenta, 24, 10, 24: 951-958, 2003.01.
53. Konno, T., Ebihara, T., Hisaeda, K., Uchiumi, T., Nakamura, T., Shirakusa, T., Kuwano, M., and Wada, M., Identification of domains participating in the substrate specificity and subcellular localization of the multidrug resistance proteins MRP1 and MRP2., J Biol Chem, 278, 25, 278: 22908-22917, 2003.01.
54. Kuwano, M., Uchiumi, T., Hayakawa, H., Ono, M., Wada, M., Izumi, H., and Kohno, K, The basic and clinical implications of ABC transporters, Y-box-binding protein-1 (YB-1) and angiogenesis-related factors in human malignancies., Cancer Sci, 94, 1, 94: 9-14, 2003.01.
55. Ushigome, F., Koyabu, N., Satoh, S., Tsukimori, K., Nakano, H., Nakamura, T., Uchiumi, T., Kuwano, M., Ohtani, H., and Sawada, Y, Kinetic analysis of P-glycoprotein-mediated transport by using normal human placental brush-border membrane vesicles., Pharm Res, 20, 1, 20: 38-44, 2003.01.
56. Ohishi Y., Oda Y., Uchiumi T., Kobayashi H., Hirakawa T., Miyamoto S.,Kinukawa N.,Nakano H., Kuwano M., and Tsuneyoshi M., ATP-binding cassette superfamily transporter gene expression in human primary ovarian carcinoma., Clin Cancer Res, 8, 12, 8:3767-3775, 2002.01.
57. Hashimoto K.,Uchiumi T., Konno T., Ebihara T., Nakamura T., Wada M., Sakisaka S., Maniwa F., Amachi T., Ueda K., and Kuwano M., Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome., Hepatology, 36, 5, 36:1236-1245, 2002.01.
58. Ashizuka, M., Fukuda, T., Nakamura, T., Shirasuna, K., Iwai, K., Izumi, H., Kohno, K., Kuwano, M., and Uchiumi, T., Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2., Mol Cell Biol, 22, 18, 22: 6375-6383, 2002.01.
59. Hayakawa, H., Uchiumi, T., Fukuda, T., Ashizuka, M., Kohno, K., Kuwano, M., and Sekiguchi, M, Binding Capacity of Human YB-1 Protein for RNA Containing 8-Oxoguanine., Biochemistry, 41, 42, 41: 12739-12744, 2002.01.
60. Kakehi, M., Koyabu, N., Nakamura, T., Uchiumi, T., Kuwano, M., Ohtani, H., and Sawada, Y, Functional characterization of mouse cation transporter mOCT2 compared with mOCT1., Biochem Biophys Res Commun, 296, 3, 296: 644-650, 2002.01.
61. Uramoto, H., Izumi, H., Ise, T., Tada, M., Uchiumi, T., Kuwano, M., Yasumoto, K., Funa, K., and Kohno, K., p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression, J Biol Chem,, 277, 35, 277: 31694-31702, 2002.01.
62. Yamamoto, C., Murakami, H., Koyabu, N., Takanaga, H., Matsuo, H., Uchiumi, T., Kuwano, M., Naito, M., Tsuruo, T., Ohtani, H., and Sawada, Y, Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier., J Pharm Pharmacol, 54, 8, 54: 1055-1063., 2002.01.
63. Zhu, H. Chang,B.-D. Uchiumi, T. and Roninson, I. B, Identification of promoter elements responsible for transcriptional inhibition of PLK1 and Topoisomerase IIa genes by p21WAF1/CIP1/SDI1., Cell cycle,, 1: 59-66, 2002.01.
64. Okamoto, M., Ono, M., Uchiumi, T., Ueno, H., Kohno, K., Sugimachi, K. and Kuwano, M., Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth facter b in human cancer cells-transcriptional activation and messenger RNA stabilization., Biochim. Biophys. Acta, 93595, 2001.01.
65. Inokuchi, A., Hinoshita, E., Wada, M., Iwamoto, Y., Kohno, K., Kuwano, M. and Uchiumi, T., Enhanced expression of Human Multidrug resistance protein 3 by bile salt in human enterocytes: a transcriptional control of plausible bile acid transporter., J. Biol. Chem., 276, 50, 276: 46822-46829, 2001.01.
66. Shibahara, K., Sugio, K., Osaki, T., Uchiumi, T., Maehara, Y., Kohno, K., Yasumoto, K., Sugimati, K. and Kuwano, M., Nuclear expression of the Y-box binding protein, YB-1, as a novel marker of disease progression in non-small-cell lung cancer., Clinical Cancer Res., 7, 10, 7: 3151-3155, 2001.01.
67. Kawakami, A., Tomofumi, M., Higuchi, R., Uchiumi, T., Kuwano, M. and Van Soest, R. W. N., Structure of a novel multidrug resistance modulator, irciniasulfonic acid, isolated from a marin sponge, Ircinia sp., Tetrahedron Lett., 42, 19, 42: 3335-3337, 2001.01.
68. Hinoshita, E., Taguchi, K., Inokuchi, A., Uchiumi, T., Kinukawa, N., Shimada, M., Tsuneyoshi, M., Sugimachi, K. and Kuwano, M., Decreased expression of an ATP-binding cassette transporter, MRP2, in human livers with hepatitis C virus infection., J. Hepatology, 35, 6, 35,765-773, 2001.01.
69. Izumi, H., Imamura, T., Nagatani, G., Ise, T., Murakami, T., Uramoto, H., Torigoe, T., Ishiguchi, H., Nomoto, M., Okamoto, T., Uchiumi, T., Kuwano, M., Funa, K. and Kohno, K., YB-1 binds preferentially to single-stranded nucleic acid and exhibit 3'-5' exonuclease activity., Nucl. Acids Res., 29: 1200-1207, 2001.01.
70. Haga, S., Hinoshita, E., Ikezaki, K., Fukui, M., Scheffer, G. L., Uchiumi, T. and Kuwano, M., Involvement of the multidrug resistance protein 3 in drug sensitivity and its expression in human glioma., Jpn. J. Cancer Res, 92, 2, 92: 211-219, 2001.01.
71. Ushigome, F., Takanaga, H., Matsuo, H., Yanai, S., Tsukimori, K., Nakano, H., Uchiumi, T., Nakamura, T., Kuwano, M., Ohtani, H., and Sawada, Y., Human placental transport of vinblastine, vincristine, digoxin and progesterone: contribution of P-glycoprotein., Eur. J. Pharmacol, 408, 1, 408: 1-10, 2000.01.
72. Okamoto, T., Izumi, H., Imamura, T., Takano, H., Ise, T, Uchiumi, T., Kuwano, M. and Kohno, K., Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression., Oncogene, 19, 54, 19: 6194-6202, 2000.01.
73. Hinoshita, E., Uchiumi, T., Taguchi, K., Kinukawa, N., Tsuneyoshi, M., Maehara, Y., Sugimachi, K. and Kuwano, M., Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas., Clin Cancer Res, 6, 6, 6:2401-2407, 2000.01.
74. Sibao, K., Takano, H., Nakamura, Y., Okazaku, K., Nagata, N., Izumi, H., Uchiumi, T., Kuwano, M., Kohno, K. and Itoh, H., Enhanced coexpression of YB-1 and DNA topoisomerase IIαgenes in human colorectal carcinomas., Int. J.Cancer, 83, 6, 83: 732-73, 1999.01.
75. Tanaka,T., Uchiumi,T., Hinoshita,E., Inokuchi,A., Toh,S., Wada,M., Takano,H., Kohno,K., and Kuwano,M., The human multispecific resistance protein2 gene : functional characterization of 5'-flanking region and expression in hepatic cells., Hepatology, 30: 1507-1512, 1999.01.
76. Kawabe, T., Chen, Z., Wada, M., Uchiumi, T., Ono, M., Akiyama, S. and Kuwano, M., Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)., FEBS Lett., 456, 2, 456: 327-331, 1999.01.
77. Chen, Z., Kawabe, T., Ono, M., Aoki, S., Sumizawa, T., Furukawa, T., Uchiumi, T., Wada, M., Kuwano, M. and Akiyama, S., Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter., Molec. Pharmacology, 56, 6, 56: 1219-1228, 1999.01.
78. Ise, T., Nagatani, G., Imamura, T., Kato, K., Takano, H., Nomoto, M., Izumi, H., Ohmori, H., Okamoto, T., Ohga, T., Uchiumi, T., Kuwano, M. and Kohno, K., Transcription factor Y box-binding protein-1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen., Cancer Res, 59, 2, 59: 342-346, 1999.01.
79. Toh, S., Wada, M., Uchiumi, T., Inokuchi, A., Makino, Y., Horie, H., Adachi, Y., Sakisaka, S. and Kuwano, M., Genomic structure of the canalicular multispecitic organic anion transporter (cMOAT) gene and mutations in the ATP binding cassette region in Dubin-Johnson syndrome., Am. J. Human Genet., 64, 3, 64: 739-746, 1999.01.
80. Ohga,T., Uchiumi,T., Makino, Y., Koike,K., Wada,M., Kuwano, M. and Kohno,K., Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene., J. Biol. Chem., 273, 11, 273: 5997-6000, 1999.01.
81. Uchiumi, T., Hinoshita, E., Haga, S., Nakamura, T., Tanaka, T., Toh, S., Furukawa, M., Kawabe, T., Wada, M., Kagotani, K., Okumura, K., Kohno, K., Akiyama, S. and Kuwano, M., Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport., Biochem. Biophys. Res. Commun, 252, 1, 252: 103-110, 1998.01.
82. Oda,Y., Sakamoto,A., Shinohara,N., Ohga,T., Uchiumi,T., Kohno,K., Tsuneyoshi,M., Kuwano,M. and Iwamoto,Y., Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human osteosarcoma., Clin Cancer Res, 4, 9, 4:2273-2277, 1998.01.
83. Furukawa,M., Uchiumi,T., Nomoto,M., Takano,H., Morimoto,R-I., Naitoh,S., Kuwano,M. and Kohno,K., The role of an inverted CCAAT element in transcriptional activation of the human DNA topoisomeraseIIα gene in response to heat shock., J. Biol. Chem., 273, 17, 273: 10550-10555, 1998.01.
84. Torigoe, K., Harada, T., Kusaba, H., Uchiumi, T., Kohno, K., E.D.Green, S. W.Scherer, L-C.Tsui, D.Schlessinger, Kuwano,M. and Wada, M., Localization of 67 exons on YAC contigs spanning 1.5 megabases around the multidrug resistance gene region of human chromosome 7q21.1., Genomics, 49, 1, 48:14-22, 1998.01.
85. Wada,M., Toh, S., Taniguchi, K., Uchiumi,T. , Kohno,K., Yoshida, I., Kimura,A., Sakisaka, S., Adachi, Y. and Kuwano,M., Mutation in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome., Human Molec. Genet., 7, 2, 7: 203-207, 1998.01.
86. Toh,S., Nakamura,T., Ohga, T., Koike,K., Uchiumi,T., Wada,M., Kuwano,M. and Kohno,K., Genomic organization of the human Y-box protein (YB-1) gene., Gene, 206, 1, 206: 93-97, 1998.01.
87. Uchiumi, T., Longo, D. and Ferris, D, Cell cycle regulation of PLK promoter., J. Bio. Chem, 272,9166-9174, 1997.01.