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Researcher information
Noriho Kamiya Last modified date：2013.5.20

Professor / Department of Applied Chemistry
Faculty of Engineering


Graduate School
Department of Chemical Systems and Engineering
Graduate School of Engineering
Undergraduate School
Department of Materials Science and Engineering
School of Engineering
Other Organization
Other
Center for Future Chemistry


E-Mail
Homepage
HP for Kamiya Labo at Future Chemistry.
[URL]
Goto Lab Home Page URL.
Phone
092-802-2807
Fax
092-802-2810
Academic Degree
Doctor of Engineering
Field of Specialization
Protein engineering, Enzyme engineering, Biotechnology
Outline Activities
My research interest has been focused on enzyme and protein engineering toward the generation of new protein-based biomaterials. To fully utilize unique protein functions, different strategies including genetic engineering, enzyme engineering, and organic synthesis should be combined and my research is actually directed to that way. Now I am interested in posttranslational, site-specific modification of functional proteins to design new nanobioarchitecture for specific functions. I am also interested in drug delivery system enabling oral administration of pharmaceutical peptides and proteins. During the course of research, I have worked with many industrial companies.
On education, after completing my Ph.D thesis, I experienced two Universities, University of Tokyo & MIT, and had two classes for undergraduate students at the former place. I spent one year at MIT as a visiting scientist and worked on the project related to protein drug delivery and protein chip technology.
Research
Research Interests
  • Design, creation and evaluation of supramolecular protein complexes.
    keyword : scaffold molecule, cellulosome, protein hybrid molecule
    2010.10～2015.03.
  • Development of novel nucleic acid-enzyme hybrid systems
    keyword : enzyme-DNA hybrid, in situ hybridization, Genomic southern blot
    2007.04～2013.03.
  • New biocatalytic systems based on the use of ionic liquids
    keyword : enzyme engineering, biocatalysis, ionic liquid, biorefinery
    2006.04～2013.03.
  • Protein engineering with post-translational protein modifying enzymes
    keyword : enzymatic protein engineering, site-specific modification, transglutaminase
    2002.04～2012.03.
  • Biocatalytic oxidation/reduction system in recombinant E. coli cells
    keyword : protein engineering, enzyme engineering, P450, Au nanoparticle
    2005.04～2014.03.
  • We have focused on the development of a novel lipid-based drug formulation toward oral delivery of pharmaceutical peptide and protein drugs.
Academic Activities
Books
 Show All Books >>
1. N. Kamiya, H. Abe,New fluorescent substrates of microbial transglutaminase and its application to covalent protein labeling,Humana Press, NY,Bioconjugation Protocols, Second Edition
Methods in Molecular Biology, Chapter 9,2011.08.
Reports
 Show All Reports >>
1. New technoogies for oriented protein immobilization.
2. Cross-linking chemistry and biotechnology by transglutaminase.
Papers
 Show All Papers >>
1. K. Minamihata, M. Goto, N. Kamiya,Protein heteroconjugation by the peroxidase-catalyzed tyrosine coupling reaction,Bioconjugate Chem.,Vol.22,pp.2332-2338,2011.12.
2. H. Abe, M. Goto, N. Kamiya,Protein lipidation catalyzed by microbial transglutaminase,Chem. Eur. J.,Vol.17,pp.14004-14008,2011.12.
3. Y. Mori, K. Minamihata, H. Abe, M. Goto, N. Kamiya,Protein assemblies by site-specific avidin-biotin interactions,Org. Biomol. Chem.,Vol.9,pp.5641-5644,2011.05.
4. Y. Mori, M. Goto, N. Kamiya,Transglutaminase-mediated internal protein labeling with a designed peptide loop,Biochem. Biophys. Res. Commun.,Vol.410,pp.829-833,2011.05.
5. T. Niide, M. Goto, N. Kamiya,Biocatalytic synthesis of gold nanoparticles with cofactor regeneration in recombinant Escherichia coli cells,Chem. Commun.,Vol.47,pp.7350-7352,2011.05.
6. K. Moriyama, K. Sung, M. Goto, N. Kamiya,Immobilization of alkaline phosphatase on magnetic particles by site-specific and covalent cross-linking catalyzed by microbial transglutaminase,J. Biosci. Bioeng.,Vol.111,pp.650-653,2011.04.
7. K. Minamihata, M. Goto, N. Kamiya,Site-specific protein cross-linking by peroxidase-catalyzed activation of a tyrosine-containing peptide tag,Bioconjugate Chem.,Vol.22,pp.74-81,2011.04.
8. M. Kitaoka, Y. Tsuruda, Y. Tanaka, M. Goto, M. Mitsumori, K. Hayashi, Y. Hiraishi, K. Miyawaki, S. Noji, N. Kamiya,Transglutaminase-mediated synthesis of a novel DNA-(enzyme)n probe for highly sensitive DNA detection,Chem. Eur. J.,Vol.19,pp.5387-5392,2011.03.
9. N. Kamiya,* H. Abe, M. Goto, Y. Tsuji, H. Jikuya,Fluorescent substrates for covalent protein labeling catalyzed by microbial transglutaminase,Org. Biomol. Chem.,Vol.7,pp.3407-3412,2009.08.
10. N. Kamiya,* Y. Shiotari, M. Tokunaga, H. Matsunaga, H. Yamanouchi, K. Nakano, M. Goto,Stimuli-responsive nanoparticles composed of naturally occurring amphiphilic proteins,Chem. Commun.,pp.5287-5289,2009.08.
11. K. Minamihata, N. Kamiya,* S. Kiyoyama, H. Sakuraba, T. Ohshima, M. Goto,Development of a novel immobilization method for enzymes from hyperthermophiles,Biotechnol. Lett.,31, 1037-1041,2009.07.
12. T. Mouri, T. Shimizu, N. Kamiya,* H. Ichinose, M. Goto*,Design of a cytochrome P450BM3 reaction system linked by two-step cofactor regeneration catalyzed by a soluble transhydrogenase and glycerol dehydrogenase,Biotechnol. Prog.,Vol.25,pp.1372-1378,2009.10.
13. N. Kamiya, S. Doi, Y. Tanaka, H. Ichinose, M. Goto,Functional immobilization of recombinant alkaline phosphatases bearing a glutamyl donor substrate peptide of microbial transglutaminase,J. Biosci. Bioeng.,104, 195-199,2007.09.
14. Y. Tanaka, Y. Tsuruda, M. Nishi, N. Kamiya, M. Goto,Exploring enzymatic catalysis at a solid surface: a case study with transglutaminase-mediated protein immobilization,Org. Biomol. Chem.,5, 1764-1770,2007.05.
15. J. Tominaga, N. Kamiya, M. Goto,An enzyme-labeled protein polymer bearing pendant haptens,Bioconjugate Chem.,18, 860-865,2007.03.
16. J. Tominaga, Y. Kemori, Y. Tanaka, T. Maruyama, N. Kamiya, M. Goto,An enzymatic method for site-specific labeling of recombinant proteins with oligonucleotides,Chem. Commun.,401-403,2007.01.
17. T.Mouri, J.Michizoe, H.Ichinose, N.Kamiya, M.Goto,A recombinant Escherichia coli whole cell biocatalyst harboring a cytochrome P450cam monooxygenase system coupled with enzymatic cofactor regeneration,Appl. Microbiol. Biotechnol.,vol.72, 514-520 (2006),2006.04.
18. T.Mouri, N.Kamiya, M.Goto,Increasing the catalytic performance of a whole cell biocatalyst harboring a cytochrome P450cam system by stabilization of an electron transfer component,Biotechnol. Lett.,vol.28, 1509-1513 (2006),2006.05.
19. H. Piao, N. Kamiya, J. Watanabe, H. Yokoyama, A. Hirata, T. Fujii, I. Shimizu, S. Ito, M. Goto,Oral delivery of diclofenac sodium using a novel solid-in-oil suspension,Int. J. Pharm.,vol.313, 159-162 (2006) ,2006.11.
20. K. Nakashima, T. Maruyama, N. Kamiya, M. Goto,Homogeneous Enzymatic Reaction in Ionic Liquids with Poly(ethylene glycol)-Modified Subtilisin,Org. Biomol. Chem.,vol.4, 3462-3467 (2006),2006.10.
21. K. Nakashima, T. Maruyama, N. Kamiya, M. Goto,Activation of lipase in ionic liquids by modification with comb-shaped poly(ethylene glycol),Sci. Technol. Adv. Mater.,vol.7, 692-698 (2006),2007.01.
22. J. Tominaga, N. Kamiya, S. Doi, H. Ichinose, T. Maruyama, M. Goto,Design of a specific peptide tag that affords covalent and site-specific enzyme immobilization catalyzed by microbial transglutaminase,Biomacromolecules,Vol.6,No.4,vol.6, 2299 -2304 (2005),2005.01.
23. N.Kamiya, S.Doi, J.Tominaga, H.Ichinose, M.Goto,Transglutaminase-mediated protein immobilization to casein nanolayers created on a plastic surface,Biomacromolecules,Vol.6,No.1,6, 35-38 (2005),2005.01.
24. T.Tanaka, N. Kamiya, T.Nagamune,N-terminal glycine-specific protein conjugation catalyzed by microbial transglutaminase,FEBS Letter,Vol.579,No.10,vol.579, 2092-2096 (2005),2005.01.
Membership in Academic Society
  • Japanese Society for Biomaterials
Awards
  • New fluorescent substrates designed for covalent protein labeling catalyzed by microbial transglutaminase
  • Functionalization of the cytochrome P450cam monooxygenase system in the cell-like aqueous compartments of water-in-oil emulsions, J. Biosci. Bioeng., 99, 12-17 (2005)


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