Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Shigeki Sasaki Last modified date:2017.07.18

Professor / Department of Chemo-Pharmaceutical Sciences / Department of Chemo-Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences


Papers
1. Kensuke Kawara, Genichiro Tsuji, Yosuke Taniguchi, Shigeki Sasaki, Synchronized Chiral Induction Between [5] Helicene-Spermine Ligand and B-Z DNA transition, Chemistry - A European Journal, 2017.01.
2. Hidenori Okamura, Yosuke Taniguchi, Shigeki Sasaki, Aminopyridinyl–Pseudodeoxycytidine Derivatives Selectively Stabilize
Antiparallel Triplex DNA with Multiple CG Inversion Sites, Angew. Chem. Int. Ed, 2016.09.
3. Fuchi Yasufumi, Talashi Fukuda, Shigeki Sasaki, Synthetic Receptor Molecules for Selective Fluorescent Detection of 8-oxo-dGTP inAqueous Media, Org. Biomol. Chem, 14, 33, 2016.07.
4. Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi, Effects of 8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNApolymerase and cell proliferation, Bioorg. Med. Chem., 24, 16, 2016.08.
5. Takamasa Nishioka, Ikuya Oshiro, Kazumitsu Onizuka, Yosuke Taniguchi, Shigeki Sasaki, Efficient thymidine-selective DNA interstrand photo-activecrosslinking by the 6-thioguanine connected via an ethylene-linker to the 2'-deoxyribose unit, Chemical and Pharmaceutical Bulletin, 2016.04.
6. Yohei Koga, Yosuke Taniguchi, Yoshiya Kikukawa, Shigeki Sasaki, Recognition and detection of 8-oxo-rG in RNA using the DNA/OMeRNA chimera probes containing fluorescent adenosine-diazaphenoxazine analogue, Bioorg. Med. Chem, 24, 6, 2016.04.
7. Yukiko Abe, Shigeki Sasaki, DNA cleavage at the AP site via b-elimination mediated by the AP site binding ligands, Bioorg. Med. Chem, 24, 4, 2016.04.
8. Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi, Inhibitory Effect of 8-Halogenated 7-Deaza-2-deoxyguanosine Triphosphates on Human 8-Oxo-2-deoxyguanosine Triphosphatase, hMTH1, Activities, CHEMBIOCHEM, 17, 7, 566-569, 2016.02.
9. Yosuke Taniguchi, Akira Tomizaki, Nozomu Matsueda, Hidenori Okamura, Shigeki Sasaki, Enhancement of TFO Triplex Formation by Conjugation with Pyrene via Click Chemistry, Chem. Pharm. Bull., 63, 11, 2015.11.
10. Fuchi Yasufumi, Shigeki Sasaki, New NitroG-Grasp Molecules with Enhanced Capture Reactivity for 8-Nitroguanosine in the Aqueous Media, Chem. Pharm. Bull., 63, 11, 2015.11.
11. Hironori Koda, Ippei Onishi, John Brazier, Shigeki Sasaki, Strong Positive Cooperativity in Binding to the A3T3 Repeat by Hoechst 33258Derivatives Attaching the Quinoline Units at the end of a Branched Linker, Bioorg. Med. Chem., 23, 15, 2015.08.
12. Hironori Koda, Ippei Onishi, John Brazier, Shigeki Sasaki, Strong Positive Cooperativity in Binding to the A3T3 Repeat by Hoechst 33258Derivatives Attaching the Quinoline Units at the end of a Branched Linker, Bioorg. Med. Chem., 23, 15, 2015.08.
13. Kenji Kikuta, Haishun Piao, John Brazier, Yosuke Taniguchi, Kazumitsu Onizuka, Fumi Nagatsugi, Shigeki Sasaki, Stabilization of the i-motif structure by theintrastrand cross-link formation, Bioorg. Med. Chem. Lett., 25, 16, 2015.08.
14. Ikuya Oshiro, Daichi Jitsuzaki, Kazumitsu Onizuka, Atsushi Nishimoto, Yosuke Taniguchi, Shigeki Sasaki, Site-specific modification of the 6-amino group ofadenosine in RNA by an inter-strand functionality-transfer reaction using an S-functionalized-4-thiothymidine, ChemBioChem, 16, 8, 2015.05.
15. Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi, Recognition and excision properties of 8-halogenated-deaza-2'-deoxyguanosine as 8-oxo-2'-deoxyguaanosine analogues and FPG and hOGG1 inhibitors, ChemBioChem, 16, 8, 2015.05.
16. Yosuke Taniguchi, Yoshiya Kikukawa, Shigeki Sasaki, Discrimination Between 8-Oxo-2'-Deoxyguanosine and 2'-Deoxyguanosine in DNA by the Single Nucleotide Primer Extension Reaction with Adap Triphosphate, Angew. Chem. Int. Ed., 54, 17, 2015.04.
17. Fuchi Yasufumi, Shigeki Sasaki, Development of New 1,3-Diazaphenoxazine Derivatives (ThioG-Grasp) to Covalently Capture 8-Thioguanosine, Molecules, 20, 1, 2015.01.
18. Hidenori Okamura, Yosuke Taniguchi, Shigeki Sasaki, An Isocytidine Derivative with a 2-Amino-6-methylpyridine Unit for SelectiveRecognition of the CG Interrupting Site in an Antiparallel Triplex DNA, ChemBioChem, 15, 16, 2014.09.
19. Daichi Jitsuzaki, Kazumitsu Onizuka, Atsushi Nishimoto, Ikuya Oshiro, Yosuke Taniguchi, Shigeki Sasaki, Remarkable acceleration of a DNA/RNA inter-strand functionality transfer reaction to modify a cytosine residue: the proximity effect via complexation with a metal cation , Nulceic Acids Research, 42, 13, 2014.06.
20. Yuma Yamada, Mai Tabata, Yukari Yasuzaki, Masatoshi Nomura, Shibata Atsushi, Yuta Ibayashi, Yosuke Taniguchi, Shigeki Sasaki, Hideyoshi Harashima, A nanocarrier system for the delivery of nucleic acids targeted to a pancreatic beta cell line, Biomaterials, 35, 24, 2014.08.
21. Shigeki Sasaki, Shiro Futaki, Life-oriented Chemistry in Pharmaceutical Sciences(Chemistry Challenge to Mystery of Life), YAKUGAKU ZASSHI, YKKZAJ 134(4)499-500(2014), 2014.04.
22. Yosuke Taniguchi, Keitaro Fukabori, Yoshiya Kikukawa, Yohei Koga, Shigeki Sasaki, 2,6-Diaminopurine nucleoside derivative of 9-ethyloxy-2-oxo-1,3-diazaphenoxazine(2-amino-Adap) for recognition of 8-oxo-dG in DNA. , Bioorg. Med. Chem. , 22(5), 1634-1641 , 2014.03.
23. Yin Yizhen, Yosuke Taniguchi, Shigeki Sasaki, Synthesis of 8-halogenated-7-deaza-2'-deoxyguanosine as an8-oxo-2'-deoxyguanosine analogue and evaluation of its base pairing properties., Tetrahedron, 70(11), 2040-2047 , 2014.03.
24. Yasufumi Fuchi, Shigeki Sasaki, Efficient Covalent Capture of 8-Nitroguanosine via a Multiple Hydrogen-Bonded Complex , Org. Lett., 16(6), 1760-1763 , 2014.03.
25. T.Goto, A.Shiina, T.Murata, M.Tomii, T.Yamazaki, T.Yoshino, O.suzuki, Y.Sogawa, K.Mizukami, N.Takagi, T.Yoshitomi, M.Etori, H.Tsuchida, T.Mikkaichi, N.Nakano, M.Takahashi, H.Takahashi, Shigeki Sasaki, Identification of the5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highlyselective PDE4B inhibitors Bioorg. , Med. Chem. Lett., 24(3), 893-899 , 2014.02.
26. Yosuke Taniguchi, Yohei Koga, Shigeki Sasaki, Synthesis of 8-oxoguanosine phosphoramidite and its incorporation into oligoribonucleotides. , Current Protocols in Nucleic Acid Chemistry, UNIT4.58 56:4.58.1-4.58.10, 2014.01.
27. T.Goto, A.Shiina, T.Yoshino, K.Mizukami, K.Hirahara, O.Suzuki, Y.Sogawa, T.Takahashi, T.Mikkaichi, N.nakao, M.Takahashi, M.Hasegawa, Shigeki Sasaki, Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidinederivatives as novel and potent PDE4 inhibitors. , Bioorg. Med. Chem. , 21 (22) 7025-7037 , 2013.11.
28. Genichiro Tuji, Kyoko Kawakami, Shigeki Sasaki, Enantioselective Binding of Chiral 1,14-Dimethyl[5]Helicene-spermine Ligands with B- and Z-DNA. , Bioorg. Med. Chem., 21 (19) 6063-6068 , 2013.10.
29. Hideaki Sasaki, Shigeki Sasaki, B-Z Transition of (dA-T)n Duplex Induced by Spermine Porphyrin-Conjugate via anIntermediate DNA Conformation. , Chem. Comm., 49(79) 9024-9026, 2013.07.
30. T.Goto, A.Shiina, T.Yoshino, K.Mizukami, K.Hirahara, O.Suzuki, Y.Sogawa, T.Takahashi, T.Mikkaichi, N.nakao, M.Takahashi, M.Hasegawa, Shigeki Sasaki, Identification of the fused bicyclic4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors

, Bioorg. Med. Chem. Lett., 23(11), 3325-3328, 2013.06.
31. Hidenori Okamura, Yosuke Taniguchi, Shigeki Sasaki, N-(Guanidinoethyl)-2'-deoxy-5-methylisocytidine exhibits a selective recognition of a CG interrupting site for the formation of anti-parallel triplexes, Org. Biomol. Chem., , 11. 3918-3924, 2013.04.
32. Atsushi Nishimoto, Daichi Jitsuzaki, Kazumitsu Onizuka, Yosuke Taniguchi, Fumi Nagatsugi, Shigeki Sasaki, 4-Vinyl-Substituted Pyrimidine Nucleosides Exhibit the Efficient and SelectiveFormation of Interstrand Cross-Links with RNA and duplex DNA, 41, 13, 2013.06.
33. Taniguchi Y., Okamura H., Fujino N., Sasaki S., Synthesis of 1'-phenyl-2-OMe ribose analogues connecting the thymine base at the 1' position through a flexible linker for the formation of a stable anti-parallele triplex DNA,, Tetrahedron, 69(2), 600-606 (2013), 2013.01.
34. Koga Y., Taniguchi Y. and Sasaki S. , Synthesis of the Oligoribonucleotides Incorporating 8-Oxo-guanosine and Evaluation of their Base Pairing Properties,, Nucleosides, Nucleotides and Nucleic Acids, , 2013.01.
35. Aoki E., Taniguchi Y., Wada Y., Sasaki S., Efficient DNA strand displacement by a W-shaped nucleoside analogue (WNA-T) containing an ortho-methyl-substituted phenyl ring, , ChemBioChem,., 13(8), 1152-1160 (2012) , 2012.12.
36. Nasr T, Taniguchi Y., Takaki T., Okamura H., Sasaki S, Properties of Oligonucleotidewith Phenyl-Substituted Carbocyclic Nucleoside Analogues for the Formation ofDuplex and Triplex DNA, , Nucleosides, Nucleotides and Nucleic Acids,, 31(12), 8441-860. (2012) , 2012.12.
37. Abe Y., Nakagawa O., Yamaguchi R., Sasaki S, Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site, Bioorg. Med. Chem. , 3470-3479 (2012). , 2012.04.
38. S. Sasaki, K. Onizuka, Y. Taniguchi, Oligonucleotide containing S-Functionalized 2'-deoxy-6-thioguanosine: Facile Tools for Base-Selective and Site Specific Internal Modification of RNA., Current Protocols in Nucleic Acid Chemistry , 2012.03.
39. Y. Taniguchi, Y. Koga, K. Fukabori, R. Kawaguchi, S. Sasaki, OFF-to-ON type fluorescent probe for the detection of 8-oxo-dG in DNA by the Adap-masked ODN probe., Bioorg. Med. Chem. Lett. , 22 (1), 543-546 (2012), 2012.03.
40. K. Onizuka, T. Nishioka, Z. Li, D. Jitsuzaki, Y. Taniguchi, S. Sasaki, An efficient and simple method for site-selective modification of O6-methyl-2’-deoxyguanosine in DNA., Chem. Commun. (2012), 48, 33, 3969-3971, 2012.03.
41. Sasaki S, Onizuka K, Taniguchi Y , The oligodeoxynucleotide probes for the site-specific modification of RNA, Chem.Soc.Rev. , 2011.04.
42. Taniguchi Y, Kawaguchi R, Sasaki S, Adenosine-1,3-diazaphenoxazine Derivative for Selective Base Pair Formation with 8-Oxo-2'-deoxyguanosine in DNA, J.Am.Chem.Soc., 133,7272-7275, 2011.03.
43. Koga Y, Fuchi Y, Nakagawa O, Sasaki S, Optimization of Fluorescence Property of the 8-OxodGclamp Derivative for Better Selectivity for 8-Oxo-2'-deoxyguanosine, Tetrahedron, 2011.02.
44. Onizuka k, Shibata A, Taniguchi Y, Sasaki S, Pin-Point Chemical Modification of RNA with DiverseMolecules through the Functionality Transfer Reaction and Copper-CatelyzedAzide-Alkyne Cycloaddition Reaction, Chem.Comm., 47(17),5004-5006, 2011.01.
45. Taniguchi Y., Nitta A., Park S. M., Kohara A., Uzu T., Sasaki S., The ODN probes conjugating the Cu(II) complex enhance the luminol chemiluminescense by assembling on the DNA template., Bioorg. Med. Chem., 2010.10.
46. Doi I., Tsuji G., Kawakami K., Nakagawa O., Taniguchi Y., Sasaki S., The Spermine-Bisaryl Conjugate as a Potent Inducer for the B to Z-DNA Transition., Chem. Eur. J. , accepted, 2010.07.
47. Nagatsugi F., Sasaki S., Synthesis of Reactive Oligonucleotides foe Gene Targeting and Their Application to Gene Expression Regulation, Bull. Chem. Soc. Jpn., 83, 744-755 , 2010.07.
48. Onizuka K., Taniguchi Y., Sasaki S., Activation and Alteration of Base Selectivity by Metal Cations in the Functionality-Transfer Reaction for RNA Modification, Bioconjugate Chem. , 21, 1508-1512 , 2010.06.
49. Fumi Nagatsugi and Shigeki Sasaki, Synthesis of Reactive Oligonucleotides for Gene Targeting and Their Application to Gene Expression Regulation , Bulletin of the Chemical Society of Japan, Vol.83, No.7 744-755
, 2010.06.
50. Taniguchi Y., Kurose Y., Nishioka T., Nagatsugi F., Sasaki S, The Alkyl-Connected 2-Amino-6-Vinylpurine (AVP) Crosslinking Agent for Improved Selectivity to the Cytosine, Bioorg. Med. Chem. , 18. 2894-2901 , 2010.03.
51. Kazumitsu Onizuka, Yosuke Taniguchi and Shigeki Sasaki*, A new Usage of Functionalized Oligodeoxynucleotide Probe for Site-Specific Modification of a Guanine Base within RNA
, Nucleic Acids Research,, 38, 1760-1766 , 2010.02.
52. Taniguchi Y., Kurose Y., Nishioka T., Nagatsugi F., Sasaki S., Evaluation of theantisense effect of PEGylatedoligodeoxynucleotidescontaining intelligent nucleoside analogues, Nucleic Acids Symp. Ser., 53,167-168 , 2009.10.
53. Onizuka K. Taniguchi Y., Nishioka T., Sasaki S., Site-specific modification of RNA by functionality-transfer ODNprobes,, Nucleic Acids Symp. Ser., 53, 67-68 , 2009.10.
54. Taniguchi Y., Uchida Y., Takaki T., Aoki E., Sasaki S., Recognition of CG interrupting site by W-shaped nucleoside analogs (WNA) having the pyrazole ring in an anti-parallel triplex DNA, Bioorg. Med. Chem., 17, 6803-6810 , 2009.09.
55. Onizuka K, Taniguchi Y., Sasaki S, A New Odorless Procedure for the synthesis of 2'deoxy-6-thioguanosine and It Incorporation Into Oligonucleotides, Nucleosides, Nucleotides, and Nucleic Acids,, 28, 752-760 , 2009.06.
56. Onizuka K, Taniguchi Y., Sasaki S, Site-specific covalent modification of nucleic acids guided by functionality-transfer oligodeoxynucleotides , Bioconjugate Chem., 20, 799-803 , 2009.05.
57. Ali M. M., Imoto S., Li Y., Sasaki S. Nagatsugi F., Incorporation of inducible nucleotide analog into DNA by DNA polymerases,, Bioorg. Med. Chem., 17, 2859-2863, 2009.04.
58. Tamer Nase, Zhichun Li, Osamu Nakagawa, Yosuke Taniguchi, Sayaka Ono, Shigeki Sasaki, Selective Fluorescence quenching of the 8-oxoG-clamp by 8-oxodeoxyguanosine in ODN , BMCL, 19, 3, 727-730, 2009.02.
59. Nagatsugi F., Nakahara R., Inoue K., Sasaki S, Synthesis and Evaluation of the Luciferase-Oligodeoxynucleotide for the Sequencse-Selective Detection of Nucleic Acids, Arch. Pharm. Chem. Life Sci, 341, 562-567 , 2008.09.
60. J. A. Brazier, I. Onishi and S. Sasaki, Binding of two bis-bipyridine minor groove binders to a DNA tempiate in the presence of Cu2+ ione, Nucleic Acids Symposium Series, NO.52 107-108 , 2008.09.
61. Y. Uchida, Y. Taniguchi, E. Aoki, M. Togo and S. Sasaki, Formation of a stable triplex incorporating a CG interrupting site by a new WNA derivative containing 3-aminopyrazole as a nucleobase, Nucleic Acids Symposium Series, NO.52 137-138, 2008.09.
62. K. Onizuka, Y. Taniguchi, T. Nishioka and S. Sasaki, Site-specific modification by functionality-transfer oligonucleotide with the photo-inducible reactivity, Nucleic Acids Symposium Series, NO.52 367-368, 2008.09.
63. Y. Kurose , Y. Taniguchi, F. Nagatsugi and S. Sasaki, Synthesis of new nucleosids analogue connecting 2-amino-6-vinylpurine to the 2’-deoxyribose skeleton via the methylene linker, Nucleic Acids Symposium Series, NO.52 43-44, 2008.09.
64. F. Nagatsugi, R. Nakahara, K. Inoue, S. Sasaki, Synthesis and Evaluation of the Luciferase-Oligodeoxynucleotide for the Sequence-Selective Detection of Nucleic Acids, Arch. Pharm. Chem. Life Sci., 341, 2008 in press, 2008.07.
65. Y. Haruta, K. Onizuka, K. Watanabe, K. Kono, A. Nohara, K. Kubota, S. Imoto, S. Sasaki, Stereoselective synthesis of (t)-2-deoxyolivin based on cycloaddition reaction between the homophthalic anhydride and the chiral cyclohexenone derivative, Tetrahedron, 64, 7211-7218 , 2008.07.
66. Taniguchi, M. Togo, E. Aoki, Y. Uchida, S. Sasak, Synthesis of p-amino-WNA derivatives to enhance the stability of the anti-parallel triplex, Tetrahedron, 64,7164-7170 2008. , 2008.07.
67. Alam Md., Majumdar A., Thazhathveetil A., Liu S.-T., Liu J.-Lan., Puri N., Cuenoud B., Sasaki S., Miller P., Seidman M., Extensive sugar modification improves triple helix forming oligonucleotide activity in vitro but reduces activity in vivo., Biochemistry, 46, 10222-10233 , 2007.11.
68. Imoto S., Ali M. M., Li Y., Sasaki S., Nagatsugi F., Enzymatic Incorporation of 2-Amino-6-Vinylpurine Derivative, Nucleic Acids Symp. Ser., 51, 357-358, 2007.11.
69. Onizuka K., Taniguchi Y., Sasaki S, Development of novel thioguanosine analogs with the ability to specifically modify cytidine, Nucleic Acids Symp. Ser., 51, 5-6, 2007.11.
70. Aoki E., Taniguchi Y., Sasaki S., Effective strand invasion ODN incorporating a new bicyclic nucleoside analogue (WNA), Nucleic Acids Symp. Ser., 51, 255-256, 2007.11.
71. Ono S., Li Z., Koga Y., Tsujimoto A., Nakagawa O., Sasaki S., Development of a Specific Fluorescent Probe for 8-Oxoguanosine, Nucleic Acids Symp. Ser., 51, 315-316, 2007.11.
72. Uzu T,Sasaki S, A New Copper(II) Complex as an Efficient Catalyst of Luminol Chemiluminescence., Organic Letters, Vol. 9, No. 21 4383-4386, 2007.08.
73. Nagatsugi F, Ogata Y, Imoto S, Sasaki S, Efficient Synthesis of 6-Substituted Purine Derivatives using Pd-Catalyzed Cross-Coupling Reactions with 2'-Deoxyguanosine 06-Tosylate, Heterocycles, Vol.73, 493-501, 2007.07.
74. Nasr T., Taniguchi Y., Sasaki S., Synthesis of 1’-Phenyl Substituted Nucleoside Analogs, Heterocycles, Vol. 71, No. 12, 2659-2668, 2007.06.
75. Nakagawa O, Ono S, Tsujimoto A, Li Z, Sasaki S, Selective Fluorescence Detection of 8-Oxoguanosine with 8-oxoG-clamp, Nucleosides, Nucleotides, and Nucleic Acids, 26, 645-649, 2007.06.
76. Nakagawa O., Ono S., Li Z., Tsujimoto A., Sasaki S.,, Specific Fluorescent Probe for 8-Oxoguanosine, Angew. Chem. Int. Ed.,, Vol.46 No.24 4500-4503, 2007.05.
77. Tsujita S., Tanada M., Kataoka T.,Sasaki S, Equilibrium shift by target DNA substrates for determination of DNA binding ligands, Bioorg. Med. Chem. Lett., 17, 68-72, 2007.01.
78. Sasaki S., Nagatsugi F.,, Application of unnatural oligonucleotides to chemical modification of gene expression, Current Opin. Chem. Biol., 10, 615-621, 2006.12.
79. Nakagawa O., Ono S., Tsujimoto A., Li Z., Sasaki S., Fluorescence detection of 8-oxoguanosine by G-clamp derivatives, Nucleic Acids Symp. Ser., 50, 21-22, 2006.11.
80. Aoki E., Taniguchi Y., Togo M., Sasaki S., Effects of the modified aromatic ring of WNA on stability of triplex DNA, Nucleic Acids Symp. Ser., 50, 185-186, 2006.11.
81. Kataoka T., Tanada M., Onishi I., Sasaki S., Recognition of DNA with assembly of minor groove binders mediated by metal complexation, Nucleic Acids Symp. Ser., 50, 161-162, 2006.11.
82. Nakayama S., Nagatsugi F., Sasaki S., Novel drug releasing system triggered by hybridization with target sequence, Nucleic Acids Symp. Ser., 50, 143-144, 2006.11.
83. Md. Monsur Ali, M. Oishi, F. Nagatsugi, K. Mori, Y. Nagasaki, K. Kataoka, S. Sasaki, Intracellular Inducible Alkylation System That Exhibit Antisense Effects with Greater Potency and Selectivity than the Natural Oligonucleotide, Angew. Chem. Int. Ed, 45,3136-3140, 2006.05.
84. Tanada M., Tsujita S., Kataoka T., Sasaki S, Cu2+-Mediated Assembly of the Minor Groove Binders on the DNA Template with Sequence Selectivity, Organic Lett., 8,No12,2475-2478, 2006.03.
85. Y. Taniguchi, A. Nakamura, Y. Senko, F. Nagatsugi, S. Sasaki, Effects of Halogenated WNA Derivatives on Sequence Dependency for Expansion of Recognition Sequences in the Non-Natural Type Triplexes, J. Org. Chem, 71,No5,2115-2122(2006), 2006.02.
86. Md. Monsur Ali, R.Nakahara, F.Nagatsugi, M. Maeda, S. Sasaki, Application of 2-Amino-6-Vinylpurine as an Efficient Agent for Conjugation of Oligonucleotides, Nucleosides, Nucleotides and Nucleic Acids, 25,159-169, 2006.01.
87. M. Tanada, S. Tsujita, S. Sasaki, Design of New Bidentate Ligands Constructed of Two Hoechst 33258 Units for Discrimination of the Length of Two A3T3 Binding Motifs, J. Org. Chem, 71, 125-134 (2006), 2006.01.
88. M. Oishi, F. Nagatsugi, S. Sasaki, Y. Nagasaki, and K. Kataoka,, Smart Polyion Complex Micelles for Targeted Intracellular Delivery of PEGylated Antisense Oligonucleotide with Acid-Labile Linkage, Chembiochem, in press., Chembiochem, 6, 4, 6, 718-725, 2005.06.
89. T. Kawasaki, F. Nagatsugi, Md. M. Ali, M. Maeda, K. Sugiyama, K. Hori and S. Sasaki, Hybridization-Promoted and Cytidine-Selective Activation for Cross-Linking with the Use of 2-Amino-6-Vinylpurine Derivatives,, J. Org. Chem., 70, 1, 70 (1), 14-23, 2005.01.
90. Y.Taniguchi, A. Nakamura, Y. Senko, K. Kodama, F. Nagatsugi, S. Sasaki, Expansion of triplex recognition codes by the use of novel bicyclic nucleoside derivatives (WNA), Nucleosides, Nucleotides and Nucleic Acids, 24, 5-7, 24, 823-827, 2005.01.
91. Ali Md. Monsur, F. Nagatsugi, S. Nakayama, Md. Rowshon Alam, T. Kawasaki, S. Sasaki, Design of highly efficient and selective transfer reaction of nitrosyl group to dC and dmC resulting in specific deamination., Nucleosides, Nucleotides and Nucleic Acids, 24, 5-7, 24, 721-724, 2005.01.
92. M. Oishi, T.Hayama, Y. Akiyama, S. Takae, A. Harada, Y. Yarnasaki, F. Nagatsugi, S. Sasaki, Y. Nagasaki, K. Kataoka, Supramolecular assemblies for the cytoplasmic delivery of antisense oligodeoxynucleotide: Polylon complex (PIC) micelles based on poly(ethylene glycol)-SS-oligodeoxynucleotide conjugate, Biomacromolecules, 6, 5, 6: 2449-2454, 2005.01.
93. Shigeki Sasaki,Yosuke Taniguchi, Ryo Takahashi, Yusuke Senko, Keiichi Kodama, Fumi Nagatsugi, Minoru Maeda, Selective Formation of Stable Triplexes Including a TA or a CG Interrupting Site with New Bicyclic Nucleoside Analogs (WNA), J. Amer. Chem. Soc., 126, 2, 126, 516-528, 2004.01.
94. Shigeki Sasaki,Fumie Kurosaki, Terushi Haradahira, Fumihiko Yamamoto, Jun Maeda, Takesh Okauchi, Kazatoshi Suzuki, Tetsuya Suhara, Minoru Maeda, Synthesis of 11C-Labeled Bis(phenylalkyl)amine and Their in Vitro and in Vivo Binding Properties in Rodent and Monkey Brains,, Biol. Pharm. Bull, 27(4), 531-537, 2004.01.
95. Nagatsugi Fumi, Sasaki Sasaki, Chemical tools for targeted mutagenesis of DNA based on triple helix formation, Biol Pharm Bull., 27, 4, 27, (4):463-467, 2004.01.
96. Md. M. Ali, Md. R. Alam, T. Kawasaki, S. Nakayama, F. Nagatsugi, S. Sasaki, Sequence- and Base-Specific Delivery of Nitric Oxide to Cytidine and 5-Methylcytidine Leading to Efficient Deamination, J. Am. Chem. Soc., 126, 29, 126, 8864-8865, 2004.01.
97. Taniguchi Y., Nakamura A., Senko Y., Sasaki S.,, Effects of 5-substituted pyrimidine nucleoside bases of WNA on stability of triplex DNA,, Nucleic Acids, Symp. Ser., 48, 69-70, 2004.01.
98. Ali M. M., Nagatsugi F., Oishi M., Nagasaki Y., Kataoka K., Sasaki S.,, Synthesis and evalutaion of the functional oligonucleotides-PEG conjugates,, Nucleic Acids, Symp. Ser., 48, 61-62, 2004.01.
99. Nagatsugi F., Nakayama S., Ali M. M., Sasaki S.,, Selective nitrosyl group transfer reaction to cytidine using oligonucleotides bearing S-nitrosothioguanosine,, Nucleic Acids, Symp. Ser., 48, 23-24, 2004.01.
100. Imoto S., Haruta Y., Watanabe K., Sasaki S.,, New DNA Binding Ligands as a Model of Chromomycin A3,, Bioorg. Med. Chem. Lett., 14, 19, 14, 4855-4859, 2004.01.
101. Tanada, Mikimasa; Shibata, Yoshihiro; Maeda, Minoru; Sasaki, Shigeki, Bipyrrole Derivatives as New DNA-Minor Groove Binders,, Heterocycles, 63, 1, 63(1), 29-39, 2004.01.
102. Fumihiko Yamamoto, Eri Kuwano, Tetsuo Kaneshiro, Shigeki Sasaki, Minoru Maeda, 125I-Labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid: synthesis and preliminary tissue distribution., J. Labelled Cpd. Radiopharm.,, 43, 737-750, 2003.01.
103. T. Fuchigami, T. Haradahira, T. Arai, T. Okauchi, J. Maeda, K. Suzuki, F. Yamamoto, T. Suhara, S. Sasaki, M. Maeda, Synthesis and Brain Regional Distribution of [11C]NPS1506 in Mice and Rat: an NMDA Receptor Antagonist, Biol. Pharm. Bull., 26, 11, 26: 1570-1573, 2003.01.
104. Hiroshi Tokiwa,, Nobuyuki Sera, Kiyoshi Fukuhara, Hideo Utsumi, Shigeki Sasaki and Naoki Miyata, Structural activity relationship between Salmonella-mutagenicity and nitro-orientation of nitroazaphenanthrenes, Chemico-Biological Interactions, 146, 1, 146 (1) , 19-25, 2003.01.
105. Nagatsugi F., Sasaki S., Miller P. S. and Seidman M. M.,, Site-Specific Mutagenesis by Triple-Helix Forming Oligonucleotides Containing a Reactive Nucleoside Analogue, Nucleic Acids Res.,, 31, 6, 31(6), e31, 2003.01.
106. Taniguchi, Yosuke; Senko, Yusuke, Kodama, Keiichi; Nakamura, Ayako, Shigeki Sasaki, Design and evaluation of novel nucleoside analogs (WNA) for specific formation of non-natural triplexes containing a TA or a CG interrupting site, Nucleic Acids Research Suppl., 3, 113-114, 2003.01.
107. Oishi M, Sasaki S, Nagasaki Y, Kataoka K., pH-responsive oligodeoxynucleotide (ODN)-poly(ethylene glycol) conjugate through acid-labile beta-thiopropionate linkage: preparation and polyion complex micelle formation, Biomacromolecules, 4, 5, 4(5), 1426-32, 2003.01.
108. Taniguchi, Yushuke; Takahasi, Ryo; Kodama, Keiji; Senko Yusuke; Maeda, Minoru; Sasaki, Shigeki,, Selective formation of non-natural type triplexes containing TA interrupting sites with the TFO incorporating W-shape nucleic acid (WNA) analogs, Nucleic Acids Res. Suppl, 2, 31-32, 2002.01.
109. Yamamoto, Fumihiko; Aoki; Mizuho, Furusawa; Yoshiya, Ando Koichi, Kuwabara; Yasuo, Masuda; Kouji, Sasaki, Shigeki; Maeda, Minoru, Synthesis and Evaluation of New 4-Bromo-1-(3-[18F]fluoropropyl)-2-nitroimidazole with a Low Energy LUMO Orbital Designed as Brain hypoxia-Targeting Imaging Agent, Biol. & Pharm. Bull, 25, 5, 25 (5) 616-621, 2002.01.
110. Nagatsugi, Fumi; Matsuyama, Yoshihisa; Maeda, Minoru; Sasaki, Shigeki, Selective Cross-linking to the Adenine of the TA Interrupting Site within Homopurin磁Homopyrimidine Duplex, Bioorg & Med. Chem Lett., 12, 487-489, 2002.01.
111. Md. Monsur Ali, Nagatsugi F., Yamamoto F., Maeda M., Sasaki S.,, 2-Amino-6-Vinylpurine as a Tool of Post Synthetic Conjugation of Oligonucleotides with Radio-, Spin-, Fluorescence Label and Peptides, Nucleic Acids Res. Supp.,, 2, 149-150, 2002.01.
112. Nagatsugi F., Sasaki S., Miller P. S. and Seidman M.M., A new reactive nucleoside analogue for highly reactive and selective cross-linking reaction to cytidine under neutral conditions, Nucleic Acids Res. Suppl.,, 2, 35-36, 2002.01.
113. Sasaki, S, Active Oligonucleotides Incorporating Alkylating Agent as Potential Sequence- and Base Selective Modifier of Gene Expression, Eur. J. Phar. Sci., 13, 1, 13(1), 43-51, 2001.01.
114. Sasaki, Shigeki; Ehara, Takeru; Sakata, Ikuhiro; Fujino, Yasuhiro; Harada, Naozumi; Kimura, Junko; Nakamura, Hideo; Maeda Minoru, Development of Novel Telomerase Inhibitors Based on a Bisndole Unit, Bioorg & Med. Chem Lett.,, 11, 4, 11(4), 583-585, 2001.01.
115. Nagatsugi, Fumi; Kawasaki, Takeshi; Tokuda, Natsuko; Maeda, Minoru; Sasaki, Shigeki, Site-Directed Alkylation to Cytidine within Duplex by the Oligonucleotides Containing Functional Nucleobases, Bistetrahydrofuran and Bisfuran Skeleton with Long Alkyl Chains, Nucleoside, Nucleotides and Nucleic Acids, 20, 4-7, 20(4-7), 915-919, 2001.01.
116. Sasaki, Shigeki; Shibata, Takayuki; Torigoe, Hidetaka; Shibata, Yoshihiro; Minoru, Maeda, Novel Class of DNA Binding Motifs Based on Bistetrahydrofuran and Bisfuran Skeleton with Long Alkyl Chains, Nucleoside, Nucleotides and Nucleic Acids, 20, 4-7, 20(4-7), 551-558, 2001.01.
117. Sasaki, Shigeki; Yamauchi, Hiroyuki; Takahashi, Ryo; Taniguchi, Yosuke; Minoru Maeda, New Base Analogs for the Formation of Non-Natural Triplexes, Nucleic Acids Res Supp., 1, 44, 23-24, 2001.01.
118. Sasaki, Shigeki; Yamauchi, Hiroyuki; Nagatsugi, Fumi; Takahashi, Ryo; Taniguchi, Yosuke; Minoru Maeda, W-Shape Nucleic Acid (WNA) for Selective Formation of Non-Natural Anti-Parallel Triplex Including a TA Interrupting Site, Tetrahedron Letters, 42, 39, 42(39), 6915-6918, 2001.01.
119. Sasaki, Shigeki; Ehara, Takeru; Alam, Md Rowshon; Fujino, Yasuhiro; Harada, Naozumi; Kimura, Junko; Nakamura, Hideo; Maeda, Minoru, Solid-Phase Synthesis of a Library Constructed of Aromatic Phosphate, Long Alkyl Chains and Tryptophane Components, and Identification of Potent Dipeptide Telomerase Inhibitors, Bioorg & Med. Chem Lett, 11, 19, 11(19), 2581-2584, 2001.01.
120. Nagatsugi, Fumi; Tokuda, Natsuko; Kawasaki, Takeshi; Maeda, Minoru; Sasaki, Shigeki, Efficient Cross-Linking to Cytidine under Neutral Conditions Using the 2-Mino-6-Vinylpurine Derivatives Having an Additional Activating Group, Nucleic Acids Res Supp., 1, 44, 87-88, 2001.01.
121. Nagatsugi, Fumi; Tokuda,Natsuko; Maeda, Minoru; Sasaki, Shigeki, A New Reactive Nucleoside Analog for Highly Reactive and Selective Cross-linking Reaction to Cytidine Under Neutral Conditions, Bioorg & Med. Chem Lett., 11, 19, 11(19), 2577-2579, 2001.01.
122. Haradahira Terushi; Zhang, Ming-Rong; Maeda, Jun; Okauchi, Takeshi; Kida, Takayo; Kawabe, K.; Sasaki, Shigeki; Suhara Tetsuya; Suzuki Kazutoshi, A prodrug of NMDA/glycine site antagonist, L-703,717, with improved BBB permeability: 4-acetoxy derivative and its positron-emitter labeled analog, Chemical & Pharmaceutical Bulletin, 49, 2, 49(2), 147-150, 2001.01.
123. Nagatsugi, Fumi, Usui, Daisuke; Kawasaki, Takeshi; Maeda, Minoru; Sasaki, Shigek, Design and Synthesis of the Novel Cross-Linking Reagents Triggered by the Triple Helix Formation, Nucleic Acids, Symp. Ser.,, 44, 39-40, 2000.01.
124. Alam, Md. Rowshon; Maeda, Minoru; Sasaki, Shigeki, DNA-Binding Peptides Searched from the Solid-Phase Combinatorial Library with the Use of the Magnetic Beads Attaching the Target Duplex DNA, Bioorg & Med. Chem.,, 8, 2, 8(2), 465-473, 2000.01.
125. Kawasaki, Takeshi; Nagatsugi, Fumi; Maeda, Minoru; Sasaki, Shigeki,, Efficient Cross-Linking to Cytidine Using Substituted Phenylsulfide Derivatives of 2-Amino-6-Vinylpurine Nucleoside via Synchronous Activation within Duplex., Nucleic Acids, Symp. Ser.,, 44, 129-130, 2000.01.
126. Ishibashi, Nobuyasu; Kuwamura,. Tsuneo; Sano, Hiromi; Yamamoto, Fumihiko; Haradahira, Terushi; Suzuki Kazutoshi; Suhara Tetsuya; Sasaki, Shigeki; Maeda, Minoru, Synthesis and Evaluation of New 18F- and 11C-Labelled 6,11-Ethanobenzo[b]quinolizi-nium Derivatives for Imaging of the NMDA Receptor at the TCP-Binding Site, J. Labelled Cpd. Radiopharm.,, 43, 375-383, 2000.01.
127. Matsuura, Naoko; Yashiki, Yoshitaka; Nakashima, Shouji; Maeda, Minoru; Sasaki, Shigeki, Shortcut Stereoselective Synthesis of 1-b-Alkyl-2-Deoxyribose Derivatives via Wittig-Horner-Emons Reaction, Heterocycles, 51 (5), 975-978, 1999.01.
128. Sakata, Kayo; Hamase, Kenji; Sasaki, Shigeki; Maeda, Minoru; Zaitsu, Kiyoshi, Reversible Fluorescence Derivatization of Amino Groups Using Dansylaminomethylmaleic Acid via Its Anhydride, Analytical Sciences, 15, 11, 15(11), 1095-1099, 1999.01.
129. Nagatsugi, F, Kawasaki, T, Usui, D, Maeda, M, Sasaki, S, Highly Efficient and Selective Cross-Linking to Cytidine Based on the New Strategy for Auto-Activation within Duplex, J. Amer. Chem. Soc.,, 121, 28, 121(28), 6753-6754, 1999.01.
130. Kawasaki, Takeshi; Nagatsugi, Fumi; Usui, Daisuke; Maeda, Minoru, Sasaki, Shigeki, Efficient Cross-Linking to Cytidine by Functional Nucleobases Capable of In Situ Activation, Nucleic Acids, Symp. Ser., 42, 43-44, 1999, 42, 43-44, 1999.01.
131. Sasaki, Shigeki; Nagatsugi, Fumi; Maeda, Minoru, 2'-Deoxy Nucleoside Derivatives of 6-Substituted 2-Aminopurine as Highly Efficient and Selective Cross-Linking Agent to Cytidine, Coll. Czech. Chem. Commun., Symp. Series, 2, 2, 114-118, 1999.01.
132. Nagatsugi, Fumi; Kawasaki, Takeshi; Tanaka, Yoshitsugu, Maeda, Minoru, Sasaki, Shigek, Structural Analysis of Cross-Linked Adducts with the Oligonucleotides Incorporating 2-Amino-6-vinylpurine, Nucleic Acids, Symp. Ser., 39, 103-104, 1998.01.
133. Sasaki,Shigeki; Hashimoto, Tomohiro; Obana, Norihiro; Yasuda, Hideyo; Uehara, Yoshimasa; Maeda, Minoru, Design of New Inhibitors for CDC2 Kinase Based on a Multiple Pseudosubstrate Structure, Bioorg. Med. Chem. Lett., 8, 9, 8(9), 1019-1022, 1998.01.
134. Matsui, Akiko; Matsuo, Hiromi; Takanaga, Hitomi; Sasaki, Shigeki; Maeda, Minoru; Sawada, Yashufumi, Prediction of Catalepsies Induced by Amiodarone, Aprindine and Procaine-Similarity in Conformation of Diethylaminoethyl Side Chain, J. Pharmacology & Experimental Therapeutics, 287, 2, 287(2), 725-732, 1998.01.
135. Haradahira, Terushi; Sasaki Shigeki; Maeda, Minoru; Kobayashi Kaoru; Inoue Osamu; Tomita Urara; Nishikawa Toru; Suzuki, Kazutoshi, Synthesis and Brain Distribution of Carbon-11 Labeled Analogs of Antagonists for the NMDA Receeptor Coupled PCP-Binding Site, J. Labelled Cpd. Radiopharm., 41, 9, 41(9), 843-858, 1998.01.
136. Sasaki, Shigeki; Maruta, Katsunori; Naito, Hiroyuki; Maemura, Rie; Kawahara, Eiji; and Maeda, Minoru, Novel Acyclic Ligands for Metal Cations Based on the Adjacent Bistetrahydrofuran as Analogs of Natural ANNONACEOUS Acetogenins, Tetrahedron, 54, 11, 54(11), 2401-2410, 1998.01.
137. Sasaki,Shigeki; Ishibashi, Nobuyasu; Kuwamura, Tshuneo; Sano, Hiromi; Matoba, Masaki; Nisikawa, Tohru; Maeda, Minoru, Excellent Acceleration of the Diels-Alder Reaction by Microwave Irradiation for the Synthesis of New Fluorine-Substituted Ligands of NMDA Receptor, Bioorg. Med. Chem. Lett., 8, 21, 8(21), 2983-2986, 1998.01.
138. Alam, Md. Rowshon; Tanaka, Yoshizugu; Maeda, Minoru; Sasaki, Shigeki, Random Search of New Peptide Ligands towards Duplex DNA by the Application of Combinatorial Technology, , Nucleic Acids, Symp. Ser., 39, 69-70, 1998.01.
139. Sasaki, Shigeki; Maruta, Katsunori; Naito, Hiroyuki; Maemura, Rie , Kawahara, Eiji; Maeda, Minoru, In Vitro Antitumor Activities of New Synthetic Bistetrahydrofuran Derivatiaves as Analogs of Annonaceous Acetogenins, Chem. Pham. Bull., 46, 1, 46(1), 154-158,, 1998.01.