Kyushu University Academic Staff Educational and Research Activities Database
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Hitoshi Kurose Last modified date:2018.06.20



Graduate School
Administration Post
Other
Other
Other
Other
Other
Other
Other
Other


E-Mail
Phone
092-642-6884
Fax
092-642-6884
Academic Degree
Ph.D.
Field of Specialization
Molecular Cardiovascular Pharmacology
Research
Research Interests
  • Cardiac fibrosis
    keyword : myofibroblast
    2018.06~2020.03.
  • Analysis of molecular mechanisms of cardiovascular diseases
    keyword : 心臓、心筋梗塞、心不全、受容体、細胞シグナリング
    2012.08~2021.03.
  • inflammation and cardiac diseases
    keyword : inflammation, cardiac hypertrophy, ischemic disease
    2009.04~2018.03.
  • Molecular mechanisms of cellular signaling in cardiac diseases
    keyword : heart, signaling
    2009.01~2018.03.
  • Mechanisms and physiological meanings of G potein-independent signaling by beta-blockers
    keyword : beta-blocker, heart, G protein
    2007.04~2014.12.
  • Role of heterotrimeric G proteins in cardiac remodeling
    keyword : fibrosis, mechanical stress, heterotrimeric G proteins
    2005.04~2018.03.
  • Role of receptor-activated TRP channels in hypertrophy and development of novel drugs targeting TRP channels
    keyword : hypertrophy, TRP channel, calcium ion
    2005.04~2014.12.
  • Molecular mechanisms of regulation of receptors
    keyword : receptor, regulation, desensitization, downregulation
    2007.04~2018.03.
Current and Past Project
  • How GPCR is regulated, and what molecules are involved in this process are analyzed.
  • Regulation of GPCRs is analyzed.
  • Role of prokineticin in the heart when the heart is exposed to ischemic stress is analyzed.
  • The roles of proton and lipids in cellular responses through signaling molecules such as G proteins and downstream signaling molecules are analyzed.
  • The roles of G proteins and downstream signaling molecules in thrombin receptor-stimulated signaling are analyzed.
Academic Activities
Papers
1. Saito M, Tanaka H, Sasaki M, Kurose H, Nakahata N., Involvement of aquaporin in thromboxane A2 receptor-mediated, G12/13/RhoA/NHE-sensitive cell swelling in 1321N1 human astrocytoma cells., Cell Signal., Vol. 22, 41-46, 2010.01.
2. Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F., Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells., J Biol Chem, Vol. 285, 4789-4797, 2010.02.
3. Guilini C, Urayama K, Turkeri G, Dedeoglu DB, Kurose H, Messaddeq N, Nebigil CG., Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration., Am J Physiol Heart Circ Physiol., Vol. 298, H844-852, 2010.03.
4. Cho D, Zheng M, Min C, Ma L, Kurose H, Park JH, Kim KM., Agonist-induced endocytosis and receptor phosphorylation mediate resensitization of dopamine D2 receptors., Mol Endocrinol., Vol. 24, 574-4586, 2010.03.
5. Malchinkhuu E, Sato K, Maehama T, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F., Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cells., Mol Biol Cell., 20, Vol. 20, 5156-5165, 2009.12.
6. Malchinkhuu E, Sato K, Maehama T, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F., Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cells., Mol Biol Cell., 20, Vol. 20, 5156-5165, 2009.12.
7. Yano T, Itoh Y, Kawamura E, Maeda A, Egashira N, Nishida M, Kurose H, Oishi R., Amphotericin B-induced renal tubular cell injury is mediated by Na+ Influx through ion-permeable pores and subsequent activation of mitogen-activated protein kinases and elevation of intracellular Ca2+ concentration., Antimicrob Agents Chemother., 53, 1420-1426, 2009.03.
8. Onohara N, Nishida M, Inoue R, Kobayashi H, Sumimoto H, Sato Y, Mori Y, Nagao T, and Kurose H, TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy, EMBO J., 25, 5305-5316, 2006.11.
9. Mangmool, S., Haga, T., Kobayashi, H., Kim, K-M., Nakata, H., Nishida, M., and Kurose, H, Clathrin required for phosphorylation and internalization of β2-adrenergic receptor by G protein-coupled receptor kinase 2 (GRK2), J. Biol. Chem., 281, 31940-31949, 2006.10.
10. Nishida, M., Tanabe, S., Maruyama, Y., Nagamatsu, Y., Takagahara, S., Turner, J. H., Kozasa, T., Kobayashi, H., Sato, Y., Kawanishi, T., Inoue, R., Nagao, T., and Kurose, H., Gα12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 MAPK by angiotensin II receptor stimulation in rat neonatal cardiomyocytes, J. Biol. Chem., 10.1074/jbc.M409710200, 280, 18, 18434-18441, 280 (18), 18434-18441, 2005.05.
11. Fujii, T., Onohara, N., Maruyama, Y., Tanabe, S., Kobayashi, H., Fukutomi, M., Nagamatsu, Y., Nishihara, N., Inoue, R., Sumimoto, H., Shibasaki, F., Nagao, T., Nishida, M., and Kurose, H, Gα12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts., J. Biol. Chem., 10.1074/jcb.M409397200, 280, 24, 23041-23047, 280 (24), 23041-23047 (2005), 2005.06.
12. Arai, K., Maruyama, Y., Nishida, Tanabe, S., Takagahara, S., Turner, J. H., Kozasa, T., Mori, Y., Nagao, T., and Kurose, H., Differential requirement of Gα12, Gα13, Gαq and Gβγ for endothelin-1-induced JNK and ERK activation., Mol. Pharmacol., 10.1124/mol.63.3.478, 63, 3, 478-488, 63, 478-488, 2003.03.
13. Maruyama, Y., Nishida, M., Sugimoto, Y., Tanabe, S., Turner, J. H., Kozasa, T., Wada, T., Nagao, T., and Kurose, H., Gα12/13 Mediate α1-Adrenergic Receptor-induced Cardiac Hypertrophy., Circ. Res., 10.1161/01.RES.0000043282.39776.7C, 91, 10, 961-969, 91, 961-969, 2002.11.
14. Nishida, M., Maruyama, Y., Tanaka, R., Kontani, K., Nagao, T., and Kurose, H., Giα and Goα are target proteins of reactive oxygen species., Nature, 408, 492-495, 2000.11.