Kyushu University Academic Staff Educational and Research Activities Database
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Yoshiyuki Shioyama Last modified date:2019.06.13



Graduate School
Undergraduate School
Other Organization


E-Mail
Phone
092-642-5695
Fax
092-642-5708
Academic Degree
Medical Doctor
Country of degree conferring institution (Overseas)
No
Field of Specialization
Radiation Oncology
Total Priod of education and research career in the foreign country
00years09months
Outline Activities
Radiation oncology and radiation therapy
Clinical oncology
High precision radiotherapy
Stereotactic radiotherapy
Intensity Modulated Radiotherapy
Particle therapy
Carbon-ion Radiotherapy
Research
Research Interests
  • Clinical evaluation of carbon-ion radiotherapy for lung cancer
    keyword : Carbon-ion radiotherapy, lung cancer
    2013.06.
  • Clinical study of incidence and predictive factors for rib fracture after SBRT
    keyword : SBRT, rib fracture, predictive factor
    2009.05.
  • Predictive factors of tumor response for radiation therapy
    keyword : uterine cervical cancer, radiotherapy, predictive factors
    2008.04.
  • Optimization of radiation therapy using functional image
    keyword : Radiotherapy, Toxicities, functional image
    2006.01Optimization of radiation therapy planning using functional images to preserve organ function.
  • Prediction of treatment related toxicities using gene polymorphism for patients receiving radiation therapy
    keyword : Radiotherapy, Toxicities, Gene polymorphism
    2003.12Study of prediction of radiation toxicities by gene polymorphism in patients receiving radiotherapy..
  • Prediction and early diagnosis of the risk of radiation pneumonitis in lung cancer patients treated with radiotherapy
    keyword : Radiotherapy, Radiation pneumonitis, Serum markers
    2002.04Study of developement of useful biological markers for prediction of radiation pneumonitis.
  • Clinical study of radiotherapy and chemoradiotherapy for head & neck malignant tumors for functional preservation
    keyword : Head and Neck cancer, Radiotherapy, Function preservation
    2002.04Clinical study of radiotherapy and chemoradiotherapy for head & neck malignant tumors.
  • Clinical study for stereotactic radiotherapy for malignant tumors in Head & Neck and Body trunk.
    keyword : Stereotactic Radiotherapy, Head & neck, Body trunk
    2003.04Clinical study for stereotactic radiotherapy for malignant tumors in Head & Neck and Body trunk..
  • Study of the respilatio gated radiotherapy for lung tumor, especially at inspiratory phase
    keyword : Lung cancer, Respiration Gated Radiotherapy
    2002.04Study of the respilatio gated radiotherapy for lung tumor, especially at inspiratory phase.
  • Clinical study of particle beam radiotharepy for malignant tumors in various organs.
    keyword : Charged particle radiotherapy, Radiation Oncology
    2000.04~2002.03Clinical study of proton beam radiotharepy for malignant tumors in various organs..
Academic Activities
Books
1. Yoshiyuki Shioyama, Katsumasa Nakamura, Hiroshi Honda, Toxicity and treatment evaluation
Toxicity and Treatment Evaluation.
In: Nagata Y(ed): Stereotactic Body Radiation Therapy, Principles and Practices
, Springer Japan, 10.1007/978-4-431-54883-6_13, 163-173, 2015.08.
2. Ayumi Nonaka, Hidetaka Arimura, Katsumasa Nakamura, Yoshiyuki Shioyama, Mazen Soufi, Taiki Magome, Hiroshi Honda, Hideki Hirata, Local image descriptor-based searching framework of usable similar cases in a radiation treatment planning database for stereotactic body radiotherapy, SPIE, 10.1117/12.2042875, 9039, 2014.01, Radiation treatment planning (RTP) of the stereotactic body radiotherapy (SBRT) was more complex compared with conventional radiotherapy because of using a number of beam directions. We reported that similar planning cases could be helpful for determination of beam directions for treatment planners, who have less experiences of SBRT. The aim of this study was to develop a framework of searching for usable similar cases to an unplanned case in a RTP database based on a local image descriptor. This proposed framework consists of two steps searching and rearrangement. In the first step, the RTP database was searched for 10 cases most similar to object cases based on the shape similarity of two-dimensional lung region at the isocenter plane. In the second step, the 5 most similar cases were selected by using geometric features related to the location, size and shape of the planning target volume, lung and spinal cord. In the third step, the selected 5 cases were rearranged by use of the Euclidean distance of a local image descriptor, which is a similarity index based on the magnitudes and orientations of image gradients within a region of interest around an isocenter. It was assumed that the local image descriptor represents the information around lung tumors related to treatment planning. The cases, which were selected as cases most similar to test cases by the proposed method, were more resemble in terms of the tumor location than those selected by a conventional method. For evaluation of the proposed method, we applied a similar-cases-based beam arrangement method developed in the previous study to the similar cases selected by the proposed method based on a linear registration. The proposed method has the potential to suggest the superior beam-arrangements from the treatment point of view..
Reports
1. Shioyama Y, Tsuji H, Suefuji H, Sinoto M, Matsunobu A, Toyama S, Nakamura K, Kudo S, Particle radiotherapy for prostate cancer, Int J Urol, 22(1):33-39, 2015, 2015.01.
2. Nakamura K, Sasaki T, Ohga S, Yoshitake T, Terashima K, Asai K, Matsumoto K, Shioyama Y, Honda H, Recent advances in radiation oncology: intensity-modulated radiotherapy, a clinical perspective, Int J Clin Oncol, 19(4):564-569, 2014, 2014.08.
Papers
1. Makoto Shinoto, Kotaro Terashima, Hiroaki Suefuji, Akira Matsunobu, Shingo Toyama, Kaori Fukunishi, Yoshiyuki Shioyama, A single institutional experience of combined carbon-ion radiotherapy and chemotherapy for unresectable locally advanced pancreatic cancer, Radiotherapy and Oncology, 10.1016/j.radonc.2018.08.026, 129, 2, 333-339, 2018.11, Purpose: The aim of this study was to evaluate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for unresectable locally advanced pancreatic cancer (LAPC). Methods and materials: Patients with LAPC treated with definitive C-ion RT between April 2014 and July 2017 were analyzed retrospectively. The prescribed dose was 55.2 Gy (relative biological effectiveness [RBE] weighted absorbed dose) in 12 fractions. Overall survival (OS), local control (LC), progression free survival (PFS), and toxicity were evaluated. Results: Sixty-four patients were enrolled. All patients completed planned course of C-ion RT. The median follow-up time for survivors from the initiation of C-ion RT was 24.4 months (range, 5.1–46.1 months). Median survival time was 25.1 months. Two-year OS, LC, and PFS were 53% (95% confidence interval [CI], 39%–66%), 82% (95% CI, 66%–91%), and 23% (95% CI, 14%–36%), respectively. Four patients experienced acute grade 3 toxicities including 3 gastrointestinal (GI) toxicities. There was no grade 3 or more late toxicity. Conclusions: The clinical results of C-ion RT for LAPC at our institution were comparable to those of a recent multi-institutional analysis..
2. Onishi H, Yamashita H, Shioyama Y, Matsumoto Y, Takayama K, Matsuo Y, Miyakawa A, Matsushita H, Aoki M, Nihei K, Kimura T, Ishiyama H, Murakami N, Nakata K, Takeda A, Uno T, Nomiya T, Takanaka T, Seo Y, Komiyama T, Marino K, Aoki S, Saito R, Araya M, Maehata Y, Tominaga L, Kuriyama K, Stereotactic body radiation therapy for patients with pulmonary interstitial change: high incidence of fatal radiation pneumonitis in a retrospective multi-institutional study, Cancers (Basel) , 10.3390/cancers10080257, 10, 8, pii: E257, 2018.08.
3. Tetsuya Inoue, Norio Katoh, Yoichi M. Ito, Tomoki Kimura, Yasushi Nagata, Kengo Kuriyama, Hiroshi Onishi, Tadamasa Yoshitake, Yoshiyuki Shioyama, Yusuke Iizuka, Koji Inaba, Koji Konishi, Masaki Kokubo, Katsuyuki Karasawa, Takuyo Kozuka, Kensuke Tanaka, Jun Sakakibara-Konishi, Ichiro Kinoshita, Hiroki Shirato, Stereotactic body radiotherapy to treat small lung lesions clinically diagnosed as primary lung cancer by radiological examination
A prospective observational study, Lung Cancer, 10.1016/j.lungcan.2018.05.025, 122, 107-112, 2018.08, Objectives: Even with advanced image guidance, biopsies occasionally fail to diagnose small lung lesions, which are highly suggestive of primary lung cancer by radiological examination. The aim of this study was to evaluate the outcome of stereotactic body radiotherapy (SBRT) to treat small lung lesions clinically diagnosed as primary lung cancer. Materials and methods: This is a prospective, multi-institutional observation study. Strict inclusion and exclusion criteria were determined in a nation-wide consensus meeting and used to include patients who were clinically diagnosed with primary lung cancer using precise imaging modalities, for whom further surgical intervention was not feasible, who refused watchful waiting, and who were highly tolerable of SBRT with informed consent. SBRT was performed with 48 Gy in 4 fractions at the tumor isocenter. Results: From August 2009 to August 2014, 62 patients from 11 institutions were enrolled. Their median age was 80 years. The tumors ranged in size from 9 to 30 mm in diameter (median, 18 mm). The median follow-up interval was 55 months. The 3-year overall survival rate was 83.3% (95% confidence interval (CI) 71.1–90.7%) for all the patients and 94.7% (95% CI 68.1–99.2%) for the patients younger than 75 years. Local failure, regional lymph node metastases and distant metastases occurred in 4 (6.4%), 3 (4.8%) and 11 (17.7%) patients, respectively. Grades 3 and 4 toxicities were observed in 8 (12.9%) patients and 1 (1.6%) patient, respectively. No grade 5 toxicities were observed. Conclusions: SBRT is safe and effective for patients with small lung lesions clinically diagnosed as primary lung cancer that satisfied the proposed strict indication criteria as previously reported. A prospective interventional study is required to ascertain if SBRT is an alternative strategy for these patients..
4. Shioyama Y, Onishi H, Takayama K, Matsuo Y, Takeda A, Yamashita H, Miyakawa A, Murakami N, Aoki M, Matsushita H, Matsumoto Y, Shibamoto Y; Japanese Radiological Society Multi-Institutional SBRT Study Group (JRS-SBRTSG) , Clinical outcomes of stereotactic body radiotherapy for patients with stage I small-cell lung cancer: analysis of a subset of the Japanese Radiological Society Multi-Institutional SBRT Study Group database, Technol Cancer Res Treat , 10.1177/1533033818783904, 17:1533033818783904, 2018, 2018.01.
5. Makoto Shinoto, Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Akihiro Nishie, Yoshiki Asayama, Ohga Saiji, Tadamasa Yoshitake, Kotaro Terashima, Kaori Asai, Keiji Matsumoto, Hiroshi Honda, Prognostic significance of a minute amount of ascites during chemoradiotherapy for locally advanced pancreatic cancer, Anticancer Research, 36, 4, 1879-1884, 2016.04, Aim: The aim of this study was to investigate the clinical factors for predicting overall survival (OS) and the significance of a minute amount of ascites on computed tomography (CT) in patients with locally advanced pancreatic cancer (LAPC) treated with chemoradiotherapy (CRT). Patients and Methods: Between 2003 and 2011, 48 consecutive patients with LAPC were treated with CRT. Various clinical factors, including ascites, were evaluated for correlation with OS. A subset analysis of 16 patients with a minute amount of ascites was also performed. Results: The median survival duration and the 1-year OS rates were 11.5 months and 50%, respectively. A minute amount of ascites on CT and elevated carbohydrate antigen 19-9 (CA19-9) level were significantly associated with poorer OS. In 16 patients with ascites, the amount of ascites increased in the course of the disease, and these were considered to be cancerous clinically, regardless of the amount. Conclusion: A minute amount of ascites and CA19-9 were important prognostic factors in CRT. Any amount of ascites was considered an early indicator of peritoneal carcinomatosis in LAPC..
6. Kaori Asai, Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Yoshio Matsuo, Ohga Saiji, Tadamasa Yoshitake, Kotaro Terashima, Makoto Shinoto, Keiji Matsumoto, Hidenari Hirata, Hiroshi Honda, Clinical characteristics and outcome of pneumothorax after stereotactic body radiotherapy for lung tumors, International Journal of Clinical Oncology, 10.1007/s10147-015-0833-4, 20, 6, 1117-1121, 2015.12, Backgound: We retrospectively investigated the clinical characteristics and outcome of pneumothorax after stereotactic body radiotherapy (SBRT) for lung tumors. Methods: Between April 2003 and July 2012, 473 patients with lung tumors were treated with SBRT. We identified 12 patients (2.5 %) with pneumothorax caused by SBRT, and evaluated the clinical features of pneumothorax. Results: All of the tumors were primary lung cancers. The severity of radiation pneumonitis was grade 1 in 10 patients and grade 2 in two patients. Nine patients had emphysema. The planning target volume and pleura overlapped in 11 patients, and the tumors were attached to the pleura in 7 patients. Rib fractures were observed in three patients before or at the same time as the diagnosis of pneumothorax. The median time to onset of pneumothorax after SBRT was 18.5 months (4–84 months). The severity of pneumothorax was grade 1 in 11 patients and grade 3 in one patient. Conclusion: Although pneumothorax was a relatively rare late adverse effect after SBRT, some patients demonstrated pneumothorax after SBRT for peripheral lung tumors. Although most pneumothorax was generally tolerable and self-limiting, careful follow-up is needed..
7. Terashima K, Shioyama Y, Nomoto S, Ohga S, Nonoshita T, Ohnishi K, Atsumi K, Yabuuchi H, Hirata H, aHonda H, A case of radiation fibrosis appearing as mass-like consolidation after SBRT with elevation of serum CEA.
, Case Report in Medicine, in press, 2010.05.
8. Isoyama Y, Shioyama Y, Nomoto S, Ohga S, Nonoshita T, Onishi K, Matsuura S, Atsumi K, Terashima K, Hirata H, Honda H. , Carboplatin and etoposide combined with radiotherapy for limited-stage small-cell esophageal carcinoma: three cases and review of the literature, Jpn J Radiol, 28(3): 181-187, 2010, 2010.04.
9. Atsumi K, Shioyama Y, Nomoto S, Ohga S, Toba T, Sasaki T, Kunitake N, Yoshitake T, Nakamura K, Honda H, Chemoradiation for Small Cell Esophageal Carcinoma: Report of 11 Cases from Multi-institution Experience., J Radiat Res, 51: 15-20, 2010
, 2010.01.
10. Nakamura K, Yoshikawa H, Akai T, Nomoto S, Shioyama Y, Kuwabara Y, Yoshimitsu K, Corrugated Fiberboard as a Positioning Insert for Patients Undergoing Radiotherapy, J Radiat Res, 51: 87-90, 2010
, 2010.01.
11. Atsumi K, Shioyama Y, Nakamura K, Nomoto S, Ohga S, Yoshitake T, Nonoshita T, Ueda M, Hirata H, Honda H, Predictive Factors of Esophageal Stenosis Associated with Tumor Regression in Radiation Therapy for Locally Advanced Esophageal Cancer, J Radiat Res, 51: 9-14, 2010, 2010.01.
12. Yoshitake T, Shioyama Y, Nakamura K, Ohga S, Nonoshita T, Ohnishi K, Terashima K, Arimura H, Hirata H, Honda H. , A clinical evaluation of visual feedback-guided breath-hold reproducibility of tumor location, Phys Med Biol, 54(23):7171-7182, 2009
, 2009.12.
13. Ohnishi K, Shioyama Y, Nomoto S, Sasaki T, Ohga S, Yoshitake T, Toba T, Atsumi K, Shiinoki T, Terashima H, Honda H. , Spontaneous pneumothorax after stereotactic radiotherapy for non-small-cell lung cancer
, Jpn J Radiol, 27(7):269-274, 2009, 2009.08.
14. Shioyama Y, Nakamura K, Ohga S, Nomoto S, Sasaki T, Yamaguchi T, Toba T, Yoshitake T, Terashima H, Honda H. , Radiation therapy for recurrent esophageal cancer after surgery: clinical results and prognostic factors., Jpn J Clin Oncol., 2007.12.
15. Shioyama Y, Nakamura K, Anai S, Sasaki T, Ohga S, Saku M, Urashima Y, Yoshitake T, Toba T, Terashima H, Honda H, Stereotactic radiotherapy for lung and liver tumors using a body cast system: Setup accuracy and preliminary clinical outcome, Radiat Med , 23(6); 407-413, 2005.08.
16. Shioyama Y, Nakamura K, Sasaki T . Ooga S, Urashima Y, Kimura M, Uehara S, Terashima H, Honda H, Clinical results of radiation therapy for stage I esophageal cancer: a single institutional experience, Am J Clinic Oncol 28: 75-80, 2005, 10.1097/01.coc.0000139021.91718.ee, 28, 1, 75-80, 28: 75-80, 2005.02.
17. Shioyama Y, Tokuuye K, Okumura T, Kagei K, Sugahara S, ,Ohara K, Akine Y, Ishikawa S, Satoh H, Sekizawa K, Clinical Evaluation of Proton Radiotherapy for Non-small-cell Lung Cancer., Int.J.Radiat Oncol Biol Phisc, 10.1016/0360-3016(02)04416-4, 56, 1, 7-13, 56: 7-13, 2003.05.
Presentations
1. Shioyama Y, Terashima K, Suefuji H, Shinoto M, Toyama S, Matsumoto K, Mtasunobu A, Fukunishi K , Results of Hypofractionated Carbon-ion Radiotherapy for Peripherally Located Stage I Non-small-cell Lung Cancer, The 60th Annual Meeting of American Society for Therapeutic Radiology and Oncology, 2018.10.
2. Shioyama Y, Treatment Strategy for Head and Neck Cancer, 日本放射線腫瘍学会第30回学術大会, 2017.11.
3. Shioyama Y, Yamamoto N, Saitoh JI, Fujii O, Matsunobu A, Ohno T, Okimoto T, Tsuji H, Kamada T, Nakano T, Nemoto K , Multi-institutional Retrospective Study of Carbon-ion Radiotherapy for Stage I Non-small cell Lung Cancer: Japan Carbon-ion Radiation Oncology Study Group, The 58th Annual Meeting of American Society for Therapeutic Radiology and Oncology, 2016.09.
4. Shioyama Y, Nagata Y, Komiyama T, Takayama K, Shibamoto Y, Ueki N, Yamada K, Kozuka T, Kimura T, Matsuo Y , Multi-institutional Retrospective Study of Stereotactic Body Radiation Therapy for Stage I Small Cell Lung Cancer: Japanese Radiation Oncology Study Group (JROSG), The 57th Annual Meeting of American Society for Therapeutic Radiology and Oncology, 2015.10.
5. Shioyama Y, Carbon-ion Radiotherapy for Early-Stage Lung Cancer: Current Status in Japan, The 15th Asian Oceanian Congress of Radiology, 2014.09.
6. Shioyama Y, Onishi H, Takayama K, Matsuo Y, Takeda A, Yamashita H, Miyakawa A, Murakami N, Aoki M, Matsushita H , Stereotactic Body Radiotherapy for 90 years or Older Patients with Stage I Non -small -cell Lung Cancer, The 56th. Annual Meeting of American Society for Therapeutic Radiology and Oncology, 2014.09.
7. Shioyama Y, Onishi H, Takayama K, Matsuo Y, Takeda A, Yamashita H, Miyakawa A, Murakami N, Aoki M, Matsushita H , Stereotactic Body Radiotherapy for Stage-I Small-cell Lung Cancer: Clinical outcomes in a Japanese Multi-institutional Retrospective Study, 55th. Annual Meeting of American Society for Therapeutic Radiology and Oncology, 2013.09.
8. Shioyama Y, Carbon-ion Radiotherapy: Current status in Japan, 37th Annual Scientific Meeting the MD Anderson Radiation Oncology, GH Fletcher Society, 2013.04.
9. Shioyama Y, Matsumoto K, Yoshitake T, Nakamura K, Sasaki T, Ohga S, Nonoshita T, Asai K, Hirata H, Honda H , Stereotactic Body Radiotherapy for Histologically Confirmed Stage I Non-small Cell Lung Cancer: Clinical Results and Prognostic Factors, 53rd. Annual Meeting of American Society for Therapeutic Radiology and Oncology , 2011.10.
10. Shioyama Y, Ohga S, Yoshitake T, Nonoshita T, Ohnishi K, Terashima K, Asai K, Nakamura K, Hirata H, Honda H , Clinical Results of Stereotactic Body Radiotherapy for Stage I Small Cell Lung Cancer: A Single Institutional Experience, 52nd. Annual Meeting of American Society for Therapeutic Radiology and Oncology, 2010.10.
11. Clinical Results of Stereotactic Body Radiotherapy for Oligometastatic Lung Tumors.
12. Visual Feedback-guided Breath-hold Technique For Radiotherapy Using A Machine Vision System With A Charge-coupled Device Camera And A Head-mounted Display: An Evaluation Of Breath-hold Reproducibility In Clinical Use..
Educational
Educational Activities
Clinical education for medical student
Other Educational Activities
  • 2016.12.
  • 2011.12.
  • 2009.07.
  • 2008.07.