|Yoshimichi Nakatsu||Last modified date：2019.06.25|
Department of Medical Biophysics and Radiation Biology, Faculty of Medical Sciences .
Doctor of Science
Country of degree conferring institution (Overseas)
Field of Specialization
Total Priod of education and research career in the foreign country
Research InterestsMembership in Academic Society
- Genomic destabilization under hypoxic culture condition
keyword : Oxidative stress, Mutation, MSI, hiPSC, MEF
- Search for environmental and genetic factors that enhance microsatellite instability in mismatch repair deficient human cells
keyword : Genomic destabilization, mismatch repair, colorectal cancer
- Effects of plasma on mammalian genome
keyword : Non-thermal plasma, rpsL-transgenic mice, ROS, NOS, mutation, cell death
- Analysis of MUTYH/MutS alpha complex induced by oxidative stress
keyword : oxidative DNA damage, mismatch repair, cell death, mutagenesis
- Mutagenesis and carcinogenesis caused by the failure of the mechanisms for DNA damage response
keyword : oxidative stress DNA repair mismatch repair cell-death
- Molecular mechanisms for DNA damage response
keyword : mutation cell-death adaptive response mismatch repair
- Molecular mechanisms for prevention and elimination of oxidative DNA damages
keyword : oxidative DNA damages, nucleotide, mutagenesis, cell death, carcinogenesis, gene-knockout mice, transgenic mice
- The MUTYH gene is known to be associated with Familial adenomatous polyposis (MAP: MUTYH -associated polyposis), and encodes a DNA repair protein that suppresses mutations caused by oxidative stress in mammalian cells. MUTYH is involved not only in the suppression of mutations but also in the cell death induced by oxidative stress. In this study, I investigate the role of MUTYH associated with mismatch repair proteins in the induction of cell death caused by oxidative stress.
- We developed an experimental system for oxidative stress-inducing mutagenesis and carcinogenesis in the intestine of mice. In oder to identify the common genes mutated in the adenomas/carcinomas induced by using this system, we analyze the genomes of adenomas/carcinomas induced in the same animals.
- Mutagenesis caused by oxidized nucleotides and it preventing mechanisms.
Analysis of cell death pathway evoked by oxidized nucleotides.
- Oxygen-induced DNA damage and its repair mechanism
|1.||Yoshimichi Nakatsu, Mutso Sekiguchi, Oxidative Damage to Nucleotide: Consequences and Preventive Mechanism, Imperial College Press, "Oxidative Stress, Disease and Cancer" Singh, KK (Ed), pp221-252, 2006.01.|
|1.||Tsuzuki T, Nakatsu Y, Nakabeppu Y, Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis, Cancer Science, 2007.08.|
- The Japanese Environmental Mutagen Society (JEMS)
- Genetic Society of Japan
- The Japan Radiation Research Society
- Japanese Cancer Association
- The Molecular Biology Society of Japan