Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Osamu Kuge Last modified date:2019.05.14

Professor / Organic and Biological Chemistry / Department of Chemistry / Faculty of Sciences


Papers
1. Haruka Sakaue, Takuya Shiota, Naoya Ishizaka, Shin Kawano, Yasushi Tamura, Kher Shing Tan, Kenichiro Imai, Chie Motono, Takatsugu Hirokawa, Kentaro Taki, Non Miyata, Osamu Kuge, Trevor Lithgow, Toshiya Endo, Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly, Molecular Cell, 10.1016/j.molcel.2019.01.003, 73, 5, 1044-1055.e8, 2019.03, The mitochondrial protein entry gate, the TOM complex, undergoes a dynamic conversion between the fully assembled trimer and the dimer lacking Tom22. Mitochondrial porin, Por1, regulates the trimer assembly by chaperoning newly imported Tom22 and dimer-trimer dependent functions of the TOM complex together with Tom6..
2. Non Miyata, Satoru Fujii, Osamu Kuge, Porin proteins have critical functions in mitochondrial phospholipid metabolism in yeast, The Journal of biological chemistry, 10.1074/jbc.RA118.005410, 293, 45, 17593-17605, 2018.11.
3. Non Miyata, 0samu Kuge, Fmp30, Mdm31, and Mdm32 Function in Ups1-independent Cardiolipin Accumulation Under Low Phosphatidylethanolamine Conditions, Contact, 10.1177/2515256418764043, 2018.04.
4. Non Miyata, Naoto Goda, Keiji Matsuo, Takeshi Hoketsu, Osamu Kuge, Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae, Scientific Reports, 10.1038/s41598-017-16661-2, 7, 1, 2017.12.
5. Non Miyata, Yasunori Watanabe, Yasushi Tamura, Toshiya Endo, Osamu Kuge, Phosphatidylserine transport by Ups2-Mdm35 in respiration-active mitochondria, Journal of Cell Biology, 10.1083/jcb.201601082, 214, 1, 77-88, 2016.07.
6. Hidenori Otera, Non Miyata, Osamu Kuge, Katsuyoshi Mihara, Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling, Journal of Cell Biology, 10.1083/jcb.201508099, 212, 5, 531-544, 2016.01, Mitochondrial fission facilitates cytochrome c release from the intracristae space into the cytoplasm during intrinsic apoptosis, although how the mitochondrial fission factor Drp1 and its mitochondrial receptors Mff, MiD49, and MiD51 are involved in this reaction remains elusive. Here, we analyzed the functional division of these receptors with their knockout (KO) cell lines. In marked contrast to Mff-KO cells, MiD49/MiD51-KO and Drp1-KO cells completely resisted cristae remodeling and cytochrome c release during apoptosis. This phenotype in MiD49/51-KO cells, but not Drp1-KO cells, was completely abolished by treatments disrupting cristae structure such as OPA1 depletion. Unexpectedly, OPA1 oligomers generally thought to resist cytochrome c release by stabilizing the cristae structure were similarly disassembled in Drp1-KO and MiD49/51-KO cells, indicating that disassembly of OPA1 oligomers is not directly linked to cristae remodeling for cytochrome c release. Together, these results indicate that Drp1-dependent mitochondrial fission through MiD49/MiD51 regulates cristae remodeling during intrinsic apoptosis..
7. Miyata N, Miyoshi T, Yamaguchi T, Nakazono T, Tani M, Kuge O, VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae, BIOCHEMICAL JOURNAL, 10.1042/BJ20150884, 472, 319-328, 2015.12.
8. Sakakibara K, Eiyama A, Suzuki S, Sakoh-Nakatogawa M, Okumura N, Tani M, Hasimoto A, Nogumo S, Kondo-Okamoto N, Kondo-Kakuta C, Asai E, Kirisako H, Nakatogawa H, Kuge O, Takao T, Ohsumi Y, Okamoto K, Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling, EMBO JOURNAL, 10.15252/embj.201591440, 34, 21, 2703-2719, 2015.11.
9. Reiko Ban-Ishihara, Shiho Tomohiro-Takayama, Motohiro Tani, Jacques Baudier, Naotada Ishihara, Osamu Kuge, COX assembly factor ccdc56 regulates mitochondrial morphology by affecting mitochondrial recruitment of Drp1, FEBS LETTERS, 10.1016/j.febslet.2015.08.039, 589, 20, 3126-3132, 2015.10.
10. Motohiro Tani, Osamu Kuge, Involvement of Sac1 phosphoinositide phosphatase in the metabolism of phosphatidylserine in the yeast Saccharomyces cerevisiae., Yeast, 10.1002/yea.3004., 2014.04.
11. Yasushi Tamura, Yoshihiro Harada, Shuh-ichi Nishikawa, Koji Yamano, Megumi Kamiya, Takuya Shiota, Takuya Kuroda, Osamu Kuge, Hiromi Sesaki, Kenichiro Imai, Kentaro Tomii, Toshiya Endo, Tam41 Is a CDP-Diacylglycerol Synthase Required for Cardiolipin Biosynthesis in Mitochondria, CELL METABOLISM, 10.1016/j.cmet.2013.03.018, 17, 5, 709-718, 2013.05.
12. Tani Motohiro, Kuge Osamu, Involvement of complex sphingolipids and phosphatidylserine in endosomal trafficking in yeast Saccharomyces cerevisiae, MOLECULAR MICROBIOLOGY, 10.1111/mmi.12057, 86, 5, 1262-1280, 2012.12.
13. Lee Shoken, Uchida Yasunori, Emoto Kazuo, Umeda, Masato, Kuge Osamu, Taguchi Tomohiko, Arai Hiroyuki, Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis, GENES TO CELLS, 10.1111/j.1365-2443.2012.01622.x, 17, 8, 728-736, 2012.08.
14. Motohiro Tani, Osamu Kuge, Global screening of yeast mutants showing high sensitivity and resistance against Aberrant Metabolisumu of sphingolipids, Science for future molecular system, 5, 148-150, 2012.02.
15. Tani M, Kuge O., Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae., Biochem Biophys Res Commun., 417, 2, 673-678, 2012.01.
16. Kuroda T, Tani M, Moriguchi A, Tokunaga S, Higuchi T, Kitada S, Kuge O., FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis., Mol Microbiol., 10.1111/j.1365-2958.2011.07569.x, 80, 1, 248-265, 2011.04.
17. Takuya Miyoshi, Osamu Kuge, Synthetic Lethal Interaction between Psd1p and the phosphatidylglycerolphosphate phosphatase Gep4p in the yeast Saccharomyces cerevisiae, Science for future molecular system, 4, 55-58, 2011.01.
18. Tani M, Kuge O., Defect of synthesis of very long-chain fatty acids confers resistance to growth inhibition by inositol phosphorylceramide synthase repression in yeast Saccharomyces cerevisiae., J Biochem., 148, 5, 565-571, 2010.11.
19. Tani M, Kuge O., Requirement of a specific group of sphingolipid-metabolizing enzyme for growth of yeast Saccharomyces cerevisiae under impaired metabolism of glycerophospholipids., Mol Microbiol. , 78, 2, 395-413, 2010.09.
20. Gilquin, B., Taillebourg, E., Cherradi, N., Hubstenberger, A., Gay, O., Merle, N., Assard, N., Fauvarque, M.-O., Tomohiro, S., Kuge, O., and Baudier, J., The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes., Mol Cell Biol., 10.1128/MCB.00007-10, 30, 8, 1984-1996, 2010.04.
21. Kuroda, T., Tani, M., Moriguchi, A., Tokunaga, S., Higuchi, T., Kitada, S., and Kuge, O., Identification of a novel gene involved in cardiolipin metabolism and mitochondrial morphology in the yeast Saccharomyces cerevisiae, Chemistry and Physics of Lipids, 10.1016/J.chemphyslip.2009.06.032, 160, Supplement, S29, 2009.08.
22. Motohiro Tani, Osamu Kuge, Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membrane, Biochem. Biophys. Res. Commun., 381, 3, 328-332, 2009.04.
23. Shiho Tomohiro, Ayako Kawaguti, Yukiyo Kawabe, Sakae Kitada, Osamu Kuge, Purification and characterization of human phosphatidylserine synthases 1 and 2, Biochem. J., 2009.03.
24. Kazuhisa Yoshino, Hiroshi Munakata, Osamu Kuge, Akio Ito, and Tadashi Ogishima, Haeme-regulated degradation of δ-aminolevulinate synthase 1 in rat liver mitochondria, J. Biochem., 142, 453-458, 2007.11.
25. Kitada S, Abe Y, Shimada H, Kusaka Y, Matsuo Y, Katayama H, Okumura S, Akao T, Mizuki E, Kuge O, Sasaguri Y, Ohba M, Ito A, Cytocydal actions of parasporin-2, an anti-tumor crystal toxin from Bacillus thuringiensis, J Biol Chem., 281 (36) 26350-26360, 2006.09.
26. Kyoko Saito, Masahiro Nishijima, Osamu Kuge, Phosphatidylserine is involved in gene expression from Sindbis virus subgenomic promoter, Biochem Biophys Res Commun., 2006.06.
27. Qizong Lao, Toshihiko Fukamachi, Hiromi Saito, Osamu Kuge, Masahiro Nishijima, Hiroshi Kobayashi, Requirement of an IkappaB-COOH terminal region protein for acidic-adaptation in CHO cells, Journal of Cellular Physiology, 207, 238-243, 2006.04.
28. Tomoko Ohsawa, Masahiro Nishijimam and Osamu Kuge, Functional analysis of Cinese hamster phosphatidylserine synthase 1 trough systematic alanine mutagenesis, Biochem. J., 10.1042/BJ20040443, 381, 853-859, Vol. 381, pp853-859, 2004.01.
29. Qizong Lao, Osamu Kuge, Toshihiko Fukamachi, Kakegawa Tomohiro, Hiromi Saito, Masahiro Nishijima, and Hiroshi Kobayashi, An IκB-β COOH terminal region protein is essential for the proliferation of CHO cells under acidic stress, Journal of Cellular Physiology, 10.1002/jcp.20221, 203, 1, 186-192, Vol. 203, pp186-192, 2004.01.
30. Osamu Kuge, Kazuhide Hasegawa, Tomoko Ohsawa, Kyoko Saito, and Masahiro Nishijima, Purification and characterization of Chinese hamster phosphatidylserine synthase 2, J. Biol. Chem., 10.1074/jbc.M307270200, 278, 43, 42692-42698, Vol. 278, No. 43, pp. 42692-42698, 2003.10.
31. Osamu Kuge, Yoshio Yamakawa, and Masahiro Nishijima, Enhancement of transport-dependent decarboxylation of phosphatidylserine by S100B protein in permeabilized Chinese hamster ovary cells, J.Biol. Chem., Vol. 276, No. 26, pp.23700-23706, 2001.06.
32. Kiyoshi Kawasaki, Osamu Kuge, Yoshio Yamakawa, and Masahiro Nishijima, Purification of phosphatidylglycerophosphate synthase from Chinese hamster ovary cells, Biochem. J., Vol. 354, pp.9-15, 2001.02.
33. Kazuo Emoto, Osamu Kuge, Masahiro Nishijima, and Masato Umeda, Isolation of a Chinese hamster ovary cell mutant defective in intramitochondrial transport of phosphatidylserine, Proc.Natl. Acad. Sci. USA, Vol. 96, No. 22, pp.12400-12405, 1999.10.
34. Osamu Kuge, Kyoko Saito, and Nishijima Masahiro, Control of phosphatidylserine synthase II activity in Chinese hamster ovary cells, J. Biol. Chem., Vol. 274, No.34, pp.23844-23849, 1999.08.
35. Kiyoshi Kawasaki, Osamu Kuge, Shao-Chun Chang, Philip N. Heacock, Minseok Rho, Kenzi Suzuki, Nishijima Masahiro, and William Dowhan, Isolation of a Chinese hamster ovary (CHO) cDNA encoding phosphatidylglycerophosphate (PGP) synthase, expression of which corrects the mitochondrial abnormalities of a PGP synthase-defective mutant of CHO-K1 cells, J. Biol. Chem., Vol. 274, No. 3. pp.1828-1834, 1999.01.
36. Kyoko Saito, Masahiro Nishijima, and Osamu Kuge, Genetic evidence that phosphatidylserine synthase II catalyzes the conversion of phosphatidylethanolamine to phosphatidylserine in Chinese hamster ovary cells, J. Biol. Chem., Vol. 273. No. 27, pp. 17199-17205, 1998.06.
37. Osamu Kuge, Kazuhide Hasegawa, Kyoko Saito, and Masahiro Nishijima, Control of phosphatidylserine biosynthesis through phosphatidylserine-mediated inhibition of phosphatidylserine synthase I in Chinese hamster ovary cells, Proc. Natl. Acad. Sci. USA, Vol. 95, pp.4199-4203, 1998.04.
38. Hanada K, Hara T, Nishijima M, Kuge O, Dickson RC, Nagiec MM., A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis., J Biol Chem., 272(51):32108-14, 1997.12.
39. Osamu Kuge, Kyoko Saito, and Masahiro Nishijima, Cloning of a Chinese hamster ovary (CHO) cDNA encoding phosphatidylserine synthase (PSS) II, overexpression of which suppresses the phosphatidylserine biosynthetic defect of a PSS I-lacking mutant of CHO-K1 cells, J. Biol. Chem., Vol. 272, No.31, pp. 19133-19139, 1997.08.
40. Kuge O, Saito K, Kojima M, Akamatsu Y, Nishijima M., Post-translational processing of the phosphatidylserine decarboxylase gene product in Chinese hamster ovary cells., Biochem J. , 319 (Pt 1):33-8, 1996.10.
41. Karasawa K, Kuge O, Kawasaki K, Nishijima M, Nakano Y, Tomita M, Yokoyama K, Setaka M, Nojima S., Cloning, expression and characterization of plasma platelet-activating factor-acetylhydrolase from guinea pig., J Biochem., 120(4):838-44, 1996.10.
42. Saito K, Kuge O, Akamatsu Y, Nishijima M., Immunochemical identification of the pssA gene product as phosphatidylserine synthase I of Chinese hamster ovary cells., FEBS Lett., 395(2-3):262-6, 1996.10.
43. Aoki K, Suzuki K, Sugano T, Tasaka T, Nakahara K, Kuge O, Omori A, Kasai M., A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations., Nat Genet., 10(2):167-74, 1995.06.
44. Osamu Kuge, Christiane Dascher, Lelio Orci, Tony Rowe, Mylene Amherdt, Helen Plutner, Mariella Ravazzola, Gary Tanigawa, James E. Rothman, and William E. Balch, Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments, J. Cell Biol., Vol. 125, No. 1, pp. 51-65, 1994.04.
45. Hara-Kuge S, Kuge O, Orci L, Amherdt M, Ravazzola M, Wieland FT, Rothman JE., En bloc incorporation of coatomer subunits during the assembly of COP-coated vesicles., J Cell Biol., 124(6):883-92, 1994.03.
46. Osamu Kuge, Sayuri Hara-Kuge, Lelio Orci, Mariella Ravazzola, Mylene Amherdt, Gary Tanigawa, Felix T. Wieland, and James E. Rothman, zeta-COP, a subunit of coatomer is required for COP-coated vesicle assembly, J. Cell Biol., Vol. 123, No. 6, pp. 1727-1734, 1993.12.
47. Osamu Kuge, Masahiro Nishijima, and Yuzuru Akamatsu, A Chinese hamster cDNA encoding a protein essential for phosphatidylserine synthase I activity, J. Biol. Chem., Vol. 266, No. 35, pp. 24184-24189, 1991.12.
48. Osamu Kuge, Masahiro Nishijima, and Yuzuru Akamatsu, A cloned gene encoding phosphatidylserine decarboxylase complements the phosphatidylserine biosynthetic defect of a Chinese hamster ovary cell mutant, J. Biol. Chem., Vol. 266, No. 10, pp. 6370-6376, 1991.01.
49. Hasegawa K, Kuge O, Nishijima M, Akamatsu Y., Isolation and characterization of a Chinese hamster ovary cell mutant with altered regulation of phosphatidylserine biosynthesis., J Biol Chem., 264(33):19887-92, 1989.11.
50. Kuge O, Akamatsu Y, Nishijima M., Abortive infection with Sindbis virus of a Chinese hamster ovary cell mutant defective in phosphatidylserine and phosphatidylethanolamine biosynthesis., Biochim Biophys Acta., 986(1):61-9, 1989.11.
51. Osamu Kuge, Masahiro Nishijima, and Yuzuru Akamatsu, Isolation of a somatic cell mutant defective in phosphatidylserine biosynthesis, Proc. Natl. Acad. Sci. USA, Vol. 82, pp. 1926-1930, 1985.04.
52. Kuge O, Nishijima M, Akamatsu Y., Phosphatidylserine biosynthesis in cultured Chinese hamster ovary cells. III. Genetic evidence for utilization of phosphatidylcholine and phosphatidylethanolamine as precursors., J Biol Chem., 261(13):5795-8, 1986.02.
53. Nishijima M, Kuge O, Akamatsu Y., Phosphatidylserine biosynthesis in cultured Chinese hamster ovary cells. I. Inhibition of de novo phosphatidylserine biosynthesis by exogenous phosphatidylserine and its efficient incorporation., J Biol Chem., 1986.05.
54. Osamu Kuge, Masahiro Nishijima, and Yuzuru Akamatsu, Phosphatidylserine biosynthesis in cultured Chinese hamster ovary cells: II. Isolation and characterization of phosphatidylserine auxotrophs, J. Biol. Chem., Vol. 261, No. 13, pp. 5790-5794, 1986.05.
55. Nitta N, Kuge O, Yui S, Negishi K, Hayatsu H., Cross-linking between 16S ribosomal RNA and protein S4 in Escherichia coli ribosomal 30S subunits effected by treatment with bisulfite/hydrazine and bromopyruvate., Eur J Biochem., 157(2):427-32, 1986.06.
56. Maeda M, Nishijima M, Takenaka Y, Kuge O, Akamatsu Y., pH-dependent Ca2+ interaction with phospholipids related to phosphatidylethanolamine N-methylation., Biochim Biophys Acta., 794(2):298-306, 1984.07.
57. Nishijima M, Kuge O, Maeda M, Nakano A, Akamatsu Y., Regulation of phosphatidylcholine metabolism in mammalian cells. Isolation and characterization of a Chinese hamster ovary cell pleiotropic mutant defective in both choline kinase and choline-exchange reaction activities., J Biol Chem., 259(11):7101-8, 1984.06.
58. Nitta N, Kuge O, Yui S, Tsugawa A, Negishi K, Hayatsu H., A new reaction useful for chemical cross-linking between nucleic acids and proteins., FEBS Lett., 166(1):194-8, 1984.01.
59. Nitta N, Sugihara K, Kuge O, Negishi K, Wataya Y, Hayatsu H., Linking of N4-aminocytosine to glutathione by use of bromopyruvate., Nucleic Acids Symp Ser., (6):s43-4, 1979.12.