Kyushu University Academic Staff Educational and Research Activities Database
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Hirata Miyuki Last modified date:2019.06.28

Assistant Professor / Social Medicine
Center for Cohort Studies
Faculty of Medical Sciences


Graduate School
Undergraduate School


E-Mail
Phone
092-642-4737
Fax
092-642-4737
Academic Degree
Doctor of Medical Sciences
Country of degree conferring institution (Overseas)
No
Field of Specialization
Hygiene 
Total Priod of education and research career in the foreign country
00years00months
Outline Activities
research
 biological monitoring of indium
 indium toxicity, arsenic toxicity, antimony toxicity

education
teach hygiene to medical students and dental students

social activitie
 social welfare corporation Warabe Fukushikai
school pharmaceutist of Kasumigaoka High School
school pharmaceutist of Hokozaki Junior High School
Research
Research Interests
  • health effects and biological monitoring of indium compounds
    metabolism and toxicity of indium compounds
    keyword : indium, industrial health, metal toxicity, biological monitoring
    1997.05~2021.03 We report that indium-thin oxide(ITO) used in the making of TFT liquid crystal displays has pulmonary toxic effects and a long biological half-time. We reported strong dose-response relationships between serum indium and effects on the lung in indium-exposed workers. Although arsenic trioxide is used in the treatment of acute promyelocytic leukemia(APL), arsenic pharmacokinetic of the patients has not been cleared well. We first report arsenic metabolites in serum and urine collected from APL patients during arsenic treatment..
Current and Past Project
  • Plasma medical innovation
  • Cohort study of rare metal-exposed workers and experimental study of rare metal-exposed rats
Academic Activities
Books
1. Handbook of raremetal.
Reports
1. Indium exposure in the hair of workers dealing with indium compounds.
2. Effective and sensitive biomarker of low indium exposure in workers.
3. Exposure-effects and exposure-response relationship between indium exposure and urine indium. Availability of urine indium as biological monitoring for indium toxicity..
Papers
1. Satoko Iwasawa, Makiko Nakano, Hiroyuki Miyauchi, Shigeru Tanaka, Yaeko Kawasumi, Ichiro Higashikubo, Akiyo Tanaka, Miyuki Hirata, Kazuyuki Omae, Personal indium exposure concentration in respirable dusts and serum indium level, Industrial Health, 10.2486/indhealth.2016-0015, 55, 1, 87-90, 2017.01.
2. Makiko Nakano, Akiyo Tanaka, Miyuki Hirata, Hiroyuki Kumazoe, Kentaro Wakamatsu, Dan Kamada, Kazuyuki Omae, An advanced case of indium lung disease with progressive emphysema, Jounal of Occupational Health, 10.1539/joh.16-0076-CS, 58, 5, 477-481, 2016.09.
3. Makiko Nakano, Akiyo Tanaka, Miyuki Hirata, Iwasawa Satoko, Kazuyuki Omae, Pulmonary effects in workers exposed to indium metal: a cross-sectional study, Jounal of Occupational Health, 10.1539/joh.4-0262-OA, 57, 4, 346-352, 2015.04.
4. Akiyo Tanaka, Miyuki Hirata, Nagisa Matsumura, Yutaka Kiyohara, Tissue distribution of indium after repeated intratrachal instillations of indium-tin oxide into the lungs of hamsters, Jounal of Occupational Health, 10.1539/joh.14-0123-BR, 57, 2, 189-192, 2015.02.
5. Akiyo Tanaka, Miyuki Hirata, Nagisa Matsumura, Kazunori Koga, Masaharu Shiratani, Yutaka Kiyohara, Comparative study on the pulmonary toxicity of indium hydroxide, indium-tin oxide, and indium oxide following intratracheal instillations into the lungs of rats., MRS Symposium Proceedings/MRS Online Proceeding Library CAMBRIDGE UNIVERSITY PRESS, 1723, 1, 2015.01.
6. Makiko Nakano, Kazuyuki Omae, Akiyo Tanaka, Miyuki Hirata, Kazuhiko Uchikawa, Takehiro Michikawa, Five-year cohort study : emphysematous progression of indium-exposed workers, Chest, 10.1378/chest.13-2484, 146, 11, 1166-1175, 2014.11.
7. Makiko Nakano, Kazuyuki Omae, Akiyo Tanaka, Hirata Miyuki, KL-6 is not ineffective biomarker of indiumu lung., Int Arch Occup Environ Health, 10.1007/s00420-013-0873-x, 86, 7, 845-846, 2013.04, 中国製のKL-6キットを用いたインジウム作業者の血清KL-6では血清インジウム濃度との相関は低い。.
8. Akiyo Tanaka, Miyuki Hirata, Masaharu Shiratani, Kazunori Koga and Yutaka Kiyohara, Subacute pulmonary toxicity of copper indium gallium diselenide following intratracheal instillations into the lungs of rats, Journal of Occupational Health, 10.1539, 54, 3, 187-195, 2012.03.
9. Hiyoyuki Miyauchi, Aoi Minozoe, Shigeru Tanaka, Miyuki Hirata, Masahiro Nakaza, Heihachiro Arito, Yoko Eitaki, Makiko Nakano and Kazuyuki Omae, Assessment of workplace air concentrations of indium dust in an indium-recycling plant, Journal of occupational Health, 10.1539, 54, 2, 103-111, 2012.02.
10. Omae K, Nakano M, Tanaka A, Hirata M, Hamaguchi T, Chonan T, Indium lung - Case reports and epidemiology, Int Arch Occup Environ Health, online 01 October 2010, 2010.10.
11. Indium lung.
12. Health effect and control of indium .
13. T Hamaguchi, K Omae, T Takebayashi, Y Kikuchi, N Yoshioka, Y Nishiwaki, A Tanaka, M Hirata, O Taguchi, T Chonan, Exposure to hardly soluble indiumn compounds in ITO production and recycling plants is a new risk for interstitial lung damage, Occup Environ Med, 65, 51-55, 2008.01.
14. A case report of indium lung injury found by clinical examination of indium.
15. Fukai Y, Hirata M, Ueno M, Ichikawa N, kobayashi H, Saitoh H, Sakurai T, Kinoshita K, Kaise T, Clinical pharmacokinetic study of arsenic trioxide in an acute promyelocytic luekemia(APL) patient: Speciation of arsenic metabolites in serum and urine, Biol Parm. Bull, 29(5), 1022-1027, 2006.05.
16. Lung damage caused by occupational exposure og indium. Leasion and diagnosis.
Presentations
1. Akiyo Tanaka, Miyuki Hirata, Nagisa Matsumura, Masaharu Shiratani, Kazunori Koga, Yutaka Kiyohara, Health effects of indium nanoparticles. The 10th Asian-European International Conference on Plasma Surface Engineering, The 10th Asian-European International Conference on Plasma Surface Engineering, 2015.09.
2. Akiyo Tanaka, Miyuki Hirata, Nagisa Matsumura, Yutaka Kiyohara, Serum surfactant protein D is a marker of lung injury caused by indium chloride, 31th International Congress on Occupational Health, 2015.06.
3. Makiko Nakano, Akiyo Tanaka, Hirata Miyuki, Satoko Iwasawa, Kazuyuki Omae, Effects of Indium Metal Exposure on the Lungs of Japanese Workers. Cross–sectional Study., European Respiratory Society International Congress., 2014.09.
4. Akiyo Tanaka, Miyuki Hirata, Kazunori Koga, Masaharu Shiratani, Nagisa Matsumura, Yutaka Kiyohara, Subchronic Pulmonary Toxicity of Copper Indium Gallium Diselenide Following Repeated Intratracheal Instillations into the Lungs of Rats, The 21st Asian Conference on Occupational Health, 2014.09.
5. Satoko Iwasawa, Makiko Nakano, Hiroyuki Miyauchi, Akiyo Tanaka, Miyuki Hirata, Kazuyuki Omae, Shigeru Tanaka, Personal indium exposure concentration in respirable dusts and serum indium level, The 21st Asian Conference on Occupational Health, The 21st Asian Conference on Occupational Health, 2014.09.
6. Akiyo Tanaka, Hirata Miyuki, Kazunori Koga, Naho Itagaki, Masaharu Shiratani, Hayashi Nobuya, Giichiro Uchida, Subacute toxicity of gallium arsenide, indium arsenide and arsenic trioxide following intermittent intratracheal instillations to the lung of rats, 8th International Conference on Reactive Plasmas/31st Symposium on Plasma Processing, 2014.02, 金属化合物半導体の粉体をラットの気管内に投与し、亜慢性肺毒性を観察した.
7. Akiyo Tanaka, Hirata Miyuki, Kazunori Koga, Hayashi Nobuya, Masaharu Shiratani, Yutaka Kiyohara, Pulmonary Toxicity of copper indium gallium diselenide particles in rats, 6th International Symposium on Nanotechnology, Occupational and Environmental Health, 6th International Symposium on Nanotechnology, Occupational and Environmental Health, 2013.10, 金属化合物半導体のCIGS(銅-インジウム-ガリウム-セレン)粉体をラットの気管内に投与し、肺毒性を長期に観察した.
8. Kazunori Koga, Akiyo Tanaka, Hirata Miyuki, Hayashi Nobuya, Naho Itagaki, Giichiro Uchida, Comparative acute pulmonary toxicity of different types of indium-tin oxide following intermittent intratracheal instillation to the lung of rats, 2013 JSAP-MRS, 2013.09, 粒子径の異なるインジウムスズ酸化物(ITO)をラット気管内に投与し、肺毒性の違いについて調べた。.
9. Subchronic toxicity of cadmium telluride intratracheally instilled into rats.
10. Makiko Nakano, Akiyo Tanaka, Miyuki Hirata, Noriyuki Yoshioka, Kazuyuki Omae, Japanese indium cohort study: Five-year follow-up., The 23rd International Conference on Epidemiology in occupational Health, 2013.06, 日本国内にあるインジウム工場の作業者のインジウム健診の5年追跡結果を発表した。肺病変では、気腫性変化が増悪していた。.
11. Monitoring of total dust and indium dust in ITO workpalce.
12. Availability of electrically-powered mask agaist ITO dust.
13. Chronic toxicity of indium hydroxide intratracheally instilled into rats.
14. Health effects of indium.
15. Health effects of thin film solar cell element - Toxicity of indium compounds instilled intratracheally on animals -.
16. Hair indium of indium exposed workers.
17. Health effect of old metal and new metal.
18. Urinary indium of indium exposed workers.
19. Pulmonary toxicity of cadmium telluride intratracheally instilled into rats.
20. Absorption,distribution, metabolism and excretion of indium compound.
21. Metabolism and pulmonary toxicity of solar cell consisted of copper-indium-gallium-diselenide following intratracheal instillations into the lungs of rats.
22. Absorption, distribution,metabolism and excretion of soluble indium compound.
23. Effect of intratracheal instillaiton of indium oxide to acatalasemic mice.
24. Distribution of antimony following administration of antimony trioxide and antimony potassium tartrate via drinking water during 90days in rats.
25. Autoantibody against granulocyte macrophage colony-stimulating factor (GM-SCF) in heavily-exposed Japanese workers.
26. Effect of intratracheal instillation of Indium oxide to acatalasemic mice.
27. Biological effects of indium nanoparticle .
28. Biological monitaring of indium compounds: Outcomes of animal and epidemiological studies.
29. The metabolism and biological effect of indium trichloride after a single intratracheal instillation in rats.
30. Tissue distribution and excretion of indium trichloride after a single intratracheal instillation in rats.
31. The exposure effects of indium compounds on the lungs. The difference of the effects between target workers and refinary/recycle workers.
32. Absorption, metabolism, and excreation of indium compounds.
33. Effect of intratracheal instillation of indium oxide to acatalasemic mice.
34. Changes in serum indium concentration from the final intratracheal instillation.
35. Metal concentrations of the lung and serum following intratracheal instillation of CIGS in rats.
36. Four-year changes of effects of indium exposure on lungs - a Japanese indium cohort study -.
37. Change of biomarkers in blood among indium refinary workers after improvement of working environment.
38. Risk assessment of health effects of CIGS semiconductor solar cell. 2. Metal concentration in blood..
39. Adverse health effects of CIGS particlesafter intratracheal instillations to the lung of rats. 2. Metal concentration in blood.
Membership in Academic Society
  • The Japanese Society for Hygiene
  • Japan Society for Occupational Heath
  • Japan Society for Biomedical Reserch on Trace Elements
  • Society of Indoor Environment, Japan
  • Japanese Arsenic Scientist's Society
Educational
Educational Activities
teach hygiene to medical students and dental students
Social
Professional and Outreach Activities
school pharmacist of Kasumigaoka High School
school pharmacist of Hakozaki Junior High School
director of Warabe social welfare corporation.