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Researcher information
Chikako Kiyohara Last modified date：2013.5.16

Assistant Professor / Department of Environmental Health and Socio-Medical Sciences
Department of Basic Medicine
Faculty of Medical Sciences


Graduate School
Department of Environmental Health and Socio-Medical Sciences
Graduate School of Medical Sciences
Undergraduate School
Department of Medicine
School of Medicine


E-Mail
Phone
092-642-6112
Fax
092-642-6115
Academic Degree
PhD
Field of Specialization
Genome epidemiology
Outline Activities
Outline of research
1) Molecular epidemiology of lung cancer
2) Study on atopic desease and bacterial community in the gastrointestinal tract
3) Molecular epidemiology on systemic lupus erythematosus
4) Molecular epidemiology of attention deficit hyperactivity disorder in school children

Outline of education
Faculty of medicine; Public Health , Core Seminar
Master Course of Medical Biochmistry; Medicine, Medical treatment and Community IV
Docter Course of Medical Sciences; Epidemiologic Reseach

Scocial:
Committee of Building Council
Research
Research Interests
  • Genome epidemioly of lung cancer
    keyword : polymorphism, drug-metabolism, DNA excision repair, inflammation
    1994.04.
  • Epidemiology of systemic lupus erythematosus
    keyword : genetic polymorphisms TNF drug-metabolizing enzyme
    2004.04.
  • Molecular epidemiology of atopic disease
    keyword : atopic dermatitis genetic polymorphism, gene-environment interaction
    2007.04～2010.03.
  • Epidemiology of attention deficit hyperactivity disorder
    keyword : maternal smoking, dopamine-related genes
    2004.04.
  • Epidemiology of Parkinson's disease
    keyword : smoking, genetic polymorphism
    2007.04.
Current and Past Project
  • The primary goals of the project are:

    To study the association between genetic polymorphisms and cancer
    To investigate the association and interaction between polymorphisms
    To determine geographic and ethnic prevalence of the polymorphisms
    To create a data base for future studies on metabolic genes and molecular epidemiology of cancer
    To facilitate collaboration between scientists from different countries
  • The International Lung Cancer Consortium (ILCCO) is an international group of lung cancer researchers, established in 2004 with the aim of sharing comparable data from ongoing lung cancer case-control and cohort studies. Questionnaire data from a total of 26000 case-control pairs, and the biological samples from the majority of the subjects would be available. These studies are from different geographical areas and ethnicities. The overall objectives are to achieve greater power, especially for subgroup analyses, reduce duplication of research effort, replicate novel findings, and afford substantial cost savings through large collaborative efforts.

    Working groups were formed to oversee research areas that were considered a priority for the consortium, including: (i) Genetic susceptibility, (ii) Young onset and family history, (iii) Never smokers, (iv) Rare histology, (v) somatic mutation, (vi) Statistics and the others. Please see Working Groups for the complete list of current working groups.
Academic Activities
Books
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Reports
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1. Kiyohara C, Ohno Y.,Sex differences in lung cancer susceptibility: a review. ,7(5):381-401.,Gend Med.,2010.10.
2. Kiyohara C*, Yoshimasu K, Takayama K, Nakanishi Y,Lung cancer susceptibility: are we on our way to identifying a high-risk group? ,3: 617-627,Future Oncol,2007.12. .
Papers
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1. Kiyohara C, Takayama K, Nakanishi Y.
,Lung cancer risk and genetic polymorphisms in DNA repair pathways: a meta-analysis.,J Nucleic Acids,Vol.2010,pp.701760,2010.10. .
2. Kiyohara C, Horiuchi T, Miyake Y, Takayama K, Nakanishi Y.,Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu and the risk of lung cancer in a Japanese population.,Oncol Rep.,Vol.23,No.5,pp.1361-1368,2010.05. .
3. Kiyohara C, Yoshimasu K.,Association between major depressive disorder and a functional polymorphism of the 5-hydroxytryptamine (serotonin) transporter gene: a meta-analysis.,Psychiatr Genet.,Vol.20,No.2,pp.49-58,2010.04. .
4. Truong T, Sauter W, McKay JD, Hosgood HD 3rd, Gallagher C, Amos CI, Spitz M, Muscat J, Lazarus P, Illig T, Wichmann HE, Bickeböller H, Risch A, Dienemann H, Zhang ZF, Naeim BP, Yang P, Zienolddiny S, Haugen A, Le Marchand L, Hong YC, Kim JH, Duell EJ, Andrew AS, Kiyohara C, Shen H, Matsuo K, Suzuki T, Seow A, Ng DP, Lan Q, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Constantinescu V, Bencko V, Foretova L, Janout V, Caporaso NE, Albanes D, Thun M, Landi MT, Trubicka J, Lener M, Lubinski J; EPIC-lung, Wang Y, Chabrier A, Boffetta P, Brennan P, Hung RJ.,International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants.,Carcinogenesis,Vol.31,No.4,pp.625-633,2010.04. .
5. Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y.,IL1B rs1143634 polymorphism, cigarette smoking, alcohol use, and lung cancer risk in a Japanese population.,J Thorac Oncol.,Vol.5,No.3,pp.299-304,2010.03. .
6. Kiyohara C, Washio M, Horiuchi T, Tada Y, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H; Kyushu Sapporo SLE (KYSS) Study Group.,Cigarette smoking, STAT4 and TNFRSF1B polymorphisms, and systemic lupus erythematosus in a Japanese population.
,J Rheumatol. ,Vol.36,No.10,pp.2095-2203,2009.10. .
7. Kiyohara C, Washio M, Horiuchi T, Tada Y, Asami T, Ide S , Takahashi H, Kobashi G and the Kyushu Sapporo SLE (KYSS) Study Group., Cigarette smoking, N-acetyltransferase 2 polymorphism and systemic lupus erythematosus in a Japanese population. ,Lupus,18(7):630-638.,2009.06. .
8. Matsusue A, Kiyohara C,Tanaka K, Sasaki S, Miyake Y,ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children.,Clin Biochem,42(6): 477-483.,2009.04. .
9. Hung RJ, Christiani DC, Risch A, Popanda O, Haugen A, Zienolddiny S, Benhamou S, Bouchardy C, Lan Q, Spitz MR, Wichmann HE, LeMarchand L, Vineis P, Matullo G, Kiyohara C, Zhang ZF, Pezeshki B, Harris C, Mechanic L, Seow A, Ng DP, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Caporaso N, Chen C, Duell EJ, Goodman G, Field JK, Houlston RS, Hong YC, Landi MT, Lazarus P, Muscat J, McLaughlin J, Schwartz AG, Shen H, Stucker I, Tajima K, Matsuo K, Thun M, Yang P, Wiencke J, Andrew AS, Monnier S, Boffetta P, Brennan P.,International lung cancer consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.,Cancer Epidemiol Biomarkers Prev. ,17(11):3081-9.,2008.11. .
10. Lee KM, Kang D, Clapper ML, Ingelman-Sundberg M, Ono-Kihara M, Kiyohara C, Min S, Lan Q, Le Marchand L, Lin P, Lung ML, Pinarbasi H, Pisani P, Srivatanakul P, Seow A, Sugimura H, Tokudome S, Yokota J, Taioli E.,CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations.,Cancer Epidemiol Biomarkers Prev. ,17(5):1120-6.,2008.05. .
11. Ozawa M, Washio M, Kiyohara C.,Factors related to starting and continuing smoking among senior high school boys in Fukuoka, Japan.,Asian Pac J Cancer Prev.
,9(2):239-45.
,2008.05. .
12. Kiyohara C, Wakai K, Mikami H, Sido K, Ando M, Ohno Y,Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of environmental tobacco smoke and lung cancer: a case-control study in Japanese nonsmoking women.,Int J Cancer,Vol.107,No.1,107: 139-144,2003.01. .
Educational
Educational Activities
Faculty of Medicine; Public Health (the fourth and the sixth years)
Faculty of Medicine; Ore Seminar (the first years)
Master Course of Medical Biochmistry; Medicine, Medical treatment and Community IV (7/7), III (7/7)
Docter Course; Epidemiologic Research


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