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データ更新日：2010.2.2
住本 英樹
（すみもと ひでき）
教授
医学研究院
基礎医学部門
生体制御学講座 生化学分野
原著論文
| 1. |
Satoru Yuzawa, Kei Miyano, Kazuya Honbou, Fuyuhiko Inagaki, Hideki Sumimoto.,The Domain Organization of p67phox, a Protein Required for Activation of the Superoxide- Producing NADPH Oxidase in Phagocytes,Journal of Innate Immunity,2009.10. |
| 2. |
Miyano K, Koga H, Minakami R, Sumimoto H.,The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases.,Biochem J. in press. ,Biochem J. in press. ,2009.06. |
| 3. |
Ogura K, Tandai T, Yoshinaga S, Kobashigawa Y, Kumeta H, Ito T, Sumimoto H, Inagaki F.,NMR structure of the heterodimer of Bem1 and Cdc24 PB1 domains from Saccharomyces cerevisiae.,J Biochem. ,J Biochem. in press,2009.05. |
| 4. |
Taura M, Miyano K, Minakami R, Kamakura S, Takeya R, Sumimoto H.,A region N-terminal to the tandem SH3 domain of p47phox plays a crucial role in the activation of the phagocyte NADPH oxidase.,Biochem J. 419(2):329- 338, 2009.,Biochem J. 419(2):329- 338, 2009.,2009.04. |
| 5. |
Maehara Y, Miyano K, Sumimoto H. ,Role for the first SH3 domain of p67phox in activation of superoxide-producing NADPH oxidases.,Biochem Biophys Res Commun. 379, 589–593.,Biochem Biophys Res Commun. 379, 589–593.,2009.02. |
| 6. |
Shono, T., Yokoyama, N., Uesaka, T., Kuroda, J., Takeya, R., Yamasaki, T., Amano, T., Mizoguchi, M., Suzuki, S. O., Niiro, H., Miyamoto, K., Akashi, K., Iwaki, T., Sumimoto, H., and Sasaki, T. ,Enhanced expression of NAPDH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival. ,Int. J. Cancer.123, 787–792, 2008.,2008.08. |
| 7. |
Mayumi, M., Takeda, Y., Hoshiko, M., Serada, K., Murata, M., Moritomo, T., Takizawa, F., Kobayashi, I., Araki, K., Nakanishi, T., and Sumimoto, H. ,Characterization of teleost phagocyte NADPH oxidase: molecular cloning and expression analysis of carp (Cyprinus carpio) phagocyte NADPH oxidase. ,Mol. Immunol. 45, 1720–1731.,Mol. Immunol. 45, 1720–1731.,2009.06. |
| 8. |
Takeya, R., Taniguchi, K., Narumiya, S., and Sumimoto, H. ,The mammalian formin FHOD1 is activated via phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells. ,EMBO J. 27, 618–628,EMBO J. 27, 618–628,2008.02. |
| 9. |
Miyano, K., and Sumimoto, H.,Role of the small GTPase Rac in p22phox-dependent NADPH oxidases.,Biochimie. 89(9):1133-1144, 2007.,Biochimie. 89(9):1133-1144, 2007.,2007.05. |
| 10. |
Tanaka, H., Minakami, R., Kanaya, H., and Sumimoto, H.,Catalytic residues of group VIB calcium-independent phospholipase A2 (iPLA2_).,Biochem. Biophys. Res. Commun.,2004, 320, 1284?1290.. |
| 11. |
Fujii, M., Inoguchi, T., Maeda, Y., Sasaki, S., Sawada, F., Saito, R., Kobayashi, K., Sumimoto, H., and Takayanagi, R. ,Pitavastatin ameliorates albuminuria and renal mesangial expansion via down-regulation of NOX4 in db/db mice.,Kidney Int. 72(4): 473-480, 2007.,Kidney Int. 72(4): 473-480, 2007.,2007.06. |
| 12. |
Shinohara, M., Shang, W. H., Kubodera, M., Harada, S., Mitsushita, J., Kato, M., Miyazaki, H., Sumimoto, H., and Kamata, T. ,Nox1 redox-signaling mediates oncogenic Ras-induced disruption of stress fibers and focal adhesions by down-regulating Rho. ,J. Biol. Chem. 282, in press.,J. Biol. Chem. 282, in press.,2007.04. |
| 13. |
Honbou K, Minakami R, Yuzawa S, Takeya R, Suzuki NN, Kamakura S, Sumimoto H, Inagaki F.,Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding. ,EMBO J. 26, 1176–1186.,EMBO J. 26, 1176–1186.,2007.02. |
| 14. |
Ueyama, T., Tatsuno, T., Kawasaki, T., Tsujibe, S., Shirai, Y., Sumimoto, H., Leto, T. L., and Saito, N. ,A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox. ,Mol. Biol. Cell 18, 441–454.,Mol. Biol. Cell 18, 441–454.,2007.02. |
| 15. |
Yamamoto, A., Kami, K., Takeya, R., and Sumimoto, H. ,Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1).,Biochem. Biophys. Res. Commun. 352, 560–565.,Biochem. Biophys. Res. Commun. 352, 560–565.,2007.01. |
| 16. |
Satoh, S., Tanaka, H., Ueda, Y., Oyama, J. I., Sugano, M., Sumimoto, H., Mori, Y., Makino, N. ,Transient receptor potential (TRP) protein 7 acts as a G protein-activated Ca2+ channel mediating angiotensin II-induced myocardial apoptosis.,Mol. Cell. Biochem. 294, 205–215.,Mol. Cell. Biochem. 294, 205–215.,2006.07. |
| 17. |
Akasaki, T., Ohya, Y., Kuroda, J., Eto, K., Abe, I., Sumimoto, H., and Iida, M. ,Increased expression of gp91phox homologues of NAD(P)H oxidase in the aortic media during chronic hypertension: involvement of renin-angiotensin system.,Hypertens. Res. 29, 813–820.,Hypertens. Res. 29, 813–820.,2006.10. |
| 18. |
Onohara, N., Nishida, M., Inoue, R., Kobayashi, H., Sumimoto, H., Sato, Y., Mori, Y., Nagao, T., and Kurose, H. ,TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy.,EMBO J. 25, 5305–5316.,EMBO J. 25, 5305–5316.,2006.11. |
| 19. |
Honbou, K., Yuzawa, S., Suzuki, N. N., Fujioka, Y., Sumimoto, H., and Inagaki, F. ,Crystallization and preliminary crystallographic analysis of p40phox, a regulatory subunit of NADPH oxidase. ,Acta Crystallogr. F Struct. Biol. Cryst. Commun. 62, 1018–1020.,Acta Crystallogr. F Struct. Biol. Cryst. Commun. 62, 1018–1020.,2006.10. |
| 20. |
Uchizono, U., Takeya, R., Iwase, M., Sasaki, N., Oku, M., Imoto, H., Iida, M., and Sumimoto, H. ,Expression of isoforms of NADPH oxidase components in rat pancreatic islets. ,Life Sci. 80, 133–139.,Life Sci. 80, 133–139.,2006.12. |
| 21. |
Takeya, R., Taura, M., Yamasaki, T., Naito, S., and Sumimoto, H. ,Expression and function of Noxo1γ, an alternative splicing form of the NADPH oxidase organizer 1. ,FEBS J. 273, 3663–3677.,FEBS J. 273, 3663–3677.,2006.08. |
| 22. |
Izaki, T., Kamakura, S., Kohjima, M., and Sumimoto, H.,Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3.,Biochem. Biophys. Res. Commun. 341, 1001–1006.,Biochem. Biophys. Res. Commun. 341, 1001–1006.,2006.03. |
| 23. |
Ogura, K., Nobuhisa, I., Yuzawa, S., Takeya, R., Torikai, S., Saikawa, K., Sumimoto, H., and Inagaki, F. ,NMR solution structure of the tandem SH3 domains of p47phox complexed with a p22phox-derived proline-rich peptide. ,J. Biol. Chem. 281, 3660–3668.,J. Biol. Chem. 281, 3660–3668.,2006.02. |
| 24. |
Miyano, K., Ueno, N., Takeya, R., and Sumimoto, H.,Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1. ,J. Biol. Chem. 281, 21857–21868.,J. Biol. Chem. 281, 21857–21868.,2006.08. |
| 25. |
Nobuhisa, I., Takeya, R., Ogura, K., Ueno, N., Kohda, D., Inagaki, F., and Sumimoto, H. ,Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent α-helix of p22phox. ,Biochem. J. 396, 183–192.,Biochem. J. 396, 183–192.,2006.05. |
| 26. |
Kuroda, J., Nakagawa, K., Yamasaki, T., Nakamura, K., Takeya, R., Kuribayashi, F., Imajoh-Ohmi, S., Igarashi, K., Shibata, Y., Sueishi, K., and Sumimoto, H. ,The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells.,Genes Cells 10, 1139–1151.,Genes Cells 10, 1139–1151.,2005.12. |
| 27. |
Sumimoto, H., Miyano, K., and Takeya, R.,Molecular composition and regulation of the Nox family NAD(P)H oxidases.,Biochem. Biophys. Res. Commun. 338, 677–686.,Biochem. Biophys. Res. Commun. 338, 677–686.,2005.12. |
| 28. |
Mizuki, K., Takeya, R., Kuribayashi, F., Nobuhisa, I., Kohda, D., Nunoi, H., Takeshige, K., and Sumimoto, H.,A region C-terminal to the proline-rich core of p47phox regulates activation of the phagocyte NADPH oxidase by interacting with the C-terminal SH3 domain of p67phox. ,Arch. Biochem. Biophys. 444, 185–194.,Arch. Biochem. Biophys. 444, 185–194.,2005.12. |
| 29. |
Tsubouchi, H., Inoguchi, T., Sonta, T., Sato, N., Sekiguchi, N., Kobayashi, K., Sumimoto, H., Utsumi, H., and Nawata, H. ,Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vivo and in vitro evaluated by electron spin resonance measurement.,Free Radic. Biol. Med.39, 444-452.,Free Radic. Biol. Med.39, 444-452.,2005.08. |
| 30. |
Ueyama, T., Eto, M., Kami, K., Tatsuno, T., Kobayashi, T., Shirai, Y., Lennartz, M. R., Takeya, R., and Sumimoto, H., and Saito, N.,Isoform-specific membrane targeting mechanism of Rac during FcγR-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosome.,J. Immunol. 175, 2381-2390.,J. Immunol. 175, 2381-2390.,2005.08. |
| 31. |
Kanaya, H., Takeya, R., Takeuchi, K., Watanabe, N., Jing, N., and Sumimoto,,Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament.,Genes Cells, 10, 665-78.,Genes Cells, 10, 665-78.,2005.07. |
| 32. |
Nakayama, M., Inoguchi, T., Sonta, T., Maeda, Y., Sasaki, S., Sawada, F., Tsubouchi, H., Sonoda, N., Kobayashi, K., Sumimoto, H., and Nawata, H.,Increased expression of NAD(P)H oxidase in islets of animal models of type II diabetes and its improvement by an AT1 receptor antagonist.,Biochem. Biophys. Res. Commun. 332, 1153-1159. ,Biochem. Biophys. Res. Commun. 332, 1153-1159. ,2005.07. |
| 33. |
Ueno, N., Takeya, R., Miyano, K., Kikuchi, H., and Sumimoto, H.,The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators.,J. Biol. Chem. 280, 23328-23339.,J. Biol. Chem. 280, 23328-23339.,2005.06. |
| 34. |
Fujii, T., Onohara, N., Maruyama, Y., Tanabe, S., Kobayashi, H., Fukutomi, M.,Nagamatsu, Y., Nishihara, N., Inoue, R., Sumimoto, H., Shibasaki, F., Nagao, T., Nishida, M., and Kurose, H. ,Gα12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts. ,J. Biol. Chem. 280, 23041-23047.,J. Biol. Chem. 280, 23041-23047.,2005.06. |
| 35. |
Yoshida, S., Ogura, K., Yokochi, M., Yuzawa, S., Horiuchi, M., Morioka, H., Sumimoto,H., and Inagaki, F. ,1H, 13C and 15N resonance assignments of the backbone and methyl groups of the 24 kDa tetratricopeptide repeat domain in p67phox.,J. Biomol. NMR 32, 176,J. Biomol. NMR 32, 176,2005.06. |
| 36. |
Izaki, T., Kamakura, S., Kohjima, M., and Sumimoto, H. ,Phosphorylation-dependent binding of 14-3-3 to Par3β, a human Par3- relatedcell polarity protein. ,Biochem. Biophys. Res. Commun. 329, 212–219.,Biochem. Biophys. Res. Commun. 329, 212–219.,2005.04. |
| 37. |
Murakami, M., Masuda, S., Ueda-Semmyo, K., Yoda, E., Kuwata, H., Takanezawa, Y., Aoki, J., Arai, H., Sumimoto, H., Ishikawa, Y., Ishii, T., Nakatani, Y., Kudo, I.,Group VIB Ca2+-independent phospholipase A2γ promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2. ,J. Biol. Chem. 280, 14028–14041.,J. Biol. Chem. 280, 14028–14041.,2005.04. |
| 38. |
Tanabe, M., Rådmark, O., Watanabe, T., Shiose, A., and Sumimoto, H. ,Cloning of rat p47phox and comparison with human p47phox.,DNA Seq. 16, 65-68.,DNA Seq. 16, 65-68.,2005.02. |
| 39. |
Kawahara, T., Kohjima, M., Kuwano, Y., Mino, H., Teshima-Kondo, S., Takeya, R., Tsunawaki, S., Wada, A., Sumimoto, H., and Rokutan, K. ,Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer Noxo1 in guinea pig gastric mucosal cells.,Am. J. Physiol. Cell Physiol. 288, C450–C457.,Am. J. Physiol. Cell Physiol. 288, C450–C457.,2005.02. |
| 40. |
Tsubouchi H, Inoguchi T, Inuo M, Kakimoto M, Sonta T, Sonoda N, Sasaki S, Kobayashi K, Sumimoto H, Nawata H. ,Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic beta-cell line, MIN6-a role of NAD(P)H oxidase in beta-cells.,Biochem Biophys Res Commun. 326, 60-65.,Biochem Biophys Res Commun. 326, 60-65.,2005.01. |
| 41. |
Takamatsu, H., Takeya, R., Naito, S., and Sumimoto, H.,On the mechanism of cell lysis by deformation. ,J. Biomech. 38, 117–124.,J. Biomech. 38, 117–124.,2005.01. |
| 42. |
Hirano, Y., Yoshinaga, S., Takeya, R., Suzuki, N. N., Horiuchi, M., Kohjima, M.,Sumimoto, H., and Inagaki, F.,Structure of a cell polarity regulator, a complex between aPKC and Par6 PB1 domains.,J. Biol. Chem. 280, 9653–9661.,J. Biol. Chem. 280, 9653–9661.,2004.12. |
| 43. |
Kojima, C., Hashimoto, A., Yabuta, I., Hirose, M., Hashimoto, S., Kanaho, Y.,Sumimoto, H., Ikegami, T., and Sabe, H. ,Regulation of Bin1 SH3 domain binding by phosphoinositides.,EMBO J. 23, 4413–4422.,EMBO J. 23, 4413–4422.,2004.11. |
| 44. |
Sumimoto, H., Ueno, N., Yamasaki, T., Taura, M., and Takeya, R. ,Molecular mechanism underlying activation of superoxide-producing NADPH oxidases: roles for their regulatory proteins.,Jpn. J. Infect. Dis. 57, S24–S25.,Jpn. J. Infect. Dis. 57, S24–S25.,2004.10. |
| 45. |
Ueyama, T., Lennartz, M. R., Noda, Y., Kobayashi, T., Shirai, Y., Rikitake , K., Yamasaki, T., Hayashi, S., Sakai, N., Seguchi, H., Sawada, M., Sumimoto, H., and Saito, N. ,Superoxide (O2-) production at phagosomal cup/phagosome throughßI PKC uring FcγR-mediated phagocytosis in microglia. ,J. Immunol. 173, 4582–4589¬.,J. Immunol. 173, 4582–4589¬.,2004.10. |
| 46. |
Hanano, T., Hara, Y., Shi, J., Morita, H., Umebayashi, C., Mori, E., Sumimoto, H., Ito, Y., Mori, Y., Inoue, R. ,Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells.,J. Pharmacol. Sci. 95, 403–419.,J. Pharmacol. Sci. 95, 403–419.,2004.08. |
| 47. |
Tanaka, H., Minakami, R., Kanaya, H., and Sumimoto, H.,Catalytic residues of group VIB calcium-independent phospholipase A2 (iPLA2γ). ,Biochem. Biophys. Res. Commun. 320, 1284–1290.,Biochem. Biophys. Res. Commun. 320, 1284–1290.,2004.08. |
| 48. |
Yuzawa, S., Yokochi, M., Fujioka, Y., Ogura, K., Kataoka, M., Sumimoto, H., and Inagaki, F. ,Sequence-specific resonance assignments of the tandem SH3 domains in an autoinhibitory form of p47phox. ,J. Biomol. NMR 29, 451-452.,J. Biomol. NMR 29, 451-452.,2004.07. |
| 49. |
Sasaki, Y., Ihara, K., Matsuura, N., Kohno, H., Nagafuchi, S., Kuromaru, R., Kusuhara, K., Takeya, R., Hoey, T, Sumimoto, H., Hara T.,Identification of a novel type 1 diabetes susceptibility gene, T-bet.,Hum. Genet. 115, 177–184.,Hum. Genet. 115, 177–184.,2004.07. |
| 50. |
Yuzawa, S., Suzuki, N. N., Fujioka, Y., Ogura, K., Sumimoto, H., and Inagaki, F. ,A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox,the regulatory subunit of the phagocyte NADPH oxidase. ,Genes Cells 9, 443–456.,Genes Cells 9, 443–456.,2004.06. |
| 51. |
Hashida, S., Yuzawa, S., Suzuki, N. N., Fujioka, Y., Takikawa, T., Sumimoto, H., Inagaki, F., and Fujii, H.,Binding of FAD to cytochrome b558 is facilitated during activation of the phagocyte NADPH oxidase, leading to superoxide production.,J. Biol. Chem. 279, 26378–26386.,J. Biol. Chem. 279, 26378–26386.,2004.06. |
| 52. |
Hirano, Y., Yoshinaga, S., Ogura, K., Yokochi, M., Noda, Y., Sumimoto, H., and Inagaki, F.,Solution structure of atypical PKC PB1 domainand its mode of interaction with ZIP/p62 and MEK5.,J. Biol. Chem. 279, 31883–31890.,J. Biol. Chem. 279, 31883–31890.,2004.05. |
| 53. |
Yuzawa, S., Ogura, K., Horiuchi, M., Suzuki, N. N., Fujioka, Y., Kataoka, M., Sumimoto, H., and Inagaki, F. ,Solution structure of the tandem SH3 domains of p47phox in an autoinhibited form.,J. Biol. Chem. 279, 29752–29760.,J. Biol. Chem. 279, 29752–29760.,2004.04. |
| 54. |
Kawahara, T., Kuwano, Y., Teshima-Kondo, S., Takeya, R., Sumimoto, H., Kishi, K., Tsunawaki, S., Hirayama, T., and Rokutan, K. ,Role of NADPH oxidase 1 in oxidative burst response to Toll-like receptor 5 signaling in large intestinal epithelial cells. ,J. Immunol. 172, 3051–3058.,J. Immunol. 172, 3051–3058.,2004.03. |
| 55. |
Mizukami, Y., Sumimoto, H., and Takeshige, K. ,Induction of cytochrome CYP4F3A in all-trans-retinoic acid-treated HL60 cells.,Biochem. Biophys. Res. Commun. 314, 104-109.,Biochem. Biophys. Res. Commun. 314, 104-109.,2004.01. |
| 56. |
Yuzawa, S., Suzuki, N. N., Fujioka, Y., Ogura, K., Sumimoto, H., and Inagaki, F.,Crystallization and preliminary crystallographic analysis of autoinhibited form of tandem SH3 domain of p47phox. ,Acta Crystallogr. D Biol. Crystallogr. 59, 1479–1480.,Acta Crystallogr. D Biol. Crystallogr. 59, 1479–1480.,2003.10. |
| 57. |
Noda, Y., Kohjima, M., Izaki, T., Ota, K., Yoshinaga, S., Inagaki, F., Ito, T., and Sumimoto, H. ,Molecular recognition in dimerization between PB1 domains. ,J. Biol. Chem. 278, 43516–43524.,J. Biol. Chem. 278, 43516–43524.,2003.10. |
| 58. |
Etoh, T., Inoguchi, T., Kakimoto, M., Sonoda, N., Kobayashi, K., Kuroda, J., Sumimoto, H., and Nawata, H.,Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in kidney of streptozotocin-induced diabetic rats and its reversibility in interventive insulin treatment. ,Diabetologia 46, 1428–1437.,Diabetologia 46, 1428–1437.,2003.09. |
| 59. |
Yoshinaga, S., Kohjima, M., Ogura, K., Yokochi, M., Takeya, R., Ito, T., Sumimoto, H., and Inagaki, F. ,The PB1 domain and the PC motif-containing region are structurally similar protein binding modules. ,EMBO J. 22, 4888–4897.,EMBO J. 22, 4888–4897.,2003.10. |
| 60. |
Ago, T., Kuribayashi, F., Hiroaki, H., Takeya, R., Ito, T., Kohda, D., and Sumimoto, H.,Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation.,Proc. Natl. Acad. Sci. USA,2003, 100, 4474?4479 (track II).,2003.01. |
| 61. |
Takeya, R., and Sumimoto, H.,Fhos, a mammalian formin, directly binds to F-actin via the N-terminal region and forms a homotypic complex via the FH2 domain to promote actin fiber formation. ,J. Cell Sci. 116, 4567–4575.,J. Cell Sci. 116, 4567–4575.,2003.11. |
| 62. |
Takeya, R., Ueno, N., Kami, K., Taura, M., Kohjima, M., Izaki, T., Nunoi, H., and Sumimoto, H. ,Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. ,J. Biol. Chem. 278, 25234–25246.,J. Biol. Chem. 278, 25234–25246.,2003.07. |
| 63. |
Inoguchi, T., Tsubouchi, H., Etoh, T., Kakimoto, M., Sonta, T., Utsumi, H., Sumimoto, H., Yu, H.Y., Sonoda, N., Inuo, M., Sato, N., Sekiguchi, N., Kobayashi, K., and Nawata, H. ,A possible target of antioxidative therapy for diabetic vascular complications-vascular NAD(P)H oxidase. ,Curr. Med. Chem. 10, 1759–1764.,Curr. Med. Chem. 10, 1759–1764.,2003.09. |
| 64. |
Inoguchi, T., Sonta, T., Tsubouchi, H., Etoh, T., Kakimoto, M., Sonoda, N., Sato, N., Sekiguchi, N., Kobayashi, K., Sumimoto, H., Utsumi, H., and Nawata, H. ,Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: Role of vascular NAD(P)H oxidase.,J. Am. Soc. Nephrol. 14 (Suppl 3), S227–S232.,J. Am. Soc. Nephrol. 14 (Suppl 3), S227–S232.,2003.08. |
| 65. |
Takeya, R., and Sumimoto, H. ,Molecular mechanism for activation of superoxide-producing NADPH oxidases. ,Mol. Cells 16, 271–277.,Mol. Cells 16, 271–277.,2003.12. |
| 66. |
Yamamori, T., Inanami, O., Sumimoto, H., Akasaki, T., Nagahata, H., and Kuwabara, M.,Relationship between p38 mitogen-activated protein kinase and small GTPase Rac for the activation of NADPH oxidase in bovine neutrophils.,Biochem. Biophys. Res. Commun. 293, 1571–1578.,Biochem. Biophys. Res. Commun. 293, 1571–1578.,2002.05. |
| 67. |
Ponting, C., Ito, T., Moscat, J., Diaz-Meco, M. T., Inagaki, F., and Sumimoto, H.,OPR, PC and AID: all in the PB1 domain. ,Trends. Biochem. Sci. 27, 10.,Trends. Biochem. Sci. 27, 10.,2002.01. |
| 68. |
Kami,K., Takeya, R., Sumimoto, H., and Kohda, D. ,Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67phox, Grb2 and Pex13p.,EMBO J. 21, 4268–4276.,EMBO J. 21, 4268–4276.,2002.08. |
| 69. |
Kuribayashi, F., Nunoi, H., Wakamatsu, K., Tsunawaki, S., Sato, K., Ito, T., and Sumimoto, H.,The adaptor protein p40phox as a positive regulator of the superoxide-producing phagocyte oxidase. ,EMBO J. 21, 6312–6320.,EMBO J. 21, 6312–6320.,2002.12. |
| 70. |
Kubo, T., Yamashita, T., Yamaguchi, A., Sumimoto, H., Hosokawa, K., and Tohyama, M. ,A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling.,J. Neurosci. 22, 8504–8513.,J. Neurosci. 22, 8504–8513.,2002.10. |
| 71. |
Kohjima, M., Noda, Y., Takeya, R., Saito, N., Takeuchi, K., and Sumimoto, H. ,PAR3β, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions. ,Biochem. Biophys. Res. Commun. 299, 641–646.,Biochem. Biophys. Res. Commun. 299, 641–646.,2002.12. |
| 72. |
Shiose, A., Kuroda, J., Tsuruya, K., Hirai, M., Hirakata, H., Naito, S., Hattori, M., Sakaki, Y., and Sumimoto, H.,A Novel Superoxide-producing NAD(P)H Oxidase in Kidney.,J. Biol. Chem. 276, 1417–1423,J. Biol. Chem. 276, 1417–1423,2001.01. |
| 73. |
Ago, T., Takeya, R., Hiroaki, H., Kuribayashi, F., Ito, T., Kohda, D., and Sumimoto, H.,The PX Domain as a Novel Phosphoinositide-Binding Module. ,Biochem. Biophys. Res. Commun. 287, 733–738. ,Biochem. Biophys. Res. Commun. 287, 733–738. ,2001.09. |
| 74. |
Terasawa, H., Noda, Y., Ito, T., Hatanaka, H., Ogura, K., Sumimoto, H., and Inagaki, F. ,Structure and ligand recognition of the PB1 domain: a novel protein module capable of binding PC motif-containing protein.,EMBO J. 20, 3947-3956,EMBO J. 20, 3947-3956,2001.08. |
| 75. |
Ito, T., Matsui, Y., Ago, T., Ohta, K., and Sumimoto, H.,Novel modular domain PB1 recognizes PC motif to mediate functional protein-protein interactions.,EMBO J. 20, 3938-3946,EMBO J. 20, 3938-3946,2001.08. |
| 76. |
Nosaka, Y., Arai, A., Kanda, E., Akasaki, T., Sumimoto, H., Miyasaka, N., and Miura, O. ,Rac Is Activated by Tumor Necrosis Factor a and Is involved in Activation of Erk. ,Biochem. Biophys. Res. Commun. 285, 675–679,Biochem. Biophys. Res. Commun. 285, 675–679,2001.07. |
| 77. |
Hiroaki, H., Ago, T., Ito, T., Sumimoto, H., and Kohda, D.,Solution structure of the PX domain, a target of the SH3 domain. ,Nature Struct. Biol. 8, 526-530,Nature Struct. Biol. 8, 526-530,2001.06. |
| 78. |
Noda, Y., Takeya, R., Ohno, S., Naito, S., Ito, T., and Sumimoto, H.,Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.,Genes Cells 6, 107–119,Genes Cells 6, 107–119,2001.02. |
| 79. |
Tanaka, H., Takeya, R., and Sumimoto, H.,A Novel Intracellular Membrane-Bound Calcium-Independent Phospholipase A2.,Biochem. Biophys. Res. Commun. 272, 320–326,Biochem. Biophys. Res. Commun. 272, 320–326,2000.06. |
| 80. |
Shiose, A., and Sumimoto, H. ,Arachidonic Acid and Phosphorylation Synergistically Induce a Conformational Change of p47phox to Activate the Phagocyte NADPH Oxidase. ,J. Biol. Chem. 275, 13793–13801.,J. Biol. Chem. 275, 13793–13801.,2000.05. |
| 81. |
Takeya, R., Takeshige, K., and Sumimoto, H.,Interaction of the PDZ Domain of Human PICK1 with Class I ADP-Ribosylation Factors. ,Biochem. Biophys. Res. Commun. 267, 149–155.,Biochem. Biophys. Res. Commun. 267, 149–155.,2000.01. |
| 82. |
Ago, T., Nunoi, H., Ito, T., and Sumimoto, H.,Mechanism for Phosphorylation-induced Activation of the Phagocyte NADPH Oxidase Protein p47phox: triple replacement of serines 303, 304, and 328 with aspartates disrupts intramolecular interaction in p47phox, thereby activating the oxidase. ,J. Biol. Chem. 274, 33644–33653.,J. Biol. Chem. 274, 33644–33653.,1999.11. |
| 83. |
Koga, H., Terasawa, H., Nunoi, H., Takeshige, K., Inagaki, F., and Sumimoto, H. ,Tetratricopeptide Repeat (TPR) Motifs of p67phoxParticipate in Interaction with the Small GTPase Rac and Activation of the Phagocyte NADPH Oxidase.,J. Biol. Chem. 274, 25051-25060.,J. Biol. Chem. 274, 25051-25060.,1999.08. |
| 84. |
Akasaki,T.,Koga,H.,andSumimoto,H.,Phosphoinositide3-Kinase-dependent and -independent Activation of the Small GTPase Rac2 in Human Neutrophils.,J. Biol. Chem. 274, 18055-18059.,J. Biol. Chem. 274, 18055-18059.,1999.06. |
| 85. |
Izuhara, K., Arinobu, Y., Sumimoto, H., Nunoi, H., Takeya, R., Higuchi, K., Takeshige, K., Hamasaki, N., and Harada, N.,Association of the interleukin-4 receptor a chain with p47phox, an activator of the phagocyte NADPH oxidase in B cells.,Mol. Immunol. 36, 45-52.,Mol. Immunol. 36, 45-52.,1999.01. |
| 86. |
Higasa, K., Manabe, J., Yubisui, T., Sumimoto, H., Pung-amritt, P., Tanphaichitr, V. S., and Fukumaki, Y.,Molecular basis of hereditary methemoglobinemia, types I and II: two novel mutations in the NADH-cytochrome b5 reductase gene.,Brit. J. Haematol. 103, 922-930.,Brit. J. Haematol. 103, 922-930.,1998.12. |
| 87. |
Kikuta, Y., Kusunose, E., Sumimoto, H., Mizukami, Y., Takeshige, K., Sakaki, T., Yabusaki, Y., and Kusunose, M. ,Purification and Characterization of Recombinant Human Neutrophil Leukotriene B4 w-Hydroxylase (Cytochrome P450 4F3). ,Arch. Biochem. Biophys. 355, 201-205.,Arch. Biochem. Biophys. 355, 201-205.,1998.07. |
| 88. |
Hata, K., Ito, T., Takeshige, K., and Sumimoto, H.,Anionic Amphiphile-independent Activation of the Phagocyte NADPH Oxidase in a Cell-free System by p47phox and p67phox, Both in C terminally Truncated Forms: Implication for regulatory SH3 domain-mediated interactions.,J. Biol. Chem. 273, 4232-4236.,J. Biol. Chem. 273, 4232-4236.,1998.02. |
| 89. |
Nakamura, R., Sumimoto, H., Mizuki, K., Hata, K., Ago, T., Kitajima, S., Takeshige, K., Sakaki, Y., and Ito, T. ,PC Motif: A novel and evolutionarily conserved sequence involved in interaction between p40phox and p67phox, SH3 domain-containing cytosolic factors of the phagocyte NADPH oxidase.,Eur. J. Biochem. 251, 483-589.,Eur. J. Biochem. 251, 483-589.. |
| 90. |
Mizuki, K., Kadomatsu, K., Hata, K., Ito, T., Fan, Q.-W., Kage, Y, Fukumaki, Y., Sakaki, Y., Takeshige, K., and Sumimoto, H. ,Functional modules and expression of mouse p40phox and p67phox, SH3 domain-containing proteins involved in the phagocyte NADPH oxidase complex.,Eur. J. Biochem. 251, 573-582.,Eur. J. Biochem. 251, 573-582.,1998.02. |
| 91. |
Hata, K., Takeshige, K., and Sumimoto, H. ,Roles for proline-rich regions of p47phox and p67phox in the phagocyte NADPH oxidase activation in vitro.,Biochem. Biophys. Res. Commun. 241, 226-231.,Biochem. Biophys. Res. Commun. 241, 226-231.,1997.12. |
| 92. |
Takeshige, K., Ito, T., and Sumimoto, H.,Activation of the phagocyte NADPH oixdase.,J. Toxicol. Sci. 21, 291-292.,1996.12. |
| 93. |
Manabe, J., Arya, R., Sumimoto, H., Yubisui, T., Layton, D.M. and Fukumaki, Y. ,Molecular analysis of hereditary methemo-globinemia: the compound heterozygosity for two novel mutations in the NADH-cytochrome b5 reductase gene results in the generalized type. ,Blood 88, 3208-3215.,Blood 88, 3208-3215.,1996.10. |
| 94. |
Ito, T., Nakamura, R., Sumimoto, H.,.Takeshige, K. and Sakaki, Y. ,An SH3 domain-mediated interaction between the phagocyte NADPH oxidase factors p40phox and p47phox.,FEBS Lett. 385, 229-232.,FEBS Lett. 385, 229-232.,1996.05. |
| 95. |
Sumimoto, H., Hata, K., Mizuki, K., Ito, T., Kage, Y., Sakaki, Y., Fukumaki, Y., Nakamura, M. and Takeshige, K. ,Assembly and activation of the phagocyte NADPH oxidase: Specific interaction of the N-terminal Src homology 3 (SH3) domain of p47phox with p22phox is required for the activation of the NADPH oxidase.,J. Biol. Chem. 271, 22152-22158.,J. Biol. Chem. 271, 22152-22158.,1996.09. |
| 96. |
Nakaike, R., Shimokawa, H., Yasutake, H., Sumimoto, H., Ito, A., Numaguchi, K., Egashira, K., Takeshige, K. and Takeshita, A.,Effects of L-arginine analogues on vasomotion of isolated porcine coronary arteries. ,Am. J. Physiol. 268, H1966-H1972.,Am. J. Physiol. 268, H1966-H1972.,1995.05. |
| 97. |
Mizukami, Y., Sumimoto, H., Isobe, R., Minakami, S. and Takeshige, K. ,w-Oxidation of lipoxin B4 by rat liver: Identification of w-carboxy metabolite of lipoxin B4.,Eur. J. Biochem. 224, 959-965.,Eur. J. Biochem. 224, 959-965.,1994.09. |
| 98. |
Sumimoto, H., Kage, Y., Nunoi, H., Sasaki, H., Nose, T., Fukumaki, Y., Ohno, M., Minakami, S. and Takeshige, K. ,Role of Src homology 3 (SH3) domains in assembly and activation of the phagocyte NADPH oxidase. ,Proc. Natl. Acad. Sci. USA 91, 5345-5349. ,Proc. Natl. Acad. Sci. USA 91, 5345-5349. ,1994.06. |
| 99. |
Fernando, M.R., Sumimoto, H., Nanri, H., Kawabata, S., Iwanaga, S., Minakami, S., Fukumaki, Y. and Takeshige, K.,Cloning and sequencing of the cDNA encoding human glutaredoxin.,Biochim. Biophys. Acta 1218, 229-231. ,1994.06. |
| 100. |
Mizukami, Y., Sumimoto, H., Isobe, R. and Minakami, S. ,w-Hydroxylation of lipoxin B4 by human neutrophil microsomes: Identification of w-hydroxy metabolite of lipoxin B4 and catalysis by leukotriene B4 w-hydroxylase (cytochrome P-450LTBw).,Biochim. Biophys. Acta 1168, 87-93. ,Biochim. Biophys. Acta 1168, 87-93. ,1993.01. |
| 101. |
Sumimoto, H., Isobe, R., Mizukami, Y. and Minakami, S. ,Formation of a novel 20-hydroxylated metabolite of lipoxin A4 by human neutrophil microsomes. ,FEBS Lett. 315, 205-210.,FEBS Lett. 315, 205-210.,1993.01. |
| 102. |
Aoyagi, K., Takeshige, K., Sumimoto, H., Nunoi, H. and Minakami, S. ,Role of Mg2+ in activation of NADPH oxidase of human neutrophils: Evidence that Mg2+ acts through G-protein. ,Biochem. Biophys. Res. Commun. 186, 391-397.,Biochem. Biophys. Res. Commun. 186, 391-397.,1992.07. |
| 103. |
Sumimoto, H., Sakamoto, N., Nozaki, M., Sakaki, H., Takeshige, K. and Minakami, S. ,Cytochrome b558, a component of the phagocyte NADPH oxidase, is a flavoprotein.,Biochem. Biophys. Res. Commun. 186, 1368-1375. ,Biochem. Biophys. Res. Commun. 186, 1368-1375. ,1992.08. |
| 104. |
Kato, H., Sumimoto, H., Pognonec, P., Chen, C.-H., Rosen, C.A. and Roeder, R.G. ,HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors. ,Genes Dev. 6, 655-666. ,Genes Dev. 6, 655-666. ,1992.04. |
| 105. |
Pognonec, P., Kato, H., Sumimoto, H., Kretzschmar, M. and Roeder, R.G.,A quick procedure for purification of functional recombinant proteins over-expressed in E. coli.,Nucl. Acids Res. 19, 6650.,Nucl. Acids Res. 19, 6650.,1991.12. |
| 106. |
Ohkuma, Y., Sumimoto, H., Hoffmann, A., Shimasaki, S., Horikoshi, M. and Roeder, R.G. ,Structural motifs and potential s homologies in the large subunit of human general transcription factor TFIIE.,Nature 354, 398-401. ,Nature 354, 398-401. ,1991.12. |
| 107. |
Malik, S., Hisatake, K., Sumimoto, H., Horikoshi, M. and Roeder, R.G.,Sequence of general transcription factor TFIIB and relationships to other initiation factors. ,Proc. Natl. Acad. Sci. USA 88, 9553-9557.,Proc. Natl. Acad. Sci. USA 88, 9553-9557.,1991.11. |
| 108. |
Sumimoto, H., Ohkuma, Y., Sinn, E., Kato, H., Shimasaki, S., Horikoshi, M. and Roeder, R.G. ,Conserved sequence motifs in the small subunit of human general transcription factor TFIIE.,Nature 354, 401-404.,1991.12. |
| 109. |
Ohkuma, Y., Sumimoto, H., Horikoshi, M. and Roeder, R.G.,Factors involved in specific transcription by mammalian RNA polymerase II: Purification and characterization of general transcription factor TFIIE.,Proc. Natl. Acad. Sci. USA 87, 9163-9167.,Proc. Natl. Acad. Sci. USA 87, 9163-9167.,1990.12. |
| 110. |
Sumimoto, H., Ohkuma, Y., Yamamoto, T., Horikoshi, M. and Roeder, R.G.,Factors involved in specific transcription by mammalian RNA polymerase II: Identification of general transcription factor TFIIG.,Proc. Natl. Acad. Sci. USA 87, 9158-9162.,Proc. Natl. Acad. Sci. USA 87, 9158-9162.,1990.12. |
| 111. |
Ishii, K., Suita, S. and Sumimoto, H.,Effect of verapamil on conversion of xanthine dehydrogenase to oxidase in ischemic rat liver.,Res. Exp. Med. 190, 389-399.,Res. Exp. Med. 190, 389-399.,1990.06. |
| 112. |
Sumimoto, H., Kusunose, E., Gotoh, Y., Kusunose, M. and Minakami, S. ,Leukotriene B4 w-hydroxylase in rat liver microsomes: Identification as a cytochrome P-450 that catalyzes prostaglandin A1 w-hydroxylation, and participation of cytochrome b5.,J. Biochem. 108, 215-221,J. Biochem. 108, 215-221.,1990.08. |
| 113. |
Gotoh, Y., Sumimoto, H. and Minakami, S.,Formation of 20-oxoleukotriene B4 by an alcohol dehydrogenase isolated from human neutrophils.,Biochim. Biophys. Acta 1043, 52-56. ,Biochim. Biophys. Acta 1043, 52-56. ,1990.03. |
| 114. |
Sumimoto, H. and Minakami, S. ,Oxidation of 20-hydroxyleukotriene B4 to 20-carboxyleukotriene B4 by human neutrophil microsomes: Role of aldehyde dehydrogenase and leukotriene B4 w-hydroxylase (cytochrome P-450LTBw) in leukotriene B4 w-oxidation.,J. Biol. Chem. 265, 4348-4353.,J. Biol. Chem. 265, 4348-4353.,1990.03. |
| 115. |
Sumimoto, H., Kikuta, Y., Kusunose, E., Kusunose, M. and Minakami, S.,Antibodies against rabbit w-hydroxylases of prostaglandins and fatty acids cross-react with leukotriene B4 w-hydroxylase in human neutrophils (cytochrome P-450LTBw).,Biochem. Int. 20, 381-387. ,Biochem. Int. 20, 381-387. ,1990.02. |
| 116. |
Nozaki, M., Takeshige, K., Sumimoto, H. and Minakami, S. ,Reconstitution of the partially purified membrane component of the superoxide-generating NADPH oxidase of pig neutrophils with phospholipid. ,Eur. J. Biochem. 187, 335-340.,Eur. J. Biochem. 187, 335-340.,1990.01. |
| 117. |
Sumimoto, H., Nozaki, M., Sasaki, H., Takeshige, K., Sakaki, Y. and Minakami, S. ,Complementary DNA for the mouse homologue of the small subunit of human cytochrome b558. ,Biochem. Biophys. Res. Commun. 165, 902-906.,Biochem. Biophys. Res. Commun. 165, 902-906.,1989.12. |
| 118. |
Takeshige, K., Sumimoto, H. and Minakami, S. ,Metabolism of stimulated polymorphonuclear leukocytes.,Biomed. Biochim. Acta 48, S25-S30.,Biomed. Biochim. Acta 48, S25-S30.,1989.02. |
| 119. |
Gotoh, Y., Sumimoto, H. and Minakami, S.,Purification and characterization of 20-hydroxy-leukotriene B4 dehydrogenase in human neutrophils.,Eur. J. Biochem. 179, 315-321.,Eur. J. Biochem. 179, 315-321.,1989.02. |
| 120. |
Osaki, M., Sumimoto, H., Takeshige, K., Cragoe, E.J., Jr., Hori, Y. and Minakami, S. ,Na+/H+ exchange modulates the production of leukotriene B4 by human neutrophils.,Biochem. J. 257, 751-758.,Biochem. J. 257, 751-758.,1989.02. |
| 121. |
Yamaoka, A., Sumimoto, H., Isobe, R. and Minakami, S.,Formation of leukotriene B4-coenzyme A ester by rat liver microsomes.,Biochem. Biophys. Res. Commun. 154, 1248-1252.,Biochem. Biophys. Res. Commun. 154, 1248-1252.,1987.04. |
| 122. |
Noda, A., Noda, H., Misaka, A., Sumimoto, H. and Tatsumi, K.,Hydrazine radical formation by rat microsomal NADPH-cytochrome P-450 reductase. ,Biochem. Biophys. Res. Commun. 153, 256-260.,Biochem. Biophys. Res. Commun. 153, 256-260.,1988.05. |
| 123. |
Sumimoto, H., Satoh, M., Takeshige, K., Cragoe, E.J., Jr. and Minakami, S.,Cytoplasmic pH change induced by leukotriene B4 in human neutrophils.,Biochim. Biophys. Acta 970, 31-38.,Biochim. Biophys. Acta 970, 31-38.,1988.06. |
| 124. |
Gotoh, Y., Sumimoto, H., Takeshige, K. and Minakami, S.,NAD+-dependent oxidation of 20-hydroxyleukotriene B4 to 20-carboxyleukotriene B4 by rat liver cytosol.,Biochim. Biophys. Acta 960, 342-350.,Biochim. Biophys. Acta 960, 342-350.,1988.06. |
| 125. |
Sumimoto, H., Takeshige, K. and Minakami, S.,Characterization of human neutrophil leukotriene B4 w-hydroxylase as a system involving a unique cytochrome P-450 and NADPH-cytochrome P-450 reductase.,Eur. J. Biochem. 172, 315-324.,Eur. J. Biochem. 172, 315-324.,1988.01. |
| 126. |
Yamaoka, A., Sumimoto, H., Takeshige, K., Itoh, T., Isobe, R., Yoshitake, J. and Minakami, S. ,Inhibition of leukotriene formation in human leukocytes by halothane. ,Biochim. Biophys. Acta 918, 284-292.,Biochim. Biophys. Acta 918, 284-292.,1987.04. |
| 127. |
Izumi, T., Shimizu, T., Kasama, T., Seyama, Y., Sumimoto, H., Takeshige, K., Minakami, S., Wetterholm, A. and Rådmark, O.,A simultaneous quantitation of leukotriene B4 and its w-oxidized products by gas chromatography-mass spectrometry.,Biochem. Biophys. Res. Commun. 134, 512-518.,Biochem. Biophys. Res. Commun. 134, 512-518.,1986.04. |
| 128. |
Sumimoto, H., Takeshige, K. and Minakami, S.,NAD+-dependent conversion of 20-OH-LTB4 to 20-COOH-LTB4 by a cell-free system of human polymorphonuclear leukocytes.,Biochem. Biophys. Res. Commun. 132, 864-870. ,Biochem. Biophys. Res. Commun. 132, 864-870. ,1984.12. |
| 129. |
Nakagawara, M., Takeshige, K., Sumimoto, H., Yoshitake, J. and Minakami, S. ,Superoxide release and intracellular free calcium of calcium-depleted human neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine. ,Biochim Biophys Acta. 805(1):97-103. ,Biochim Biophys Acta. 805(1):97-103. ,1984.09. |
| 130. |
Sumimoto, H., Takeshige, K., Sakai, H. and Minakami, S.,A cell-free preparation of human neutrophils catalyzing NADPH-dependent conversion of leukotriene B4.,Biochem. Biophys. Res. Commun. 125, 615-621.,Biochem. Biophys. Res. Commun. 125, 615-621.,1984.12. |
| 131. |
Sumimoto, H., Takeshige, K. and Minakami, S. ,Superoxide production of human polymorphonuclear leukocytes stimulated by leukotriene B4.,Biochim. Biophys. Acta 803, 271-277.,Biochim. Biophys. Acta 803, 271-277.,1984.04. |
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