| Takanari Kitazono | Last modified date：2013.6.7 |
Graduate School
Undergraduate School
Other Organization
Administration Post
Other
Phone
092-642-5250
Fax
092-642-5271
Academic Degree
PhD
Field of Specialization
cerebrovascular disorder
Outline Activities
[Research]
I have been investigating the mechanisms of cerebrovascular responses both in vivo and in vitro. I have shown, using a cranial window technique, the important role of potassium channels in the dilator responses of rat basilar artery in vivo. Moreover, I have examined the vascular responses during chronic hypertension and found that the activities of both nitric oxide and potassium channels are impaired in the basilar artery during chronic hypertension, which may contribute to the development of cerebrovascular lesions in hypertensice subjects. Recently, I am studying the molecular identity of NADPH oxidase in the endothelial and smooth mauscle cells and found that NOX4 is the major catalytic subunit of NADPH oxidase in the endothelial cells.
I have been investigating the mechanisms of cerebrovascular responses both in vivo and in vitro. I have shown, using a cranial window technique, the important role of potassium channels in the dilator responses of rat basilar artery in vivo. Moreover, I have examined the vascular responses during chronic hypertension and found that the activities of both nitric oxide and potassium channels are impaired in the basilar artery during chronic hypertension, which may contribute to the development of cerebrovascular lesions in hypertensice subjects. Recently, I am studying the molecular identity of NADPH oxidase in the endothelial and smooth mauscle cells and found that NOX4 is the major catalytic subunit of NADPH oxidase in the endothelial cells.
Research
Research Interests
- An epidemiological study of acute stroke patients, the Fukuoka Stroke Registry (FSR)
keyword : stroke, cohort study, epidemiology, database
2007.06. - Genomics of brain infarction
keyword : brain infarction, genomics, SNP
2005.04. - Molecular biology of CNS pericytes
keyword : cerebral microcirculation, pericyte
2004.04. - Study on cerebrovascular responses
keyword : responses of cerebral arteries, nitric oxide, potassium channels, hypertension
1991.09.
- Using our original multi-center stroke data base (Fukuoka Stroke Registry; FSR), we have been investigating the clinical features of stroke patients in Japan.
- I have been investigating the molecular identity and the functional role of the NAD(P)H oxidase in the vascular endothelial and smooth muscle cells.
- Using cranial window technique and other pharmacological techniques, I have been investigating the regulation mechanisms of cerebral circulation. I focus on the changes of cerebrovascular responses during chronic hypertension.
Reports
| 1. | Ago T, Kuroda J, Kamouchi M, Sadoshima J, Kitazono T.,Pathological roles of NADPH oxidase-nox family proteins in the vascular system.,2011.07. |
| 2. | Kamouchi M, Ago T, Kitazono T.,Brain pericytes: emerging concepts and functional roles in brain homeostasis.,31: 175-193,Cell Mol Neurobiol,2011.03. |
Papers
| 1. | Arimura K, Ago T, Kamouchi M, Nakamura K, Ishitsuka K, Kuroda J, Sugimori H, Ooboshi H, Sasaki T, Kitazono T.,PDGF receptor β signaling in pericytes following ischemic brain injury.,Cur Neurovasc Res,Vol.9,pp.1-9,2012.02. |
| 2. | Kamouchi M, Matsuki T, Hata J, Kuwashiro T, Ago T, Sambongi Y, Fukushima Y, Sugimori H, Kitazono T; for the FSR investigators.,Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: the Fukuoka Stroke Registry.,Stroke,Vol.42,pp.2788-2794,2011.10. |
| 3. | Nakamura K, Kamouchi M, Kitazono T, Kuroda J, Matsuo R, Hagiwara N, Ishikawa E, Ooboshi H, Ibayashi S, Iida M,Role of NHE1 in calcium signaling and cell proliferation in human CNS pericytes,American Journal of Physiology,294: H1700-H1707,2008.04. |
| 4. | Kuroda J, Kitazono T, Ago T, Ninomiya T, Ooboshi H, Kamouchi M, Kumai Y, Hagiwara N, Yoshimura S, Tamaki K, Kusuda K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Asano K, Tanizaki Y, Kiyohada Y, Ibayashi S, Iida M,NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: the Fukuoka Stroke Registry and the Hisayama Study,European Journal of Neurology,14: 12-16,2007.10. |
| 5. | Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y.,A nonsynonymous SNP IN PRKCH (protein kinase Cη) increases the risk of cerebral infarction.,Nat Genet,Vol.39,No.2,pp.212-217,2007.02. |
| 6. | Ago T, Kitazono T, Kuroda J, Kumai Y, Kamouchi M, Ooboshi H, Wakisaka M, Kawahara T, Rokutan K, Ibayashi S, Iida M.,NAD(P)H oxidases in rat basilar arterial endothelial cells.,Stroke,Vol.36,No.5,pp.1040-1046,2005.05. |
| 7. | Ago, T., Kitazono, T., Ooboshi, H., Matsuo, R., Takada, J., Wakisaka, M., Ibayashi, S., Iida, M,NOX4 as the major catalytic component of an endothelial NAD(P)H oxidase.,Circuration,Vol.109,No.2,109: 227-233,2004.01. |
| 8. | Kitazono, T., Ago, T., Kamouchi, M., Santa, N., Ooboshi, H., Fujishima, M., Ibayashi, S.,Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo.,Journal of Hypertension,Vol.20,No.5,20: 879-884,2002.01. |
| 9. | Wakisaka, M., Kitazono, T., Kato, M., Nakamura, U., Yoshioka, M., Uchizono, Y., Yoshinari, M.,Sodium-coupled glucose transporter as a functional glucose sensor of retinal microvascular circulation.,Circulation Research,Vol.88,No.11,88 1183-1188,2001.01. |
| 10. | Kitayama, J., Kitazono, T., Ibayashi, S., Nagao, T., Wakisaka, M., Watanabe, Y., Fujishima, M.,Role of phosphatidylinositol 3-kinase in acetylcholine-induced dilatation of rat basilar artery in vivo.,Stroke,Vol.31,No.10,31: 2487-2493,2000.01. |
| 11. | Kitazono, T., Padgett, R.C., Armstrong, M.L., Tompkins, P.K., Heistad, D.D.,Evidence that angiotensin II is present in human monocytes.,Circulation,91: 1129-1134,1995.01. |
| 12. | Kitazono, T., Heistad, D.D., Faraci, F.M.,Enhanced responses of the basilar artery to activation of endothelin B receptors in stroke-prone spontaneously hypertensive rats.,Hypertension,25: 490-494,1995.01. |
| 13. | Taguchi, H., Faraci, F.M., Kitazono, T., Heistad, D.D.,Relaxation of the aorta during hypertension is impaired in chronically hypertensive rats.,Hypertension,25: 735-738,1995.01. |
| 14. | Taguchi, H., Heistad, D.D., Kitazono, T., Faraci, F.M.,Dilatation of cerebral arterioles in response to activation of adenylate cyclase is dependent on activation of Ca2+-dependent K+ channels.,Circulation Research,76: 1057-1062,1995.01. |
| 15. | Taguchi H, Heistad DD, Kitazono T, Faraci FM,ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia.,Circulation Research,74: 1005-1008,1994.01. |
| 16. | Kitazono, T., Faraci, F.M., Heistad, D.D.,Effect of norepinephrine on rat basilar artery in vivo.,American Journal of Physiology,264: H178-H182,1993.01. |
| 17. | Kitazono, T., Heistad, D.D., Faraci, F.M.,Role of ATP-sensitive K+ channels in CGRP-induced dilatation of the basilar artery in vivo.,American Journal of Physiology,265: H581-H585,1993.01. |
| 18. | Kitazono, T., Heistad, D.D., Faraci, F.M.,ATP-sensitive potassium channels in the basilar artery during chronic hypertension.,Hypertension,22: 677-681,1993.01. |
| 19. | Kitazono, T., Takeshige, K., Cragoe, E.J., Jr., Minakami, S.,Involvement of calcium and protein kinase C in the activation of the Na+/H+ exchanger in cultured bovine aortic endotehlial cells stimulated by extracellular ATP.,Biochimica et Biophysica Acta,Vol.1013,No.2,1013: 152-158,1989.01. |
Presentations
| 1. | Hypertension and chronic kidney disease (CKD) in acute stroke patients; the Fukuoka Stroke Registry. |
| 2. | Molecular epidemiology of cerebrovascular disease; The Hisayama Study and the Fukuoka Stroke Registry (FSR). |
Educational
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