福岡脳卒中データベース研究（The Fukuoka Stroke registry; FSR）
キーワード：脳卒中、コホート、疫学、登録研究
2007.06.

脳梗塞に関する遺伝子解析研究
キーワード：脳梗塞、遺伝子解析、SNP
2005.04.

脳微小循環における周皮細胞に関する分子生物学的研究
キーワード：脳微小循環、周皮細胞、ペリサイト
2004.04.

脳血管反応に関する研究
キーワード：脳血管反応、一酸化窒素、カリウムチャンネル、高血圧
1991.09.

脳卒中、腎臓病、糖尿病、高血圧、消化管疾患を対象としたコホート研究
2007.06
九州大学大学院医学研究院病態機能内科学を中心に関連施設と共同で、日本人における脳卒中、腎臓病、糖尿病、高血圧、消化管疾患の臨床像を明らかにするための多施設共同研究を行っている。.

血管壁における活性酸素生成酵素NAD(P)Hオキシダーゼに関する研究
2001.04, 九州大学大学院医学研究院病態機能内科学
血管壁に存在する活性酸素生成酵素NAD(P)Hオキシダーゼに関する分子生物学的検討を行っている。内皮細胞や平滑筋細胞に存在するNAD(P)Hオキシダーゼ分子種の同定やその機能について検討している。.

脳循環調節機構に関する研究
1991.09, 九州大学大学院医学研究院病態機能内科学
頭窓法を中心とした薬理学的手法を用いて脳循環調節機構、特に高血圧に伴う脳血管反応性の変化について検討している。.

主要著書

主要原著論文

1.	Ninomiya T, Kanzaki N, Hirakawa Y, Yoshinari M, Higashioka M, Honda T, Shibata M, Sakata S, Yoshida D, Teramoto T, Takemoto S, Nishimoto S, Hata J, Kitazono T., Serum Ethylamine Levels as an Indicator of l-Theanine Consumption and the Risk of Type 2 Diabetes in a General Japanese Population: The Hisayama Study, Diabetes Care., 2019.07.
2.	Ogawa A, Toyoda K, Kitagawa K, Kitazono T, Nagao T, Yamagami H, Uchiyama S, Tanahashi N, Matsumoto M, Minematsu K, Nagata I, Nishikawa M, Nanto S, Abe K, Ikeda Y; PRASTRO-I Study Group., Comparison of Prasugrel and Clopidogrel in Patients With Non-Cardioembolic Ischaemic Stroke: A Phase 3, Randomised, Non-Inferiority Trial (PRASTRO-I), Lancet Neurol., 2019.03.
3.	Yoshikawa Y, Ago T, Kuroda J, Wakisaka Y, Tachibana M, Komori M, Shibahara T, Nakashima H, Nakashima K, Kitazono T., Nox4 Promotes Neural Stem/Precursor Cell Proliferation and Neurogenesis in the Hippocampus and Restores Memory Function Following Trimethyltin-Induced Injury, Neuroscience., 2019.02.
4.	Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kang D, Kitazono T., Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry., Diabetes Care., 2018.05.
5.	Ago T, Matsuo R, Hata J, Wakisaka Y, Kuroda J, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators., Insulin resistance and clinical outcomes after acute ischemic stroke., Neurology., 90, 17, e1470-e1477, 2018.04.
6.	Matsuo R, Yamaguchi Y, Matsushita T, Hata J, Kiyuna F, Fukuda K, Wakisaka Y, Kuroda J, Ago T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators, Association Between Onset-to-Door Time and Clinical Outcomes After Ischemic Stroke., Stroke, 48, 11, 3049-3056, 48(11):3049-3056, 2017.11.
7.	Oishi E, Ohara T, Sakata S, Fukuhara M, Hata J, Yoshida D, Shibata M, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T, Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study., Circulation, 136, 6, 516-525, 136(6):516-525, 2017.08.
8.	Tachibana M, Ago T, Wakisaka Y, Kuroda J, Shijo M, Yoshikawa Y, Komori M, Nishimura A, Makihara N, Nakamura K, Kitazono T, Early Reperfusion After Brain Ischemia Has Beneficial Effects Beyond Rescuing Neurons., Stroke, 48, 8, 2222-2230, 48(8):2222-2230, 2017.08.
9.	Seki T, Goto K, Kiyohara K, Kansui Y, Murakami N, Haga Y, Ohtsubo T, Matsumura K, Kitazono T, Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in Hypertension., Hypertension, 69, 1, 143-153, 2017.01.
10.	Matsuo R, Michikawa T, Ueda K, Ago T, Nitta H, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators, Short-Term Exposure to Fine Particulate Matter and Risk of Ischemic Stroke., Stroke, 47, 12, 3032-3034, 2016.12.
11.	Eriguchi M, Tsuruya K, Haruyama N, Yamada S, Tanaka S, Suehiro T, Noguchi H, Masutani K, Torisu K, Kitazono T, Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease., Kidney Int, 87, 116-127, 2015.01.
12.	Ishitsuka K, Kamouchi M, Hata J, Fukuda K, Matsuo R, Kuroda J, Ago T, Kuwashiro T, Sugimori H, Nakane H, Kitazono T; FSR Investigators, High blood pressure after acute ischemic stroke is associated with poor clinical outcomes: Fukuoka Stroke Registry., Hypertension, 63, 54-60, 2014.01.
13.	Nakamura A, Ago T, Kamouchi M, Hata J, Matsuo R, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T; Fukuoka Stroke Registry Investigators, Intensity of anticoagulation and clinical outcomes in acute cardioembolic stroke: the Fukuoka Stroke Registry., Stroke, 44, 3239-3242, 2013.11.
14.	Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y, Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009)., Circulation, 128, 1198-1205, 2013.09.
15.	Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y, Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study., Kidey Int, 84, 373-380, 2013.08.
16.	Nakamura K, Kamouchi M, Arimura K, Nishimura A, Kuroda J, Ishitsuka K, Tokami H, Sugimori H, Ago T, Kitazono T, Extracellular acidification activates cAMP responsive element binding protein via Na+/H+ exchanger isoform 1-mediated Ca2+ oscillation in central nervous system pericytes., Arterioscler Thromb Vasc Biol, 32, 2670-2677, 2012.11.
17.	Kumai Y, Kamouchi M, Hata J, Ago T, Kitayama J, Nakane H, Sugimori H, Kitazono T, for the FSR Investigators, Proteinuria and clinical outcomes after ischemic stroke., Neurology, 78, 1909-1915, 2012.06.
18.	Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, Yoshimura A, Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain., Nat Med, 18, 911-918, 2012.06.
19.	Arimura K, Ago T, Kamouchi M, Nakamura K, Ishitsuka K, Kuroda J, Sugimori H, Ooboshi H, Sasaki T, Kitazono T., PDGF receptor β signaling in pericytes following ischemic brain injury., Cur Neurovasc Res, 9, 1-9, 2012.02.
20.	Yamada S, Taniguchi M, Tokumoto M, Toyonaga J, Fujisaki K, Suehiro T, Noguchi H, Iida M, Tsuruya K, Kitazono T., The antioxidant tempol ameliorates arterial medial calcification in uremic rats: important role of oxidative stress in the pathogenisis of vascular calcification in chronic kidney disease., J Bone Miner Res, 27, 2, 474-485, 2012.02.
21.	Kamouchi M, Matsuki T, Hata J, Kuwashiro T, Ago T, Sambongi Y, Fukushima Y, Sugimori H, Kitazono T; for the FSR investigators., Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: the Fukuoka Stroke Registry., Stroke, 42, 2788-2794, 2011.10.
22.	Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitaozono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M., Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke., Hum Mol Genet, 19, 6, 1137-1146, 2010.03.
23.	Nakamura K, Kamouchi M, Kitazono T, Kuroda J, Matsuo R, Hagiwara N, Ishikawa E, Ooboshi H, Ibayashi S, Iida M, Role of NHE1 in calcium signaling and cell proliferation in human CNS pericytes, American Journal of Physiology, 294: H1700-H1707, 2008.04.
24.	Kuroda J, Kitazono T, Ago T, Ninomiya T, Ooboshi H, Kamouchi M, Kumai Y, Hagiwara N, Yoshimura S, Tamaki K, Kusuda K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Asano K, Tanizaki Y, Kiyohada Y, Ibayashi S, Iida M, NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: the Fukuoka Stroke Registry and the Hisayama Study, European Journal of Neurology, 14: 12-16, 2007.10.
25.	Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y., A nonsynonymous SNP IN PRKCH (protein kinase Cη) increases the risk of cerebral infarction., Nat Genet, 39, 2, 212-217, 2007.02.
26.	Ago T, Kitazono T, Kuroda J, Kumai Y, Kamouchi M, Ooboshi H, Wakisaka M, Kawahara T, Rokutan K, Ibayashi S, Iida M., NAD(P)H oxidases in rat basilar arterial endothelial cells., Stroke, 10.1161/01.STR.0000163111.05825.0b, 36, 5, 1040-1046, 2005.05.
27.	Ago, T., Kitazono, T., Ooboshi, H., Matsuo, R., Takada, J., Wakisaka, M., Ibayashi, S., Iida, M, NOX4 as the major catalytic component of an endothelial NAD(P)H oxidase., Circuration, 10.1161/01.CIR.0000105680.92873.70, 109, 2, 227-233, 109: 227-233, 2004.01.
28.	Kitazono, T., Ago, T., Kamouchi, M., Santa, N., Ooboshi, H., Fujishima, M., Ibayashi, S., Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo., Journal of Hypertension, 10.1097/00004872-200205000-00022, 20, 5, 879-884, 20: 879-884, 2002.01.
29.	Wakisaka, M., Kitazono, T., Kato, M., Nakamura, U., Yoshioka, M., Uchizono, Y., Yoshinari, M., Sodium-coupled glucose transporter as a functional glucose sensor of retinal microvascular circulation., Circulation Research, 10.1161/hh1101.091265, 88, 11, 1183-1188, 88 1183-1188, 2001.01.
30.	Kitayama, J., Kitazono, T., Ibayashi, S., Nagao, T., Wakisaka, M., Watanabe, Y., Fujishima, M., Role of phosphatidylinositol 3-kinase in acetylcholine-induced dilatation of rat basilar artery in vivo., Stroke, 31, 10, 2487-2492, 31: 2487-2493, 2000.01.
31.	Kitazono, T., Ibayashi, S., Nagao, T., Fujii, K., Kagiyama, T., Fujishima, M., Role of tyrosine kinase in dilator responses of the basilar artery in vivo., Hypertension, 31, 3, 861-865, 31: 861-865, 1998.01.
32.	Taguchi, H., Heistad, D.D., Kitazono, T., Faraci, F.M., Dilatation of cerebral arterioles in response to activation of adenylate cyclase is dependent on activation of Ca2+-dependent K+ channels., Circulation Research, 76: 1057-1062, 1995.01.
33.	Taguchi, H., Faraci, F.M., Kitazono, T., Heistad, D.D., Relaxation of the aorta during hypertension is impaired in chronically hypertensive rats., Hypertension, 25: 735-738, 1995.01.
34.	Kitazono, T., Heistad, D.D., Faraci, F.M., Enhanced responses of the basilar artery to activation of endothelin B receptors in stroke-prone spontaneously hypertensive rats., Hypertension, 25: 490-494, 1995.01.
35.	Kitazono, T., Padgett, R.C., Armstrong, M.L., Tompkins, P.K., Heistad, D.D., Evidence that angiotensin II is present in human monocytes., Circulation, 91: 1129-1134, 1995.01.
36.	Taguchi H, Heistad DD, Kitazono T, Faraci FM, ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia., Circulation Research, 74: 1005-1008, 1994.01.
37.	Kitazono, T., Heistad, D.D., Faraci, F.M., ATP-sensitive potassium channels in the basilar artery during chronic hypertension., Hypertension, 22: 677-681, 1993.01.
38.	Kitazono, T., Heistad, D.D., Faraci, F.M., Role of ATP-sensitive K+ channels in CGRP-induced dilatation of the basilar artery in vivo., American Journal of Physiology, 265: H581-H585, 1993.01.
39.	Kitazono, T., Faraci, F.M., Heistad, D.D., Effect of norepinephrine on rat basilar artery in vivo., American Journal of Physiology, 264: H178-H182, 1993.01.
40.	Kitazono, T., Takeshige, K., Cragoe, E.J., Jr., Minakami, S., Intracellular pH changes of cultured bovine aortic endothelial cells in response to ATP addition., Biochemical and Biophysical Research Communication, 10.1016/S0006-291X(88)80427-3, 152, 3, 1304-1309, 152: 1304-1309, 1988.01.

主要総説, 論評, 解説, 書評, 報告書等

1.	Ago T, Kuroda J, Kamouchi M, Sadoshima J, Kitazono T., Pathological roles of NADPH oxidase-nox family proteins in the vascular system., 2011.07.
2.	Kamouchi M, Ago T, Kitazono T., Brain pericytes: emerging concepts and functional roles in brain homeostasis., Cell Mol Neurobiol, 31: 175-193, 2011.03.

主要学会発表等

1.	北園孝成、鴨打正浩, 脳卒中発症後の降圧治療の現状と課題．, 第34回日本高血圧学会総会, 2011.10.
2.	北園孝成、鴨打正浩, Fukuoka Stroke Registryにみる日本人の脳卒中．, 第36回日本脳卒中学会総会, 2011.08.
3.	北園孝成、杉森　宏、新田裕史、吾郷哲朗、桑城貴弘、鴨打正浩, エアロゾルの脳卒中発症に及ぼす影響に関する研究－Fukuoka Stroke Registry (FSR)．, 第36回日本脳卒中学会総会, 2011.07.
4.	北園孝成、鴨打正浩、吾郷哲朗、粟野秀人、鈴木一夫、清原　裕., 脳梗塞のバイオマーカー探索研究（REBIOS）., 第33回日本分子生物学会年会/第83回日本生化学会大会合同大会, 2010.12.
5.	北園孝成、鴨打正浩、中根　博、尾前　豪、杉森　宏、吾郷哲朗、桑城貴弘、飯田三雄、佐渡島省三., 多施設共同脳卒中データベース（Fukuoka Stroke Registry）から見えてきた脳梗塞急性期の病態と予後., 第35回日本脳卒中学会総会, 2010.04.
6.	北園孝成、熊井康敬、杉森　宏、中根　博、鴨打正浩、大星博明、井林雪郎、飯田三雄、佐渡島省三, 多施設共同脳卒中データベース（Fukuoka Stroke Registry; FSR）からみた脳梗塞急性期症例の高血圧ならびに慢性腎臓病（CKD）の実態, 第34回日本脳卒中学会総会, 2009.03.
7.	北園孝成、久保充明、秦　淳、清原　裕、井林雪郎、飯田三雄, 脳血管障害の分子疫学：久山町研究と福岡脳卒中データベース研究（ＦＳＲ）, 第49回日本神経学会総会, 2008.05.

所属学会名

学協会役員等への就任

学会大会・会議・シンポジウム等における役割

学会誌・雑誌・著書の編集への参加状況

学術論文等の審査

海外渡航状況, 海外での教育研究歴