| Hiroki Shibata | Last modified date：2012.8.10 |
Graduate School
Other Organization
Administration Post
Other
Homepage
http://www.gen.kyushu-u.ac.jp/~byouin/.
Phone
092-642-6168
Fax
092-632-2375
Academic Degree
Ph D.
Field of Specialization
Genetics、Population Genetics
Outline Activities
What makes us human? The genetic and evolutionary basis of the highly sophisticated function of human brain, such as cognition and intelligence is largely unknown. Psychiatric diseases are the natural model of the dysfunction of human brain function and the susceptibility genes for psychiatric diseases are the strong candidates for the genes involved in the evolutionary process of human brain function. To clarify the mode and the target of the natural selection that shaped human brain function, I am working on the following projects:
1. Comparative genomics of the glutamate receptor genes in primates:
2. Population genetics of the genes associated with major psychiatric diseases such as schizophrenia.
I am also working on the following basic medical research projects:
3. Genome wide association study of complex diseases such as schizophrenia.
4. Genetic analysis of rare monogenic diseases using next generation sequencer.
1. Comparative genomics of the glutamate receptor genes in primates:
2. Population genetics of the genes associated with major psychiatric diseases such as schizophrenia.
I am also working on the following basic medical research projects:
3. Genome wide association study of complex diseases such as schizophrenia.
4. Genetic analysis of rare monogenic diseases using next generation sequencer.
Research
Research Interests
Membership in Academic Society
- Exome sequencing approach to identify the responsible variant for a hereditary motor and sensory neuropathy
keyword : Hereditary motor and sensory neuropathy, linkage analysis, next generation sequencer, exome sequencing
2010.04. - Evolutionary study of schizophrenia-associated genes.
keyword : schizophrenia, glutamate receptor, molecular evolution, genetic diversity, natural selection
2004.04.
Papers
| 1. | Hiroki Goto, Kazunori Watanabe, Naozumi Araragi, Rui Kageyama, Kunika Tanaka, Yoko Kuroki, Atsushi Toyoda, Masahira Hattori, Yoshiyuki Sakaki, Asao Fujiyama, Yasuyuki Fukumaki, Hiroki Shibata.,The identification and functional implications of human-specific "fixed" amino acid substitutions in the glutamate receptor family.,BMC Evolutionary Biology.,9: 224,2009.09 http://www.biomedcentral.com/1471-2148/9/224. |
| 2. | Hiroki Shibata, Ayako Tani, Tomoyuki Chikuhara, Rumiko Kikuta, Mayumi Sakai, Hideaki Ninomiya, Nobutada Tashiro, Nakao Iwata, Norio Ozaki and Yasuyuki Fukumaki. ,Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia. ,Psychiatric Res. ,167：88-96.,2009.04. |
| 3. | Shibata H, Aramaki T, Sakai M, Ninomiya H, Tashiro N, Iwata N, Ozaki N and Fukumaki Y.,Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia.,Psychiatry Res.,141: 39-51,2006.01. |
| 4. | Makino C, Shibata H, Ninomiya H, Tashiro N, Fukumaki Y.,Identification of single-nucleotide polymorphisms in the human N-methyl-D-aspartate receptor subunit NR2D gene, GRIN2D, and association study with schizophrenia.,Psychiatr Genet.,15 (3): 215-221.,2005.09. |
| 5. | Deng XD, Shibata H, Ninomiya H, Tashiro N, Iwata N, Ozaki N and Fukumaki Y.,Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia.,BMC Psychiatry,4(1): 21,2004.08. |
| 6. | Takaki H, Kikuta R, Shibata H, Ninomiya H, Tashiro N and Fukumaki Y.,Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia.,Am J Med Genet.,128B: 6-14.,2004.07. |
| 7. | The Japanese Schizophrenia Sib-pair Linkage Group.,Initial genome-wide scan for linkage with schizophrenia in the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG) families.,Am J Med Genet.,120B(1): 22-8.,2003.07. |
| 8. | Fujii Y, Shibata H, Kikuta R, Makino C, Tani A, Hirata N, Shibata A, Ninomiya H, Tashiro N, Fukumaki Y.,Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia.,Psychiatric Genetics.,13(2):71-6.,2003.06. |
| 9. | Makino C, Fujii Y, Kikuta R, Hirata N, Tani A, Shibata A, Ninomiya H, Tashiro N, Shibata H, Fukumaki Y.,Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region.,Am J Med Genet.,116B (1): 17-22.,2003.01. |
| 10. | Shibata H, Shibata A, Ninomiya H, Tashiro N, Fukumaki Y.,Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2) with schizophrenia.,Psychiatry Res.,113(1-2): 59-67.,2002.12. |
| 11. | Tani A, Kikuta R, Itoh K, Joo A, Shibata H, Ninomiya H, Tashiro N and Fukumaki Y.,Polymorphism analysis of upstream regions of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1): implications for schizophrenia.,Schizophr Research,58 (1):83-86.,2002.11. |
| 12. | Shibata H, Joo A, Fujii Y, Tani A, Makino C, Hirata N, Kikuta R, Ninomiya H, Tashiro N, Fukumaki Y.,Association study of polymorphisms in the coding region of the GluR5 kainate receptor gene (GRIK1) with schizophrenia.,Psychiatric Genetics,11 (3): 139-144.,2001.09. |
| 13. | Kiehl TR, Shibata H, Huynh DP, Vo T, Pulst SM.,Identification and expression of a mouse ortholog of A2BP1.,Mammalian Genome.,12 (8): 595-601.,2001.08. |
| 14. | Shibata H, Huynh DP, Pulst SM.,A novel protein with RNA binding motif binds to C-terminal ataxin-2.,Human Molecular Genetics,9 (9): 1303-1313.,2000.05. |
| 15. | Shibata H, Tahira T, Hayashi K.,RNA-primed PCR.,Genome Research,5 (4): 400-403.,1995.11. |
| 16. | Shibata H, Yamazaki T.,Molecular evolution of the duplicated Amy locus in the Drosophila melanogaster species subgroup: concerted evolution only in coding region and an excess of nonsynonymous substitutions in speciation.,Genetics,141 (1): 223-236.,1995.09. |
Presentations
| 1. | Molecular Evolutionary Study Of The Ionotropic Glutamate-Receptor Gene Family As Schizophrenia Susceptibility Genes: Human-Specific Balancing Selection In GRIN2B Upstream Region. |
- Society of Evolutionary Studies, Japan
- The Genetics Society of Japan
- The Molecular Biology Society of Japan
- The American Society of Human Genetics
- The Japan Society of Human Genetics
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