Kyushu University Academic Staff Educational and Research Activities Database
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Ohnaka Keizo Last modified date:2019.06.14

Graduate School
Undergraduate School

Academic Degree
Field of Specialization
Geriatric Medicine, Endocrinology and Metabolism
Outline Activities
1) Investigation of the mechanism of geriatric diseases and development of new therapeutic approach
2) Investigation of the significance of various hormones in geriatrics
3) Regeneration therapy against the elderly
Research Interests
  • Molecular epidemiological study on lifestyle-related diseases
    keyword : lifestyle-related diseases, gene polymorphism
  • Molecular epidemiological study on cancer
    keyword : cancer, gene polymorphism
  • Study on mechanism of osteoporosis and develpoment of new theraputic approach to osteoporosis
    keyword : osteoporosis, osteoblast
    2001.04~2020.03Investigation of the action of hormones and drugs on primary cultured human osteoblasts, and development of new therapeutic approach to osteoporosis..
  • Association study of SNPs of the genes with bone mineral density in postmenopausal women
    keyword : osteoporosis, gene polymorphism
    2005.04~2020.03Association study of SNPs of various genes with bone mineral density in postmenopausal women.
Academic Activities
1. Clinical handbook for Cushing syndrome "Epidemiological survey for Cushing syndrome"(p38-40).
2. Clinical handbook for geriatiric medicine "Taste disorder"(p48-49), "Finger tremor"(P96-97).
3. Parathyroid disease (p1050-1059) in Gerontrology, 3rd ed (Eds, Ouchi Y, Akiyama H)..
4. Prevention and treaiment of glucocorticoid-induced osteopororsis (p113-118).
5. Clinical handbook for osteoporisis "Glucocorticoid-induced osteopororsis"(p38-44).
6. Osteoporosis and prevention of bone fracture.(Guidebook for Geriatric Medicine, Volume 5). "Treatment of osteopororsis. Estrogen"(p88-94).
7. Geriatric medicine(2nd ed)."Understanding the laboratory examination in the elderly"(p136-139).
8. Geriatric medicine(2nd ed)."Disorders of pituitary and adrenal glands"(p344-349).
9. Pharma Navigator-bisphosphonate- "Glucocorticoid-induced osteopororsis"(p64-77).
10. Annual review of internal medicine 2004. "Adrenal gland"(p160-164).
11. Keizo Ohnaka, Ryoichi Takayanagi, Encyclopedia of Endocrine Diseases, Academic Press, "DHEA and the Elderly" Volume I, p647-650, 2004.03.
12. Endocrinolgy at bedside. "Hormone replacement therapy"(p223-232).
13. Strategy for the management of disorders and nutritional problems in the elderly. "Management of hyperuricemia in the elderly"(p195-199).
14. Geriatric medicine."Understanding the laboratory examination in the elderly(p120-123)".
1. Glucocorticoid-induced osteoporosis.
2. Bone metabolism and osteoporosis.
3. sex hormones and aging.
4. DHEA and bone metabolism.
5. DHEA and bone metabolism.
6. Aging and DHEA.
7. Takayanagi R, Inoguchi T, Ohnaka K., Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus., J Clin Biochem Nutr., 48(1):72-77, 2011. , 2011.01.
8. Ohnaka K, Kono S., Bilirubin, cardiovascular diseases and cancer: epidemiological perspectives., Expert Rev Endocrinol Metab, 5(6): 891-904, 2010., 2010.10.
9. Prevention and treatment of glucocorticoid-induced osteoporosis.
10. Vascular aging and hormones.
11. Glucocorticoid-induced osteoporosis.
12. Acute adrenocortical insufficiency.
13. Chronic adrenocortical insufficiency (primary,secondary).
14. Pathogenesis of glucocorticoid-induced osteoporosis.
15. Change of endothelial function with aging.
16. Novel mechanism of glucocorticoid-induced osteoporosis -Inhibition of Wnt signaling by glucocorticoid-.
17. Vascular disorders of diabetics in the elderly.
1. Hirata A, Keizo Ohnaka, Tashiro N, Wang Z, Kohno M, Kiyohara C, Suminori Kono, Takayanagi R, Effect modification of green tea on the association between rice intake and the risk of diabetes mellitus: a prospective study in Japanese men and women, Asia Pac J Clin Nutr, 26, 3, 545-555, 2017.05.
2. Nisa H, Hirata A, Kohno M, Kiyohara C, Keizo Ohnaka, High-Sensitivity C-Reactive Protein and Risks of All-Cause and Cause-Specific Mortality in a Japanese Population, Asian Pac J Cancer Prev, 17, 5, 2643-2648, 2016.05.
3. Ohnaka K, Ikeda M, Maki T, Okada T, Shimazoe T, Adachi M, Nomura M, Takayanagi R, Kono S, Effects of 16-Week Consumption of Caffeinated and Decaffeinated Instant Coffee on Glucose Metabolism in a Randomized Controlled Trial., J Nutr Metab, 10.1155/2012/207426, 35, 8, 825-831, 2012, Article ID 207426, 9 pages, 2012.11.
4. Ohnaka K, Kono S, Inoguchi T, Yin G, Morita M, Adachi M, Kawate H, Takayanag R, Inverse associations of serum bilirubin with C-reactive protein, glycated hemoglobin, and prevalence of diabetes mellitus in middle-aged and elderly Japanese men and women, Diabetes Res Clin Pract, 10.1016/j.diabres.2009.12.022, 88, 4, 103-110, 2010.04.
5. Ohnaka K, Yamamoto K, Nakamura K, Adachi M, Kawate H, Kono S, Takayanagi R, Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women, Geriatr Gerontrol Int, 9: 304-309, 2009.05.
1. Hoirun Nisa, Akie Hirata, Michiko Kohno, Chikako Kiyohara, Keizo Ohnaka, High-Sensitivity C-Reactive Protein and Risks of All-Cause and Cause-Specific Mortality in Japan., The 21st IAGG World Congress of Gerontology and Geriatrics, 2017.07.
2. Ohnaka K, Kohno M, Adachi M, Kawate H, Nomura M, Kono S, Takayanag R, A randomized controlled trial of 16-week consumption of caffeinated and decaffeinated instant coffee on glucose metabolism in overweight men, 95th Annual Meeting of The Endocrine Society, 2013.06.
3. Effects of glucocorticoid on bone.
4. UGT1A1 genetic polymorphisms and colorectal cancer risk:The Fukuoka Colorectal Cancer Study.
5. Diabetes mellitus and osteoporosis.
6. Inverse associations of serum bilirubin with glycated hemoglobin and prevalence of diabetes mellitus in middle-aged and elderly Japanese men and women..
7. Effect of high serum bilirubin on the prevalence of ischemic heart disease and stroke in middle-aged and elderly Japanese men and women.
8. Association of single nucleotide polymorphisms in Wnt signal-related genes with bone mineral density in Japanese women.
9. Genome-wide assosiation study of SNPs with bone mineral density in Japanese: the Fukuoka osteoporosis cohort study.
10. Association study of protein S polymorphism with plasma protein S level and the prevalence of inherited protein S deficiency in Japanese elderly women.
11. Glucocorticoid enhances the expression of frizzled-related protein 3 by in cultured human osteoblasic cells.
12. Association analysis of SNPs in Wnt singnaling genes and BMD.
13. Novel mechanism of glucocorticoid-induced osteoporosis: suppression of Wnt signaling by glucocorticoid.
14. Glucocorticoid suppresses the canonical Wnt signal in primary cultured human osteoblasts.
15. Glucocorticoid enhances the expression of dickkopf-1 in primary cultured human osteoblasts: novel mechanism of glucocorticoid-induced osteoporosis.
16. Molecular mechanism of glucocorticoid-induced osteoporosis.
Membership in Academic Society
  • The Japanese Society of Internal Medicine
  • The Japan Geriatrics Society
  • The Japan Endocrine Sciety
  • The Japan Diabetes Society
  • Japan Osteororosis Sciety
  • Japanese Sciety of Bone and Mineral Research
  • Japan Hormonal Steroid Society
Educational Activities
Research instruction and education for graduate students. Writing textbook and review papers.
Professional and Outreach Activities
Member, committee for osteoporosis examination, Fukuoka Medical Association (2016~).