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Researcher information
Toshiyuki Sasaguri Last modified date：2012.6.29

Professor / Science for Biological Information
Department of Basic Medicine
Faculty of Medical Sciences


Graduate School
Department of Medical Sciences
Graduate School of Medical Sciences
Department of Medicine
Graduate School of Medical Sciences
Undergraduate School
Department of Biomedical Science
School of Medicine
Department of Biomedical Science
School of Medicine
Department of Medicine
School of Medicine


E-Mail
Homepage
http://www.med.kyushu-u.ac.jp/recnet_fukuoka/index.html
Internet site of the Research Ethics Committee Network Fukuoka (RecNet Fukuoka).
http://www.med.kyushu-u.ac.jp/clipharm/
Internet site of the Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University.
Phone
092-642-6080
Fax
092-642-6084
Academic Degree
medical doctor
Field of Specialization
pharmacology, clinical pharmacology, internal medicine, research ethics
Research
Research Interests
  • Pharmacogenomic research on the pharmacokinetics and pharmacodynamics of organic nitrates
    keyword : organic nitrates, glyceryl trinitrate, isosorbide dinitrate, aldehyde dehydrogenase 2, vascular dilatation, blood flow, tolerance, oxidative stress
    2008.04.
  • Research on the prevention and therapeutics of colon cancers
    keyword : non-steroidal anti-inflammatory drugs, colon cancer
    2002.04.
  • Research on the molecular pathogenesis and novel therapeutics of chronic heart failure
    keyword : heart failure, cardiomyopathy, cardiac hypertrophy, contractile proteins, Ca sensitizers, β blockers, anti-thyroidal drugs, COX2 inhibitors, anti-depressants
    2001.04.
  • Biomedical research ethics
    keyword : clinical research, clinical trial, informed consent, research ethics committee
    2001.04.
  • Pharmacological action and clinical application of differentiation-inducing factor derived from Dictyostelium discoideum
    keyword : Dictyostelium discoideum, cell cycle, cell differentiation, inflammation, atherosclerosis, cancer
    1998.10.
  • Research on the relation between mechanical stresses and vascular disorders
    keyword : mechanical stress, shear stress, stretch stimulation, vascular endothelial cells, vascular smooth muscle cells
    1996.10～2010.03.
  • Research on the pharmacological actions and the clinical application of prostaglandin J2 family
    keyword : prostaglandin D2, prostaglandin D2, vascular smooth muscle, cell proliferation, cell cycle
    1990.10～2010.03.
Academic Activities
Books
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Reports
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1. Takahashi-Yanaga, F. & Sasaguri, T.,Drug Development Targeting the Glycogen Synthase Kinase-3beta (GSK-3beta)-Mediated Signal Transduction Pathway: Inhibitors of the Wnt/beta-Catenin Signaling Pathway as Novel Anticancer Drugs.,J. Pharmacol. Sci. 109(2), 179-183,2009.02.
2. Takahashi-Yanaga, F., Sasaguri, T.,GSK-3β regulates cyclin D1 expression: A new target for chemotherapy,Cell Signal.,2007.01.
3. Takahashi-Yanaga, F., Sasaguri, T.,The Wnt/β-catenin signaling pathway as a target in drug discovery,J. Pharmacol. Sci.,2007.01.
4. Sasaguri, T., Miwa, Y.,Prostaglandin J2 family and the cardiovascular system,Current Vascular Pharmacology 2, 103-114,2004.01.
Papers
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1. Matsumura, K., Arima, H., Tominaga, M., Ohtsubo, T., Sasaguri, T., Fujii, K., Fukuhara, M., Uezono, K., Morinaga, Y., Ohta, Y., Otonari, T., Kawasaki, J., Kato, I., Tsuchihashi, T. for the COMFORT Investigators,Does a Combination Pill of Antihypertensive Drugs Improve Medication Adherence in Japanese?,Circ J,Vol.76,No.6,pp.1415-1422,2012.06.
2. Jingushi, K., Takahashi-Yanaga, F., Yoshihara, T., Shiraishi, F., Watanabe, Y., Hirata, M., Morimoto, S., & Sasaguri, T.,DIF-1 Inhibits the Wnt/β-catenin Signaling Pathway by Inhibiting TCF7L2 Expression in Colon Cancer Cell Lines.,Biochem Pharmacol,Vol.83,No.1,pp.47-56,2012.01.
3. Sakata, S., Yoshihara, T., Arima, H., Shiraishi, F., Oniki, H., Takahashi-Yanaga, F., Matsumura, K., & Sasaguri, T.,Differential effects of organic nitrates on arterial diameter among healthy Japanese participants with different mitochondrial aldehyde dehydrogenase 2 genotypes: randomised crossover trial.,BMJ Open,2011.07.
4. Fan, X., Takahashi-Yanaga, F., Morimoto, S., Zhan, D.-Y., Igawa, K., Tomooka, K., & Sasaguri, T.,Celecoxib and 2,5-dimethyl-celecoxib prevent cardiac remodeling inhibiting Akt-mediated signal transduction in an inherited DCM mouse model.,J. Pharmacol. Exp. Ther.,2011.07.
5. Sasaguri, T., Shiraishi, F., Yoshihara, T., Takahashi-Yanaga, F., & Morimoto, S.,β1-adrenergic receptor gene polymorphisms and the acute response to atenolol in healthy young Japanese subjects.,J. Pharmacol. Sci.,Vol.115,No.4,pp.490-499,2011.04.
6. Miwa, Y., Tsuchihashi, T., Ohta, Y., Tominaga, M., Kawano, Y., Sasaguri, T., Ueno, M., & Matsuoka, H.,Antiproteinuric effect of cilnidipine in hypertensive japanese treated with renin-angiotensin-system inhibitors - A multicenter, open, randomized trial using 24-hour urine collection.,Clin. Exp. Hypertens.,Vol.32,No.6,pp.400-405,2010.12.
7. Yoshihara, T., Takahashi-Yanaga, F., Shiraishi, F., Morimoto, S., Watanabe, Y., Hirata, M., Hoka, S., & Sasaguri, T.,Anti-angiogenic effects of differentiation-inducing factor-1 involving VEGFR-2 expression inhibition independent of the Wnt/beta-catenin signaling pathway.,Mol. Cancer,Vol.9,No.1,pp.245,2010.07.
8. Tadano, N., Du C.-K., Yumoto, F., Morimoto, S., Ohta, M., Xie, M.-F., Nagata, K., Zhan, D.-Y., Lu, Q.-W., Miwa, Y., Takahashi-Yanaga, F., Tanokura, M., Ohtsuki, I., & Sasaguri, T.,Biological actions of green tea catechins on cardiac troponin C.,Br. J. Pharmacol.,Vol.161,No.5,pp.1034-1043,2010.05.
9. Wang, Y.-Y., Morimoto, S., Du, C.-K., Lu, Q.-W., Zhan, D.-Y., Tsutsumi, T., Ide, T., Miwa, Y., Takahashi-Yanaga, F., & Sasaguri, T. ,Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy.,Cardiovasc. Res.,2010.03.
10. Matsuda, T., Takahashi-Yanaga, F., Yoshihara, T., Maenaka, K., Watanabe, Y., Miwa, Y., Morimoto, S., Kubohara, Y., Hirata, M., & Sasaguri, T.,Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity.,J. Pharmacol. Sci.,Vol.112,No.3,pp.320-326,2009.03.
11. Ohmine, T., Miwa, Y., Takahashi-Yanaga, F., Morimoto, S., Maehara, Y., & Sasaguri, T.,The involvement of aldosterone in cyclic stretch-mediated activation of NADPH oxidase in vascular smooth muscle cells.,Hypertens Res,Vol.32,No.8,pp.690-699,2009.08.
12. Zhan, D.-Y., Morimoto, S., Du, C.-K., Wang, Y.-Y., Lu, Q.-W., Tanaka, A., Ide, T., Miwa, Y., Takahashi-Yanaga, F., & Sasaguri, T. ,Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation.,Cardiovasc Res,Vol.84,No.1,pp.67-71,2009.01.
13. Yao, H., Takashima, Y., Mori, T., Uchino, A., Hashimoto, M., Yuzuriha, T., Miwa, Y., & Sasaguri, T.,Hypertension and white matter lesions are independently associated with apathetic behavior in healthy elderly subjects: the Sefuri brain MRI study.,Hypertens Res,Vol.32,No.7,pp.586-590,2009.07.
14. Tadano, N., Morimoto, S., Takahashi-Yanaga, F., Miwa, Y., Ohtsuki, I., & Sasaguri, T.,Propyl gallate, a strong antioxidant, increases the Ca2+ sensitivity of cardiac myofilament.,J. Pharmacol. Sci.,109(3), 456-458,2009.06.
15. Tanaka, R., Miwa, Y., Mou, K., Tomikawa, M., Eguchi, N., Urade, Y., Takahashi-Yanaga, F., Morimoto, S., Wake, N., & Sasaguri, T.,Knockout of the l-pgds gene aggravates obesity and atherosclerosis in mice. ,Biochem. Biophys. Res. Commun.,378(4), 851-856,2009.01.
16. Miwa, Y., Oda, H., Shiina, Y., Shikata, K., Tsushima, M., Nakano, S., Maruyama, T., Kyotani, S., Eguchi, N., Urade, Y., Takahashi-Yanaga, F., Morimoto, S., & Sasaguri, T.,Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects., Hypertens Res., 31(10), 1931-1939,2008.10.
17. Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Miwa, Y., Morimoto, S., Hirata, M., & Sasaguri, T.,Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells.,Biochem. Biophys. Res. Commun.,377(4), 1185-1190,2008.04.
18. Ohmine, T., Miwa, Y., Yao, H., Yuzuriha, T., Takashima, Y., Uchino, A., Takahashi-Yanaga, F., Morimoto, S., Maehara, Y., Sasaguri, T.,Association between arterial stiffness and cerebral white matter lesions in community-dwelling elderly subjects,Hypertens. Res.,31(1), 75-81,2008.01.
19. Du, C.-K., Morimoto, S., Nishii, K., Minakami, R., Ohta, M., Tadano, N., Lu, Q.-W., Wang, Y.-Y., Zhan, D.-Y., Mochizuki, M., Kita, S., Miwa, Y., Takahashi-Yanaga, F., Iwamoto, T., Ohtsuki, I., Sasaguri, T.,Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation,Circ. Res.,101(2), 185-194,2007.07.


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