九州大学 研究者情報
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基本情報 研究活動 教育活動 社会活動 病院臨床活動
清水 真弓(しみず まゆみ) データ更新日:2019.09.11

講師 /  九州大学病院 口腔包括診療科 口腔画像診断科


主な研究テーマ
CTおよびCBCTの定量的画質評価法の開発
キーワード:画質評価、定量的、開発
2012.04.
シェーグレン症候群のシンチグラフィーによる診断
キーワード:シェーグレン症候群、シンチグラフィー、核医学、診断
2010.04.
IgG4関連涙腺・唾液腺炎(ミクリッツ病)の画像診断
キーワード:ミクリッツ病、画像診断、超音波診断
2007.04.
シェーグレン症候群の超音波診断
キーワード:シェーグレン症候群、超音波、診断
2001.04.
口腔癌転移性リンパ節超音波像を利用した定量的診断所見の開発
キーワード:転移、リンパ節、超音波、定量、診断
2003.04~2005.03.
最適画像処理による歯科疾患定量的自動診断システムの開発
キーワード:画像処理、歯科疾患、定量的、自動診断
2002.06~2004.03.
超音波ドプラ法を用いた顎関節部疼痛の定量評価法の研究
キーワード:超音波、ドプラ法、顎関節、疼痛、定量評価法、診断
2001.06~2004.03.
微小血流三次元表示によるリンパ節内微小転移巣の超音波診断に関する実験的研究
キーワード:三次元表示、リンパ節、転移、超音波診断、ドプラ法
2001.06~2003.04.
超音波唾液腺造影法 -唾液腺疾患における新しい診断法の確立-
キーワード:超音波、ドプラ法、唾液腺造影法、唾液腺疾患、実験的研究、診断
1998.06~2001.03.
実験誘発閉塞性唾液腺炎の超音波およびMRI診断
キーワード:実験、唾液腺炎、超音波、MRI、診断
1997.04~2000.03.
耳下腺腫瘍の超音波診断
キーワード:耳下腺、腫瘍、超音波、診断
1993.10~2001.08.
従事しているプロジェクト研究
超音波エラストグラフィを用いた損傷定量化による唾液腺疾患の非侵襲的診断法の確立
2018.04~2021.03, 代表者:清水真弓, 九州大学, 九州大学
超音波エラストグラフィによる唾液腺疾患の定量評価.
シェーグレン症候群国際基準への超音波診断導入のための基礎的研究
2015.04~2018.03, 代表者:清水真弓, 九州大学, 九州大学
超音波を用いたシェーグレン症候群の撮像法と評価法の均一化を計る。.
シェーグレン症候群の非侵襲的画像診断法の確立
2013.04~2015.03, 代表者:清水真弓, 九州大学
近赤外線、MRI、超音波を用いたシェーグレン症候群の非侵襲的画像診断法の確立.
超音波唾液腺造影法 - 唾液腺疾患における新しい 診断法の確立と臨床応用のための検討
2009.04~2012.03, 代表者:清水真弓, 九州大学
超音波造影剤を用いた唾液腺疾患の超音波像の描出.
口腔癌転移性リンパ節超音波像を利用した定量的診断所見の開発
2003.04~2006.03, 代表者:三輪邦弘, 福岡歯科大学, 福岡歯科大学
口腔癌転移性リンパ節超音波像を利用し、主観が入らない定量的診断基準を開発する。.
最適画像処理による歯科疾患定量的自動診断システムの開発
2002.06~2004.03, 代表者:吉浦一紀, 九州大学
最適画像処理による歯科疾患定量的自動診断システムの開発.
超音波ドプラ法を用いた顎関節部疼痛の定量評価法の研究
2001.06~2004.03, 代表者:徳森謙二, 九州大学
超音波ドプラ法を用い、顎関節部疼痛の定量評価法を開発する。.
微小血流三次元表示によるリンパ節内微小転移巣の超音波診断と治療に関する実験的研究 
2001.06~2003.04, 代表者:清水真弓, 九州大学
リンパ節内微小血流を三次元表示し、血流パターンを明確にすることにより正診率の向上を狙った。.
研究業績
主要著書
1. Shimizu M (Ghom AG 編者), Textbook of Oral Radiology, ELSEVIER, Salivary Gland Disoders P 553-562., 2008.07.
主要原著論文
1. Sakamoto M, Moriyama M, Shimizu M, Chinju A, Mochizuki K, Munemura R, Ohyama K, Maehara T, Ogata K, Ohta M, Yamauchi M, Ishiguro N, Matsumura M, Ohyama Y, Kiyoshima T, Nakamura S. , The diagnostic utility of submandibular gland sonography and labial salivary gland biopsy in IgG4-related dacryoadenitis and sialadenitis: Its potential application to the diagnostic criteria. , Mod Rheumatol., 10.1080/14397595.2019.1576271, 2019.03.
2. Mayumi Shimizu, Warangkana Weerawanich, Sonographic diagnosis in the head and neck region – From the educational lecture in the 56th general assembly and annual scientific congress of Japanese Society for Oral and Maxillofacial Radiology –, Oral Radiology, 10.1007/s11282-018-0353-9, 35, 2, 101-126, 2018.11, Sonography is a simple, inexpensive, and non-invasive diagnostic modality. Although tissues behind bony structures and deep
tissues are not delineated, sonography can depict superficial soft tissues very clearly. In the head and neck region, however,
it has not yet been used widely, as the anatomical structures are complicated, and considerable experience is needed both to
perform an examination and to make a diagnosis. To perform examinations efficiently, operators must be familiar with the
sonographic system in use, and take images at standard planes. To make a correct diagnosis, operators require knowledge
of the sonographic anatomy on standard planes, representative sonographic signs and artifacts, and common diseases and
their typical sonographic findings. In this paper, we have explained the sonographic anatomy on standard planes, and the
sonographic findings of common diseases in the oral and maxillofacial region..
3. Warangkana Weerawanich, Mayumi Shimizu, Yohei Takeshita, Kazutoshi Okamura, Shoko Yoshida, Gainer R Jasa, Kazunori Yoshiura., Determination of optimum exposure parameters for dentoalveolar structures of the jaws using the CB MercuRay system with cluster signal-to-noise analysis, Oral Radiology, 10.1007/s11282-018-0348-6, 2018.09, Objectives: To find the optimum cone beam CT exposure parameters for specific
diagnostic tasks.
Methods: A Teflon phantom attached to a half mandible in a large container was
scanned in dental (D), implant (I) and panoramic (P) modes. An identical phantom in a
small container was scanned in D mode. Both were scanned at 60, 80, 100, and 120
kV. The image quality of anatomical structures: dentin-enamel junction (1), lamina dura
and periodontal ligament (PDL) space (2), trabecular pattern (3), cortex-spongy bone
junction (4) and pulp chamber and root canal (5) was evaluated by observers, and the
diagnostic image quality was analyzed with cluster signal-to-noise analysis. We then
evaluated correlations between the two image qualities and calculated the threshold of
acceptable diagnostic image quality. Optimum exposure parameters were determined
from images with an acceptable diagnostic image quality level.
Results: For small container, the optimum exposure parameters were D mode, 80 kV
for 1, 3 and 4 and D mode, 100 kV for 5. For large containers, they were D mode, 120
kV for 1, 3 and 5 and D mode, 100 kV for 4. I mode, 120 kV reached the acceptable
level for 4. No images reached acceptable level for 2.
Conclusions: There were no optimum exposure parameters for evaluation of lamina
dura and PDL space. D mode was sufficient for the other structures; however, the tube
voltage required for each structure was different. Smaller patients required lower tube
voltage. I mode, 120 kV may be used for larger lesions..
4. Warangkana Weerawanich, Mayumi Shimizu, Yohei Takeshita, Kazutoshi Okamura, Shoko Yoshida, Gainer R Jasa, Kazunori Yoshiura., Evaluation of cone-beam computed tomography diagnostic image quality using cluster signal-to-noise analysis, Oral Radiology, https://doi.org/10.1007/s11282-018-0325-0, 35, 3, 59-67, 2018.04, Objectives: 1) We sought to assess correlation among four representative parameters from a cluster signal-to-noise curve (true positive rate [TPR] corresponding to background noise, accuracy corresponding to background noise, maximum TPR, and maximum accuracy) and the diagnostic accuracy obtained in the identification of the mandibular canal using data from observers in a previous study, under the same exposure conditions. 2) We sought to clarify the relationship between the hole depths of a phantom and diagnostic accuracy.
Materials and Methods: CBCT images of a Teflon plate phantom with holes of decreasing depths from 0.7–0.1 mm were analysed using the FindFoci plugin of ImageJ. Subsequently, we constructed cluster signal-to-noise curves by plotting TPRs against false-positive rates (FPRs). The four parameters were assessed in the correlation with diagnostic accuracy obtained from observers. To analyse image contrast ranges related to detection of mandibular canals, we determined five ranges of hole depths, to represent different contrast ranges: 0.1–0.7, 0.1–0.5, 0.2–0.6, 0.2–0.7 and 0.3–0.7 mm; and evaluated their correlations with diagnostic accuracy obtained from observers.
Results: Accuracy corresponding to background noise had the highest correlation with the diagnostic accuracy among the four representative parameters. Regarding the ranges of hole depths, 0.3–0.7 and 0.1–0.7 mm had the highest correlation with diagnostic accuracy in the mandibles with distinct and indistinct mandibular canals, respectively.
Conclusions: The accuracy corresponding to background noise obtained from the cluster signal-to-noise curve can be used to evaluate the effects of exposure conditions on diagnostic accuracy..
5. Yohei Takeshita, Mayumi Shimizu, Gainer Raul Jasa, Warangkana Weerawanich, Kazutoshi Okamura, Shoko Yoshida, Kenji Tokumori, Junichi Asaumi, Kazunori Yoshiura, Prediction of detectability of the mandibular canal by quantitative image quality evaluation using cone beam CT, Dentomaxillofacial Radiology, in press, 2018.01, Objectives: To compare the results of a new quantitative image quality evaluation method that requires no observers with the results of receiver operating characteristic (ROC) analysis in detecting the mandibular canal in cone beam CT (CBCT) images.

Methods:
A Teflon (polytetrafluoroethylene) plate phantom with holes of different depths was scanned with two CBCT systems. One CBCT system was equipped with an image intensifier (Experiment 1), and the other was equipped with a flat panel detector (Experiment 2). Holes that were above the threshold gray value (ΔG), calculated using just-noticeable difference (JND), were extracted. The number of extracted holes was used as the index of the image quality, and was compared with the Az values calculated by ROC analysis to detect the mandibular canal.

Results: The number of extracted holes reflected the influence of different scanning conditions, and showed a strong correlation with the Az values calculated by ROC analysis. Indices of the number of extracted holes corresponding to high Az values for detecting the mandibular canal were obtained in both experiments.

Conclusions: Our image quality evaluation method applying JND to images of a standardized phantom is a quantitative method that could be useful for evaluating the detectability of the mandibular canal in CBCT images.
.
6. Warangkana Weerawanich, Mayumi Shimizu, Kazutoshi Okamura, Shoko Yoshida, Kazunori Yoshiura, Cluster signal-to-noise analysis for evaluation of the information content in an image, Dentomaxillofacial Radiology, in press, 2017.10, Objectives: 1) To develop an observer-free method of analyzing image quality related to the observer performance in the detection task and 2) to analyze observer behavior patterns in the detection of small mass changes in CBCT images. Materials and Methods: Thirteen observers detected holes in a Teflon phantom in CBCT images. Using the same images, we developed a new method, cluster signal-tonoise analysis, to detect the holes by applying various cut-off values using ImageJ and reconstructing cluster signal-to-noise curves. We then evaluated the correlation between cluster signal-to-noise analysis and the observer performance test. We measured the background noise in each image to evaluate the relationship with false positive rates (FPRs) of the observers. Correlations between mean FPRs and intra and inter-observer variations were also evaluated. Moreover, we calculated true positive rates (TPRs) and accuracies from background noise and evaluated their correlations with TPRs from observers. Results: Cluster signal-to-noise curves were derived in cluster signal-to-noise analysis. They yield the detection of signals (true holes) related to noise (false holes). This method correlated highly with the observer performance test (R² = 0.9296). In noisy images, increasing background noise resulted in higher FPRs and larger intra- and inter-observer variations. TPRs and accuracies calculated from background noise had high correlation with actual TPRs from observers; R² was 0.9244 and 0.9338, respectively. Conclusion: Cluster signal-to-noise analysis can simulate the detection performance of observers and thus replace the observer performance test in the evaluation of image quality. Erroneous decision-making increased with increasing background noise..
7. Yohei Takeshita, Mayumi Shimizu, Kazutoshi Okamura, Shoko Yoshida, Warangkana Weerawanich, Kenji Tokumori, Gainer Raul Jasa, Kazunori Yoshiura, A new method to evaluate image quality of CBCT images quantitatively without observers, Dentomaxillofacial Radiology, in press, 2017.03, Objectives: To develop an observer-free method for quantitatively evaluating the image quality of CBCT images by applying just-noticeable difference (JND).
Methods: We used two test objects: (1) a Teflon (polytetrafluoroethylene) plate phantom attached to a dry human mandible; and (2) a block phantom consisting of a Teflon step phantom and an aluminum step phantom. These phantoms had holes with different depths. They were immersed in water and scanned with a CB MercuRay at tube voltages of 120, 100, 80, and 60 kV. Superimposed images of the phantoms with holes were used for evaluation. The number of detectable holes was used as an index of image quality. In detecting holes quantitatively, the threshold gray value (ΔG) which differentiated holes from the background was calculated using a specific threshold (the JND), and we extracted the holes with gray values above ΔG. The indexes obtained by this quantitative method (the extracted hole values) were compared with the observers’ evaluations (the observed hole values). In addition, the contrast-to-noise ratio (CNR) of the shallowest detectable holes and the deepest undetectable holes were measured to evaluate the contribution of CNR to detectability.
Results: The results of this evaluation method corresponded almost exactly with the evaluations made by observers. The extracted hole values reflected the influence of different tube voltages. All extracted holes had an area with a CNR of ≥1.5.
Conclusions: This quantitative method of evaluating CBCT image quality may be more useful and less time-consuming than evaluation by observation..
8. Gainer Raul Jasa, Mayumi Shimizu, Kazutoshi Okamura, Kenji Tokumori, Yohei Takeshita, Warangkana Weerawanich, Kazunori Yoshiura, Effects of exposure parameters and slice thickness on detecting clear and unclear mandibular canals using cone beam CT, Dentomaxillofacial Radiology, in press, 2017.03, Objectives The purpose of this study was to clarify the effects of exposure parameters and image processing methods when using cone beam CT (CBCT) to detect clear and unclear mandibular canals (MCs).
Methods Twenty-four dry half mandibles were divided into two groups with clear and unclear MCs based on a previous CBCT study. Mandibles were scanned using a CBCT system with varying exposure parameters (tube voltages 60, 70, and 90 kV; and tube currents 2, 5, 10 and 15 mA) to obtain a total of 144 scans. The images were processed with different slice thicknesses using ImageJ software. Five radiologists evaluated the cross-sectional images of the first molar region to detect the MCs. The diagnostic accuracy of varying exposure parameters and image processing conditions was compared with areas under the curves (Az) in receiver operating characteristic (ROC) analysis.
Results: The Az values for clear MCs were higher than those for unclear MCs. With increasing exposure voltages and currents, Az values increased, but no significant differences were found with high voltages and currents in clear MCs (p = 0.6825 and p = 0.7156). The Az values of serial images were higher than those of overlaid images (p < 0.0001), and those for thicker slices were higher than those for thinner slices (p < 0.0001).
Conclusions: Our findings indicate that detection of unclear MCs requires either higher exposure parameters or processing of the images with thicker slices. To detect clear MCs, lower exposure parameters can be used..
9. Mayumi Shimizu, Kazutoshi Okamura, Yoshitaka Kise, Yohei Takeshita, Hiroko Furuhashi, Warangkana Weerawanich, Moriyama Masafumi, Yukiko Ohyama, Furukawa Sachiko, Seiji Nakamura, Kazunori Yoshiura, Effectiveness of imaging modalities for screening IgG4-related dacryoadenitis and sialadenitis (Mikulicz’s disease) and for differentiating it from Sjögren’s syndrome (SS), with an emphasis on sonography., Arthritis Research & Therapy, 10.1186/s13075-015-0751-x, 17, 233, 2015.08, Introduction: The aim of this study was to clarify the effectiveness of various imaging modalities and characteristic imaging features in the screening of IgG4-related dacryoadenitis and sialadenitis (IgG4-DS), and to show the differences in the imaging features between IgG4-DS and Sjögren’s syndrome (SS).
Methods: Thirty-nine patients with IgG4-DS, 51 with SS and 36 with normal salivary glands were enrolled. Images of the parotid and submandibular glands obtained using sonography, 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT), computed tomography (CT) and magnetic resonance imaging (MRI) were retrospectively analyzed. Six oral and maxillofacial radiologists randomly reviewed the arranged image sets under blinded conditions. Each observer scored the confidence rating regarding the presence of the characteristic imaging findings using a 5-grade rating system. After scoring various findings, diagnosis was made as normal, IgG4-DS or SS, considering all findings for each case.
Results: On sonography, multiple hypoechoic areas and hyperechoic lines and/or spots in the parotid glands and obscuration of submandibular gland configuration were detected mainly in patients with SS (median scores 4, 4 and 3, respectively). Reticular and nodal patterns were observed primarily in patients with IgG4-DS (median score 5). FDG-PET/CT revealed a tendency for abnormal 18F-FDG accumulation and swelling of both the parotid and submandibular glands in patients with IgG4-DS, particularly in the submandibular glands. On MRI, SS had a high score regarding the findings of a salt-and-pepper appearance and/or multiple cystic areas in the parotid glands (median score 4.5). Sonography showed the highest values among the four imaging modalities for sensitivity, specificity and accuracy. There were significant differences between sonography and CT (p = 0.0001) and between sonography and FDG-PET/CT (p = 0.0058) concerning accuracy.
Conclusions: Changes in the submandibular glands affected by IgG4-DS could be easily detected using sonography (characteristic bilateral nodal/reticular change) and FDG-PET/CT (abnormal 18F-FDG accumulation). Even inexperienced observers could detect these findings. In addition, sonography could also differentiate SS. Consequently, we recommend sonography as a modality for the screening of IgG4-DS, because it is easy to use, involves no radiation exposure and is an effective imaging modality..
10. Moriyama Masafumi, Tanaka A, Maehara T, YUKIKO OHYAMA, Mayumi Shimizu, Nakashima H, Hayashida Jun-Nosuke, Shinozaki S, Kubo Y, Furukawa S, Kikuta T, Seiji Nakamura, Clinical characteristics of Mikulicz's disease as an IgG4-related disease., Clin Oral Invest, 10.1007/s00784-012-0905-z, 2013.05.
11. Shimizu M, Moriyama M, Okamura K, Kawazu T, Chikui T, Goto TK, Ohyama Y, Nakamura S, Yoshiura K., Sonographic diagnosis for Mikulicz disease, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 108:105-113, 2009.07.
12. Mayumi Shimizu, Ussmuller J, Hartwein J, Donath K. , A comparative study of sonographic and histopathologic findings of tumorous lesions in the parotid gland, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 88, 6, 723-737, 1999.12, Objective. The purpose of this study was to clarify characteristic sonomorphologic features of parotid lesions statistically and to propose new criteria for the differential diagnosis. Study design. Eighty-six tumorous lesions were analyzed with regard to the following sonomorphologic features: boundary, shape, echo intensity level, distribution of internal echoes, and acoustic enhancement. Stepwise polychotomous logistic regression analysis was performed to assess characteristic sonographic features. As dependent variables, we used "pleomorphic adenoma," "Warthin tumor," "malignant tumors" and "other benign lesions"; as predictor variables, we used the aforementioned sonomorphologic features. Proportion of the occurrence of each dependent variable was calculated. Results. Lobular shape and homogeneous internal echoes predicted pleomorphic adenoma. A lesion with multiple anechoic areas would be Warthin tumor with very high sensitivity. Malignant tumors showed either heterogeneous internal echoes without characteristic structures or polygonal shape. Conclusions. These sonomorphologic features should be observed to make more exact differential diagnoses for operation and therapy planning..
13. Mayumi Shimizu, Ussmuller J, Hartwein J, Donath K, Kinukawa N., Statistical study for sonographic differential diagnosis of tumorous lesions in the parotid gland, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 10.1016/S1079-2104(99)70120-4, 88, 2, 226-233, 1999.01, [URL], Objective. The purpose of this study was to clarify characteristic sonomorphologic features of parotid lesions statistically and to propose new criteria for the differential diagnosis. Study design. Eighty-six tumorous lesions were analyzed with regard to the following sonomorphologic features: boundary, shape, echo intensity level, distribution of internal echoes, and acoustic enhancement. Stepwise polychotomous logistic regression analysis was performed to assess characteristic sonographic features. As dependent variables, we used "pleomorphic adenoma," "Warthin tumor," "malignant tumors" and "other benign lesions"; as predictor variables, we used the aforementioned sonomorphologic features. Proportion of the occurrence of each dependent variable was calculated. Results. Lobular shape and homogeneous internal echoes predicted pleomorphic adenoma. A lesion with multiple anechoic areas would be Warthin tumor with very high sensitivity. Malignant tumors showed either heterogeneous internal echoes without characteristic structures or polygonal shape. Conclusions. These sonomorphologic features should be observed to make more exact differential diagnoses for operation and therapy planning..
主要総説, 論評, 解説, 書評, 報告書等
1. 清水真弓, 歯科放射線科医に必要な超音波検査の知識, 歯科放射線 , 2018.12.
2. Mayumi Shimizu, Warangkana Weerawanich, Sonographic diagnosis in the head and neck region – From the educational lecture in the 56th general assembly and annual scientific congress of Japanese Society for Oral and Maxillofacial Radiology –, Oral Radiology, 2018.10, Sonography is an easy to apply, inexpensive, and non-invasive diagnostic modality.
Although tissues behind bony structures and deep tissues are not delineated, sonography
can depict superficial soft tissues very clearly. In the head and neck region, however, it
has not yet been widely performed, as the anatomical structures are complicated, and
considerable experience is needed both to perform an examination and to make a
diagnosis.
To perform examinations smoothly, operators must be familiar with the sonographic
system in use, and take images at standard planes. To make a correct diagnosis, operators
require knowledge of the sonographic anatomies on those planes, representative
sonographic signs and artifacts, and common diseases and their typical sonographic
findings.
In this paper, we have explained the sonographic anatomies on standard planes, and
sonographic findings of common diseases in the oral and maxillofacial regions..
3. 清水 真弓, 特集:唾液腺のIgG4関連疾患とシェーグレン症候群を取り巻く新しい概念と画像診断
IgG4関連涙腺唾液腺炎とシェーグレン症候群の画像診断 ―各種モダリティにおける画像所見―
, 臨床放射線, 2014.08.
4. 清水真弓、岡村和俊、吉浦一紀、神田重信, シェーグレン症候群の超音波画像診断, 歯科放射線, 44巻、1号、19-52., 2004.04.
主要学会発表等
1. 坂本瑞樹、森山雅文、清水真弓、鎮守晃、望月敬太、宗村龍佑、大山恵子、前原隆、緒方謙一、太田美穂、山内昌樹、石黒乃理子、松村万由、中村誠司, IgG4 関連涙腺・唾液腺炎の診断における口唇腺生検および超音波検査の有用性, 第12回IgG4研究会, 2019.03.
2. 清水真弓, シェーグレン症候群における唾液腺シンチグラフィの有用性の検討, 第38回日本画像医学会学術集会, 2019.03.
3. 清水真弓, 岡村和俊, 松本妃可, 吉浦一紀, シェーグレン症候群の超音波診断における読影トレーニングの効果の検討, NPO法人日本歯科放射線学会 第38回関西・九州合同地方会, 2019.01.
4. 坂本瑞樹、森山雅文、清水真弓、鎮守晃、望月敬太、宗村龍佑、大山恵子、前原隆、緒方謙一、太田美穂、山内昌樹、石黒乃理子、松村万由、中村誠司, IgG4 関連涙腺・唾液腺炎の診断における口唇腺生検および超音波検査の有用性, 第28回日本口腔内科学会・第31回日本口腔診断学会 合同学術大会, 2018.09.
5. 森山雅文、清水真弓、坂本瑞樹、鎮守晃、望月敬太、宗村龍佑、前原隆、山内昌樹、石黒乃理子、中村誠司, シンポジウム3:IgG4 関連ミクリッツ病、眼病変の診断基準と診療指針  「IgG4 関連涙腺・唾液腺炎(ミクリッツ病)の病態と診断」, 第27回日本シェーグレン症候群学会学術集会, 2018.09.
6. 清水 真弓, Weerawanich W, 徳森 謙二, 岡村 和俊, 吉浦 一紀, 唾液腺シンチグラフィー定量解析によるシェーグレン症候群の診断, 第26回日本シェーグレン症候群学会学術集会, 2017.09.
7. Shimizu M, Weerawanich W, Okamura K, Yoshiura K, Analysis on the factors related to the sonographic diagnosis for Sjögren’s syndrome (SS), The 11th ACOMFR, 2016.11.
8. 清水 真弓, シェーグレン症候群の超音波診断能に関わる因子の検討, 第25回日本シェーグレン症候群学会学術集会, 2016.09.
9. Mayumi Shimizu, Imaging features for Sjögren's syndrome, The 10th Asian Oceanian Congress of Neuroradiology , 2015.11.
10. 清水 真弓, シンポジウム1「唾液腺疾患の成り立ちと治療」IgG4関連涙腺唾液腺炎とシェーグレン症候群の画像診断, 第25回日本口腔内科学会学術大会 , 2015.09.
11. 清水 真弓, IgG4関連涙腺唾液腺炎(IgG4-DS)とシェーグレン症候群(SS)の各種モダリティにおける診断精度の検討, 第34回日本画像医学会, 2015.02.
12. 清水真弓, 教育講演:口腔・頭頚部のIgG4関連疾患 
 IgG4唾液腺疾患の画像診断, 第33回日本画像医学会, 2014.02.
13. 清水真弓, シンポジウム 
“唾液腺のIgG4関連疾患とシェーグレン症候群を取り巻く新しい概念と画像診断”「IgG4関連疾患とシェーグレン症候群の画像診断 ー各種モダリティーにおける画像所見ー」, 第53回日本核医学会総会学術総会, 2013.11.
14. Mayumi Shimizu, Kazutoshi Okamura, Koichiro Abe, Moriyama Masafumi, Yukiko Ohyama, Seiji Nakamura, Kazunori Yoshiura, Imaging diagnosis for Sjögren's syndrome by scintigraphy - Comparison with sonography and sialography -, 12th International Symposium on Sjögren's Syndrome, 2013.10.
15. Mayumi Shimizu, Moriyama Masafumi, Kazutoshi Okamura, Toshiyuki Kawazu, Toru Chikui, Yukiko Ohyama, Koichiro Abe, Fukukawa S, Seiji Nakamura, Kazunori Yoshiura, Imaging diagnosis for IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), 12th International Symposium on Sjögren's Syndrome, 2013.10.
16. Mayumi Shimizu, Moriyama Masafumi, Kazutoshi Okamura, Toshiyuki Kawazu, Toru Chikui, YUKIKO OHYAMA, Koichiro Abe, Fukukawa S, Seiji Nakamura, Kazunori Yoshiura, Effectiveness of imaging modalities for diagnosing IgG4-related dacryoadenitis and sialoadenitis, so called Mikulicz’s disease, 19th ICDMFR, 2013.06.
17. 清水真弓, 頭頚部IgG4関連疾患の画像診断, 第32回画像医学会, 2013.02.
18. Shimizu M, Okamura K, Abe K, Ohyama Y, Nakamura S, Yoshiura K., Imaging diagnoses for Sjogren syndrome. - Comparison of sonography with scintigraphy -, 8th ACOMFR, 2010.11.
19. Shimizu M, Okamura K, Yoshiura K, Ohyama Y, Nakamura S, Kinukawa N., Sonographic diagnosis for Sjógren’s syndrome, 16th ICDMFR, 2007.06.
20. 清水真弓, ワークショップ:唾液腺疾患の画像診断 2.耳下腺腫瘍の超音波診断, 第26回日本画像医学会, 2007.02.
作品・ソフトウェア・データベース等
1. 清水真弓, ホームページ, 2003.08
Hamburg大学の症例を用いた 耳下腺腫瘍の超音波像による鑑別診断.
学会活動
所属学会名
International Association of Dentomaxillofacial Radiology
日本歯科放射線学会
日本口腔科学会
日本超音波医学会
日本画像医学会
日本シェーグレン症候群学会
日本口腔外科学会
学協会役員等への就任
2012.04~2020.03, 日本歯科放射線学会, 用語委員会委員.
2014.04~2018.03, 日本歯科放射線学会, 代議員.
学会大会・会議・シンポジウム等における役割
2019.06.14~2019.06.16, 日本歯科放射線学会第60回学術大会・第16回定例総会, 座長.
2016.10.28~2016.10.30, 日本歯科放射線学会第21回臨床画像大会, 指定講演者.
2015.11.05~2015.11.07, The 10th Asian Oceanian Congress of Neuroradiology, シンポジスト.
2015.10.23~2015.10.25, 日本歯科放射線学会第20回臨床画像大会, 準備委員長.
2015.09.18~2015.09.19, 第25回日本口腔内科学会学術大会, シンポジスト.
2015.06.05~2015.06.07, 日本歯科放射線学会第56回総会・学術大会, 指定講演者.
2014.12.06~2014.12.06, 日本歯科放射線学会関西・九州合同地方会, 座長(Chairmanship).
2014.10.31~2014.11.02, 日本歯科放射線学会第19回臨床画像大会, 座長(Chairmanship).
2014.02.21~2014.02.22, 第33回日本画像医学会, 指定講演者.
2013.11.08~2013.11.10, 第53回日本核医学会学術総会, シンポジスト.
2013.02.22~2013.02.22, 第32回日本画像医学会, 指定講演者.
2007.02.01~2007.02.01, 第26回日本画像医学会, シンポジスト.
2006.06.01~2006.06.01, 第5回九州シェーグレン症候群研究会, 指定講演者.
2003.08.01~2003.08.01, 日本歯科放射線学会九州サマーセミナー, 座長(Chairmanship).
2003.05.01~2003.05.01, 臨床画像大会, シンポジスト.
学術論文等の審査
年度 外国語雑誌査読論文数 日本語雑誌査読論文数 国際会議録査読論文数 国内会議録査読論文数 合計
2019年度      
2018年度      
2017年度      
2016年度    
2015年度      
2014年度      
2013年度      
2012年度      
2011年度      
2010年度    
2009年度      
2008年度      
2007年度      
2006年度      
2005年度      
2004年度      
2003年度      
2002年度      
その他の研究活動
海外渡航状況, 海外での教育研究歴
Hamburg University, Germany, 1993.10~1995.09.
外国人研究者等の受入れ状況
2020.01~2020.03, 1ヶ月以上, 共和国大学, Uruguay, 共和国大学.
2019.10~2020.01, 1ヶ月以上, Bayero University, Nigeria, Bayero University.
2018.11~2018.12, 1ヶ月以上, Bayero University, Nigeria, Bayero University.
2016.02~2016.03, 1ヶ月以上, 共和国大学, Uruguay, 共和国大学.
2015.02~2015.03, 1ヶ月以上, 共和国大学, Uruguay, 共和国大学.
2014.02~2014.03, 1ヶ月以上, 共和国大学, Uruguay, 共和国大学.
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2018年度~2020年度, 基盤研究(C), 代表, 超音波エラストグラフィを用いた損傷定量化による唾液腺疾患の非侵襲的診断法の確立.
2015年度~2017年度, 基盤研究(C), 代表, シェーグレン症候群国際診断基準への超音波診断導入のための基礎的研究.
2012年度~2014年度, 一般研究(C), 代表, 近赤外線、MRI、超音波を用いたシェーグレン症候群の非侵襲的画像診断法の確立.
2009年度~2011年度, 一般研究(C), 代表, 超音波唾液腺造影法-唾液腺疾患における新しい診断法の確立と臨床応用のための検討.
2004年度~2005年度, 一般研究(C), 分担, 体内電気水圧破壊装置を応用した内視鏡下唾石摘出法の開発に関する実験的研究.
2002年度~2003年度, 一般研究(C), 分担, 最適画像処理による歯科疾患定量的自動診断システムの開発.
2001年度~2002年度, 一般研究(C), 代表, 微小血流三次元表示によるリンパ節内微小転移巣の超音波診断と治療に関する実験的研究.
2001年度~2003年度, 一般研究(C), 分担, 超音波ドプラ法を用いた顎関節部疼痛の定量評価方法の研究.
1998年度~1999年度, 基盤研究(B), 代表, 超音波唾液腺造影法 - 唾液腺疾患における新しい診断法の確立.
2006年度~2008年度, 一般研究(C), 分担, 造影MRIを用いた頭頸部 Kinetic Analysisの試み.
科学研究費補助金の採択状況(文部科学省、日本学術振興会以外)
2003年度~2004年度, 廃棄物処理等科学研究費 (環境省), 分担, 口腔癌転移性リンパ節超音波像を利用した定量的診断所見の開発.

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pure2017年10月2日から、「九州大学研究者情報」を補完するデータベースとして、Elsevier社の「Pure」による研究業績の公開を開始しました。
 
 
九州大学知的財産本部「九州大学Seeds集」