Kyushu University Academic Staff Educational and Research Activities Database
List of Presentations
Hidefumi Maeda Last modified date:2019.05.30

Professor / Oral Rehabilitation / Department of Dental Science / Faculty of Dental Science


Presentations
1. Aoi Nozu, Sayuri Hamano, Atsushi Tomokiyo, Daigaku Hasegawa, Shinichiro Yoshida, Hideki Sugii, Hiromi Mitarai, Keita Ipposhi, Naohisa Wada, Hidefumi Maeda., Effects of TNF-alpha on Senescent human dental pulp cells., Kyudai Oral Bioscience & OBT Research Center Joint International Symposium 2019, 2019.03.
2. Fujino S, Hamano S, Tomokiyo A, Hasegawa D, Yoshida Y, Sugii H, Washio A, Mitarai H, Nozu A, Arima M, Wada N, KitamuraC, Maeda H, Effects of dopamine on odontoblastic differentiation. , The IFEA 11th World Endodontic Congress 2018, 2018.10.
3. Arima M, Hasegawa D, Yoshida S, Mitarai H, Tomokiyo A, Hamano S, Sugii H, Wada N, Maeda H. , R-spondin2 Enhances Osteoblastic Differentiation of Immature Human Periodontal Ligament Cells., The 96th General Session & Exhibition of the IADR., 2018.07.
4. Tomokiyo A, Hamano S, Hasegawa D, Sugii H, Yoshida S, Mitarai H, Sonoda M, Nozu A, Wada N, Maeda H., Discoloration of White Mineral Trioxide Aggregate Immersed in Various Solutions., The 96th General Session & Exhibition of the IADR., 2018.07.
5. Sugii H, Grimaldi A, Li J, Parada C, Ho T-V, Feng J, Jing J, Yuan Y, Guo Y, Maeda H, Chai Y., Dlx5 Plays a Critical Role During Soft Palate Muscle Development., The 96th General Session & Exhibition of the IADR., 2018.07.
6. Nozu A, Hamano S, Tomokiyo A, Hasegawa D, Sugii H, Yoshida S, Mitarai H, Taniguchi S, Wada N, Maeda H., Odontoblastic differentiation of senescence dental pulp cells treated by TNF-α., The 96th General Session & Exhibition of the IADR., 2018.07.
7. Arima M, Hasegawa D, Yoshida S, Mitarai H, Tomokiyo A, Hamano S, Sugii H, Wada N, Maeda H., R-spondin2 enhances osteogenesis of immature human periodontal ligament cells through the canonical Wnt signaling pathway., Kyudai Oral Bioscience 2018, 2018.02.
8. Hidefumi Maeda, Differentiation and Aging of Pulp Cells., The 19th Scientific Congress of Asia Pacific Endodontic Confederation and 18th IACDE & IES PG Convention, 2017, 2017.04.
9. Hiromi Mitarai, Naohisa Wada, Daigaku Hasegawa, Shinichiro Yoshida, Mai Arima, Atsushi Tomokiyo, Sayuri Hamano, Hidefumi Maeda, Transgelin mediates TGF-beta1-induced human periodontal ligament cell proliferation., 95th General Session & Exhibition of the IADR, 2017.03.
10. Hiromi Mitarai, Naohisa Wada, Daigaku Hasegawa, Shinichiro Yoshida, Mai Arima, Atsushi Tomokiyo, Sayuri Hamano, Suguru Serita, Hiroyuki Mizumachi, Hidefumi Maeda, Transgelin mediates the proliferation of human periodontal ligament cells induced by TGF-β1., Kyudai Oral Bioscience 2017, 2017.02.
11. Shinichiro Yoshida, Naohisa Wada, Daigaku Hasegawa, Atsushi Tomokiyo, Sayuri Hamano, Hiromi Mitarai, Hideki Sugii, Hidefumi Maeda, Semaphorin 3A Induces Odontoblastic Phenotype in Dental Pulp Stem Cells., 94th General Session & Exhibition of the IADR., 2016.06.
12. Daigaku Hasegawa, Naohisa Wada, Sayuri Hamano, Atsushi Tomokiyo, Shinichiro Yoshida, Hiromi Mitarai, Mai Sonoda, Hideki Sugii, Hidefumi Maeda, Identification of a Novel Periodontal Ligament Stem Cell Marker., 94th General Session & Exhibition of the IADR., 2016.06.
13. Sayuri Hamano, Atsushi Tomokiyo, Naohisa Wada, Daigaku Hasegawa, Hideki Sugii, Shinichiro Yoshida, Suguru Serita, Hiroyuki Mizumachi, Hiromi Mitarai, Hidefumi Maeda, Directing Human iPS Cells Toward PDL Stem Cells., 94th General Session & Exhibition of the IADR., 2016.06.
14. Hideki Sugii, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, 吉田 晋一郎, Suguru Serita, Hiroyuki Mizumachi, Hiromi Mitarai, Aoi Nozu, Marina Ogawa, Mai Sonoda, Naohisa Wada, Hidefumi Maeda, Activin A reversely works between human pre-osteoblastic cells and periodontal ligament cells on their osteoblastic differentiation. , 2nd symposium of Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers, 2016.02.
15. Hidefumi Maeda, How can we save a severely-damaged tooth?, Kyudai Oral Bioscience 2016, 2016.02.
16. 吉田 晋一郎, Naohisa Wada, Daigaku Hasegawa, Atsushi Tomokiyo, Sayuri Hamano, Hiromi Mitarai, Suguru Serita, Hiroyuki Mizumachi, Hidefumi Maeda, Semaphorin 3A induces odontoblastic phenotype in dental pulp stem cells., Kyudai Oral Bioscience 2016, 2016.02.
17. Glial cell line-derived neurotrophic factor (GDNF) from human periodontal ligament cells treated with proinflammatory cytokines promotes neurocytic differentiation of PC12 cells..
18. The contribution of Calcium-sensing receptor on mineralization of human dental pulp cells..
19. Fluid analysis of laser-activated irrigation in apical ramification of the simulated canal model..
20. Transgelin is involved in the expression of alpha-SMA in periodontal ligament cells..
21. Generation of neural crest like-cells from human periodontal ligament- and foreskin-derived induce pluripotent stem cells..
22. Myna N. Zakaria, Toru Takeshita, Michiko Furuta, Hidefumi Maeda, Akifumi Akamine, Yoshihisa Yamashita, Oral Mycobiome in Japanese Elderly Adults., 93rd General Session & Exhibition of the IADR. , 2015.03.
23. Daigaku Hasegwa, Naohisa Wada, Hidefumi Maeda, Shinichiro Yoshida, Hiromi Mitarai, Atsushi Tomokiyo, Monnouchi Satoshi, Sayuri Hamano, Asuka Yuda, Akifumi Akamine, The Effects of Wnt5a on Human Periodontal Ligament Cells., 93rd General Session & Exhibition of the IADR., 2015.03.
24. Sayuri Hamano, Hidefumi Maeda, Daigaku Hasegawa, Monnouchi Satoshi, Naohisa Wada, Atsushi Tomokiyo, Asuka Yuda, Hideki Sugii, Shinichiro Yoshida, Akifumi Akamine, Effect of β2 Adrenergic Receptor on Human Periodontal Ligament Cells. , 93rd General Session & Exhibition of the IADR., 2015.03.
25. Asuka Yuda, Hidefumi Maeda, Fujii Shinsuke, Monnouchi Satoshi, Naohisa Wada, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, Hideki Sugii, Shinichiro Yoshida, Akifumi Akamine, Collaborative Activity of CTGF/CCN2 and TGF-β1 on Osteogenesis and Fibrogenesis., 93rd General Session & Exhibition of the IADR., 2015.03.
26. Daigaku Hasegawa, naohisa wada, Hidefumi Maeda, Shinichiro Yoshida, Monnouchi Satoshi, Koori Katsuaki, Sayuri Hamano, Hiromi Mitarai, Akifumi Akamine, The Effects of Wnt5a on Human Periodontal Ligament Cells. , Kyudai Oral Bioscience 2014 —8th International Symposium —, 2014.02.
27. Hidefumi Maeda, To seek a longer conservation method of tooth, 1st International Conference on Dental & Oral Health, 2013.08, In Japan, we meet the aging of society, and along with this, people desire to retain their teeth as long as possible. Periodontitis, caries, fracture, and orthodontic issue are known to be as major causes of tooth loss. To correct these problems, clinicians and researchers have made efforts to develop novel and unique therapies. In this context, we have focused on treatment for caries and fracture. To address this issue, we have been attempting to clarify the mechanism of the regeneration of periodontal ligament (PDL) tissue and to develop functional filling materials to permit this event. For the former agenda, we have investigated to define PDL stem cells, signaling and scaffolds based on tissue engineering standpoint. Firstly we have established and characterized two undifferentiated human PDL clonal cell lines that had been immortalized by gene transfer, and then examined the effects of various cytokines and calcium on these cell lines. For the latter agenda, we have prepared calcium-modified 4-META/MMA-TBB resin, and evaluated its bioactive features, such as biocompatibility, formation of hydroxyapatite on its surface, and differentiation-inducing activity for human PDL cells. Thus to elucidate above-described three elements optimal to allow periodontal regeneration, and to develop functional filling materials with characteristics as a scaffold for that will lead us to pioneer a new dental therapy for longer conservation of tooth. This technique may be also prospective in further application for developing the implant retaining PDL tissue or a treatment of periodontitis..
28. ZAKARIA MN, Hidefumi Maeda, naohisa wada, Akifumi Akamine, Molecular Assessment of Bacterial Community in Persistent Apical Periodontitis Granulomatous Tissue: 16S rDNA Clone Library Analysis. , The 9th World Endodontic Congress of IFEA., 2013.05.
29. 吉田晋一郎, naohisa wada, 前田 英史, 長谷川大学, 佐藤浩美, Monnouchi Satoshi, Akifumi Akamine, Dental Pulp Stem Cells on Bone Tissue Express Periodontal Ligament-related gene., The 9th World Endodontic Congress of IFEA., 2013.05.
30. 門野内 聡, 前田 英史, 祐田明香, 赤峰 昭文, Localization of βig-h3 and Collagen Type I in Dental Pulp., The 9th World Endodontic Congress of IFEA., 2013.05.
31. 前田 英史, 郡 勝明, 和田 尚久, 友清 淳, 門野内 聡, 山本直秀, 赤峰 昭文, Evaluation of calcium-modified 4-META/MMA-TBB resin on its bioactive feature. , The 9th World Endodontic Congress of IFEA., 2013.05.
32. 郡勝明, 前田 英史, 和田 尚久, 友清 淳, 門野内 聡, 山本直秀, 赤峰 昭文, Extracellular Calcium Regulates Osteoblastic Differentiation of Undifferentiated PDL Cells., 91st General Session & Exhibition of the IADR, 2013.03.
33. 山本直秀, 前田 英史, 友清 淳, 和田 尚久, 門野内 聡, 郡勝明, 赤峰 昭文, Roles of Glial Cell-Derived Neurotrophic Factor in Periodontal Ligament Cells., 91st General Session & Exhibition of the IADR, 2013.03.
34. 和田 尚久, 前田 英史, 長谷川大学, S. GRONTHOS, P.M. BARTOLD, D. MENICANIN, 藤井 慎介, Hiroko Wada, Atsushi Tomokiyo, Monnouchi Satoshi, Akifumi Akamine, Conversion of periodontal ligament cells into multipotent stem-like cells., 91st General Session & Exhibition of the IADR., 2013.03.
35. 前田 英史, 友清 淳, 郡勝明, 山本直秀, 和田 尚久, 門野内 聡, 濱野さゆり, 祐田明香, 赤峰 昭文, CaCl2-added Resin Exerts Bioactive Effects on Periodontal Ligament Cells. , 91st General Session & Exhibition of the IADR., 2013.03.
36. 和田 尚久, 前田 英史, 長谷川大学, Gronthos S, Bartold PM, Menicanin D, 藤井 慎介, 和田 裕子, 友清 淳, 門野内 聡, 赤峰 昭文, Induction of stem/undifferentiated cells from periodontal ligament cells by Sema3A. , The Australian Health and Medical Research Congress 2012, 2012.11.
37. The effects of Dioxins on osteoblastic differentiation of human periodontal ligament cells.
38. The effects of Sema3A on stemness induction of human periodontal ligament cells.
39. Exposure to transforming growth factor-beta1 after basic fibroblast growth factor promotes the fibroblastic differentiation of human periodontal ligament stem/progenitor cell lines. .
40. Potency of Mechanical Load in Differentiation of Periodontal Ligament Stem Cells..
41. Stretched periodontal ligament cells up-regulate Interleukin-11 to regenerate osteoblastic metabolism..
42. The effects of passive ultrasonic irrigation on root irrigation -SEM observation-.
43. Stretch loading induces the expression of interleukin-11 in human periodontal ligament cells..
44. Resin-based sealers exhibit high sealing ability; thus, they are useful for endodontic
treatment. Some reports concerning cytotoxicity of the eluent from these sealers,
however, have been presented. The purpose of this study was to evaluate the effects
of a polymethyl methacrylate resin-based sealer (Superbond Sealer™, SB) on
proliferation and osteogenic differentiation of human periodontal ligament cells
(HPLCs) in vitro, compared with an epoxy resin-based sealer (AH Plus™, AH). HPLCs
were obtained from two patients with informed consent. SB or AH discs washed for 7
days after setting (washed) or unwashed discs just after setting for 24 hr (unwashed)
were prepared. Cells cultured on these discs were evaluated by scanning electron
microscopy (SEM) and WST-1 proliferation assays. The osteogenic differentiation
of HPLCs cultured on these discs was examined by gene expression analysis of
osteopontin (OPN) and osteocalcin (OCN) by quantitative RT-PCR. HPLCs exhibited
growth on washed SB discs, whereas unwashed SB and AH discs and washed AH discs
inhibited their proliferation. SEM observation revealed that HPLCs tightly attached
onto the surface of washed SB discs, although few cells were observed on other discs.
HPLCs significantly upregulated gene expression of OPN and OCN when cultured
on washed SB discs in osteogenic differentiation medium for 2 weeks whereas other
discs did not induce their differentiation. These results indicate that, although SB
initially exerted cytotoxic effects on HPLCs, these effects reduced during washing for
7 days compared to AH. Washed SB might allow HPLCs to differentiate into osteogenic
cells under the osteogenic environment. This study was supported by the Ministry of
Education, Culture, Sports, Science and Technology in Japan..
45. The roles of stretch loading in human periodontal ligament cells..
46. Contribution of mechanical load to the regeneration of human periodontal ligament tissues..
47. Calcium hydroxide intracanal medication influences the gutta-percha-filled area with resin-based root canal sealer (Part 1)..
48. The effects of calcium on differentiation of human periodontal ligament stem/progenitor cell lines..
49. The effects of basic fibroblast growth factor on the fibroblastic differentiation of human undifferentiated periodontal ligamen cell lines..
50. The effects of glial cell-derived neurotrophic factor on chemotaxis of human periodontal ligament cells..
51. Immunomodulatory properties of human periodontal ligament cells and dental pulp cells..
52. Characteristics of Superbond sealer –Its effects on proliferation and differentiation of human periodontal ligament cells-
.
53. The roles of angiotensin II in stretched periodontal ligament cells. .
54. Fibroblastic cells from human periapical granulation tissue preferentially form calcified matrices in boiled decalcified rat bone..
55. Angiotensin II mediates the loading signal in human periodontal ligament cells..
56. What are the characteristics of PDL stem cells?.
57. Angiotensin II is involved in the loading signal in stretched human PDL cells..
58. What characteristics do PDL stem cells have?.
59. MTA stimulates BMP2 expression in human PDL cells. .
60. Expression and effects of TGFβ-1 in periodontal ligament tissue..
61. Calcium-releasing Agent Exhibits Bioactive Effects in Endodontic Therapy..
62. Influence of calcium hydroxide intracanal medication on apical leakage..
63. A Multipotent hPDL Cell Line Promotes Neurocytic Differentiation and Migration..
64. MTA induces mineralization of human periodontal ligament cells..
65. Effects of root canal irrigants on the removal of smear layer; SEM images of root canal dentin..
66. SEM images of root canal dentin irrigated with Smearclean− Comparison with ultrasonic irrigation −..
67. Establishment and Characterization of Human Periodontal Ligament Cell Lines with Multipotencies..
68. Effects of One-step Adhesive Resins on Cytotoxity and Differentiation to Odontoblasts.
69. Effects of root-end filling materials on the osteoblast-like differentiation of human periodontal ligament cells..
70. Effects od One-step Adhesive Resins on Cytotoxity and Differentiation to Odontoblasts..
71. Effects of bFGF and EMD on human periodontal ligament cells..
72. Characterization of clonal human periodontal ligament cell lines..
73. Influence of EMD and bFGF on mineralization in human periodontal ligament cell lines..
74. Cloning and Characterization of the Annexin II Receptor..
75. Cloning of Immortalized Human Periodontal Ligament Cells and Their Characterization.
76. Establishment of Cell Line Of Human Epithelial Rests of Malassez..
77. Establishment of Human Periodontal Ligament Cell Lines and Their Characterization..
78. Establishment of Human Periodontal Ligament Cell Lines and Their Characterization..
79. Fibroblastic Cells from Human Periapical Granulation Tissue (HFC) Preferentially Form Calcified Matrices in Rat Decalcified and Boiled Bone (DBB)..
80. LPS stimulates OPG and RANKL expression in periodontal ligament..
81. Iron Deprivation Blocks Normal Human CD34 Cell Myelomonocytic Lineage Differentiation By Inhibiting Expression of p21(WAF1/CIP1)..
82. Measles Virus Preferentially Induces Vitamin D Receptor Gene Activation in Pagetic Osteoclast Precursors..
83. Osteoclast Inhibitory Peptide-1/hSca Mediates Interferon-Gamma Inhibition of osteoclast Formation..
84. Characterization and Cloning of the Annexin II Receptor..
85. Identification of Novel 60 and 15-17 kDa Vitamin D Receptor (VDR) Binding Peptides in Osteoclast Precursors Infected with Measles Virus (MV) That Are Also Present with Paget's Disease..
86. Mapping and Characterization of the Functional Domain of Osteoclast Inhibitory Peptide-1/hSca..
87. Characterization of the Annexin II Receptor on Marrow Stromal Cells..
88. Fibroblastic cells from periapical granuloma have the ability to mineralize..
89. Limited and Selective Localization of the Lysosomal Membrane Glycoproteins LGP85 and LGP96 in Rat Osteoclasts..
90. Biochemical Properties of the Monomeric Mutant of Human Cathepsin E Expressed in Chinese Hamster Ovary Cells: Comparison with Dimeric Forms of the Natural and Recombinant Cathepsin E..