Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Hidefumi Maeda Last modified date:2019.05.30

Professor / Oral Rehabilitation / Department of Dental Science / Faculty of Dental Science

1. Atsushi Tomokiyo, Naohisa Wada, Hidefumi Maeda, Contribution of stem cells to dental tissue regeneration; isolation, function, and application. , Frontiers in Stem Cell and Regenerative Medicine Research Vol. 2, 2016, 3-38, 2016.07.
2. Naohisa Wada, Atsushi Tomokiyo, Hidefumi Maeda, Future Perspectives in Dental Stem Cell Engineering and the Ethical Considerations. , Dental Stem Cells. , 2016.06.
3. Hidefumi Maeda, Akifumi Akamine, Quest for the development of tooth root/periodontal ligament complex by tissue engineering. , Integr Mol Med. , 1(2): 22-25, 2014. Doi: 10.15761/IMM.1000106, 2014.10, The life-span of the tooth is intimately-associated with healthiness of periodontal ligament (PDL) which is a connective tissue situated between bone and cementum that covers tooth root surface. However, once this tissue is severely damaged by deep caries, periodontitis, and trauma, this leads to severe difficulty in its regeneration, resulting in tooth loss and decreased quality of life. The development of the therapy for generation and regeneration of the periodontal tissue is an urgent issue. Therefore, researchers have tried to improve efficiently-generative and regenerative medicine using stem cells, signal molecules, and scaffolds, requisite for tissue regeneration. In recent studies, a dental follicle tissue that is composed of stem cell population potentially differentiating into PDL tissue, cementum, and alveolar bone is of current interest. More recently a revolutionary and attractive study reporting the development of bio-hybrid implant that reserved newly-formed cementum/PDL tissue complex on its surface was introduced. In this review, we describe comprehensive reports that tried to develop the cementum/PDL complex by tissue engineering and future prospects..
4. Hidefumi Maeda, Atsushi Tomokiyo, naohisa wada, Koori Katsuaki, Giichiro Kawachi, Akifumi Akamine, Regeneration of the periodontium for preservation of the damaged tooth, Hindawi Publishing Corporation, 2014.10, The population of the world grows every year, and life expectancy tends to increase. Thus, longterm preservation of teeth in aged individuals is an urgent issue. The main causes of tooth loss are well known to be periodontitis, caries, fractures, and orthodontic conditions. Although implant placement is a widely accepted treatment for tooth loss, most patients desire to preserve their own teeth. Many clinicians and researchers are therefore challenged to treat and preserve
teeth that are irreversibly affected by deep caries, periodontitis, fractures, and trauma. Tissue engineering techniques are beneficial in addressing this issue; stem
cells, signal molecules, and scaffolds are the main elements of such techniques. In this review, we describe these three elements with respect to their validation for regeneration of the periodontium and focus particularly on the potency of diverse scaffolds. In addition, we provide a short overview of the ongoing studies of 4-methacryloxyethyl trimellitate anhydride/methyl methacrylate-tri-n-butyl-borane resin including calcium chloride or hydroxyapatite for periodontium regeneration..
5. Hidefumi Maeda, naohisa wada, Atsushi Tomokiyo, Monnouchi Satoshi, Akifumi Akamine, Prospective Potency of TGF-1 on Maintenance and Regeneration of Periodontal Tissue., Elsevier Adadmic Press, 2013.06.
6. Hidefumi Maeda, Shinsuke Fujii, Atsushi Tomokiyo, Naohisa Wada and Akifumi Akamine, Potentials of periodontal ligament stem/progenitor cell lines in regeneration studies, Quintessence, 2011.12.
7. Hidefumi Maeda, Atsushi Tomokiyo, Shinsuke Fujii, Naohisa Wada and Akifumi Akamine, Promise of periodontal ligament stem cells, BioMed Central, 2011.07.