Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Yasunori AYUKAWA Last modified date:2019.04.04

Associate Professor / Division of Oral Rehabilitation / Department of Dental Science / Faculty of Dental Science

1. Tsuruta K, Ayukawa Y, Matsuzaki T, Kihara M, Koyano K., The influence of implant—abutment connection on the screw loosening and microleakage , International Journal of Implant Dentistry, 4, 11, 2018.06.
2. Mariko Urata, Shoichiro Kokabu, Takuma Matsubara, Goro Sugiyama, Chihiro Nakatomi, Hiroshi Takeuchi, Shizu Hirata-Tsuchiya, Kazuhiro Aoki, Yukihiko Tamura, Yasuko Moriyama, Yasunori Ayukawa, Miho Matsuda, Min Zhang, Kiyoshi Koyano, Chiaki Kitamura, Eijiro Jimi, A peptide that blocks the interaction of NF-κB p65 subunit with Smad4 enhances BMP2-induced osteogenesis, Journal of Cellular Physiology, 10.1002/jcp.26571, 233, 7356-7366, 2018.01.
3. Zhang H, Moriyama Y, Ayukawa Y, Rakhmatia YD, Tomita Y, Yasunami N, Koyano K., Generation and histomorphometric evaluation of a novel fluvastatin-containing poly(lactic-co-glycolic acid) membrane for guided bone regeneration, Odontology, 2018.06.
4. Kanazawa M,Atsuta I,Ayukawa Y,Yamaza T,Kondo R,Matsuura Y,Koyano K, The influence of systemically or locally administered mesenchymal stem cells on tissue repair in a rat oral implantation model, International Journal of Implant Dentistry, 4, 2, 2018.01.
5. Mieda M, Atsuta I, Morita T, Ayukawa Y, Tsukiyama Y, Sawae Y, Koyano K. , The effective design of zirconia coping on titanium base in dental implant superstructure., Dent Mater J, 2018.06.
6. Matsuzaki M, Ayukawa Y, Sakai N, Matsuzaki T, Yasuyuki Matsushita, Koyano K, A comparison of the peri-implant bone stress generated by the preload with screw tightening between 'bonded' and 'contact' model., Computer methods in biomechanics and biomedical engineering, 20, 393-402, 2016.09.
7. Hideo Shimizu, Yohei Jinno, Yasunori Ayukawa, Ikiru Atsuta, Takaaki Arahira, Mitsugu Todo, Kiyoshi Koyano, Tissue reaction to a novel bone substitute material fabricated with biodegradable polymer-calcium phosphate nanoparticle composite, Implant Dentistry, in press, 2016.10, Purpose: The aim of this study was to evaluate the effectiveness of a novel bone substitute material fabricated using a biodegradable polymer-calcium phosphate nanoparticle composite. Methods: Porous structured poly-l-lactic acid (PLLA) and hydroxyapatite (HA) nanoparticle composite, which was fabricated using solid-liquid phase separation and freeze-drying methods, was grafted into bone defects created in rat calvarium or tibia. Rats were killed 4 weeks after surgery, and histological analyses were performed to evaluate new bone formation. Results: Scanning electron microscopic observation showed the interconnecting pores within the material and the pore diameter was approximately 100 to 300 m. HA nanoparticles were observed to be embedded into the PLLA beams. In the calvarial implantation model, abundant blood vessels and fibroblastic cells were observed penetrating into pores, and in the tibia model, newly formed bone was present around and within the composite. Conclusions: The PLLA-HA nanoparticle composite bone substitute developed in this study showed biocompatibility, elasticity, and operability and thus has potential as a novel bone substitute..
8. Shinichiro Kuroshima, Masaru Kaku, Takashi Matsuura, Ikiru Atsuta, Yasunori Ayukawa, Takashi Sawase, Medication-Related Osteonecrosis of the Jaw; What Should We Do as Prosthodontists?, Journal of Prosthodontic Research, in press, 2016.10.
9. Noriyuki Yasunami, Yasunori Ayukawa, Akihiro Furuhashi, Ikiru Atsuta, Rakhmatia Yunia D, Yasuko Moriyama, Masuzaki Tomohiro, Kiyoshi Koyano, Acceleration of hard and soft tissue healing in the oral cavity by a single transmucosal injection of fluvastatin-impregnated poly (lactic-co-glycolic acid) microspheres. An in vitro and rodent in vivo study., Biomedical Materials, 11, 1, 015001, 2015.12.
10. Hideaki Tanaka, Takeshi Toyoshima, Ikiru Atsuta, Yasunori Ayukawa, Masanori Sasaki, Yasuyuki Matsushita, Ryu Hiraoka, Kiyoshi Koyano, Seiji Nakamura, Additional effects of platelet rich fibrin on bone regeneration in sinus augmentation with deproteinized bovine bone mineral: preliminary results , Implant Dentistry, 24, 6, 669-674, 2015.12.
11. Takeshi Toyoshima, Hideaki Tanaka, Yasunori Ayukawa, Miori Howashi, Masuzaki Tomohiro, Takahiro Kiyosue, Kiyoshi Koyano, Seiji Nakamura, Primary Stability of a Hybrid Implant Compared with Tapered and Cylindrical Implants in an Ex Vivo Model, Clinical Implant Dentistry andRelated Research, 10.1111/cid.12205, 17, 5, 950-956, 2015.10.
12. Wakana Oshiro, Yasunori Ayukawa, Ikiru Atsuta, Akihiro Furuhashi, Junichi Yamazoe, Ryosuke Kondo, Mami Sakaguchi, Yuri Matsuura, Yoshihiro Tsukiyama, Kiyoshi Koyano, Promoting effect of CaCl2 hydrothermal treatment to titanium implant surface for early epithelial sealing., Colloids and Surfaces B: Biointerfaces, 131, 1, 141-147, 2015.10.
13. Yasunori Ayukawa, Yumiko Suzuki, Kanji Tsuru, Kiyoshi Koyano, Kunio Ishikawa, Histological comparison in rats between carbonate apatite fabricated from gypsum and sintered hydroxyapatite on bone remodeling., Biomed Research International, 579541, 2015.07.
14. Yunia Dwi Rakhmatia, Yasunori Ayukawa, Akihiro Furuhashi, Ikiru Atsuta, Kiyoshi Koyano, Fibroblast attachment onto novel titanium mesh membranes for guided bone regeneration, Odontology, 10.1007/s10266-014-0151-8, 103, 2, 218-226, 2015.05.
15. Yunia Dwi Rakhmatia, Yasunori Ayukawa, Akihiro Furuhashi, Kiyoshi Koyano, Micro-CT and histomorphometric analyses of novel titanium mesh membranes for guided bone regeneration: A study on rat calvarial defects, International Journal of Oral and Maxillofacial Implants, 2014.12.
16. Miori Howashi, Yoshihiro Tsukiyama, Yasunori Ayukawa, Kei Isoda-Akizuki, Masafumi Kihara, Yu Imai, Motofumi Sogo, Kiyoshi Koyano, Relationship between the CT Value and Cortical Bone Thickness at Implant Recipient Sites and Primary Implant Stability with Comparison of Different Implant Types, Clinical Implant Dentistry andRelated Research, 18, 1, 107-116, 2014.11.
17. Yoichiro Ogino, Yasunori Ayukawa, Yoko TOMITA, Kiyoshi Koyano, Prosthetic aspects in adult osteoporosis, Journal of Prosthetic Dentistry, 2014.10.
18. Ikiru Atsuta, Yasunori Ayukawa, Akihiro Furuhashi, Yoichiro Ogino, Moriyama Yasuko, Yoshihiro Tsukiyama, Kiyoshi Koyano, In vivo and in vitro studies of epithelial cell behavior around titanium implants with machined and rough surface, Clinical Implant Dentistry andRelated Research, 10.1111/cid.12043, 16, 5, 772-781, 2014.10.
19. Akinari Nakagawa, Naoki Shitara, Yasunori AYUKAWA, Kiyoshi Koyano, Kenji Nishimura, Implant treatment followed by living donor lung transplant: A follow-up case report, Journal of Prosthodontic Research,, 58, 2, 127-131, 2014.04.
20. Toshio Takano, Yin-Ji Li, Akiko Kukita, Takayoshi Yamaza, Yasunori Ayukawa, Kanako Moriyama, Norihisa Uehara, Hisayuki Nomiyama, Kiyoshi Koyano, Toshio Kukita, Mesenchymal Stem Cells Markedly Suppress Inflammatory Bone Destruction in Rats with Adjuvant-Induced Arthritis, Laboratory Investigation, 94, 286-296, 2014.03.
21. Ryosuke Kondo, Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Yuri Matsuura, Akihiro Furuhashi, Yoshihiro Tsukiyama, Kiyoshi Koyano, Therapeutic Interaction of Systemically-administered Mesenchymal Stem Cells with Peri-implant Mucosa, PLoS One, 10.1371/journal.pone.0090681, 9, 3, e90681, 2014.03.
22. Koichi Yamane, Yasunori Ayukawa, Toru Takeshita, Akihiro Furuhashi, Yoshihisa Yamashita, Kiyoshi Koyano, Bacterial adhesion affinities of various implant abutment materials, Clinical Oral Implants Research, 24, 1310-1315, 2013.12.
23. Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Akihiro Furuhashi, Kiyoshi Koyano, The role of phosphoinositide 3-kinase in adhesion of oral epithelial cells to titanium, Archives of Oral Biology, 2013.11.
24. Ikiru Atsuta, Yasunori Ayukawa, Akihiro Furuhashi, Takayoshi Yamaza, Hideyuki Okwachi, Kiyoshi Koyano, Promotive effect of insulin-like growth factor-1 for epithelial sealing to titanium implants, Journal of Biomedical MAterials Research A, 101, 2896-2904, 2013.10.
25. Daisuke Kondo, YOICHIRO OGINO, Yasunori AYUKAWA, Shinji Sakai, KOEI KAWAKAMI, kiyoshi koyano, Bone regeneration of rat tibia defects with enzymatically hydrogelation of gelatin derivative and recombinant human platelet-derived growth factor-BB complex, Int J Oral Maxillofac Implants, 2013.08.
26. Akira Takahashi, Akiko Kukita, Li YinJi, Jing-qi Zhang, Hisayuki Nomiyama, Takayoshi Yamaza, Yasunori AYUKAWA, kiyoshi koyano, Toshio Kukita, Tunneling Nanotube Formation is Essential for the Regulation of Osteoclastogenesis, J Cellular Biochem, 114, 6, 1238-1247, 2013.06.
27. Akihiro Furuhashi, Yasunori AYUKAWA, ATSUTA IKIRU, Rakhmatia YD, Noriyuki Yasunami, kiyoshi koyano, Influence of titanium surface topography on peri-implant soft tissue integration, Key Engineering Materials, 529-530, 559-564, 2013.04.
28. ATSUTA IKIRU, Yasunori AYUKAWA, Takayoshi Yamaza, Akihiro Furuhashi, Ryosuke Kondo, kiyoshi koyano, Expression of Integrin alpha-3 and beta-4 subunits on the process of peri-implant epithelium formation, Key Engineering Materials, 529-530, 407-412, 2013.04.
29. Daisuke Esaki, Yasuyuki Matsushita, Yasunori AYUKAWA, NOBUO SAKAI, Yoshinori Sawae, kiyoshi koyano, Relationship between the magnitude of immediate loading and peri-implant bone strength in dogs., Clinical Oral Implants Research, 10.1111/j.1600-0501.2011.02305.x, 23, 11, 1290-1296, 2012.11.
30. Takashi Kono, Yasunori AYUKAWA, Moriyama Yasuko, Kosaku Kurata, Hiroshi Takamatsu, kiyoshi koyano, The Effect of Low-Magnitude, High-Frequency Vibration Stimuli on the Bone Healing of Rat Incisor Extraction Socket., Journal of Biomechanical Engineering, 134, 9, 091001-1-091001-6, 2012.09.
31. Koichi Yamane, Yasunori AYUKAWA, Toru Takeshita, Akihiro Furuhashi, Yoshihisa Yamashita, kiyoshi koyano, Bacterial adhesion affinities of various implant abutment materials, Clinical Oral Implants Research, 10.1111/j.1600-0501.2012.02574.x, in press, 2012.08.
32. Isoda K, Ayukawa Y, Tsukiyama Y, Sogo M, Matsushita Y, Koyano K., Relationship between the bone density estimated by cone-beam computed tomography and the primary stability of dental implants, Clinical Oral Implants Research, 10.1111/j.1600-0501.2011.02203.x, 23, 7, 832-836, 2012.07.
33. Okawachi H, Ayukawa Y, Atsuta I, Furuhashi A, Sakaguchi M, Yamane K, Koyano K., Effect of titanium surface calcium and magnesium on adhesive activity of epithelial-like cells and fibroblasts, Biointerphases, 10.1007/s13758-012-0027-9, 7, 27, 2012.04.
34. Atsuta I, Ayukawa Y,Ogino Y, Moriyama Y, Koyano K., Evaluations of epithelial sealing and peri-implant epithelial down-growth around “step-type” implants, Clinical Oral Implants Research, 10.1111/j.1600-0501.2011.02163.x, 23, 4, 459-466, 2012.04.
35. Akihiro Furuhashi, Yasunori AYUKAWA, ATSUTA IKIRU, Hideyuki Okawachi, kiyoshi koyano, The difference of fibroblast behavior on titanium substrata with different surface characteristics, Odontology, 100, 2, 199-205, 2012.04.
36. Zhang L, Ayukawa Y, LeGeros RZ, Matsuya S, Koyano, K, Ishikawa K., Tissue-response to calcium-bonded titanium surface., Journal of Biomedical Materials Research , 95A, 1, 33-39, 2010.05.
37. Moriyama Y, Ayukawa Y, Ogino Y, Atsuta I, Todo M, Takao Y, Koyano K., Local application of fluvastatin improves peri-implant bone quantity and mechanical property. A rodent study., Acta Biomaterialia, 6, 4, 1610-1618, 2010.04.
38. Masuzaki T, Ayukawa Y, Moriyama Y, Jinno Y, Atsuta I, Ogino Y, Koyano K., The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia., Biomaterials, 31, 12, 3327-3334, 2010.04.
39. Ayukawa Y, Ogino Y, Moriyama Y, Atsuta I, Jinno Y, Kihara M, Tsukiyama Y, Koyano K., Simvastatin enhances bone formation around titanium implants in rat tibiae., Journal of Oral Rehabilitation, 37, 2, 123-130, 2009.11.
40. Moriyama Y, Ayukawa Y, Kabemura K, Matsushita Y, Kihara M, Tsukiyama Y, Todo M, Takao Y, Koyano K., The alteration of peri-implant bone response exposed to static lateral load, Journal of Biomechanical Science and Engineering, 4, 3, 326-335, 2009.07.
41. Jinno Y, Ayukawa Y, Ogino Y, Atsuta I, Tsukiyama Y, Koyano K., Vertical bone augmentation with fluvastatin in an injectable delivery system: a rat study. , Clinical Oral Implants Research, 20, 8, 756-760, 2009.05.
42. Ogino Y, Ayukawa Y, Kukita T, Atsuta I, Koyano K., Platelet-rich plasma suppresses osteoclastogenesis by promoting the secretion of osteoprotegerin in vitro., Journal of Periodontal Research, 44, 2, 217-224, 2009.04.
43. Ayukawa Y, Yasukawa E, Moriyama Y, Ogino Y, Wada H, Atsuta I, Koyano K., Local application of statin promoted bone repair through the suppression of osteoclasts and the enhancement of osteoblasts at bone-healing sites in rats. , Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 107, 3, 336-342, 2009.03.
44. Moriyama Y, Ayukawa Y, Ogino Y, Atsuta I, Koyano K., Topical application of statin affects the bone healing around implants, Clinical Oral Implants Research, 19, 6, 600-605, 2008.05.
45. Ogino Y, Ayukawa, Y, Kukita T, Koyano K., The contribution of platelet-derived growth factor, transforming growth factor-beta1 and insulin-like growth factor-I in platelet-rich plasma (PRP) to the proliferation of osteoblast-like cells., Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 101:724-729, 2006.06.
46. Ogino Y, Ayukawa, Y, Tsukiyama Y, Koyano K., The effect of platelet-rich plasma on the cellular response of rat bone marrow cells in vitro., Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 10.1016/j.tripleo.2005.03.007, 100, 3, 302-307, 100:302-307, 2005.09.
47. Okamura A, Ayukawa Y, Iyama S, Koyano K, Effect of the difference of bone turnover on peri-titanium implant osteogenesis in ovariectomized rats, Journal of Biomedical Materials Research, 10.1002/jbm.a.30110, 70A, 3, 497-505, 70A: 497-505, 2004.07.
48. Ayukawa Y, Okamura A, Koyano K, Simvastatin promotes osteogenesis around titanium implants. A histological and histometrical study in rats, Clinical Oral Implants Research, 10.1111/j.1600-0501.2004.01015.x, 15, 3, 346-350, 15(3):346-350, 2004.06.
49. H. Ikeda, T. Yamaza, M. Yoshinari, Y. Ohsaki, Y. Ayukawa, M.A. Kido, T. Inoue, M. Shimono, K. Koyano, T. Tanaka, Ultrastructural and immunoelectron microscopic studies of the peri-implant epitherium-implant (Ti-6Al-4V) interface of rat maxilla, J Periodontol, 10.1902/jop.2000.71.6.961, 71, 6, 961-973, Vol.71,pp.961-973, 2000.01.
50. Y. Ayukawa, F. Takeshita, T. Inoue, M. Yoshinari, M. Shimono, T. Suetsugu, T. Tanaka, An immunmoelectron microscopic localization of noncollagenous bone proteins (osteocalcin and osteopontin) at the bone-titanium interface, J Biomed Mater Res, 10.1002/(SICI)1097-4636(199807)41:1<111::AID-JBM14>3.0.CO;2-Q, 41, 1, 111-119, Vol.41,pp.111-119, 1998.01.
51. F. Takeshita, K. Murai, S. Iyama, Y. Ayukawa, T. Suetsugu, Uncontrolled diabetes hinders bone formation around titanium implants in rat tibiae, A study using light, fluorescence microscopies and image processing, J Periodontol, 69, 3, 314-320, Vol.69,pp.314-320, 1998.01.
52. Y. Ayukawa, F. Takeshita, M. Yoshinari, T. Inoue, Y. Ohtsuka, M. Shimono, T. Suetsugu, T. Tanaka, An immunocytochemical study for lysosomal cathepsins B and D related to the intracellular degradation of titanium at the bone-titanium interface, J Periodontol, 69, 1, 62-68, Vol.69,pp.62-68, 1998.01.
53. F. Takeshita, Y. Ayukawa, K. Murai, T. Suetsugu, Long-term evaluation of bone-titanium interface in rat tibiae using light microscopy, transmission electron microscopy and image processing, J Biomed Mater Res, 10.1002/(SICI)1097-4636(199711)37:2<235::AID-JBM13>3.0.CO;2-D, 37, 2, 235-242, Vol.37,pp.235-242, 1997.01.
54. F. Takeshita, K. Murai, Y. Ayukawa, T. Suetsugu, Effects of aging on titanium implants inserted into the tibiae of rats using light microscopy, SEM, and image processing,, J Biomed Mater Res, 34, 1, 1-8, Vol.34,pp.1-8, 1997.01.
55. S. Iyama, F. Takeshita, Y. Ayukawa, M. A. Kido, T. Suetsugu, T. Tanaka, A study of regional distribution of bone formed around hydroxyapatite implants in the tibiae of streptozotocin-induced diabetic rats using multiple fluorescent labeling and confocal laser scanning microscopy, J Periodontol, Vol.68,pp.1169-1175, 1997.01.
56. F. Takeshita, Y. Ayukawa, S. Iyama, T. Suetsugu, M. Oishi, Histological comparison of early wound healing following dense HA granule grafting and barrier placement in surgically-created bone defects neighboring implants, J Periodontol, 68, 10, 924-932, Vol.68,pp.924-932, 1997.01.
57. F. Takeshita, H. Takata, Y. Ayukawa, T. Suetsugu, Histomorphometric analysis of the response of rat tibiae to shape memory alloy (nitinol), Biomaterials, 10.1016/S0142-9612(96)00051-8, 18, 1, 21-25, Vol.18,pp.21-25, 1997.01.
58. Y. Ayukawa, F. Takeshita, T. Inoue, M. Yoshinari, Y. Ohtsuka, K. Murai, M. Shimono, T. Suetsugu, T. Tanaka, An ultrastructural study of the bone-titanium interface using pure titanium plastic and pure titanium rod implants, Acta Histochem Cytochem, 29, 3, 243-254, Vol.29,pp.243-254, 1996.01.
59. F. Takeshita, Y. Ayukawa, S. Iyama, T. Suetsugu, M. A. Kido, A histologic evaluation of retrieved hydroxyapatite-coated blade form implants using scanning electron, light, and confocal laser scanning microscopies, J Periodontol, 67, 10, 1034-1040, Vol.67,pp.1034-1040, 1996.01.
60. F. Takeshita, Y. Matsushita, Y. Ayukawa, T. Suetsugu, Fractures of hydroxyapatite-coated blade implants connected with natural teeth. A histological study using SEM, light microscopy, and an image processing system, J Periodontol, 67, 2, 86-92, Vol.67,pp.86-92, 1996.01.
61. K. Murai, F. Takeshita, Y. Ayukawa, T. Kiyoshima, T. Suetsugu, T. Tanaka, Light and electron microscopic studies of bone-titanium interface in the tibiae of young and mature rats, J Biomed Mater Res, 10.1002/(SICI)1097-4636(199604)30:4<523::AID-JBM11>3.0.CO;2-I, 30, 4, 523-533, Vol.30,pp.523-533, 1996.01.