Kyushu University Academic Staff Educational and Research Activities Database
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Noriatsu Shigemura Last modified date:2018.06.28

Professor / Oral Biological Sciences
Department of Dental Science
Faculty of Dental Science

Graduate School
Undergraduate School
Other Organization

laboratory of taste perception .
Research and Development Center for Taste and Odor Sensing, Kyushu University .
Academic Degree
Field of Specialization
Oral Neuroscience
Research Interests
  • Molecular and neural mechanisms of taste perception
    keyword : Taste, Taste disorder, Life style diseases, Gene, SNP, human, mouse
    2000.04analysis of molecular and neural mechanisms of taste in both mouse and human.
Academic Activities
1. Shigemura N, Taste Sensing Systems Influencing Metabolic Consequences., Current Oral Health Reports, 4(2), 79-86, 2017.06.
1. Noriatsu Shigemura, Yuzo Ninomiya, Recent Advances in Molecular Mechanisms of Taste Signaling and Modifying., Int Rev Cell Mol Biol., 323, 71-106, 2016.02.
2. Noriatsu Shigemura, Modulation of Taste Responsiveness by Angiotensin II., Food Science and Technology Research, 21 , 6, 757-764, 2015.06.
3. Noriatsu Shigemura, Angiotensin II and taste sensitivity., Japanese Dental Science Review, 51, 2, 51-8, 2015.05.
4. Noriatsu Shigemura, Shusuke Iwata, Keiko Yasumatsu, Tadahiro Ohkuri, Nao Horio, Keisuke Sanematsu, Ryusuke Yoshida, Robert F Margolskee, Yuzo Ninomiya, Angiotensin II modulates salty and sweet taste sensitivities., J Neurosci., 33, 15, 6267-6277, 2013.04, アンジオテンシンIIは、視床下部、副腎や血管などに発現するAT1受容体を介して、血圧や体内Na+濃度を調節する鍵ホルモンとして知られている。我々は、このアンジオテンシンIIが末梢の味覚器にも働き、塩味感受性を低下させ NaCl溶液の摂取量を増加させること、さらに甘味感受性を増強することで糖分摂取にも影響することを明らかにした。この“味覚を介したNa+/糖ホメオスタシス維持機構”のさらなる解明は、高血圧や肥満・糖尿病などの生活習慣病に対する新たな予防・治療法の開発”に繋がることが期待される。.
5. Shigemura N, Shirosaki S, Sanematsu K, Yoshida R, Ninomiya Y., Genetic and molecular basis of individual differences in human umami taste perception., PLoS One., 4(8):e6717., 2009.08.
6. Shigemura N, Shirosaki S, Ohkuri T, Sanematsu K, Islam AA, Ogiwara Y, Kawai M, Yoshida R, Ninomiya Y., Variation in umami perception and in candidate genes for the umami receptor in mice and humans.
, Am J Clin Nutr. , 90(3):764S-769S., 2009.09.
7. Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, Nikolaev VO, Lohse MJ, Shigemura N, Ninomiya Y, Kojima I., Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion., PLoS One., 4(4):e5106, 2009.04.
8. Nakamura Y, Sanematsu K, Ohta R, Shirosaki S, Koyano K, Nonaka K, Shigemura N, Ninomiya Y., Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels., Diabetes. , 57(10):2661-5., 2008.10.
9. Shigemura, N., Nakao, K., Yasuo, T., Murata, Y., Yasumatsu, K., Nakashima, A., Katsukawa, H., Sako, N., Ninomiya, Y. , Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin. , Biochem. Biophys. Res. Commun., 367, 356-363 , 2008.03.
10. Shigemura, N., Ohkuri, T., Sadamitsu, C., Yasumatsu, K., Yoshida, R., Beauchamp, G.K., Bachmanov, A.A., Ninomiya, Y. , Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC α subunit in mice., Am. J. Physiol. Regul Integr. Comp. Physiol., 294, R66-R75 , 2008.01.
11. Talavera K, Yasumatsu K, Voet T, Droogmans G, Shigemura N, Ninomiya Y, Margolskee RF, Nilius B., Heat-activation of the taste channel TRPM5 underlies thermal sensitivity to sweet., Nature, 438(7070):1022-5, 2005.12.
12. Shigemura N, Islam AA, Sadamitsu C, Yoshida R, Yasumatsu K, Ninomiya Y., Expression of amiloride-sensitive epithelial sodium channels in mouse taste cells after chorda tympani nerve crush., Chemical Senses, 10.1093/chemse/bji046, 30, 6, 531-538, 30(6):531-8, 2005.07.
13. Shigemura, N., Yasumatsu, K., Yoshida, R., Sako, N., Katsukawa, H., Nakashima K., Imoto, T., Ninomiya, Y., The role of the dpa locus in mice. Jan;30 (2005), Chemical Senses, 10.1093/chemse/bjh125, 30, I84-i85, Suppl 1:i84-i85, 2005.01.
14. Shigemura N, Ohta R, Kusakabe Y, Miura H, Hino A, Koyano K, Nakashima K, Ninomiya Y., Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures., Endocrinology, 10.1210/en.2003-0602, 145, 2, 839-847, 2003.10.
15. Shigemura N, Miura H, Kusakabe Y, Hino A, Ninomiya Y., Expression of leptin receptor (Ob-R) isoforms and signal transducers and activators of transcription (STATs) mRNAs in the mouse taste buds., Arch Histol Cytol., 10.1679/aohc.66.253, 66, 3, 253-260, 66(3):253-60., 2003.08.
16. Ninomiya, Y., Shigemura, N., Yasumatsu, K., Ohta, R., Sugimoto, K., Nakashima, K. and Lindemann, B., Leptin and sweet taste., Vitam. Horm., 10.1016/S0083-6729(02)64007-5, 64, 221-248, 64: 221-247, 2002.05.
1. Noriatsu Shigemura, Ryusuke Yoshida, Keiko Yasumatsu, Tadahiro Ohkuri, Shusuke Iwata, Shingo Takai, Masafumi Jyotaki, Mayu Niki, Keisuke Sanematsu, Yuzo Ninomiya, Hormonal modulation of salty and sweet taste sensitivities., The 91st Annual Meeting of the Physiology Society of Japan, 2014.03, 血圧を調節する鍵ホルモンであるアンジオテンシンIIは、中枢性に作用して塩分嗜好性を増強するのみならず、末梢の味覚器にも働き、塩味感受性を低下させ NaCl溶液の摂取量を増加させること、さらに甘味感受性を増強することで糖分摂取増加させることを明らかにした。また摂食調節因子であるレプチンと内因性カンナビノイドは中枢性に拮抗的に働くだけでなく、味覚器にも作用し、甘味感受性を拮抗的に調節することで、エネルギー摂取量を制御していることを明らかにした。以上のことから、新たなホルモンを介した脳-味覚連関による合目的な体内栄養維持機構が存在する可能性が示唆された。.
2. Noriatsu Shigemura, Taste perception and food intake, 86th Annual meeting of the Japanese Pharmalogical Society, 2013.03, Information derived from taste receptor cells, such as sweet, bitter, salty, sour and umami is important for evaluating the quality of food components. Modulation of the gustatory information influences food preference and intake. Even so, the molecular mechanisms for modulating taste sensitivity are poorly understood. Our recent studies have demonstrated that sweet and salty taste sensitivities are affected by hormones. Angiotensin II (AngII), which plays important roles in the maintenance of sodium homeostasis by acting on AngII type 1 receptor in various organs including brain and kidney, modulates peripheral salt and sweet taste sensitivities, and this modulation influences ingestive behavior in mice. Leptin (an anorexigenic mediator) and endocannabinoids (orexigenic mediators), which reciprocally regulate food intake via central nervous systems, modulate palatability of foods by altering sweet taste responses. Thus peripheral modulations of taste information by these hormones critically influence food intake, and may play important roles in regulating sodium and energy homeostasis. Understanding basic principles about these taste modulations may lead us to design novel strategies to maintain and improve the quality of life in patients with medical treatment..
3. The dpa locus may influence behavioral and neural responses to umami

Noriatsu Shigemura1, Keiko Yasumatsu1,2 , Yuriko Kawato1,2 , and Yuzo Ninomiya 1,2
(1 Sect. of Oral Neurosci., Grad. Sch. of Dent. Sci., Kyushu Univ., 2 BRAIN).
4. Behavioral and molecular analyses in the dpa
(D-phenylalanine sensitivity) congenic strain

Shigemura Noriatsu1, Kawato Yuriko1, Furuta Hiroki2, Yoshida
Ryusuke2, and Ninomiya Yuzo2

1Sect. Oral Neurosci., Grad. Sch. Dental Sci., Kyushu Univ., Fukuoka,
Japan, 2Bio-oriented Tech. Res. Adv. Ins. (BRAIN), Saitama, Japan;
Other Educational Activities
  • 2018.05.
  • 2017.05.