Kyushu University Academic Staff Educational and Research Activities Database
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YUJI ISHII Last modified date:2019.06.20

Associate Professor / Department of Medico-Pharmaceutical Sciences
Department of Pharmaceutical Health Care and Sciences
Faculty of Pharmaceutical Sciences


Undergraduate School


Homepage
http://www.phar.kyushu-u.ac.jp
Academic Degree
Ph. D. (Doctor of Pharmaceutical Sciences)
Country of degree conferring institution (Overseas)
No
Field of Specialization
Drug Metabolism, Environmental Toxicology
Total Priod of education and research career in the foreign country
01years03months
Outline Activities
I'm belonging to the laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Science. My current research field involves drug metabolism and environmental pharmaceutical science. I cover two lectures for master qualification and six lectures for bachelor. My current students for research in our laboratory are one (2nd year) and three (1st year) students for Ph.D. course; one research student; two (2nd year) and two (1st year) students for master qualification; two (4th year) students for Bachelor of Pharmaceutical Sciences; one (6th year), and three (4th year) students for Bachelor of Clinical Pharmaceutics. I also cover six lecture subjects for Safety Education, Biochemistry and Molecular Biology III, IV, Society and Health, Hygienic Chemistry, and Toxicology (including food hygienic and drug metabolism). I'm involved in a lecture with experiment for bachelor.
Research
Research Interests
  • Drug metabolizing enzyme complex
    keyword : cytochrome P450; UDP-glucuronosyltransferase; glucuronidation
    2003.04.
  • Mechanism of the toxicity caused by dioxins
    keyword : dioxins; polychrolinated biphenyl; Yusho
    2003.04.
Academic Activities
Books
1. Amit V. Pandey, Colin J. Henderson, Yuji Ishii, Michel Kranendonk, Wayne L. Backes, Ulrich M. Zanger, Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, Frontiers Media SA, 2018.01, [URL].
2. YUJI ISHII, Yuu Miyauchi, Hideyuki Yamada, Chapter 18: Cytochrome P450-Dependent Change in UDP-Glucuronosyltransferase Function and Its Reverse Regulation
in
"Fifty Years of Cytochrome P450 Research"
, Springer Japan, 2014.06.
Reports
1. ISHII YUJI, Arief Nurrochmad, Yamada, H., Modulation of UDP-glucuronosyltransferase activity by endogenous compounds, Drug Metabolism and Pharmacokinetics, 2010.04, [URL].
2. ISHII YUJI, Shuso Takeda, Yamada, H., Modulation of UDP-glucuronosyltransferase activity by protein-protein association, Drug Metabolism Reviews, 2010.01, [URL].
Papers
1. Yuu Miyauchi, Sora Kimura, Akane Kimura, Ken-ichi Kurohara, Yuko Hirota, Keiko Fujimoto, Peter I. Mackenzie, Yoshitaka Tanaka, YUJI ISHII, Investigation of the Endoplasmic Reticulum Localization of UDP-Glucuronosyltransferase 2B7 with Systematic Deletion Mutants., Mol. Pharmacol., doi: 10.1124/mol.118.113902, 95, 5, 551-562 (2019), 2019.04.
2. Masahiro Yahata, Yuji Ishii, Tetsuya Nakagawa, Takao Watanabe, Kiyoko Bando, Species differences in metabolism of a new antiepileptic drug candidate, DSP-0565 [2-(2'-fluoro[1,1'-biphenyl]-2-yl)acetamide]., Biopharm. Drug Dispos.,, doi: 10.1002/bdd.2180, in press., 2019.03.
3. Kenji Takeuchi, Chie Yokouchi, Hirohiko Goto, Ken Umehara, Hideyuki Yamada, YUJI ISHII, Alleviation of fatty liver in a rat model by enhancing N(1)-methylnicotinamide bioavailability through aldehyde oxidase inhibition., Biochem. Biophys. Res. Commun., pii: S0006-291X(18)32406-9. doi: 10.1016/j.bbrc.2018.11.008., 507, 1-4, 203-210, 2018.11.
4. Yukiko Hattori, Tomoki Takeda, Arisa Nakamura, Kyoko Nishida, Yuko Shioji, Haruki Fukumitsu, Hideyuki Yamada, YUJI ISHII, The aryl hydrocarbon receptor is indispensable for dioxin-induced defects in sexually-dimorphic behaviors due to the reduction in fetal steroidogenesis of the pituitary-gonadal axis in rats, Biochemical Pharmacology, https://doi.org/10.1016/j.bcp.2018.05.008, 154, 213-221, (2018), 2018.05.
5. Tomoki Takeda, Yukiko Komiya, Takayuki Koga, Ishida Takumi, YUJI ISHII, Yasushi Kikuta, Nakaya Michio, Hitoshi Kurose, Takehiko Yokomizo, Takao Shimizu, Uchi Hiroshi, Masutaka Furue, Hideyuki Yamada, Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration, J Biol Chem, 10.1074/jbc.M116.764332, 292, 10586, 10586-10599, (2017), 2017.05.
6. Ayumi Kurita, Yuu Miyauchi, Shin'ichi Ikushiro, Peter I. Mackenzie, Hideyuki Yamada, YUJI ISHII, Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation, J. Pharmacol. Exp. Ther., https://doi.org/10.1124/jpet.117.240382, 361, 2, 199-208, 2017.02.
7. Tatsuro Nakamura, Naho Yamaguchi, Yuu Miyauchi, Tomoki Takeda, Yasushi Yamazoe, Kiyoshi Nagata, Peter I. Mackenzie, Hideyuki Yamada, YUJI ISHII, Introduction of an N-glycosylation site into UDP-glucuronosyltransferase 2B3 alters its sensitivity to cytochrome P450 3A1-dependent modulation., Front. Pharmacol., doi: 10.3389/fphar.2016.00427, 7, 427, 2016.10.
8. Ren-Shi Li, Tomoki Takeda, Takashi Ohshima, Hideyuki Yamada, YUJI ISHII, Metabolomic profiling of brain tissues of mouse chronically exposed to heroin., Drug Metab. Pharmacokinet., 10.1016/j.dmpk.2016.10.410, 32, 1, 108-111, (2017), 2016.10.
9. Tomoki Takeda, Yuki Matsuo, Kyoko Nishida, Akihisa Fujiki, Yukiko Hattori, Takayuki Koga, YUJI ISHII, Hideyuki Yamada, α-Lipoic acid potentially targets AMP-activated protein kinase and energy production in the fetal brain to ameliorate dioxin-produced attenuation in fetal steroidogenesis., J. Toxicol. Sci, 10.2131/jts.42.13., 42, 1, 13-23, 2016.10.
10. Yuu Miyauchi, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada, YUJI ISHII, Suppression of cytochrome P450 3A4 function by UDP-glucuronosyltransferase (UGT) 2B7 through a protein-protein interaction: Cooperative roles of the cytosolic carboxyl-terminal domain and the luminal anchoring region of UGT2B7., Mol. Pharmacol., 88, 800-812, 2015.08.
11. Junki Taura, Tomoki Takeda, Misaki Fujii, Yukiko Hattori, YUJI ISHII, Hiroaki Kuroki, Kiyomi Tsukimori, Uchi Hiroshi, Masutaka Furue, Hideyuki Yamada, 2,3,4,7,8-Pentachlorodibenzofuran is far less potent than 2,3,7,8-tetrachlorodibenzo-p-dioxin in disrupting the pituitary-gonad axis of the rat fetus. , Toxicol. Appl. Pharmacol., doi: 10.1016/j.taap.2014.09.001, 281, 1, 48-57, 2014.09.
12. Tomoki Takeda, Junki Taura, Yukiko Hattori, YUJI ISHII, Hideyuki Yamada, Dioxin-induced retardation of development through a reduction in the expression of pituitary hormones and possible involvement of an aryl hydrocarbon receptor in this defect: a comparative study using two strains of mice with different sensitivities to dioxin., Toxicol. Appl. Pharmacol., doi: 10.1016/j.taap.2014.04.022., 278, 3, 220-229, 2014.08.
13. Tomoki Takeda, Misaki Fujii, Yukiko Hattori, Midori Yamamoto, Takao Shimazoe, YUJI ISHII, Masaru Himeno, Hideyuki Yamada, Maternal Exposure to Dioxin Imprints Sexual Immaturity of the
Pups through Fixing the Status of the Reduced Expression of
Hypothalamic Gonadotropin-Releasing Hormone, Mol Pharmacol, http://dx.doi.org/10.1124/mol.113.088575, 85, 1, 74-82, 2014.01.
14. YUJI ISHII, Hiroki Koba, Kousuke Kinoshita, Toshiya Oizaki, Yuki Iwamoto, Shuso Takeda, Yuu Miyauchi, Yoshio Nishimura, Natsuki Egoshi, Futoshi Taura, Satoshi Morimoto, Shin'ichi Ikushiro, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada, Alteration of the Function of the UDP-Glucuronosyltransferase 1A Subfamily by Cytochrome P450 3A4: Different Susceptibility for UGT Isoforms and UGT1A1/7 Variants, Drug Metabolism and Disposition, doi:10.1124/dmd.113.054833, 2013.11.
15. YUJI ISHII, Kie An, Yoshio Nishimura, Hideyuki Yamada, ATP Serves as an Endogenous Inhibitor of UDP-Glucuronosyltransferase (UGT): A New Insight into the 'Latency' of UGT, Drug Metabolism and Disposition, doi:10.1124/dmd.112.046862, 40, (11), 2081-2089, 2012.11.
16. YUJI ISHII, Naoko Iida, Yuu Miyauchi, Hideyuki Yamada, Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols, Biological & Pharmaceutical Bulletin, 35, 10, 1811-1817, 2012.10.
17. Takeda T, Fujii M, Taura J, Ishii Y, Yamada H. , Dioxin Silences Gonadotropin Expression in Perinatal Pup by Inducing Histone Deacetylase: a New Insight into the Mechanism for the Imprinting of Sexual Immaturity by Dioxin., J. Biol. Chem., 287, 18440-18450, 2012.04.
18. Takeda S, Ishii Y, Iwanaga M, Nurrochmad A, Ito Y, Mackenzie PI, Nagata K, Yamazoe Y, Oguri K, Yamada H. , Interaction of Cytochrome P450 3A4 and UDP-Glucuronosyltransferase 2B7: Evidence for Protein-Protein Association and Possible Involvement of CYP3A4 J-Helix in the Interaction. , Molecular Pharmacology, 75(4); 956-964. , 2009.04.
19. YUJI ISHII, Megumi Iwanaga, Yoshio Nishimura, Shuso Takeda, Shin'ichi Ikushiro, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Yamada, H., Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): Evidence for the functionally active UGT in P450-UGT complex., Drug Metabolism and Pharmacokinetics, http://doi.org/10.2133/dmpk.22.367, 22, 5, 367-376, 2007.10, [URL].
20. Nishimura Y, Maeda S, Ikushiro, S., Mackenzie PI, Ishii Y, and Yamada, H., , Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: structure-effect relationships and evidence for an allosteric mechanism. , Biochim. Biophys. Acta, 1770(11):1557-1566. , 2007.10.
21. Takeda S, Kitajima Y, Ishii Y, Mackenzie PI, Oguri K, Yamada H, Inhibition of UDP-Glucuronosyltransferase 2B7-Catalyzed Morphine Glucuronidation by Ketoconazole: Dual mechanisms involving A novel non-competitive mode, Drug Metabolism and Disposition, 34(8): 1277-1282, 2006.05.
22. Okamura K, Ishii Y, Ikushiro S, Mackenzie PI, Yamada H, Fatty acyl-CoA as an endogenous activator of UDP-glucuronosyltransferases, Biochemical and Biophysical Research Communications, 345: 1649-1656., 2006.05.
23. Mutoh J, Taketoh J, Okamura K, Kagawa T, Ishida T, Ishii Y, Yamada H, Fetal Pituitary Gonadotropin as an Initial Target of Dioxin in Its Impairment of Cholesterol Transportation and Steroidogenesis in Rats, Endocrinology, 147: 927-936., 2006.02.
24. Takeda S, Ishii Y, Mackenzie PI, Nagata K, Yamazoe Y, Oguri K, Yamada H, Modulation of UDP-Glucuronosyltransferase 2B7 Function by Cytochrome P450s In Vitro: Differential Effects of CYP1A2, CYP2C9 and CYP3A4., Biological and Pharmaceutical Bulletin, 10.1248/bpb.28.2026, 28, 10, 2026-2027, 28: 2026-2027, 2005.10.
25. Ishii Y, Akazawa D, Aoki Y, Yamada H, Oguri K, Suppression of carbonic anhydrase III mRNA level by an arylhydrocarbon receptor ligand in primary cultured hepatocytes of rat., Biological and Pharmaceutical Bulletin, 10.1248/bpb.28.1087, 28, 6, 1087-1090, 28: 1087 - 1090., 2005.07.
26. Ishida T, Kan-o S, Mutoh J, Takeda S, Ishii Y, Hashiguchi I, Akamine A, Yamada H, 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced change in intestinal function and pathology: evidence for the involvement of arylhydrocarbon receptor-mediated alteration of glucose transportation., Toxicology and Applied Pharmacology, 10.1016/j.taap.2004.09.014, 205, 1, 89-97, 205: 89 - 97., 2005.07.
27. Takeda S, Ishii Y, Iwanaga M, Mackenzie PI, Nagata K, Yamazoe Y, Oguri K, Yamada H, Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4, Molecular Pharmacology, 10.1124/mol.104.007641, 67, 3, 665-672, 67(3): 665-672., 2005.03.
28. Ishii Y, Miyoshi A, Maji D, Yamada H, Oguri K, Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UGT2B21-catalyzed chloramphenicol glucuronidation, Drug Metabolism and Disposition, 10.1124/dmd.32.10., 32, 10, 1057-1060, 32(10): 1057-1060, 2004.10.
29. Ishii Y, Kato H, Hatsumura M, Ishida T, Ariyoshi N, Yamada H and Oguri K, Role of the dioxin-like toxic compound coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl in reducing hepatic alcohol dehydrogenase levels in rats in vivo. , Journal of Health Science, 10.1248/jhs.47.575, 47, 6, 575-578, 2001.12.
30. Ishii, Y; Miyoshi, A; Watanabe, R; Tsuruda, K; Tsuda, M; Yamaguchi-Nagamatsu, Y; Yoshisue, K; Tanaka, M; Maji, D; Ohgiya, S; Oguri, K, Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation, Molecular Pharmacology, 60, 5, 1040-1048, 2001.11.
Educational
Educational Activities
I'm belonging to the laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Science. My current research field involves drug metabolism and environmental pharmaceutical science. I cover two lectures for master qualification and six lectures for bachelor. My current students for research in our laboratory are one (2nd year) and three (1st year) students for Ph.D. course; one research student; two (2nd year) and two (1st year) students for master qualification; two (4th year) students for Bachelor of Pharmaceutical Sciences; one (6th year) and three (4th year) students for Bachelor of Clinical Pharmaceutics. I also cover six lecture subjects for Safety Education, Biochemistry and Molecular Biology III, IV, Society and Health, Hygienic Chemistry, and Toxicology (including food hygienic and drug metabolism). I'm involved in a lecture with experiment for bachelor.
Social
Professional and Outreach Activities
No remark.