Kyushu University Academic Staff Educational and Research Activities Database
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Kenji Hamase Last modified date:2017.08.16

Graduate School
Undergraduate School

Academic Degree
Field of Specialization
Drug Discovery and Evolution
Research Interests
  • Chiral amino acid metabolomics studies and clinical applications
    keyword : Chiral amino acids, Clinical metabolomics
  • Determination of D-amino acids in mammals and the study of their functions
    keyword : D-amino acids
  • Sensitive determination of hormones
    keyword : Sensitive determination
  • Development of novel functional reagents
    keyword : functional reagents
Academic Activities
1. Akiko MORIKAWA, Kenji HAMASE, Tomohiro OHGUSU, Sachise ETOH, Hiroyuki TANAKA, Ichiro KOSHIISHI, Yukihiro SHOYAMA and Kiyoshi ZAITSU, Immunohistochemical localization of D-alanine to β-cells in rat pancreas, Biochemical and Biophysical Research Communications, 355, 872-876, 2007.04.
2. Kenji HAMASE, Akiko MORIKAWA, Tomohiro OHGUSU, Wolfgang LINDNER and Kiyoshi ZAITSU, Comprehensive analysis of branched aliphatic D-amino acids in mammals using an integrated multi-loop two-dimensional column-switching high-performance liquid chromatographic system combining reversed-phase and enantioselective columns, Journal of Chromatography A, 1143, 105-111, 2007.03.
3. Kenji HAMASE, Sayaka TAKAGI, Akiko MORIKAWA, Ryuichi KONNO, Akira NIWA, and Kiyoshi ZAITSU, Presence and origin of large amounts of D-proline in the urine of mutant mice lacking D-amino acid oxidase activity, Analytical and Bioanalytical Chemistry, 386, 705-711, 2006.10.
4. Junzo HIRANO, Kenji HAMASE, Hiroko FUKUDA, Tatsunosuke TOMITA and Kiyoshi ZAITSU, Novel stable fluorophore, 6-methoxy-4-quinolone, with strong fluorescence in wide pH range of aqueous media, and its application as a fluorescent labeling reagent, Journal of Chromatography A, 1059, 1-2, 1059, 225-231, 2004.12.
5. Kenji HAMASE, Junzo HIRANO, Yuki KOSAI, Tatsunosuke TOMITA and Kiyoshi ZAITSU, A Sensitive Internal Standard Method for the Determination of Melatonin in Mammals using Precolumn Oxidation Reversed-Phase High-Performance Liquid Chromatography, Journal of Chromatography B, 811, 2, 811, 237-241, 2004.11.
6. Hua ZHAO, Kenji HAMASE, Akiko MORIKAWA, Zongyin Qiu and Kiyoshi ZAITSU, Determination of D- and L-Enantiomers of Threonine and allo-Threonine in Mammals using Two-Step High-Performance Liquid Chromatography, Journal of Chromatography B, 810, 2, 810, 245-250, 2004.10.
7. Junzo HIRANO, Kenji HAMASE, Takeyuki AKITA and Kiyoshi ZAITSU, Crystal Structure of N-[(6-Methoxy-4-oxo-1,4-dihydroquinolin-3-yl)methyl]-2,2-dimethylpropanamide, Analytical Sciences, 20, x115-x116, 2004.09.
8. Koji YAMAMOTO, Kenji HAMASE and Kiyoshi ZAITSU, 2-Amino-3-phenylpyrazine, a Sensitive Fluorescence Prelabeling Reagent for the Chromatographic or Electrophoretic Determination of Saccharides, Journal of Chromatography A, 1004, 1-2, 1004, 99-106, 2003.07.
9. Tatsunosuke TOMITA, Kenji HAMASE, Hiromi HAYASHI, Hiroko FUKUDA, Junzo HIRANO and Kiyoshi ZAITSU, Determination of Endogenous Melatonin in the Individual Pineal Glands of Inbred Mice using Precolumn Oxidation Reversed-Phase Micro-High-Performance Liquid Chromatography, Analytical Biochemistry, 316, 2, 316, 154-161, 2003.05.
10. Akiko MORIKAWA, Kenji HAMASE and Kiyoshi ZAITSU, Determination of D-Alanine in the Rat Central Nervous System and Periphery using Column-Switching High-Performance Liquid Chromatography, Analytical Biochemistry, 312, 1, 312, 66-72, 2003.01.
11. Kenji HAMASE, Tomomi INOUE, Akiko MORIKAWA, Ryuichi KONNO and Kiyoshi ZAITSU, Determination of Free D-Proline and D-Leucine in the Brains of Mutant Mice Lacking D-Amino-Acid Oxidase Activity, Analytical Biochemistry, 298, 2, 298, 253-258, 2001.11.
12. Tomomi INOUE, Kenji HAMASE, Akiko MORIKAWA and Kiyoshi ZAITSU, Determination of Minute Amounts of D-Leucine in Various Brain Regions of Rat and Mouse Using Column-Switching High-Performance Liquid Chromatography, Journal of Chromatography B, 744, 1, 744, 213-219, 2000.07.
13. Kenji HAMASE, Tatsunosuke TOMITA, Ayako KIYOMIZU and Kiyoshi ZAITSU, Determination of Pineal Melatonin by Precolumn Derivatization Reversed-Phase High Performance Liquid Chromatography and Its Application to the Study of Circadian Rhythm in Rats and Mice, Analytical Biochemistry, 279, 1, 279, 106-110, 2000.01.