Kyushu University Academic Staff Educational and Research Activities Database
List of Books
Masahiro Goto Last modified date:2019.07.26

Professor / Applied Chemistry / Department of Applied Chemistry / Faculty of Engineering


Books
1. Uju, Agung Tri Wijayanta, Masahiro Goto, Noriho Kamiya, High yield hydrolysis of seaweed-waste biomass using peracetic acid and ionic liquid treatments, American Institute of Physics Inc., 10.1063/1.5024058, 1931, 2018.02, Seaweed is one of the most promising bioethanol feedstocks. This water plant has high carbohydrate content but low lignin content, as a result it will be easier to be hydrolysed. This paper described hydrolysis of seaweed-waste biomass from the carrageenan (SWBC) industry using enzymatic saccharification or ionic liquids-HCl hydrolysis. In the first work, SWBC pretreated by peracetic acid (PAA) followed by ionic liquid (IL) caused enhance the cellulose conversion of enzymatic saccharification. At 48h saccharification, the value conversion almost reached 100%. In addition, the untreated SWBC also produced the cellulose conversion 77%. In the second work, SWBC or Bagasse with or without pretreated by PAA was hydrolyzed using ILs-HCl hydrolysis. The ILs used were 1-buthyl-3-methylpyridium chloride, [Bmpy][Cl] and 1-butyl-3-metyl imidazolium chloride ([Bmim][Cl]). [Bmpy][Cl]-HCl hydrolysis produced higher cellulose conversion than [Bmim][Cl]-HCl hydrolysis. The phenomenon was clearly observed on the Bagasse, which without pretreated by PAA. Furthermore, SWBC hydrolyzed by both ILs in the presence low concentration of HCl produced cellulose conversion 70-98% at 60-90 min of hydrolysis time. High cellulose conversion of SWBC on the both hydrolysis was caused by SWBC had the low lignin (4%). Moreover, IL treatments caused lowering of cellulose hydrogen bonds or even changed the cellulose characteristics from cellulose I to cellulose II which easily to be hydrolyzed. In the case of [Bmpy][Cl], this IL may reduce the degree polymerization of celluloses..
2. M. Moniruzzaman, H. Mahmood, Masahiro Goto, Ionic Liquid Based Nanocarriers for Topical and Transdermal Drug Delivery, Royal Society of Chemistry, 10.1039/9781788011839-00390, 390-403, 2018.01, In the pharmaceutical industry, there are challenges in topical and transdermal administration of drugs, which are sparingly soluble in water and most organic solvents. Ionic liquids (ILs) have been found to be very effective for dissolution of sparingly soluble drugs. However, hydrophilic IL-borne drugs cannot penetrate into or across the skin because of the highly hydrophobic barrier function of the outer skin. In this chapter we report a novel IL-in-oil (IL/o) microemulsion (ME) that is able to dissolve a significant amount of sparingly soluble drug, acyclovir, in the IL core while the continuous oil phase can provide the desired features for topical/transdermal transport through the skin. The ME is composed of a blend of the nonionic surfactants polyoxyethylene sorbitan monooleate (Tween 80) and sorbitan laurate (Span 20), isopropyl myristate (IPM) as an oil phase, and the IL [C1mim][(MeO)2PO2] (dimethylimidazolium dimethylphosphate) as a dispersed phase. The size and size distribution of the aggregates in the MEs were characterized by dynamic light scattering, showing formation of the nanocarrier in the size range 8-34 nm. In vitro drug permeation studies into and across the skin showed that the IL/o ME increased drug administration compared with other formulations. The safety profile of the new carrier was evaluated using a cytotoxicity assay on the human epidermal model LabCyte. We believe that these IL-assisted nonaqueous MEs can serve as a versatile and efficient nanodelivery system for sparingly soluble drug molecules..
3. Momoko Kitaoka, Masahiro Goto, Related topic
Solid-in-oil technique to increase skin permeation
, Springer Japan, 10.1007/978-4-431-56526-0_18, 225-232, 2017.11, Solid-in-oil (S/O) nanodispersion systems represent a new technology that has been developed in the last decade. Nano-sized, solid-state, hydrophilic drug molecules can be dispersed in an oil vehicle by coating the drug with hydrophobic surfactants; these materials are designated here as S/O nanodispersions. Conventional S/O nanodispersion systems were devised to maintain hydrophilic enzymes in their active form in organic solvents. Because the coated molecules are stable in non-aqueous media, S/O nanodispersion systems can be successfully applied in oral and skin drug deliveries. It is known that the permeability of hydrophilic drugs through the skin decreases when the molecular weight of the drug exceeds 500 Da. In addition, hydrophobic molecules tend to permeate through the skin preferentially, compared with hydrophilic molecules, because the outermost layer of the skin is hydrophobic. In our experiments, the permeation of hydrophilic biomolecules such as peptides and proteins through the skin increased by 4-7 times when their molecules were coated with lipophilic surfactants and dispersed in an oil vehicle. Here, we introduce an efficient method for drug delivery through the skin, using the S/O nanodispersion technique..
4. Momoko Kitaoka, Masahiro Goto, Transcutaneous immunization using nano-sized drug carriers, Humana Press Inc., 10.1007/978-1-4939-3121-7_18, 39, 349-367, 2016.08, Growing knowledge about the immune system in the skin and recent advances in the preparation of nano-sized particles have encouraged research into the induction of an adaptive immune response via the trans-cutaneous route. Because the skin is abundant in dendritic cell subsets, vaccine administration through the transcutaneous route has promise for simple and efficient immunization and immunotherapy methods, which would provide a welcome alternative to the conventional injection technique. Strategies using a nanoparticle-based protein delivery into the skin depend on the types of nanoparticles, such as soft vesicular nanoparticles, hard inorganic and polymer nanoparticles, and surfactant-coated solid-in-oil nanoparticles. Here, we discuss the skin structure and the immune system in the skin, as well as the types of nanoparticles, routes of administration, and effects of adjuvants. In addition, a detailed description of the preparation and characteristics of solid-in-oil nanoparticles is provided for the future development of an efficient transcutaneous immunization system..
5. Masahiro Goto, K. Kondo, F. Nakashio, Protein extraction by reversed micelles using new surfactants, London, UK; Elsevier, 1992.01, A surfactant plays a key role in the protein extraction by reversed micelles. Extraction of some proteins by new reversed micelle was carried out using dioleyl phosphoric acid (abbrievated DOLPA) instead of conventional surfactant AOT. Large protein more than 50 000 of molecular weight, which is difficult to dissolve into AOT reversed micelle, could be easily extracted by DOLPA reversed micelle. Denaturation of the proteins was depressed by using DOLPA reversed micelle because of the poor solubility of the DOLPA to the aqueous solution. Further, hybrid reversed micelle of DOLPA and AOT was investigated. It is found that extracted ratio of alpha- chymotrypsin was increased by use of the hybrid reversed micelle. (A).
6. Masahiro Goto, K. Kondo, F. Nakashio, Protein extraction by reversed MiCelles using new surfactants, 10.1016/B978-0-444-88677-4.50123-9, 1845-1850, 1992.01, A surfactant plays a key role in the protein extraction by reversed micelles. In this study, extraction of some proteins by new reversed micelle was carried out using dioleyl phosphoric acid (abbreviated DOLPA) instead of conventional surfactant AOT. Large protein more than 50000 of molecular weight, which is difficult to dissolve into AOT reversed micelle, could be easily extracted by DOLPA reversed micelle. Denaturation of the proteins was depressed by using DOLPA reversed micelle because of the poor solubility of the DOLPA to the aqueous solution. Further, hybrid reversed micelle of DOLPA and AOT was investigated. It is found that extracted ratio of a - chymotrypsin was increased by use of the hybrid reversed micelle..
7. F. Nakashio, Masahiro Goto, K. Kondo, New surfactants for metal extraction by liquid surfactant membranes, London, UK; Elsevier, 1992.01, New amphoteric surfactants which possess an acceleration effect and give a stable emulsion were prepared for metal extraction by liquid surfactant membranes (LSM). Copper extraction by LSM using the amphoteric surfactants was carried out in a stirred tank and the W/O emulsion was demulsified by a continuous electrical coalescer. By using the amphoteric surfactants, the extraction rate was increased about ten times as compared with the nonionic and cationic surfactants. Furthermore, the emulsion made of the amphoteric surfactant could be efficiently demulsified by an electrical coalescer. (from Authors).
8. F. Nakashio, M. Matsumoto, Masahiro Goto, J. Irie, K. Kondo, DEVELOPMENT OF NEW SURFACTANT IN LIQUID SURFACTANT MEMBRANE PROCESS., DECHEMA, 1, 573-579, 1986.12, The application of liquid surfactant membrane (LSM) to metal recovery is an attractive approach to separation processes. The purpose of this work is to develop new surfactants because they act as the carrier of water and/or solutes in the internal and feed solutions. In this study, derivatives of glutamic acid di-alkyl ester and di-alkyl type quaternary ammonium salts were prepared. Copper extraction was carried out in a stirred tank. W/O emulsion made of the surfactant was de-emulsified by a continuous electrical coalescer..
9. F. Nakashio, Masahiro Goto, K. Kondo, New surfactants for metal extraction by liquid surfactant membranes, 10.1016/B978-0-444-88677-4.50060-X, 1459-1468, 1992.01, New amphoteric surfactants which possess an acceleration effect and give a stable emulsion were prepared for metal extraction by liquid surfactant membranes (henceforth LSM). Copper extraction by LSM using the amphoteric surfactants was carried out in a stirred tank and the W/O emulsion was demulsified by a continuous electrical coalescer. The amphoteric surfactants formed a stable emulsion at low concentration which is about one-tenth the corresponding concentration of Span 80 or Polyamine. By using the amphoteric surfactants, the extraction rate was increased about ten times as compared with the nonionic and cationic surfactants. The acceleration effect is considered to be caused by an electrostatic interaction between copper ion and hydrophilic phosphoric-group of the amphoteric surfactants. The increase of the extraction rate leads to shortening the operation time in the LSM process. Furthermore, the emulsion made of the amphoteric surfactant could be efficiently demulsified by an electrical coalescer..
10. Masahiro Goto, Transcutaneous Immunization Using Nano-sized Drug Carriers, Nanomaterials in Pharmacology, Humana Press, 2016.12.
11. Masahiro Goto, Application of Ionic Liquids on Rare Earth Green Separation and Utilization, 2016.04.
12. Development & Applications of Transdermal Drug Delivery Systems.
13. Rare metal separation by solvent extraction using ionic liquids.
14. Muhammad Moniruzzaman and Masahiro Goto, Nanoscale Biocatalysis, Humana Press, Chapter 4, Molecular Assembly Assisted Biocatalytic Reactions in Ionic Liquids, pp37-50, 2011.05.
15. Masahiro Goto, Ion Exchange and Solvent Extraction, Marcel Dekker, Volume 14, 2001.10.