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Last modified date：2010.2.8
Hiroyuki Ijima
Associate Professor
Graduate School
Undergraduate School
E-Mail
Homepage
Phone
092-802-2758
Fax
092-802-2758
Academic Degree
Doctor of Engineering
Field of Specialization
Biochemical Engineering, Medical Engineering, Bioreactor, Biomaterial, Liver Tissue Engineering
Research
Research Interests
- Development of hybrid-type artificial liver support system
keyword : Hybrid-type artificial liver, Hepatocytes organoid, Hepatic failure rat model, Liver regeneration, High density culture, Bioreactor
1990.07.
- Development of functional substratum and system for animal cell culture
keyword : Animal cell culture, Culture substratum, Useful biological material, Bioreactor, Hydroxyl apatite, RGD, High density culture, Mass culture
1997.04.
- Development of hybrid-type artificial kidney
keyword : Hybrid-type artificial kidney, Renal proximal tubule cell, MDR, Active transport, RGD
2002.05～2006.03.
- Development of tissue-engineered liver
keyword : Liver tissue engineering, Regenerative medicine, Angiogenesis, Scaffold, Cytokine, Hepatocytes organoid, Functional biomaterials
2002.05.
- Development of a cell function simulator
keyword : Drug metabolism simylator, Hepatocytes organoid, cell function, bioreactor，
2004.04.
- Development of high density mass production procedd of ES cell-derived functional cells
keyword : ES cell, High density culture, mass production, bioreactor, culture system, maintenance of undifferentiated condition, differentiation, functional cell
2004.11.
Academic Activities
Papers
| 1. |
Yung-Te Hou, Hiroyuki Ijima, Shunichi Matsumoto, Takafumi Kubo, Takayuki Takei, Shinji Sakai, and Koei Kawakami,Effect of a hepatocyte growth factor/heparin-immobilized collagen system on albumin synthesis and spheroid formation by hepatocytes,Journal of Bioscience and Bioengineering,Vol.??, No.??, pp.???-???. |
| 2. |
Hiroyuki Ijima,Practical and functional culture technologies for primary hepatocytes,Biochemical Engineering Journal,Vol.48, No.3, pp.332-336,2010.02. |
| 3. |
Hiroyuki Ijima, Hiroshi Mizumoto, Kohji Nakazawa, Toshihisa Kajiwara, Taku Matsushita, Kazumori Funatsu,Hepatocyte growth factor and epidermal growth factor promote spheroid formation in polyurethane foam/hepatocyte culture and improve expression and maintenance of albumin production,Biochemical Engineering Journal,Vol.47, No.1-3, pp.19-26,2009.12. |
| 4. |
Hiroyuki Ijima, Takafumi Kubo, Yung-Te Hou,Primary rat hepatocytes form spheroids on hepatocyte growth factor/heparin-immobilized collagen film and maintain high albumin production,Biochemical Engineering Journal,Vol.46, No.2, pp.227-233,2009.10. |
| 5. |
Hiroyuki IJIMA, Shohei KURODA, Koei KAWAKAMI,Degoxin transport by renal proximal tubule cells is enhanced on adhesive synthetic RGD peptide,The International Journal of Artificial Organs,Vol.30, No.1, pp.25-33,2007.01. |
| 6. |
Hiroyuki Ijima, Koei Kawakami,Promote a monolayer formation and highly express the ammonia metabolism of primary rat hepatocyte on a RGD-containing peptide coated polystyrene dish,Journal of Bioscience and Bioengineering,Vol.100, No.1, pp.62-66,2005.07. |
| 7. |
Shinji Sakai, Kenji Kawabata, Tsutomu Ono, Hiroyuki Ijima, Koei Kawami,Development of mammalian cell-enclosing subsieve-size agarose capsules (<100um) for cell therapy,Biomaterials,Vol.26, pp.4786-4792,2005.01. |
| 8. |
Koei Kawakami, Yoshihide Sera, Shinji Sakai, Tsutomu Ono, Hiroyuki Ijima,Development and Characterization of a Silica Monolith Immobilized Enzyme Micro-bioreactor,Industrial & Engineering Chemistry Research,Vol.44, No.1, pp.236-240,2005.01. |
Presentations
| 1. |
Organoid formation and the function expression of primary rat hepatocytes are improved by culturing with hepatocyte growth factor-immobilized culture substratum. |
Membership in Academic Society
- The Society of Chemical Engineers, Japan
- Japanese Society for Artificial Organs
- The Society for Biotechnology, Japan
- The Japanese Society for Regenerative Medicine
- The Japanese Society for Biomaterials
- Japan Bioindustry Association
- Japanese Society for Alternative to Animal Experiments
- Japanese Association for Animal Cell Technology
Educational
Educational Activities
Biomaterial engineering
The second basics physical chemistry and practice
The second/the third materials science engineering expriment
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