Kyushu University Academic Staff Educational and Research Activities Database
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Hiroyuki Ijima Last modified date:2017.12.07

Professor / Molecular and Biochemical Systems Engineering
Department of Chemical Engineering
Faculty of Engineering

Graduate School
Undergraduate School

Academic Degree
Doctor of Engineering
Field of Specialization
Biochemical Engineering, Medical Engineering, Bioreactor, Biomaterial, Liver Tissue Engineering
Research Interests
  • Development of hybrid-type artificial liver support system
    keyword : Hybrid-type artificial liver, Hepatocytes organoid, Hepatic failure rat model, Liver regeneration, High density culture, Bioreactor
    1990.07We developed a novel bioreactor and application system to patients. The bioreactor realized an induction of self organoid fomation and optimization of microenvironment for cell functions by using chemical engineering protocols. Furthermore, we succesfully developed hepatic failure animal model for estimating the performance of the artificial liver system..
  • Development of functional substratum and system for animal cell culture
    keyword : Animal cell culture, Culture substratum, Useful biological material, Bioreactor, Hydroxyl apatite, RGD, High density culture, Mass culture
    1997.04Macroporous hydroxyapatite culture substratum and packed-bed type bioreactor were developed. We suceeded mass production of colony stimulating factor using this system. Now, we focused optimization of this system and improvement of geometry, porosity and strength of the substratum..
  • Development of hybrid-type artificial kidney
    keyword : Hybrid-type artificial kidney, Renal proximal tubule cell, MDR, Active transport, RGD
    2002.05~2006.03We focused to develop a hybrid artificial kidney with renal proximal tubule cells immobilized on adhesive synthetic RGD peptide. Immobilized cells express the selective active transport of drugs in vitro culture using transwell. Furthermore, RGD-immobilized hollow fiber module was developed. Extracorporeal circulation system equipped hepotocyte-immobilized module and renal proximal tubule cells immobilized module was developed. Blood purification effect of severe hepatic failure rat induced by acetaminophen can be expressed by using this system..
  • Development of tissue-engineered liver
    keyword : Liver tissue engineering, Regenerative medicine, Angiogenesis, Scaffold, Cytokine, Hepatocytes organoid, Functional biomaterials
  • Development of a cell function simulator
    keyword : Drug metabolism simylator, Hepatocytes organoid, cell function, bioreactor,
  • Development of high density mass production procedd of ES cell-derived functional cells
    keyword : ES cell, High density culture, mass production, bioreactor, culture system, maintenance of undifferentiated condition, differentiation, functional cell
Academic Activities
1. Shintaro Nakamura, Takafumi Kubo, Hiroyuki Ijima, Heparin-conjugated gelatin as a growth factor immobilization scaffold, Journal of Bioscience and Bioengineering, 115, 5, 2013.05.
2. Yung-Te Hou, Hiroyuki Ijima, Nana Shirakigawa, Takayuki Takei, Koei Kawakami, Development of growth factor-immobilizable material for hepatocyte transplantation, Biochemical Engineering Journal, 69, 172-181, 2012.12.
3. Nana Shirakigawa, Hiroyuki Ijima, and Takayuki Takei, Decellularized liver as a practical scaffold with a vascular network template for liver tissue engineering, Journal of Bioscience and Bioengineering, 114, 5, 546-551, 2012.11.
4. Yung-Te Hou, Hiroyuki Ijima, Takayuki Takei, Koei Kawakami, Growth factor/heparin-immobilized collagen gel system enhances viability of transplanted hepatocytes and induces angiogenesis, Journal of Bioscience and Bioengineering, 112, 3, 265-272, 2011.09.
5. Hiroyuki Ijima, Yung-Te Hou, Takayuki Takei, Development of hepatocyte-embedded hydrogel-filled macroporous scaffold cultures using transglutaminase, Biochemical Engineering Journal, 52, 276-281, 2010.11.
6. Yung-Te Hou, Hiroyuki Ijima, Shunichi Matsumoto, Takafumi Kubo, Takayuki Takei, Shinji Sakai, and Koei Kawakami, Effect of a hepatocyte growth factor/heparin-immobilized collagen system on albumin synthesis and spheroid formation by hepatocytes, Journal of Bioscience and Bioengineering, 110, 2, 208-216, 2010.08.
7. Hiroyuki Ijima, Practical and functional culture technologies for primary hepatocytes, Biochemical Engineering Journal, 48, 3, 332-336, Vol.48, No.3, pp.332-336, 2010.02.
8. Hiroyuki Ijima, Hiroshi Mizumoto, Kohji Nakazawa, Toshihisa Kajiwara, Taku Matsushita, Kazumori Funatsu, Hepatocyte growth factor and epidermal growth factor promote spheroid formation in polyurethane foam/hepatocyte culture and improve expression and maintenance of albumin production, Biochemical Engineering Journal, 47, 1-3, 19-26, Vol.47, No.1-3, pp.19-26, 2009.12.
9. Hiroyuki Ijima, Takafumi Kubo, Yung-Te Hou, Primary rat hepatocytes form spheroids on hepatocyte growth factor/heparin-immobilized collagen film and maintain high albumin production, Biochemical Engineering Journal, 46, 2, 227-233, Vol.46, No.2, pp.227-233, 2009.10.
10. Hiroyuki IJIMA, Shohei KURODA, Koei KAWAKAMI, Degoxin transport by renal proximal tubule cells is enhanced on adhesive synthetic RGD peptide, The International Journal of Artificial Organs, Vol.30, No.1, pp.25-33, 2007.01.
11. Hiroyuki Ijima, Koei Kawakami, Promote a monolayer formation and highly express the ammonia metabolism of primary rat hepatocyte on a RGD-containing peptide coated polystyrene dish, Journal of Bioscience and Bioengineering, Vol.100, No.1, pp.62-66, 2005.07.
12. Shinji Sakai, Kenji Kawabata, Tsutomu Ono, Hiroyuki Ijima, Koei Kawami, Development of mammalian cell-enclosing subsieve-size agarose capsules (<100um) for cell therapy, Biomaterials, 26, 23, Vol.26, pp.4786-4792, 2005.01.
13. Koei Kawakami, Yoshihide Sera, Shinji Sakai, Tsutomu Ono, Hiroyuki Ijima, Development and Characterization of a Silica Monolith Immobilized Enzyme Micro-bioreactor, Industrial & Engineering Chemistry Research, 44, 1, Vol.44, No.1, pp.236-240, 2005.01.
1. Nana Shirakigawa, Hiroki Sakamoto, Cho Jaeyong, Daisuke Imai, Yo-ichi Yamashita, Ken Shirabe, Yoshihiko Maehara, Hiroyuki Ijima, Fundamental technology for the creation of whole liver engineering, and functional evaluation of recellularized liver, 2015 4th TERMIS World Congress (Tissue Engineering and Regenerative Medicine International Society), 2015.09.08.
2. Hiroyuki Ijima, Shintaro Nakamura, Jingia Ye, Nana Shirakigawa, Daisuke Imai, Yo-ichi Yamashita, Ken Shirabe, Yoshihiko Maehara, Fundamental technology for the creation of Whole Liver Engineering, TERMIS-AP 2014 (Tissue Engineering and Regenerative Medicine International Society, Asia-Pacific Annual Conference 2014), 2014.09.26.
3. Basic Study for Liver Tissue Engineering by Using Decellularized Organ.
4. Cell-embedded functional gel-filled scaffold culture for liver tissue engineering
Hiroyuki Ijima, Nana Shirakigawa, Yung-Te Hou, Shintaro Nakamura, Takayuki Takei, Koei Kawakami .
5. Organoid formation and the function expression of primary rat hepatocytes are improved by culturing with hepatocyte growth factor-immobilized culture substratum.
Membership in Academic Society
  • The Society of Chemical Engineers, Japan
  • Japanese Society for Artificial Organs
  • The Society for Biotechnology, Japan
  • The Japanese Society for Regenerative Medicine
  • The Japanese Society for Biomaterials
  • Japan Bioindustry Association
  • Japanese Society for Alternative to Animal Experiments
  • Japanese Association for Animal Cell Technology
  • Base structure consisting of an endothelialized vascular-tree network and hepatocytes for whole liver engineering
    (JBB Volume 116, Issue 6, December 2013, Pages 740-745)
Other Educational Activities
  • 2008.12.
Professional and Outreach Activities
International collaboration for the development of cell chip using non-adhesive single cell culture technology .