九州大学 研究者情報
論文一覧
井嶋 博之(いじま ひろゆき) データ更新日:2017.11.10

教授 /  工学研究院 化学工学部門 分子・生物システム工学


原著論文
1. Hiroyuki Ijima, Practical hybrid artificial liver support system and whole liver engineering, Proceedings of 5th International Symposium & Exhibition on Aqua Science and Water Resources (ISASWR'17), 50-53, 2017.08.
2. Takatyku Nagai, Yasuhiro Ikegami, Hideyuki Mizumachi, Nana Shirakigawa, Hiroyuki Ijima, Development of an in situ evaluation system for neural cells using ECM-modeled gel culture, Journal of Bioscience and Bioengineering, 430-438, Final version published online: 04-Sep-2017, 2017.09.
3. Apeksha Damania, Mohsin Hassan, Nana Shirakigawa, Hiroshi Mizumoto, Anupam Kumar, Shiv K. Sarin, Hiroyuki Ijima, Masamichi Kamihira, Ashok Kumar, Alleviating liver failure conditions using an integrated hybrid cryogel based cellular bioreactor as a bioartificial liver support, Scientific Reports, 7:40323, 1-11, 2017.01.
4. Nana Shirakigawa, Yuta Hara, Hiroyuki Ijima, Tissue-Engineered Bioreactors with Flow Channels Molded by Polypod Particles Advanced Biomedical Engineering, Advanced Biomedical Engineering, 5, 105-110, 2016.08.
5. Jingjia Ye, Nana Shirakigawa, Hiroyuki Ijima, Fetal liver cell-containing hybrid organoids improve cell viability and albumin production upon transplantation, Journal of Bioscience and Bioengineering, 121, 6, 701-708, 2016.06.
6. Nana Shirakigawa, Tadamitsu Ideguchi, Kazuyuki Ichikawa, Takahisa Izumi, Michiko Higashi, Shizunari Yamamoto, Hiroyuki Ijima, Quantitative analysis of vascular structure in decellularized liver using 3D computed tomography, Advanced Biomedical Engineering, 4, 179-185, ABE No.15001 (Accepted, Aug 24/2015), 2015.12.
7. Jingjia Ye, Nana Shirakigawa, Hiroyuki Ijima, Hybrid organoids consisting of extracellular matrix gel particles and hepatocytes for transplantation, Journal of Bioscience and Bioengineering, 120, 2, 231-237, 2015.08.
8. Eric M. Jeffries, Shintaro Nakamura, Kee-Won Lee, Jimmy Clampffer, Hiroyuki Ijima, Yadong Wang, Micropatterning Electrospun Scaffolds to Create Intrinsic Vascular Networks, Macromolecular Bioscience, 14, 11, 1514-1520, 2014.11.
9. Hideyuki Mizumachi, Hiroyuki Ijima, Reliable Evaluation of Human Umbilical Vein Endothelial Cell Number by Water-soluble Tetrazolium Salts-8 Assay Using Charcoal/dextran-treated Fetal Bovine Serum , Advanced Biomedical Engineering, 3, 1-6, 2014.03.
10. Hideyuki Mizumachi, Hiroyuki Ijima, Measuring stability of vascular endothelial growth factor using an immobilization technique, Advanced Biomedical Engineering, 2, 130-136, 2013.12.
11. Shintaro Nakamura, Hiroyuki Ijima, Solubilized matrix derived from decellularized liver as a growth factor-immobilizable scaffold for hepatocyte culture, Journal of Bioscience and Bioengineering, 116, 6, 746-753, 2013.12.
12. Nana Shirakigawa, Takayuki Takei, Hiroyuki Ijima, Base structure consisting of an endothelialized vascular-tree network and hepatocytes for whole liver engineering, Journal of Bioscience and Bioengineering, 116, 6, 740-745, 2013.12.
13. Nana Shirakigawa, Hiroyuki Ijima, Nucleus number in clusters of transplanted fetal liver cells increases by partial hepatectomy of recipient rats, Journal of Bioscience and Bioengineering, 115, 5, 568-570, 568-570, 2013.05.
14. Shintaro Nakamura, Takafumi Kubo, Hiroyuki Ijima, Heparin-conjugated gelatin as a growth factor immobilization scaffold, Journal of Bioscience and Bioengineering, 115, 5, 562-567, 2013.05.
15. Yung-Te Hou, Hiroyuki Ijima, Nana Shirakigawa, Takayuki Takei, Koei Kawakami, Development of growth factor-immobilizable material for hepatocyte transplantation, Biochemical Engineering Journal, 69, 172-181, 2012.12.
16. Nana Shirakigawa, Hiroyuki Ijima, and Takayuki Takei, Decellularized liver as a practical scaffold with a vascular network template for liver tissue engineering, Journal of Bioscience and Bioengineering, 114, 5, 546-551, 2012.11.
17. Hiroyuki Ijima, Nana Shirakigawa, Hideyuki Mizumachi, Shintaro Nakamura, Hepatocyte embedded-functional gel-filled scaffold is effective for the construction of liver tissue-like structure, Journal of Tissue Engineering and Regenerative Medicine, 6, Supplement 1, 122, 2012.09.
18. N. Amimoto, T. Miyazawa, H. Tani, Hiroshi Mizumoto, Kohji Nakazawa, Hiroyuki Ijima, Kazumori Funatsu, Toshihisa Kajiwara, In vitro and ex vivo functional evaluation of a hollow fiber type bioartificial liver module immobilizing ES-derived hepatic cells, Journal of Tissue Engineering and Regenerative Medicine, 6, Supplement 1, 123, 2012.09.
19. Nana Shirakigawa, Hiroyuki Ijima, Endothelialized vascular tree in decellularized liver for liver tissue engineering, Journal of Tissue Engineering and Regenerative Medicine, 6, Supplement 1, 173, 2012.09.
20. Shintaro Nakamura, Hiroyuki Ijima, Solubilized matrix from decellulalized liver as a functional material for tissue engineering, Journal of Tissue Engineering and Regenerative Medicine, 6, Supplement 1, 173, 2012.09.
21. Nana Shirakigawa, Hiroyuki Ijima, Tadamitsu Ideguchi, Kazuyuki Ichikawa, Takahisa Izumi, Michiko Higashi, Shizunari Yamamoto, Yoshihiko Onizuka, Quantitative analysis of vascular tree structure in decellularized liver for tissue engineering, Journal of Tissue Engineering and Regenerative Medicine, 6, Supplement 1, 319, 2012.09.
22. Hiroyuki Ijima, Hideyuki Mizumachi, Development of evaluation system of growth factors on their stability and biological activity, Journal of Tissue Engineering and Regenerative Medicine, 6, Supplement 1, 323, 2012.09.
23. Takayuki Takei, Kaoru Ikeda, Hiroyuki Ijima, Masahiro Yoshida and Koei Kawakami, A comparison of sodium sulfate, sodium phosphate, and boric acid for preparation of immobilized Pseudomonas putida F1 in poly(vinyl alcohol) beads, Polymer Bulletin, 69, 3, 363-373, 2012.06.
24. Mizumoto H, Hayashi S, Matsumoto K, Ikeda K, Kusumi T, Inamori M, Nakazawa K, Ijima H, Funatsu K, Kajiwara T, Evaluation of a hybrid artificial liver module based on a spheroid culture system of embryonic stem cell-derived hepatic cells, Cell transplantation, 21, 2, 421-418, 2012.02.
25. Takayuki TAKEI, Naoya KISHIHARA, Hiroyuki IJIMA, Koei KAWAKAMI, Fabrication of capillary-like network in matrix of water-soluble polymer using poly(methyl methacrylate) microfibers, Artificial cells, blood substitutes, and biotechnology, 40, 1-2, 66-69, in press, 2012.02.
26. Takayuki Takei, Hideki Nakahara, Hiroyuki Ijima, Koei Kawakami, Synthesis of a chitosan derivative soluble at neutral pH and gellable by freezing-thawing, and its application in wound care, Acta Biomaterialia, 8, 2, 686–693, 2012.02.
27. Takayuki Takei, Kotaro Sugihara, Hiroyuki Ijima, Koei Kawakami, In situ gellable sugar beet pectin via enzyme-catalyzed coupling reaction of feruloyl groups for biomedical applications, Journal of Bioscience and Bioengineering, 112, 5, 491–494, 2011.11.
28. Yung-Te Hou, Hiroyuki Ijima, Takayuki Takei, Koei Kawakami, Growth factor/heparin-immobilized collagen gel system enhances viability of transplanted hepatocytes and induces angiogenesis, Journal of Bioscience and Bioengineering, 112, 3, 265-272, 2011.09.
29. Amimoto N, Mizumoto H, Nakazawa K, Ijima H, Funatsu K, Kajiwara T, An evaluation of the utility of the hepatic differentiation method using hollow fiber/organoid culture for the development of a hybrid artificial liver device, Biochemical Engineering Journal, 56, 1-2, 69-74, 2011.09.
30. Amimoto N, Mizumoto H, Nakazawa K, Ijima H, Funatsu K, Kajiwara T, Hepatic Differentiation of Mouse Embryonic Stem Cells and Induced Pluripotent Stem Cells During Organoid Formation in Hollow Fibers, Tissue Eng Part A, 17, 15-16, 2071-2078, 2011 May 11. [Epub ahead of print], 2011.08.
31. Nana SHIRAKIGAWA, Takayuki TAKEI, Hiroyuki IJIMA, Koei KAWAKAMI, Optimization of Decellularized Conditions of Liver for the Development of Liver Tissue Engineering, Histology and Histopathology, 26, Supplement 1, 401, 2011.06.
32. Hiroyuki IJIMA, Nana SHIRAKIGAWA, Yung-Te HOU, Shintaro NAKAMURA, Takayuki TAKEI, Koei KAWAKAMI, Hepatocyte-embedded Functional Hydrogel-filled Scaffold System for Liver Tissue Engineering, Histology and Histopathology, 26, Supplement 1, 399, 2011.06.
33. Hiroyuki IJIMA, Shintaro NAKAMURA, Nana SHIRAKIGAWA, Hideyuki MIZUMACHI, Takayuki TAKEI, Koei KAWAKAMI, Growth factor-immobilized extracellular matrix for the culture of functional cells, Histology and Histopathology, 26, Supplement 1, 354, 2011.06.
34. Takayuki TAKEI, Kaoru IKEDA, Hiroyuki IJIMA, Koei KAWAKAMI, Fabrication of Poly(vinyl alcohol) Hydrogel Beads Crosslinked Using Sodium Sulfate for Microorganism Immobilization, Process Biochemistry, 46, 2, 566–571, 2011.02.
35. Takayuki TAKEI, Mitsunobu SATO, Hiroyuki IJIMA, Koei KAWAKAMI , In Situ Gellable Oxidized Citrus Pectin for Localized Delivery of Anti-Cancer Drugs and Prevention of Homotypic Cancer Cell Aggregation, Biomacromolecules, 11, 12, 3525–3530, 2010.12.
36. Hiroyuki Ijima, Yung-Te Hou, Takayuki Takei, Development of hepatocyte-embedded hydrogel-filled macroporous scaffold cultures using transglutaminase, Biochemical Engineering Journal, 52, 276-281, 2010.11.
37. Yung-Te Hou, Hiroyuki Ijima, Shunichi Matsumoto, Takafumi Kubo, Takayuki Takei, Shinji Sakai, and Koei Kawakami, Effect of a hepatocyte growth factor/heparin-immobilized collagen system on albumin synthesis and spheroid formation by hepatocytes, Journal of Bioscience and Bioengineering, 110, 2, 208-216, 2010.08.
38. Takayuki TAKEI, Kaoru IKEDA, Hiroyuki IJIMA, Koei KAWAKAMI, Masahiro YOSHIDA, Yasuo HATATE, Preparation of polymeric microcapsules enclosing microbial cells by radical suspension polymerization via water-in-oil-in-water emulsion, Polymer Bulletin, 65, 3, 283-291, 2010.06.
39. Changjun MU, Shinji SAKAI, Hiroyuki IJIMA, Koei KAWAKAMI, Preparation of Cell-enclosing Microcapsules through Photopolymerization of Methacrylated Alginate Solution Triggered by Irradiation with Visible Light, Journal of Bioscience and Bioengineering, Vol.109, No.6, pp.618-621, 2010.06.
40. Hiroyuki Ijima, Practical and functional culture technologies for primary hepatocytes, Biochemical Engineering Journal, 48, 3, 332-336, Vol.48, No.3, pp.332-336, 2010.02.
41. Hiroyuki Ijima, Ryohei Ogata, Yusuke Murasawa, Pi-Chao Wang, Albumin production activity of primary rat hepatocytes is improved on type V collagen, Journal of Bioscience and Bioengineering, 109, 2, 179-181, Vol.109, No.2, pp.179-181, 2010.02.
42. Hiroyuki Ijima, Hiroshi Mizumoto, Kohji Nakazawa, Toshihisa Kajiwara, Taku Matsushita, Kazumori Funatsu, Hepatocyte growth factor and epidermal growth factor promote spheroid formation in polyurethane foam/hepatocyte culture and improve expression and maintenance of albumin production, Biochemical Engineering Journal, 47, 1-3, 19-26, Vol.47, No.1-3, pp.19-26, 2009.12.
43. Hiroyuki Ijima, Takafumi Kubo, Yung-Te Hou, Primary rat hepatocytes form spheroids on hepatocyte growth factor/heparin-immobilized collagen film and maintain high albumin production, Biochemical Engineering Journal, 46, 2, 227-233, Vol.46, No.2, pp.227-233, 2009.10.
44. Akira Ito, Hideaki Jitsunobu, Yoshinori Kawabe, Hiroyuki Ijima, Masamichi Kamihira, Magnetic Separation of Cells in Coculture Systems Using Magnetite Cationic Liposomes, Tissue Engineering Part C: Methods, Vol.15, No.3, pp.413-423, 2009.09.
45. Hiroyuki Ijima, Yung-Te Hou, Takafumi Kubo, Ryohei Ogata, Nana Shirakigawa, Takayuki Takei, Shinji Sakai, KOEI KAWAKAMI, Basic Study for Liver Tissue Engineering by Developing Hepatocytes-Embedded Functional Hydrogel-Filled Scaffold Culture, Tissue Engineering and Regenerative Medicine, 6, Supplement 1, S32, 2009.09.
46. Hiroshi Mizumoto, S. HAYASHI, K. IKEDA, Kohji NAKAZAWA, Hiroyuki Ijima, Kazumori Funatsu, Toshihisa Kajiwara, Evaluation of a Hybrid Artificial Liver Module Based on a Spheroid Culture System of ES Cell-derived Hepatic Cells, Tissue Engineering and Regenerative Medicine, 6, Supplement 1, S116, 2009.09.
47. Hiroyuki Ijima, Yasuo Kakeya, Toru Yokonuma, Yung-Te Hou, Takayuki Takei, Composition of culture medium is more important than co-culture with hepatic non-parenchymal cells in albumin production activity of primary rat hepatocytes, and the effect was enhanced by hepatocytes spheroid culture in collagen gel, Biochemical Engineering Journal, 45, 3, 226-231, Vol.45, No.3, pp.226-231, 2009.08.
48. Tomoaki Kusumi, Kazuhisa Ishihara, Hiroshi Mizumoto, Kohji Nakazawa, Hiroyuki Ijima, Kazumori Funatsu, Toshihisa Kajiwara, Evaluation of a bioreactor with stacked sheet shaped organoids of primary hepatocytes, Journal of Bioscience and Bioengineering, Vol.107, No.5, pp.552–555, 2009, 2009.05.
49. Hiroyuki Ijima, Yasuo Kakeya, Takahiro Ogata, Takanori Sakai, Development of a practical small-scale circulation bioreactor and application to a drug metabolism simulator, Biochemical Engineering Journal, 44, 2-3, 292-296, Vol.44, No.2-3, pp.292-296, 2009.05.
50. Akira Ito, Takehiko Kiyohara, Yoshinori Kawabe, Hiroyuki Ijima, Masamichi Kamihira, Enhancement of Cell Function through Heterotypic Cell-Cell Interactions Using E-Cadherin-Expressing NIH3T3 Cells, Journal of Bioscience and Bioengineering, Vol.105, No.6, pp.679-682, 2008.06.
51. Hiroyuki IJIMA, Yasuo KAKEYA, Monolayer culture of primary rat hepatocytes on an Arg-Gly-Asp (RGD)-immobilized polystyrene dish express liver-specific functions of albumin production and p-acetamidophenol metabolism the same as for spheroid culture, Biochemical Engineering Journal, 40, 2, 387-391, Vol.40, No.2, pp.387-391, 2008.06.
52. Hiroshi MIZUMOTO, Kazuhisa ISHIHARA, Kohji NAKAZAWA, Hiroyuki IJIMA, Kazumori FUNATSU, Toshihisa KAJIWARA, A new culture technique for hepatocyte organoid formation and long-term maintenance of liver-specific functions, Tissue Engineering Part C: Method, 14, 2, 387-391, 2008.06.
53. K. MATSUMOTO, H. MIZUMOTO, K. NAKAZAWA, H. IJIMA, K. FUNATSU, T. KAJIWARA, Hepatic differentiation of mouse embrionic stem cells in a three-dimensional culture system using polyurethane foam, Journal of Bioscience and Bioengineering, Vol.105, No.4, pp.350-354, 2008, 2008.04.
54. H. Mizumoto, K. Aoki, K. Nakazawa, H. Ijima, K. Funatsu, and T. Kajiwara, Hepatic Differentiation of Embryonic Stem Cells in HF/Organoid Culture, Transplantation Proceedings, Vol.40, pp.611-613, 2008, 2008.02.
55. K. Matsumoto, H. Mizumoto, K. Nakazawa, H. Ijima, K. Funatsu, and T. Kajiwara, Hepatic Differentiation of Mouse Embryonic Stem Cells in a Bioreactor Using Polyurethane/Spheroid Culture, Transplantation Proceedings, Vol.40, pp.614-616, 2008, 2008.02.
56. Hiroyuki IJIMA, Takeshi MATSUO, Koei KAWAKAMI, The mixed co-culture effect of primary rat hepatocytes and bone marrow cells is caused by soluble factors derived from bone marrow cells, Journal of Bioscience and Bioengineering, 105, 3, 226-231, Vol.105, No.3, pp.226-231, 2008.03.
57. Takayuki TAKEI, Shinsuke YAMAGUCHI, Shinji SAKAI, Hiroyuki IJIMA, Koei KAWAKAMI, Novel Technique to Fabricate Double-Layered Tubular Construct Composed of Two Vascular Cell Types in Collagen Gel as Template of Three-dimensional Tissue, Journal of Bioscience and Bioengineering, Vol.105, No.5, pp.435-438, 2007.11.
58. Hiroyuki Ijima, Toru Yokonuma, Yasuo Kakeya, Shinji Sakai, Koei Kawakami, Expression and maintenance of liver specific function of primary rat heptaocytes co-cultured with hepatic non-parenchymal cells in collagen gel, Proceedings of TERMIS-NA 2007 Conference and Exposition, No.1218, 2007.07.
59. Hiroyuki Ijima, Toru Yokonuma, Shinji Sakai, Koei Kawakami, Spheroid formation and expression fo liver specific function of primary rat hepatocytes co-cultured with hepatic non-parenchymal cells, ASAIO journal, Vol.53, No.2, p.7A, 2007.03.
60. Takayuki TAKEI, Shinji SAKAI, Hiroyuki IJIMA, Koei KAWAKAMI, Expression of a Liver-Specific Function by a Hepatoblastoma Cell Line Cocultured with Three-Dimensional Endothelialized Tubes in Collagen Gels, Journal of Bioscience and Bioengineering, Vol.103, No.2, pp.200-202, 2007.02.
61. Takayuki TAKEI, Shinji SAKAI, Toru YOKONUMA, Hiroyuki IJIMA, Koei KAWAKAMI, Fabrication of Artificial Endothelialized Tubes with Predetermined Three-dimensional Configuration from Flexible Cell-enclosing Alginate Fibers, Biotechnology Progress, Vol.23, No.1, pp.182-186, 2007.02.
62. Hiroyuki IJIMA, Shohei KURODA, Koei KAWAKAMI, Degoxin transport by renal proximal tubule cells is enhanced on adhesive synthetic RGD peptide, The International Journal of Artificial Organs, Vol.30, No.1, pp.25-33, 2007.01.
63. 村上 直・藤田 哲也・小野 努・境 慎司・井嶋 博之・川上 幸衛, ホスファチジルグリセロール含有リポソームへのタンパク質の保持特性に及ぼす脂質組成の影響, 化学工学論文集, Vol.32, No.6, pp.514-517, 2006.12.
64. Takayuki TAKEI, Shinji SAKAI, Hiroyuki IJIMA, Koei KAWAKAMI, Development of Mammalian Cell-enclosing Calcium-alginate Hydrogel Fibers in a Coflowing-stream, Biotechnology Journal, Vol.1, No.9, 1014-1017, 2006.09.
65. Takayuki TAKEI, Shinji SAKAI, Tsutomu ONO, Hiroyuki IJIMA, Koei KAWAKAMI, Fabrication of Endothelizlized Tube in Collagen Gel as Starting Point for Self-developing Capillary-like Network to Construct Three-dimensional Organs in Vitro, Biotechnology and Bioengineering, Vol.95, No.1, pp.1-7, 2006, 2006.09.
66. Sunao MURAKAMI, Tsutomu ONO, Shinji SAKAI, Hiroyuki IJIMA, Koei KAWAKAMI, Effect of Diglucosamine on the Entrapment of Protein into Liposomes, Journal of Liposome Research, Vol.16, No.2, pp.103-112, 2006.05.
67. Shinji Sakai, Kenji Kawabata, Shinji Tanaka, Norifumi Harimoto, Ichiro Hashimoto, Changjun Mu, Brian Salmons, Hiroyuki Ijima, Koei Kawakami, Subsieve-size agarose capsules enclosing ifosfamide-activating cells: a strategy toward chemotherapeutic targeting to tumors, Molecular Cancer Therapeutics, 4, 11, 1786-1790, Vol.4, pp.1786-1790, 2005.11.
68. Takayuki Takei, Hiroyuki Ijima, Shinji Sakai, Tsutomu Ono, Koei Kawakami, Enhanced angiogenesis in bFGF-containing scaffold promoted viability of enclosed hepatocytes and maintained hepatospecific glycogen storage capacity, Journal of Chemical Engineering of Japan, 38, 11, 913-917, Vol.38, No.11, pp.913-917, 2005, 2005.11.
69. Hiroyuki Ijima, Sunao Murakami, Takeshi Matsuo, Takayuki Takei, Tsutomu Ono, Koei Kawakamii, Enhancement of liver specific functions of primary rat hepatocytes co-cultured with bone marrow cells on tissue culture treated polystyrene surfaces, Journal of Artificial Organs, Vol.8, No.2, pp.104-109, 2005.08.
70. Shinji Sakai, Hiroki Masuhara, Yusuke Yamada, Tsutomu Ono, Hiroyuki Ijima, Koei Kawakami, Transition of mechanical property of porous alginate scaffold with cells during culture period, Journal of Bioscience and Bioengineering, 100, 1, 127-129, Vol.100, No.1, pp.127-129, 2005.07.
71. Hiroyuki Ijima, Koei Kawakami, Promote a monolayer formation and highly express the ammonia metabolism of primary rat hepatocyte on a RGD-containing peptide coated polystyrene dish, Journal of Bioscience and Bioengineering, Vol.100, No.1, pp.62-66, 2005.07.
72. Shinji Sakai, Kenji Kawabata, Tsutomu Ono, Hiroyuki Ijima, Koei Kawakami, Higher viscous solution induces smaller droplets for cell-enclosing capsules ina co-flowing stream, Biotechnology Progress, 21, 3, 994-997, Vol.21, pp.994-997, 2005, 2005.06.
73. Hiroyuki IJIMA, Takeshi MATSUO and Koei KAWAKAMI, Development of a Functional Culture Medium for Primary Rat Hepatocytes, Proceedings of 7th Asia-Pacific Biochemical Engineering Conference, 2005, 2005.05.
74. Sunao MURAKAMI, Shinji SAKAI, Tsutomu ONO, Hiroyuki IJIMA and Koei KAWAKAMI, Preparation of Chitosan Oligosaccharide-Phospholipid Complex, Proceedings of 7th Asia-Pacific Biochemical Engineering Conference, 2005, 2005.05.
75. Shinji Sakai, Kenji Kawabata, Tsutomu Ono, Hiroyuki Ijima, Koei Kawami, Development of mammalian cell-enclosing subsieve-size agarose capsules (<100um) for cell therapy, Biomaterials, 26, 23, 4786-4792, Vol.26, pp.4786-4792, 2005.01.
76. Koei Kawakami, Yoshihide Sera, Shinji Sakai, Tsutomu Ono, Hiroyuki Ijima, Development and Characterization of a Silica Monolith Immobilized Enzyme Micro-bioreactor, Industrial & Engineering Chemistry Research, 44, 1, 236-240, Vol.44, No.1, pp.236-240, 2005.01.
77. Tsutomu Ono, Mai Nagatomo, Tomoaki Nagao, Hiroyuki Ijima, Koei Kawakami, Non-aggregating refolding of Ribonclease A using reverse micellar dialysis, Biotechnology and Bioengineering, 89, 3, 290-295, Vol.89, No.3, pp.290-295, 2005.02.
78. H. Ijima, S. Kuroda, K. Kawakami, Digoxin transport by renal proximal tubule cells is enhanced on adhesive synthetic RGD peptide, Proceedings of 10th Asian Pacific Confederation of Chemical Engineering (APCChE) Congress, 2004.10.
79. T. Takei, H. Ijima, S. Sakai, T. Ono, K. Kawakami, Development of bFGF sustained-release bioabsorbable sponge and enhancement of angiogenesis in it, Proceedings of 10th Asian Pacific Confederation of Chemical Engineering (APCChE) Congress, 2004.10.
80. M. Morita, T. Ono, S. Sakai, H.Ijima, K. Kawakami, Development of DNA-containing nano scale vesicle by reverse micelles, Proceedings of 10th Asian Pacific Confederation of Chemical Engineering (APCChE) Congress, 2004.10.
81. S. Sakai, K. Kawabata, T. Ono, H. Ijima, K. Kawakami, Preparation of Mammalian Cell-Enclosing Subsieve-Sized Capsules (<100 um) in a Coflowing Stream, Proceedings of 10th Asian Pacific Confederation of Chemical Engineering (APCChE) Congress, 2004.10.
82. H. Ijima, T. Takei, K. Kawakami, Development of basic fibroblast growth factor sustained-releasable acidic gelatin-coated porous scaffold and its application to tissue engineering, ASAIO Journal, Vol.50, No.2, p.159, 2004.03.
83. H. Ijima, M. Nakashima, S. Furuta, T. Ono, K. Kawakami, Hydrothermal synthesis of porous hydroxyapatite plates from gypsum: Use as an animal cell culture substratum, Journal of Chemical Engineering of Japan, 37, 4, 531-535, 531-535, Vol.37, No.4, pp.531-535, 2004.04.
84. S. Sakai, K. Kawabata, T. Ono, H. Ijima, K. Kawakami, Preparetion of mammalian cell-enclosing subsieve-sized capsules (<100um) in a coflowing stream, Biotechnology and Bioengineering, 86, 2, 168-173, Vol.86, No.2, pp.168-173, 2004.04.
85. S. Murakami, H. Ijima, T. Ono, K. Kawakami, Development of co-culture system of hepatocytes with bone marrow cells for expression and maintenance of hepatic functions, The International Journal of Artificial Organs, 27, 2, 118-126, Vol.27, No.2, pp.118-126, 2004.02.
86. H. Ijima, Y. Wang, R. Langer, Spheroid formation and expression of liver specific function of primary rat hepatocytes co-cultured with bone marrow cells, Biochemical Engineering Journal, 20, 2-3, 223-228, 223-228, Vol.20, No.2-3, pp.223-228, 2004.08.
87. H. Ijima, T. Ohchi, T. Ono, K. Kawakami, Hydroxyapatite for use as an animal cell culture substratum obtained by an alternate soaking process, Biochemical Engineering Journal, 20, 2-3, 155-161, 155-161, Vol.20, No.2-3, pp.155-161, 2004.08.
88. S. Sakai, T. Ono, H. Ijima, K. Kawakami, MIN6 cells-enclosing aminopropyl-silicate membrane templated by alginate gels differences in guluronic acid content, International Journal of Pharmaceutics, 270, 1-2, 65-73, Vol.270, pp.65-73, 2004.02.
89. S. Sakai, T. Ono, H. Ijima, K. Kawakami, Proliferation and insulin secretion function of mouse insulinoma cells encapsulated in alginate/sol-gel synthesized aminopropyl-silicate/alginate microcapsule, Journal of Sol-Gel Science and Technology, 28, 2, 267-272, Vol.28, pp.267-272, 2003.09.
90. Y. Yamashita, M. Shimada, E. Tsujita, K. Shirabe, H. Ijima, K. Nakazawa, R. Sakiyama, J. Fukuda, K. Funatsu, K. Sugimachi, Efficacy of a larger version of the hybrid artificial liver support system using a polyurethane foam/spheroid packed-bed module in a warm ischemic liver failure pig model for preclinical experiment, Cell Transplantation, 12, 2, 101-107, Vol.12, No.2, pp.101-107, 2003.01.
91. S. Sakai, T. Ono, H. Ijima, K. Kawakami, Modification of porous aminopropyl-silicate microcappsule membrane by electrically-bonded external anionic polymers, J. Biomater. Sci. Polymer Edn., 14, 7, 643-652, Vol.14, No.7, pp.643-652, 2003.01.
92. J. Fukuda, K. Okamura, K. Nakazawa, H. Ijima, Y. Yamashita, M. Shimada, K. Shirabe, E. Tsujita, K. Sugimachi, K. Funatsu, Efficacy of a polyurethane foam/spheroid artificial liver by using human hepatoblastoma cell line (Hep G2), Cell Transplantation, 12, 1, 51-58, Vol.12, No.1, pp.51-58, 2003.01.
93. K. Kawakami, Y. Matsui, T. Ono, H. Ijima, Enhancement of protease activity in transesterification of glycidol with vinyl n-butyrate by entrapment into alkyl-substituted silicates and pretreatment with a substrate, Biocatalysis and Biotransformation, 21, 1, 49-52, Vol.21, No.1, pp.49-52, 2003.02.
94. R. Sakiyama, K. Nakazawa, H. Ijima, H. Mizumoto, T. Kajiwara, M. Ito, H. Ishibashi, K. Funatsu, Recovery of rats with fulminant hepatic failure by using a hybrid artificial liver support system with polyurethane foam/rat hepatocyte spheroid, International Journal of Artificial Organs, 25, 12, 1144-1152, Vol.25, No.12, pp.1144-1152, 2002.12.
95. S. Sakai, T. Ono, H. Ijima, K. Kawakami, In vitro and in vivo evaluation of alginate/sol-gel synthesized aminopropyl-silicate/alginate membrane for bioartificial pancreas, Biomaterials, 23, 21, 4177-4183, Vol.23, No.21, pp.4177-4183, 2002.11.
96. 中澤浩二,水本博,井嶋博之,船津和守, 肝細胞組織体の新規形成法と肝小葉類似構造を有する新規人工肝臓モジュールの開発, 人工臓器, Vol.31, No.1, 23-24, 2002.01.
97. Y. Yamashita, M. Shimada, E. Tsujita, K. Shirabe, H. Ijima, K. Nakazawa, R. Sakiyama, J. Fukuda, K. Funatsu, K. Sugimachi, High metabolic function of primary human and porcine hepatocytes in a polyurethane foam/spheroid culture system in plasma from patients with fulminant hepatic failure, Cell Transplantation, 11, 4, 379-384, Vol.11, No.4, 379-384, 2002.01.
98. S. Sakai, T. Ono, H. Ijima, K. Kawakami, Permeability of alginate/sol-gel synthesized aminopropyl-silicate/alginate membrane templated by calcium-alginate gel, Journal of Membrane Science, 205, 1-2, 183-189, Vol.205, No.1-2, pp.183-189, 2002.08.
99. Shinji Sakai, Tsutomu Ono, Hiroyuki Ijima, Koei Kawakami, Permeability of a sol-gel synthesized aminopropyl-silicate-titanate hybrid membrane for the microcapsule-shaped bioartificial pancreas, Journal of Artificial Organs, Vol.5, pp.54-59, 2002, 2002.01.
100. S. Sakai, T. Ono, H. Ijima, K. Kawakami, Aminopropyl-silicate membrane for microcapsule-shaped bioartificial organs: control of molecular permeability, Journal of Membrane Science, 202, 1-2, 73-80, Vol.202, No.1-2, pp.73-80, 2002.06.
101. S. Furukawa, T. Ono, H. Ijima, K. Kawakami, Effect of imprinting sol-gel immobilized lipase with chiral template substrates in esterification of (R)-(+)- and (S)-(-)-glycidol, Journal of Molecular Catalysis B-Enzymatic, 17, 1, 23-28, Vol.17, No.1, pp.23-28, 2002.03.
102. Y. Yamashita, M. Shimada, H. Ijima, K. Nakazawa, K. Funatsu, Hybrid artificial liver support system, Surgery, 131, 1, S334-S340, Vol.131, No.1, S334-S340, 2002.01.
103. K. Nakazawa, H. Ijima, J. Fukuda, R. Sakiyama, Y. Yamashita, M. Shimada, K. Shirabe, E. Tsujita, K. Sugimachi, K. Funatsu, Development of a hybrid artificial liver using polyurethane foam/hepatocyte spheroid culture in a preclinical pig experiment, The International Journal of Artificial Organs, 25, 1, 51-60, Vol.25, No.1, pp.51-60, 2002.01.
104. S. Furukawa, T. Ono, H. Ijima, K. Kawakami, Activation of protease by sol-gel entrapment into organically modified hybrid silicates, Biotechnology letters, 24, 1, 13-16, Vol.24, No.1, pp.13-16, 2002.01.
105. S. Sakai, T. Ono, H. Ijima, K. Kawakami, Newly developed aminopropyl-silicate immunoisolation membrane for a microcapsule-shaped bioartificial pancreas, Annals of the New York Academy of Science, 944, 277-283, Vol.944, pp.277-283, 2001.01.
106. H. Ijima, A. Noguchi, T. Katsuno, T. Ono, K. Nakazawa, K. Funatsu, Evaluating the performance of a hybrid artificial liver support system with a recoverable hepatic failure rat model, Annals of the New York Academy of Science, 944, 344-349, Vol.944, pp.344-349, 2001.01.
107. S. Sakai, T. Ono, H. Ijima, K. Kawakami, Synthesis and transport characterization of alginate/aminopropylsilicate/alginate microcapsule: application to bioartificial pancreas, Biomaterials, 22, 21, 2827-2834, Vol.22, No.21, pp.2827-2834, 2001.11.
108. J. Fukuda, R. Sakiyama, K. Nakazawa, H. Ijima, Y. Yamashita, M. Shimada, K. Shirabe, E. Tsujita, K. Sugimachi, K. Funatsu, Mass preparation of primary porcine hepatocytes and the design of a hybrid artificial liver module using spheroid culture for a clinical trial, The International Journal of Artificial Organs, 24, 11, 799-806, Vol.24, No.11, pp.799-806, 2001.11.
109. J. Fukuda, K. Okamura, R. Sakiyama, K. Nakazawa, H. Ijima, Y. Yamashita, M. Shimada, K. Shirabe, S. Tanaka, E. Tsujita, K. Sugimachi, K. Funatsu, Development of a hybrid artificial liver support system for a clinical trial, Hepatology, 34, 4, 304A-304A, Vol.34, No.4, p.304A, 2001.10.
110. K. Nakazawa, H. Mizumoto, K. Ishihara, H. Ijima, K. Funatsu, Establishment of novel hepatocyte organoid culture and its application to development of hybrid artificial liver module, Hepatology, 34, 4, 662A-662A, Vol.34, No.4, p.662A, 2001.10.
111. S. Furukawa, T. Ono, H. Ijima, K. Kawakami, Enhancement of activity of sol-gel immobilized lipase in organic media by pretreatment with substrate analogues, Journal of Molecular Catalysis B-Enzymatic, 15, 1-3, 65-70, Vol.15, No.1-3, pp.65-70, 2001.09.
112. Y. Yamashita, M. Shimada, E. Tsujita, S. Tanaka, H. Ijima, K. Nakazawa, R. Sakiyama, J. Fukuda, T. Ueda, K. Funatsu, K. Sugimachi, Polyurethane foam/spheroid culture system using human hepatoblastoma cell line (Hep G2) as a possible new hybrid artificial liver, Cell Transplantation, 10, 8, 717-722, Vol.10, No.8, pp.717-722, 2001.01.
113. 藤井政徳,山下洋市,調憲,井嶋博之,中澤浩二,船津和守,杉町圭蔵, ヒト肝細胞人工肝臓作製に関する基礎研究:ヒト肝腫瘍由来細胞株(Hep G2, Huh 7)における細胞外マトリクス(I型コラーゲン)の肝細胞機能発現への影響に関する研究, 福岡医学会雑誌, Vol.92, No.8, pp.299-305, 2001.01.
114. S. Sakai, T. Ono, H. Ijima, K. Kawakami, Control of transport characteristic of membrane by multi-layering of polyelectrolyte complex toward microcapsule-shaped bioartificial pancreas, Kagaku Kogaku Ronbunshu, 27, 2, 165-168, Vol.27, No.2, pp.165-168, 2001.03.
115. K. Funatsu, H. Ijima, K. Nakazawa, Y. Yamashita, M. Shimada, K. Sugimachi, Hybrid artificial liver using hepatocyte organoid culture, Artificial Organs, 25, 3, 194-200, Vol.25, No.3, pp.194-200, 2001.03.
116. Y. Yamashita, M. Shimada, E. Tsujita, T. Rikimaru, H. Ijima, K. Nakazawa, R. Sakiyama, J. Fukuda, K. Funatsu, K. Sugimachi, The efficacy of nafamostat mesilate on the performance of a hybrid artificial liver using a polyurethane foam/prcine hepatocyte spheroid culture system in hyman plasma, The International Journal of Artificial Organs, 24, 1, 34-40, Vol.24, No.1, pp.34-40, 2001.01.
117. H. Ijima, K. Nakazawa, M. Kaneko, J. Fukuda, M. Shimada, Y. Yamashita, T. Gion, K. Shirabe, K. Sugimachi and K. Funatsu, Development of a hybrid artificial liver support system and preclinical animal experiment, Journal of Artificial Organs, Vol.3, No.2, pp.112-116, 2000.12.
118. 井嶋博之,川上幸衛, 動物細胞培養担体としてのヒドロキシアパタイト, 粉体と工業, Vol.32,No.11,pp.61-67, 2000.11.
119. S. Sakai, T. Ono, H. Ijima, K. Kawakami, Fabrication and evaluation of sol-gel synthesized microcapsule as a bioartificial pancreas, Proceedings of the 5th Kyushu/Pusan-Kyoungnam & 4th Kyushu/Taipei Chemical Engineering Conference, pp.90-91, 2000.12.
120. T. Ono, G. Kojima, H. Ijima, K. Kawakami, Enzyme immobilization in nanosilica particles prepared by reversed micelles, Proceedings ofYABEC 2000 Symposium, pp.27, 2000.11.
121. 中澤浩二,井嶋博之,船津和守, ハイブリッド型の人工肝臓と人工膵臓の発展, バイオサイエンスとインダストリー, Vol.58, No.11, pp.777-780, 2000.11.
122. 古川真也,小野努,井嶋博之,川上幸衛, ゾル—ゲル法により調製した有機—無機ハイブリッドシリカ固定化リパーゼの触媒性能, 化学工学論文集, Vol.26, No.6, pp.882-886, 2000.11.
123. S. Sakai, T. Ono, H. Ijima, K. Kawakami, Control of molecular weight cut-off for immunoisolation by multilayering glycol chitosan-alginate polyion complex on alginate-based microcapsule, Journal of Microencapsulation, 17, 6, 691-699, Vol.17, NO.6, pp.691-699, 2000.11.
124. Y. Yamashita, M. Shimada, T. Gion, H. Hasegawa, H. Ijima, K. Nakazawa, R. Sakiyama, J. Fukuda, K. Funatsu, K. Sugimachi, Hybrid artificial liver using a polyurethane foam packed-bed culture system, New Aspects of High Technology in Medicine (Proceedings of the World Congress of High-Tech Medicine), 313-316, pp.313-316, 2000.10.
125. G. Kojima, T. Ono, H. Ijima, K. Kawakami, Preparation of enzyme-entrapped nanosilica particles by using reversed micelles, Proceedings of the 13th Symposium on Chemical Engineering, Kyushu-Taejon/Chungnam, Vol.13, pp.395-396, 2000.10.
126. T. Ohchi, K. Nakao, T. Ono, H. Ijima, K. Kawakami, The formation and evaluation of a hydroxyapatite as an animal cell culture substratum, Proceedings of the 13th Symposium on Chemical Engineering, Kyushu-Taejon/Chungnam, Vol.13, pp.299-300, 2000.10.
127. S. Shimono, F. Abe, T. Ono, H. Ijima, K. Kawakami, Effect of reactivation conditions on stability of immobilized pseudomonas putida KF715-D6 in biodegradation of trichloroethylene, Proceedings of the 13th Symposium on Chemical Engineering, Kyushu-Taejon/Chungnam, Vol.13, pp.295-296, 2000.10.
128. K. Yamamoto, T. Ono, H. Ijima, K. Kawakami, Cell-free protein synthesis using template DNA in reversed micelles, Proceedings of the 13th Symposium on Chemical Engineering, Kyushu-Taejon/Chungnam, Vol.13, pp.275-276, 2000.10.
129. H. Ijima, K. Nakazawa, S. Koyama, M. Kaneko, T. Matsushita, T. Gion, K. Shirabe, M. Shimada, K. Takenaka, K. Sugimachi and K. Funatsu, Conditions required for a hybrid artificial liver support system using PUF/hepatocyte-spheroid packed-bed module and it's use in dogs with liver failure, The International Journal of Artificial Organs, 23, 7, 446-453, Vol.23, No.7, pp.446-453, 2000.07.
130. H. Ijima, K. Nakazawa, S. Koyama, M. Kaneko, T. Matsushita, T. Gion, K. Shirabe, M. Shimada, K. Takenaka, K. Sugimachi and K. Funatsu, Development of a hybrid artificial liver using a polyurethane foam/hepatocyte-spheroid packed-bed module, The International Journal of Artificial Organs, 23, 6, 389-397, Vol.23, No.6, pp.389-397, 2000.06.
131. 山下洋市,島田光生,調憲,祇園智信,濱津隆之,力丸竜也,井嶋博之,中澤浩二,金子充,福田淳二,船津和守,杉町圭蔵, 臨床応用可能な人工肝臓の開発, 肝臓, Vol.41, No.3, pp.229-230, 2000.03.
132. 藤井康雄,中澤浩二,井嶋博之,船津和守, 臨床治療用ハイブリッド型人工肝臓補助システムの開発—九州大学倫理委員会への申請—, 化学工学, Vol.64, No.2, pp.74-77, 2000.02.
133. K. Nakazawa, H. Mizumoto, M. Kaneko, H. Ijima, T. Gion, M. Shimada, K. Shirabe, K. Takenaka, K. Sugimachi, K. Funatsu, Formation of porcine hepatocyte spheroid multicellular aggregates (spheroid) and analysis of drug metabolic functions, Cytotechnology, 31, 1-2, 61-68, Vol.31, No.1-2, pp.61-68, 1999.01.
134. H. Mizumoto, M. Hayakami, K. Nakazawa, H. Ijima, K. Funatsu, Formation of cylindrical multicellular aggregate (cylindroid) and expression of liver specifuc functions of primary rat hepatocytes, Cytotechnology, 31, 1-2, 69-75, Vol.31, No.1-2, pp.69-75, 1999.01.
135. S. Sakai, T. Ono, H. Ijima, K. Kawakami, Transport characterization of barium alginate gel beads multilayered with glycol chitosan-alginate polyion complex for bioartificial pancreas, Proceedings of APBioChEC'99, 1999.11.
136. S. Furukawa, T. Ono, H. Ijima, K. Kawakami, Esterification characteristics of lipase immobilized into organic-inorganic hybrid silicates, Proceedings of APBioChEC'99, 1999.11.
137. S. Shimono, N. Nakamura, T. Ono, H. Ijima, K. Kawakami, A. Suyama, K. Furukawa, Degradation of trichloroethylene by immobilized whole cells of recombinant pseudomonas putida KF715-D6, Proceedings of APBioChEC'99, 1999.11.
138. A. Noguchi, T. Katsuno, T. Ono, H. Ijima, K. Nakazawa, K. Funatsu, Study of an artificial liver support system with recoverable hepatic failure rat model, Proceedings of the 12th Symposium on Chemical Engineering, Taejon/Chungnam-Kyushu, Vol.12, pp.341-342, 1999.10.
139. S. Furukawa, T. Ono, H. Ijima, K. Kawakami, A kinetic study of menthol esterification with butyric acid catalyzed by organic-inorganic hybrid gel-immobilized lipase in organic media, Proceedings of the 12th Symposium on Chemical Engineering, Taejon/Chungnam-Kyushu, Vol.12, pp.209-210, 1999.10.
140. H. Hasegawa, M. Shimada, T. Gion, H. Ijima, K. Nakazawa, K. Funatsu, K. Sugimachi, Modulation of immunologic reactions between cultured porcine hepatocytes and human sera, ASAIO Journal, 45, 5, 392-396, Vol.45, No.5, pp.392-396, 1999.09.
141. 山下洋市,調憲,島田光生,井嶋博之,中澤浩二,船津和守,杉町圭蔵, 臨床応用可能な人工肝臓の開発, 治療:The Journal of Therapy, Vol.81, No.9, pp.146-147, 1999.09.
142. K. Nakazawa, H. Ijima, M. Kaneko, J. Fukuda, T. Gion, M. Shimada, K. Shirabe, K. Takenaka, K. Sugimachi, K. Funatsu, Development of a hybrid artificial liver support system and its application to hepatic failure animals, Tissue Engineering for Therapeutic Use 3, 1175, 43-52, pp.43-52, 1999.09.
143. K. Nakazawa, H. Ijima, M. Kaneko, J. Fukuda, M. Shimada, T. Utsunomiya, T. Gion, Y. Yamashita, K. Sugimachi, K. Funatsu, Spheroid formation of primary hepatocytes using polyurethane foam and maintenance of liver-specific functions, ASAIO Journal, Vol.45, No.2, p.202, 1999.05.
144. H. Ijima, K. Nakazawa, M. Kaneko, T. Katsuno, J. Fukuda, M. Shimada, T. Utsunomiya, T. Gion, Y. Yamashita, K. Sugimachi and K. Funatsu, Preclinical animal experiment of a hybrid artificial liver, ASAIO Journal, Vol.45, No.2, pp.201, 1999.05.
145. M. Kaneko, T. Ito, K. Nakazawa, H. Ijima, T. Matsushita, T. Gion, M. Shimada, K. Shirabe, H. Hasegawa, K. Takenaka, K. Sugimachi, K. Funatsu, Development of a hybrid artificial liver support system with porcine hepatocyte spheroids for preclinical use, Animal Cell Technology: Basic & Spplied Aspects, 277-281, Vol.10, pp.277-281, 1999.05.
146. H. Mizumoto, M. Kaneko, K. Nakazawa, H. Ijima, T. Matsushita, K. Funatsu, Formation of cylindrical multicellular aggregate (Cylindroid) of rat hepatocytes on pressed sheet of polyurethane foam, Animal Cell Technology: Basic & Spplied Aspects, 229-233, Vol.10, pp.229-233, 1999.05.
147. T. Gion, M. Shimada, K. Shirabe, K. Nakazawa, H. Ijima, T. Matsushita, K. Funatsu, K. Sugimachi, Evaluation of a hybrid artificial liver using a polyurethane foam packed-bed culture system in dogs, Journal of Surgical Research, 82, 2, 131-136, Vol.82, No.2, pp.131-136, 1999.04.
148. H. Ijima, K. Nakazawa, K. Funatsu, Development of a hybrid artificial liver, Organ Biology, Vol.5, No.4, pp., 1998.12.
149. H. Ijima, K. Nakazawa, M. Kaneko, H. Mizumoto, T. Matsushita, T. Gion, M. Shimada, K. Shirabe, K. Takenaka, K. Sugimachi and K. Funatsu, The formation of a spheroid of primary hepatocytes and the expression of liver-specific functions depend on the characteristics of polyurethane foam, Journal of Artificial Organs, Vol.1,pp.83-88, 1998.01.
150. S. Furukawa, T. Iwabe, H. Ijima, K. Kawakami, Efficient immobilization of lipase by sol-gel method into organic-inorganic hybrid silicates, Proceedings of the 11th Symposium on Chemical Engineering Kyushu-Taejon/Chungnam, 1998.10.
151. S. Sakai, Y. Ishimaru, K. Yamamoto, H. Ijima, K. Kawakami, Development of biomaterials for microencapsulation of islets toward bioartificial pancreas, Proceedings of the 11th Symposium on Chemical Engineering Kyushu-Taejon/Chungnam, 1998.10.
152. A. Noguchi, T. Katsuno, K. Ohno, H. Ijima, K. Nakazawa, K. Funatsu, K. Kawakami, A novel method for evaluating the performance of an artificial liver using rats, Proceedings of the 11th Symposium on Chemical Engineering Kyushu-Taejon/Chungnam, 1998.10.
153. K. Funatsu, H. Ijima, K. Nakazawa, M. Kaneko, T. Gion, M. Shimada, K. Shirabe, K. Takenaka, K. Sugimachi, Preclinical test of hybrid artificial liver support system using liver failure dogs and pigs, Hepatology, 28, 4, 751A-751A, Vol.28, No.4, p.751A, 1998.10.
154. M. Kaneko, J. Fukuda, H. ijima, K. Nakazawa, T. Gion, M. Shimada, K. Shirabe, K. Takenaka, K. Sugimachi, K. Funatsu, Development of hybrid artificial liver support system using spheroid culture and application to warm ischemic liver failure in dog and pig as a preclinical test, Materials Science & Engineering C-Biomimetic and Supramolecular Systems, 6, 4, 245-248, Vol.6, No.4, pp.245-248, 1998.12.
155. K. Nakazawa, H. Ijima, M. Kaneko, T. Katsuno, T. Matsushita, T. Gion, M. Shimada, K. Shirabe, K. Takenaka, K. Sugimachi, K. Funatsu, Effect of in vitro hybrid artificial liver support system in human plasma of hepatic failure patient, Proceedings of the Joint International Meeting of the Japanese Association for Animal Cell Technology and the European Society for Animal Cell Technology (JAACT/ESACT'98), 1998.07.
156. H. Ijima, K. Nakazawa, M. Kaneko, T. Katsuno, T. Matsushita, T. Gion, M. Shimada, K. Shirabe, K. Takenaka, K. Sugimachi, K. Funatsu, Preclinical test of hybrid artificial liver support system using liver failure dogs and pigs, Proceedings of the Joint International Meeting of the Japanese Association for Animal Cell Technology and the European Society for Animal Cell Technology (JAACT/ESACT'98), 1998.07.
157. H. Ijima, K. Nakazawa, H. Mizumoto, T. Matsushita and K. Funatsu, Formation of a spherical multicellular aggregate (spheroid) of animal cells in the pores of polyurethane foam as a cell culture substratum and its application to a hybrid artificial liver, Journal of Biomaterials Science (Polymer Edition), 9, 7, 765-778, Vol.9,pp.765-778, 1998.01.
158. H. Ijima, T. Matsushita, K. Nakazawa, Y. Fujii and K. Funatsu, Hepatocyte spheroids in polyurethane foams: Functional analysis and application for a hybrid artificial liver, Tissue Engineering, 4, 2, 213-226, Vol.4, No.2, pp.213-226, 1998.01.
159. 中澤浩二,井嶋博之,金子充,伊東俊純,松下琢,祇園智信,調憲,島田光生,竹中賢治,杉町圭蔵,船津和守, 初代ブタ肝細胞のポリウレタンフォーム(PUF)/スフェロイド培養法を用いたハイブリッド型人工肝臓開発のための培養条件の検討, 人工臓器, Vol.27, No.1, pp.222-226, 1998.01.
160. K. Funatsu, K. Matsunaga, H. Ijima, T. Matsushita, Finite element analysis of 3-dimensional flow in agitated bioreactors, Animal Cell Technology: Basic & Applied Aspects, 75-82, Vol.8, pp.75-82, 1997.01.
161. 井嶋博之,小山伸吾,中澤浩二,松下琢,船津和守,祇園智信,調憲,島田光生,竹中賢治,杉町圭蔵, PUF/肝細胞スフェロイド充填層型人工肝臓のイヌ温虚血肝不全モデルへの適用, 肝臓病学の最前線, Vol.1997,pp.345-350, 1997.01.
162. 井嶋博之,和田茂久,中澤浩二,松下 琢,船津和守, PUF/肝細胞スフェロイド充填層型人工肝臓の薬物誘導肝不全ラットへの適用— システムの最適化による治療効果の向上 —, 人工臓器, Vol.26,No.3,pp.719-723, 1997.01.
163. 中澤浩二,水本博,井嶋博之,松下琢,船津和守, PUF/肝細胞スフェロイド培養法を利用した薬物代謝シミュレータの開発 ‐人工肝臓装置によるアセトアミノフェン代謝の研究‐, 人工臓器, Vol.26, No.3, pp.713-718, 1997.01.
164. 松下琢,小山伸吾,井嶋博之,中澤浩二,祇園智信,調憲,島田光生,竹中賢治,杉町圭蔵,船津和守, PUF/肝細胞スフェロイド充填層型人工肝臓のイヌ温虚血肝不全モデルへの適用, 人工臓器, Vol.26, No.2, pp.455-459, 1997.01.
165. H. Ijima, T. Matsushita, K. Nakazawa, S. Koyama, T. Gion, K. Shirabe, M. Shimada, K. Takenaka, K. Sugimachi and K. Funatsu, Spheroid formation of primary dog hepatocytes using polyurethane foam and its application to hybrid artificial liver, Animal Cell Technology: From Vaccines to Genetic Medicine, 577-583, pp.577-583, 1997.01.
166. 和田茂久,井嶋博之,松下琢,船津和守, 肝不全ラットを用いた体外循環によるPUF/肝細胞スフェロイド充填層型人工肝臓の性能評価 −最適装置条件の検討−, 人工臓器, Vol.25, No.3, pp.678-682, 1996.01.
167. 松下琢,井嶋博之,和田茂久,船津和守, 肝不全ラット体外循環によるポリウレタンフォーム(PUF)/肝細胞スフェロイド充填層型人工肝臓の性能評価, 人工臓器, Vol.24, No.3, pp.815-820, 1995.01.
168. H. Ijima, T. Matsushita, M. Taga, S. Wada, K. Hamazaki, N. Koide and K. Funatsu, Establishment of a rat extracorporeal circulation system to estimate the performance of a hybrid artificial liver, Animal Cell Technology: Basic & Applied Aspects, 395-399, Vol.6,pp.395-399, 1994.01.
169. Kazumori Funatsu, Yasuhiko Kawakubo, Hiroyuki Ijima, Taku Matsushita, High density culture of animal cells and its application to hybrid artificial liver support systems in Japan, Artificial Organs Today, Vol.3, No.4, pp.253-274, 1994.01.
170. 松下琢,井嶋博之,船津和守,浜崎啓介,小出典男, 初代肝細胞のPUF/スフェロイド培養系を用いたハイブリッド型人工肝臓の開発, 人工臓器, Vol.23, No.2, pp.469-472, 1994.01.
171. 井嶋博之,松下 琢,船津和守, 多細管型PUF充填層を用いたハイブリッド型人工肝臓の開発, 人工臓器, Vol.23,No.2,pp.463-468, 1994.01.
172. 井嶋博之,松下 琢,船津和守, 初代肝細胞のPUF/スフェロイド培養系を用いたハイブリッド型人工肝臓の開発, — アンモニア処理能力の評価 — ,人工臓器, Vol.22,No.1,pp.171-176, 1993.01.
173. 松下琢,井嶋博之,船津和守, 肝実質細胞のポリウレタンフォーム孔内三次元培養法を利用したハイブリッド型人工肝臓の開発, 人工臓器, Vol.31, No.3, pp.1050-1054, 1992.01.
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