| Hiroshi Mizumoto | Last modified date：2013.5.15 |
Associate Professor /
Molecular and Biochemical Systems Engineering
Department of Chemical Engineering
Faculty of Engineering
Department of Chemical Engineering
Faculty of Engineering
Graduate School
Undergraduate School
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Homepage
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Description about our research, publications and members.
Academic Degree
Doctor of engineering
Field of Specialization
Bioengineering
Outline Activities
We have developed the original techniques of organoid formation and applied these to develop the hybrid artificial liver. We established the spheroid formation using the polyurethane foam as scaffold of cell culture and developed the hybrid artificial liver support system for clinical use of acute liver failure. The system was applied to the large scaled animal and the clinical effectiveness was proved. We also established the maintenance of liver functions for several months using the hollow fiber as the scaffold and using the centrifugal-force-induced organoid formation and developed the hybrid artificial liver with lobule like structure for chronic liver failure.
Research
Research Interests
Membership in Academic Society
- In Vitro Reconstruction of Three Dimensional Hematopoietic Microenvironment for Mouse Bone Marrow Cells Using Polyurethane Foam
keyword : bone marrow, hematopoietic stem cell, three dimensional culture, regenerative medicine
2006.04. - Development of mass cultivation system for embryonic stem cell
keyword : embryonic stem cell, mass cultivation system, regenerative medicine
2005.04. - Development of hybrid artificial liver support system
keyword : hybrid artificial liver, bioreactor, artificial organs, regenerative medicine, hepatocyte, stem cell
2000.04. - Development of three dimensional culture system for animal cells and application to regenerative medicine technology
keyword : three dimensional culture, multicellular organoid, regenerative medicine, stem cell
2000.04.
Books
| 1. | Bioengineering and Biomedical Engineering: 6.2 Artificial Organs, H. Mizumoto, T. Kajiwara, K. Funatsu, CORONA PUBLISHING CO., LTD., pp.201-210, April, 2006. |
| 2. | Shokuhin Setsubi, Kiki-Jiten: Chap. 6 Large-Scale Cell Culture System, H. Mizumoto, K. Funatsu, Industrial Research Center of Japan, Inc., pp.400-404, July, 2002. |
Reports
| 1. | Hybrid artificial liver using hepatocyte organoid, H. Mizumoto, K. Nakazawa, H. Ijima, K. Funatsu, T. Kajiwara, Regenerative Medicine, Vol. 5, pp.389-394, August, 2006. |
| 2. | Development of a hybrid artificial liver using hepatocyte organoid culture, K. Aoki, H. Mizumoto, K. Nakazawa, T. Kajiwara, K. Funatsu, Book Chemical Engineering Symposium Series 79, pp. 80-83, January, 2006. |
| 3. | Development of Hybrid Artificial Liver Using Hollow Fiber, H. Mizumoto, K. Nakazawa, T. Kajiwara, K. Funatsu, Seikei-Kakou, Vol.14, No.12, pp.781-786, December, 2002. |
Papers
| 1. | H. MIZUMOTO, S. HAYASHI, K. MATSUMOTO, K. IKEDA, T. KUSUMI, M. INAMORI, K. NAKAZAWA, H. IJIMA, K. FUNATSU, T. KAJIWARA,Evaluation of a Hybrid Artificial Liver Module Based on a Spheroid Culture System of Embryonic Stem Cell-Derived Hepatic Cells,Cell Transplantation,Vol.21,No.2-3,pp.421-428,2012.02. |
| 2. | N. AMIMOTO, H. MIZUMOTO, K. NAKAZAWA, H. IJIMA, K. FUNATSU, T. KAJIWARA,Hepatic Differentiation of Mouse Embryonic Stem Cells and Induced Pluripotent Stem Cells During Organoid Formation in Hollow Fibers,Tissue Engineering Part A,Vol.17,No.15-16,pp.831-839,2011.08. |
| 3. | M. INAMORI, H. MIZUMOTO, T. KAJIWARA,An Approach for Formation of Vascularized Liver Tissue by Endothelial Cell-covered Hepatocyte Spheroid Integration,Tissue Engineering Part A,Vol. 15, No. 8, pp. 2029-2037,2009.08. |
| 4. | H. MIZUMOTO, K. ISHIHARA, K. NAKAZAWA, H. IJIMA, K. FUNATSU, T. KAJIWARA,A New Culture Technique for Hepatocyte Organoid Formation and Long-Term Maintenance of Liver Specific Functions,Tissue Engineering Part C: Methods,Vol. 14, No. 2, pp. 167-175,2008.06. |
| 5. | H. MIZUMOTO, K. AOKI, K. NAKAZAWA, H. IJIMA, K. FUNATSU, T. KAJIWARA,Hepatic Differentiation of Embryonic Stem Cells in HF/Organoid Culture,Transplantation Proceedings,Vol. 40, No. 2, pp. 611-613,2008.03. |
| 6. | K. AOKI, H. MIZUMOTO, K. NAKAZAWA, K. FUNATSU, T. KAJIWARA,Evaluation of a hybrid artificial liver module with liver lobule-like structure in rats with liver failure,The International Journal of Artificial Organs,Vol. 31, No. 1, pp.55-61,2008.02. |
| 7. | K. Ishihara, H. Mizumoto, K. Nakazawa, T. Kajiwara, K. Funatsu,Formation of a sheet-shaped organoid using rat primary hepatocytes for long-term maintenance of liver-specific functions,The International Journal of Artificial Organs,Vol.29, No.3, 318-328,2006.03. |
| 8. | J. Fukuda, H. Mizumoto, K. Nakazawa, T. Kajiwara, K. Funatsu,Hepatocyte organoid culture in elliptic hollow fibers to develop a hybrid artificial liver,The International Journal of Artificial Organs,Vol.27,No.12,Vol.27, No. 12, pp.1091-1099,2004.12. |
| 9. | H. Mizumoto, K. Funatsu,Liver regeneration by using a hybrid artificial liver,Artificial Organs,Vol. 12, No. 1, 51-58,2004.01. |
- The Japanese Society for Regenerative Medicine
- Japanese Society of Alternative to Animal Experiments
- The Society of Polymer Science, Japan
- Japanese Association for Animal Cell Technology
- Japanese Society for Artificial Organs
- The Society of Chemical Engineers, Japan
- The SCEJ technology Award, April, 2004
- Japanese Society for Artificial Organs Original Award, November, 2001
Educational
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