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Yuji Oshima Last modified date:2018.06.28

Professor / Animal and Marine Bioresource Sciences
Department of Bioresource Sciences
Faculty of Agriculture

Graduate School
Undergraduate School

Home page of Marine Environmental Science .
Academic Degree
A study on drug metabolizing enzyme activities of aquatic organism living in polluted area.
Field of Specialization
Fisheries Environmental Science
Research Interests
  • Effect of microplastic on aquatic animals
    keyword : microplastic aquatic animals
  • Study on tributyltin binding proteins
    keyword : lipocalin
  • A study on mass death of Pen shell using mRNA-Seq
    keyword : mRNA-Seq penshell 大量へい死
  • Mixture toxicity of tributyltin and PCBs
    keyword : Mixture toxicity
  • Effect of chemicals on behavior of fish
    keyword : behavior chemical
  • Pollution and its effect of tributyltin on aquatic organism
    keyword : tributyltin pollution effect
    1996.04~2003.01Pollution of tribtyltin in costal area and its effect on fish and bivalves.
  • Endocrine disruption of aquatic organism
    keyword : Endocrine disruption
    1996.04Endocrine disrution on fish.
  • Removal of PCBs from fish meat
    keyword : PCB fish meat
  • Pharmacokinetics of pharmaceuticals for fish
    keyword : modeling fish pharmaceutical
    1994.04~2003.01Pharmacokinetics of fish drugs.
Academic Activities
1. 大嶋 雄治, トリブチルスズの魚貝類への影響に関する生殖生理学的および生化学的研究. , 日本水産学会誌, Vol. 75 (2009) No. 3 pp.354-356., 2009.08.
2. Yuji Oshima, Kei Nakayama, Takashi Hano, Sang Gyoon Kim, Yohei Shimasaki, Ik Joon Kang, Tsuneo Honjo. , Toxic Interactions Between Tributyltin and Polychlorinated Biphenyls in Aquatic Organisms Ed T. Arai et al (eds.), , Environmental Impact of Antifouling Biocides, 2009. 195-205, 2009.02.
3. Kei Nakayama, Yuji Oshima, Adverse effects of tributyltin on reproduction of Japanese medaka, Oryzias latipes. , Coastal Marine Science, 2008.04.
1. M. Honda, X. Qiu, J. Koyama, S. Uno, S. L. Undap, Y. Shimasaki, Y. Oshima, Wharf roach Ligia sp: A novel environmental indicator for polycyclic aromatic hydrocarbons contamination at coastal area., Int J Environ Res, 12, 1-11, 2018.03.
2. Kase, Y., Ogiso, S., Ikari, T., Sekiguchi, T., Sasayama, Y., Kitani, Y., Shimasaki, Y., Oshima Y., Kambegawa, A., Tabuchi, Y., Hattpri A., and Suzuki, N, Immunoreactive calcitonin cells in the nervous system of polychaete Perinereis aibuhitensis, Journal of the Faculty of Agriculture, Kyushu University, 62, 381-385, 2017.01.
3. M. Honda, H. Gunjikake, S. Matsui, Y. Shimasaki, Y. Oshima, Effect of repeated exposure to low oxygen on respiratory metabolism and vertical movements in the pen shell Atrina lischkeana., Journal of the Faculty of Agriculture, Kyushu University, 62, 387-392, 2017.01.
4. Qiu, X., Tanoue, W., Kawaguchi, A., Yanagawa, T., Seki, M., Shimasaki, Y., Honjo, T., Oshima, Y.,, Interaction patterns and toxicities of binary and ternary pesticide mixtures to Daphnia magna estimated by an accelerated failure time model. Sci. Total Environ. . doi:10.1016/j.scitotenv.2017.07.034, Sci. Total Environ., 10.1016/j.scitotenv.2017.07.034, 607-608, 367-374, 2018.01, Organisms in natural environments are often exposed to a broad variety of chemicals, and the multi-chemical mixtures exposure may produce significant toxic effects, even though the individual chemicals are present at concentrations below their no-observed-effect concentrations. This study represents the first attempt that uses the accelerated failure time (AFT) model to quantify the interaction and toxicity of multi-chemical mixtures in environmental toxicology. We firstly conducted the acute immobilization tests with Daphnia magna exposed to mixtures of diazinon (DZN), fenitrothion (MEP); and thiobencarb (TB) in single, binary, and ternary formula- tions, and then fitted the results to the AFT model. The 48-h EC50 (concentration required to immobilize 50% of the daphnids at 48 h) values for each pesticide obtained from the AFT model are within a factor of 2 of the cor- responding values calculated from the single pesticide exposure tests, indicating the methodology is able to pro- vide credible toxicity values. The AFT model revealed either significant synergistic (DZN and MEP; DZN and TB) or
Daphnia magna
Interactive mixtures Synergism
1. Introduction
Organisms in natural environments are often exposed to a broad va- riety of anthropogenic and natural chemicals. In aquatic ecosystems, pesticides are rarely detected as single compounds but most often are found as mixtures (Gilliom, 2007; Kikuchi et al., 2000; Kreuger, 1998; Sakai, 2002; Tsuda et al., 2011). For example, N90% of agricultural streams with developed watersheds in the United States that were sur- veyed in 1992–2001 were found to contain three or more pesticides, and N20% of those streams contained ten or more pesticides (Gilliom, 2007). Monitoring efforts in Europe and Japan have also revealed that water samples collected from the vicinity of agricultural activities con- tain multiple pesticides (Kikuchi et al., 2000; Kreuger, 1998; Sakai, 2002; Tsuda et al., 2011). Moreover, experimental data have suggested that multi-chemical mixtures can produce significant toxic effects, even though the individual chemicals are present at concentrations below their no-observed-effect concentrations (Arnold et al., 1996; Deneer et al., 1988; Faust et al., 2003; Silva et al., 2002). Therefore, the risk as- sessment of chemical mixtures in the environment has become an area of great concern to both the public and regulatory authorities (Backhaus et al., 2010; Backhaus and Faust, 2012; Belden et al., 2007). However, many challenges remain to be addressed before sufficiently robust ways can be found to assess the risk of exposures to chemical mixtures, especially in ecotoxicology (Backhaus et al., 2010; Backhaus and Faust, 2012; Belden et al., 2007; Kortenkamp et al., 2007).
Generally, the concentration addition (CA) and independent action (IA) models are the two classical reference models for predicting the mixture toxicity, both of which assume that there is no interaction be- tween compounds in a mixture (Bliss, 1939; Loewe and Muischnek, 1926). The CA model, which assumes that the chemicals in a mixture act via similar mechanisms, is also known as “toxic unit summation”, since in this model one chemical can be replaced by an equal fraction of an equi-effective concentration of another, without changing the overall effect (Faust et al., 1994; Kortenkamp et al., 2009). Alternatively, the IA model originates from statistical considerations of independent responses and is applied for mixtures where the components affect or- ganisms through different modes of action (Altenburger et al., 2003; Bliss, 1939). The interactions of chemicals in a mixture cannot tested for directly from the CA or IA models, but are detected from the devia- tions between predicted and actually observed values (Belden et al., 2007; Kortenkamp et al., 2009). As a graphical application of CA model, the isobologram is a curve that reveals whether a toxicant mix- ture displays additivity, synergism or antagonism by plotting the con- centrations of two chemicals against each other and representing the amount of the toxicants in the formulations that produces a given ef- fects (Altenburger et al., 1990; Kortenkamp and Altenburger, 1998).
Both CA and IA models have been successfully applied to mixtures of various environmental toxicants, which are well summarized in several reviews (Baas et al., 2010; Backhaus and Faust, 2012; Belden et al., 2007; Cedergreen, 2014; Kortenkamp et al., 2009). However, some studies also indicated that there are some limitations in the application of CA and IA models to predict the impacts of more complex multi-chemical (e.g. ternary or more) mixtures (Chou, 2006; Jonker et al., 2005; Rider and LeBlanc, 2005). Recently, some success in improving the applicabil- ity (and predictive power) of these two models for evaluation of the antagonistic (MEP and TB) interactions in binary mixtures, while the interaction pattern of ternary mixture depended on both the concentration levels and concentration ratios of pesticides. With a factor of 2, the AFT model accurately estimated the toxicities for 78% of binary mixture formulations that exhibited significant syn- ergistic effects, and the toxicities for all the ternary formulations. Our results showed that the AFT model can pro- vide a simple and efficient way to quantify the interactions between pesticides and to assess the toxicity of their mixtures. This ability may greatly facilitate the ecotoxicological risk assessment of exposure to multi-chemical mixtures..
5. Honda, M., Muta, A., Shimazaki, A., Akasaka, T., Yoshikuni, M., Shimasaki, Y., Oshima, Y.,, High concentrations of perfluorooctane sulfonate in mucus of tiger puffer fish Takifugu rubripes: a laboratory exposure study., Environ Sci Pollut Res Int, 10.1007/s11356-017-0537-6, 186, 133-138, 2018.01.
6. Khalil, F., Qiu, X., Kang, I.J., Abo-Ghanema, I., Shimasaki, Y., Oshima, Y.,, Comparison of social behavior responses of Japanese medaka ( Oryzias latipes ) to lethal and sublethal chlorpyrifos concentrations at different exposure times., Ecotoxicology and Environmental Safety, 10.1016/j.ecoenv.2017.07.007, 145, 78-82, 2018.01.
7. Mukai, K., Teramoto, A., Qiu, X., Shimasaki, Y., Kato-Unoki, Y., Lee, J.M., Mizoguchi, N., Khanam, M.R.M., Satone, H., Tatsuke, T.,Kusakabe, T., Oshima, Y.,, Gene structure and cDNA sequence of 2-Cys peroxiredoxin in the harmful algal bloom species Chattonella marina and its gene transcription under different light intensities., European Journal of Phycology, 10.1080/09670262.2017.1346206, 53, 29-38, 2018.01.
8. Kang, I.J., Qiu, X., Moroishi, J.,Oshima, Y., Sound production in Japanese medaka (Oryzias latipes) and its alteration by exposure to aldicarb and copper sulfate., Chemosphere, 10.1016/j.chemosphere.2017.04.088, 530–535, 530-535, 2017.06.
9. Khanam, M.R.M., Shimasaki, Y., Hosain, M.Z., Mukai, K., Tsuyama, M., Qiu, X., Tasmin, R., Goto, H., Oshima, Y.,, Diuron causes sinking retardation and physiochemical alteration in marine diatoms Thalassiosira pseudonana and Skeletonema marinoi-dohrnii complex., Chemosphere, 10.1016/j.chemosphere.2017.02.054, 175, 200-209, 2017.06.
10. Sekiguchi, T., Kuraku, S., Tatsumi, K., Shimasaki, Y., Oshima, Y., Suzuki, N.,, Identification and Molecular Characterization of the Stanniocalcin Family Gene from the Inshore Hagfish, Eptatretus burgeri., Journal of the Faculty of Agriculture, Kyushu University,, 62, 93-98, 2017.06.
11. Qiu, X., Mukai, K., Shimasaki, Y., Tsuyama, M., Matsubara, T., Nakajima, Y., ... Oshima, Y., Potential Maximum Quantum Yield of Photosystem II Reflects the Growth Rate of Chattonella marina in Field Bloom Samples., Journal of the Faculty of Agriculture, Kyushu University,, 61, 331-335, 2016.06.
12. Liu Hongbo, Chen Xiubao, Shimasaki Yohei, Kang Ik Joon, Oshima Yuji, Yang Jian , The valve movement response of three freshwater mussels Corbicula fluminea Müller 1774, Hyriopsis   cumingii Lea 1852, and Anodonta woodiana Lea 1834 exposed to copper. , Hydrobiologia, 270, 1-13, 2016.06.
13. Qiu, X., Undap, S.L., Honda, M., Sekiguchi, T., Suzuki, N., Shimasaki, Y., Ando, H., Sato-Okoshi, W., Wada, T., Sunobe, T., Takeda, S., Munehara, H., Yokoyama H., Momoshima, N. and Oshima, Y. , Pollution of radiocesium and radiosilver in wharf roach (Ligia sp.) by the Fukushima Dai-ichi Nuclear Power Plant accident. , J Radioanal Nucl Chem., 311, 121-126, 2016.06.
14. Suzuki, N., Sato, M., Nassar, F. H., Abdel-gawad, F. Kh., Bassem, S.M., Yachiguchi, K., Tabuchi, Y., Endo, M., Sekiguchi, T., Urata, M., Hattori, A., Mishima, H., Shimasaki, Y., Oshima, Y., Hong, C.-S., Makino, F., Tang, N., Toriba, A. and Hayakawa, K.:, Seawater polluted with highly concentrated polycyclic aromatic hydrocarbons suppresses osteoblastic activity in the scales of goldfish, Carassius auratus. , Zool. Sci., 33, 407-413, 2016.06.
15. Liu, H., Chen, X., Su, Y., Qiu, X., Kang., IJ., Shimasaki, Y., Oshima Y., Yang, J. , Effects of Calcium and Magnesium Ions on Acute Copper Toxicity to Glochidia and Early Juveniles of the Chinese Pond Mussel Anodonta woodiana. , Bull of Env Cont Toxi., 97, 504-509, 2016.06.
16. Satone H, Nonaka S, Lee JM, Shimasaki Y, Kusakabe T, Kawabata S, Oshima Y. , Tetrodotoxin and tributyltin-binding abilities of recombinant pufferfish saxitoxin and tetrodotoxin binding proteins of Takifugu rubripes. , Toxicon. 125:50-52(2017), 125, 50-52, 2017.06.
17. Chen K, Tsutsumi Y, Yoshitake S, Qiu X, Xu H, Hashiguchi Y, Honda M, Tashiro K, Nakayama K, Hano T, Suzuki N, HayakawaK, Shimasaki Y, Oshima Y. , Alteration of development and gene expression induced by in ovo-nanoinjection of 3-hydroxybenzo[c]phenanthrene into Japanese medaka (Oryzias latipes) embryos. , Aquatic Toxicology, 182, 194-204, 2017.06.
18. Yohei Shimasaki, Michito Tsuyama, Rumana Tasmin, Mst Ruhina Margia Khanam, Xuchun Qiu, Yuji Oshima, Comparative study of toxicological responses of chlorophyll-related parameters in the marine diatom Skeletonema sp. exposed to tributyltin and Irgarol. Jpn., Jpn. J. Environ. Toxicol., 18, 2015.06, Yohei Shimasaki, Michito Tsuyama, Rumana Tasmin, Mst Ruhina Margia Khanam, Xuchun Qiu, Yuji Oshima .
19. Wilmy Etwil Pelle, Masashi Kamo, Takehiko I. Hayashi, Takeshi Kimura, Yohei Shimasaki, Yuji Oshima, Biotic ligand model of copper toxicity to Japanese medaka (Oryzias latipes) in low-hardness water
, 日本環境毒性学会, 18, 2, 59-71, 2015.12.
20. Liu Hongbo, Chen Xiubao, Yohei Shimasaki, Kang Ik Joon, Yamasaki Y, Yuji Oshima, Yang Jian, The valve movement response of three freshwater mussels Corbicula fluminea Müller 1774, Hyriopsis cumingii Lea 1852, and Anodonta woodiana Lea 1834 exposed to copper .
, Hydrobiologia, 10.1007/s10750-015-2560-2, 1-13, 2015.10.
21. Nobuo Suzuki, Somei, M, Atsuhiko HATTORI, Seki, A, Sekiguchi, T, Tabuchi, Y, Mishima, H, Kase, Y, Kaminishi, A, Yachiguchi, K, Kitamura, K, Yuji Oshima, Kazuichi HAYAKAWA, Yano, S, Hattori, A, Novel tryptophan derivatives as potentially effective therapeutic drugs to treat bone diseases., J. Life Sci., in press, in press, 2015.06, Suzuki, N., Somei, M., Seki, A., Sekiguchi, T., Tabuchi, Y., Mishima, H., Kase, Y., Kaminishi, A., Yachiguchi, K., Kitamura, K., Oshima, Y., Hayakawa, K., Yano, S. and Hattori, A.: Am. .
22. Rumana Tasmin, Yohei Shimasaki, Yoshida Y, Matsubara T, Yamasaki Y, Kawaguchi M, Honda M, Mouri K, Nakajima Y, Tasmin R, Kuno K, Kawamura Y, Yuji Oshima, Allelopathic effects of Skeletonema spp. may influence interspecific competition and bloom formation of co-occurring harmful flagellates., Journal of the Faculty of Agriculture, Kyushu University. , 59, 382, 2014.06, Allelopathic effects of Skeletonema spp. may influence interspecific competition and bloom formation of co-occurring harmful flagellates. .
23. Rumana Tasmin, Yohei Shimasaki, Michito Tsuyama, Xuchun Qiu, Khalil F, Okino N, Naotaka Yamada,, Shinji FUKUDA, Yuji Oshima, Kang IJ, Elevated water temperature reduces the acute toxicity of the widely used herbicide diuron to a green alga, Pseudokirchneriella subcapitata. , Environ Sci Poll Res, 21, 1070, 2014.06, Tasmin R, Shimasaki Y, Tsuyama M, Qiu X, Khalil F, Okino N, Yamada N, Fukuda S, Kang IJ, Oshima Y. .
24. Rumana Tasmin, Yohei Shimasaki, Xuchun Qiu, Masato Honda, Michito Tsuyama, Naotaka Yamada,, Shinji FUKUDA, Yuji Oshima, Elevated temperatures and low nutrients decrease the toxicity of diuron for growth of the green alga Pseudokirchneriella subcapitata. , J J Env Tox , 17, 5-10, 2014.02.
25. Nobuo Suzuki, Yusuke MARUYAMA, Masaki NAKANO, Atsuhiko HATTORI, Masato Honda, Toshio Skiguchi, Hiroyuki MISHIMA, Shigehito WADA, Ajai K. SRIVASTAV, Kazuichi HAYAKAWA, 大嶋 雄治, Increased PGE2 Has a Positive Correlation with Plasma Calcium during Goldfish Reproduction.
, J. Fac. Agr, Kyu. Univ., 59, 97-101, 2014.02.
26. Suzanne L Undap, Masato Honda, Natalie D. RUMAMPUK, Suguru INOUE, 島崎 洋平, Rizald Max ROMPAS, 望岡 典隆, 大嶋 雄治, Monitoring of Tributyltin Contamination of Demersal Fish in Coastal Water in East China Sea , J. Fac. Agr, Kyu. Univ. , 59, 103-107, 2013.10.
27. Masato Honda, Akemi Muta, Taiki Akasaka, Yoshiyuki Inoue, 島崎 洋平, Kurunthachalam Kannan, 沖野 望, 大嶋 雄治, Identification of perfluorooctane sulfonate binding protein in the plasma of tiger pufferfish Takifugu rubripes, Ecotox. Environ. Saf. , 104, 409-413, 2013.07.
28. Suzanne L Undap, Satoshi Matsunaga, Masato Honda, Toshio Skiguchi,, Nobuo Suzuki,, Fatma Khalil, Xuchun Qiu, 島崎 洋平, Hironori Ando, Waka Sato-Okoshi, Tomoki Sunobe, Satoshi Takeda, Hiroyuki Munehara, 大嶋 雄治, Accumulation of organotins in wharf roach (Ligia exotica Roux) and its ability to serve as a biomonitoring species for coastal pollution, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 10.1016/j.ecoenv.2013.06.019, 96, 75-79, 2013.10.
29. 島崎 洋平, 津山 孝人, Rumana Tasmin, Xuchun Qiu, Motoyuki Shimizu, Yusuke Sato, Yasuhiro Yamasaki,, Yoko Kato-Unoki, Atsushi Nukata, Hirofumi Ichinose, Hiroyuki Wariishi, Tsuneo Honjo, 大嶋 雄治, Thiobencarb Herbicide Reduces Growth, Photosynthetic Activity, and Amount of Rieske Iron-Sulfur Protein in the Diatom Thalassiosira pseudonana, JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 10.1002/jbt.21505, 27, 9, 437-444, 2013.09.
30. Fatma Khalil, Ik Joon Kang, Suzanne Undap, Rumana Tasmin, Yohei Shimasaki, Yuji Oshima, Alterations in social behavior of Japanese medaka (Oryzias latipes) in response to sublethal chlorpyrifos exposure. , Chemoshphere, 92, 125-130, 2013.02.
31. Hano T, Oshima Y, Kinoshia M, Tanaka M, Mishima N, Wakamatsu Y, Ozato K, Shi-masaki Y, Honjo T. , Evaluation of the effects of ethinylestradiol (EE2) on sexual differentiation in the olvas-GFP/STII-YI medaka (transgenic Oryzias latipes) strain as estimated by proliferative activity of germ cells. , Aquat Toxicol , (accepted), 2011.04.
32. Satone H, Lee JM, Oba Y, Kusakabe T, Akahoshi E, Miki S, Suzuki N, Sasayama Y, Nassef M, Shimasaki Y, Kawabata S, Honjo T, Oshima Y , Tributyltin-binding protein type 1, a lipocalin, prevents inhibition of osteoblastic activity by tributyltin in fish scales. , Aquat Toxicol , 103, 79-84, 2011.04.
33. Nakayama K, Sei N,. Handoh I, Shimasaki Y, Honjo T, Oshima Y. , Effects of polychlorinated biphenyls on liver function and sexual characteristics in Japanese medaka (Oryzias latipes). , Mar Poll Bull , 28:, (in printing), 2011.04.
34. Nassef M, Kato-Unoki Y, Furuta T, Nakayama K, Satone H, Shimasaki Y, Honjo T, Oshima Y. , Molecular cloning, sequencing, and gene expression analysis of tributyltin-binding protein type 1 in Japanese medaka fish, Oryzias latipes. , Zoological Science , 28:, 281-285, 2011.04.
35. Nassef M, Tawaratsumida T, oba Y, Satoe H, Nakayama K, Shimasaki Y, Honjo T, Oshima Y. , Induction of tributyltin-binding protein type 2 in Japanese flounder, Paralichthys olivaceus, by exposure to tributyltin-d27. , Mar Poll Bull , 62, 412-414, 2010.04.
36. Qiu X, Yamasaki Y, Shimasaki Y, Gunjikake H, Shikata T, Matsubara T, Nagasoe S, Honjo T, Oshima Y. , Growth interactions between raphidophytes Chattonella antiqua and Heterosigma akashiwo. , Thalasas, 27, 33-45, 2010.04.
37. Oba Y, Yamauchia A, Hashiguchi Y, Satonea H, Miki S, Nassef M, Shimasaki Y, Kitano T, Nakao M, Kawabata S, Honjo T, Oshima Y, Purification and charac-terization of tributyltin-binding protein of tiger puffer, Takifugu rubripes. , Comp Biol phys C., 153, 17-23, 2010.04.
38. 本田匡人,郡司掛博昭,松井繁明,諸石淳也,姜益俊,島崎洋平,大嶋雄治. , サルボウガイ(Scapharca subcrenata)の呼吸代謝に及ぼす低酸素の影響. , 九州大学農学部学芸誌, 65, 31-37, 2010.07.
39. Nassef M , Matsumoto S, Seki M, khalil F, Kang IJ, Shimasaki Y, Oshima Y, Honjo T. , Acute effects of triclosan, diclofenac and carbamazepine on feeding performance of Japanese medaka fish (Oryzias latipes) , Chemosphere, 80: 1095-1100, 79:966-973 , 2010.04, The toxicity of three pharmaceutical and personal care products (PPCPs) – carbamazepine (CBMZ), diclofenac (DCF), and triclosan (TCS) – was examined by measuring their effects on feeding behavior and swimming speed of adult Japanese medaka fish (Oryzias latipes). Medaka were exposed to 6.15 mg L−1 CBMZ, 1.0 mg L−1 DCF, 0.17 mg L−1 TCS, or no PPCP (control) for 9 d. Fish behaviors were monitored during days 5–9 of the exposure period. Feeding behavior (time to eat midge larvae, TE) and swimming speed (SS) of individual exposed and control fish were tracked in two dimensions, using an automated system with a digital charge-coupled device camera. As a result, feeding behavior was affected by exposure to CBMZ and DCF, while SS was altered by exposure to CBMZ and TCS. Thus, TCS, DCF and CBMZ appear to affect fish behaviors through different mechanisms. Overall, the results suggest that behavioral changes may provide a sensitive indicator for assessing the toxicity of PPCPs to aquatic organisms..
40. Nassef M, Kim SG, Seki M, Kang IJ, Hano T, Shimasaki Y, Oshima Y. , In ovo nanoinjection of triclosan, diclofenac and carbamazepine affects embryonic development of medaka fish (Oryzias latipes). , Chemosphere , 79:966-973 , 2010.03.
41. Hano T, Kinoshita M, Tanaka M, Y. W, Ozato O, Shimasaki Y, Oshima Y and Honjo T., Ovo nanoinjection of nonylphenol affects embryonic development of olvas-GFP/ST-II YI medaka, Oryzias latipes., Chemosphere , 77:1594-1599., 2009.08.
42. Nassef M, Matsumoto S, Seki M, Kang IJ, Moroishi J, Shimasaki Y and Oshima Y., Pharmaceuticals and personal care products toxicity to medaka fish. . , J. Fac. Agr. Kyushu Univ. 2009;55:407-411., 76: 1013-1015., 2009.08.
43. Kang IJ, Moroishi J, Nakamura A, Nagafuchi K, Kim SG, Oshima Y. , Biological monitoring of detection of toxic chemicals in water by the swimming behavior of small freshwater fish., Journal of the Faculty of Agriculture Kyushu University, 54: 209-214, 2009.02.
44. Satone H, Oshima Y, Shimasaki Y, Tawaratsumita T, Oba Y, Takahashi E, Kitano T, Kawabata S, Kakuta Y, Honjo T., Tributyltin-binding protein type 1 has a distinctive lipocalin-like structure and is involved in the excretion of tributyltin in Japanese flounder, Paralichthys olivaceus. , Aquatic Toxicology, 90: 292-299., 2008.12.
45. Kang IJ, Yokota H, Oshima Y, Tsuruda Y, Shimasaki Y, and Honjo T. , The effects of methyltestosterone on the sexual development and reproduction of adult medaka (Oryzias latipes). , Aquatic Toxicology , 87: 37-46., 2008.04.
46. Nakayama K, Sei N, Oshima Y, Tashiro K, Shimasaki Y, Honjo T., Alteration of gene expression profiles in the brain of Japanese medaka (Oryzias latipes) exposed to KC-400 or PCB126. , Marine Pollution Bulletin , 2008.03.
47. Shimasaki Y, Oshima Y, Inoue Y, Shibata H, Nakayama K, Inoue S, Imoto H, Kang IJ, Honjo T. , Distribution of tributyltin in tissues of mature Japanese whiting, Sillago japonica and their eggs. , Journal of Faculty of Agriculture Kyushu University, 53: 67-72., 2008.02.
48. Hano T, Oshima Y, Kim SG, Satonne H, Ooba Y, Kitano T, Inoue S, Shimasaki Y, Honjo T., Tributlyltin causes abnormal development in embryo of medaka, Oryzias latipes., Chemosphere, 69: 927-933, 2007.10.
49. Inoue, S., Y. Oshima, H. Usuki, M. Hamaguchi, Y. Hanamura, N. Kai, Y. Shimasaki, T. Honjo. , Effect of tributyltin on veliger larvae of the Manila clam, Ruditapes philippinarum, , Chemosphere, 66, 1353-1357, 2007.01.
50. Hano, T., Y. Oshima, M. Kinoshita, M. Tanaka, N. Mishima, T. Ohyama, T. Yanagawa, Y. Wakamatsu, K. Ozato, T. Honjo., Quantitative bioimaging analysis of gonads in olvas-GFP/ST-II YI medaka (transgenic Oryzias latipes) exposed to ethinylestradiol., Environ Sci Tech, 41, 1473-1479., 2007.01.
51. K. Nakayama, Y. Oshima, T. Tachibana, M. Furuse, T. Honjo, Alteration of monoamine concentrations in the brain of medaka, Oryzias latipes, exposed to tributyltin. , , Environmental Toxicology, , 22,53-57, 2007.01.
52. S. Inoue, Y. Oshima, S. Abe, R. Wu, K. Nakayama, T. Honjo, Effects of tributyltin on energy metabolism of pen shell (Atrina pectinata japonica), Chemosphere, , 66, 1226-1229, 2007.01.
53. Inoue S, Oshima Y, Usuki H, Hamaguchi M, Hanamura Y, Kai N, Shimasaki Y, Honjo T., Effects of tributyltin maternal and/or waterborne exposure on the embryonic development of the Manila clam, Ruditapes philippinarum, Chemosphere, 63,881-888, 2006.04.
54. Shimasaki Y, Oshima Y, Inoue S, Inoue Y, Kang I J, Nakayama K, Imoto H and Honjo H., Effect of tributyltin on reproduction in Japanese whiting, Sillago japonica., Mar Env Res, 62 Suppl 1:S245-8, 2006.04.
55. Kang IJ, Hano T, Oshima Y, Yokota H, Tsuruda Y, Shimasaki Y, Honjo T., Anti-androgen flutamide affects gonadal development and reproduction in medaka (Oryzias latipes)., Mar Env Res., 62 Suppl 1:S253-7, 2006.04.
56. Inoue S, Abe S, Oshima Y, Kai N, Honjo T., Tributyltin contamination of the bivalves in coastal areas around northern kyushu, Japan., Environmental Toxicology, 10.1002/tox.20177, 21, 3, 244-249, 21:244-249, 2005.01.
57. Nakayama K, Oshima Y, Hiramatsu, Shimasaki Y, and Honjo T., Effects of polychlorinated biphenyls on the schooling behavior of Japanese medaka, Oryzias latipes., Environ Toxicol Chem, 10.1897/04-518R2.1, 24, 10, 2588-2593, 24: 2588-2593, 2005.01.
58. Oshima Y, Takeda T, Katayama S, Inoue Y, Inoue S, Nakayama K, Shimasaki Y, and Honjo T., Relationship between temperature and pharmacokinetic parameters of florfenicol in carp (Cyprinus carpio), Jpn J Environ Toxicol, 7:61-68, 2005.01.
59. Oshima Y, Koyama J, Nakayama K, Inoue Y, Shimasaki Y, Inoue S and Honjo T., Use of hepatic CYP1A1 activity in Japanese flounder to monitor oil dispersed from the Nakhodka spill, Jpn J Environ Toxicol, 7:123-129, 2005.01.
60. Nakayama K, Oshima Y, Nagafuchi K, Hano T, Shimasaki Y, and Honjo T., Early life stage toxicity in offspring from exposed parent medaka, Oryzias latipes, to mixtures of tributyltin and polychlorinated biphenyls., Environ Toxicol Chem (accepted), 10.1897/04-157R.1, 24, 3, 591-596, 24, 591?596, 2004.01.
61. Hano T, Oshima Y, Oe T, Kinoshita M, Tanaka M, Wakamatsu Y, Ozato K, Honjo T., A quantitative bioimaging analysis in the evaluation of sexual differentiation on germ cells of olvas-GFP/ST II-YI medaka, Oryzias latipes, nanoinjected with ethinyl estradiol., Environ Toxicol Chem, 24:70-77, 2004.01.
62. Omura M, Shimasaki Y, Oshima Y, Nakayama K, Kubo K, Saou S, Ogata R, Hirata M, Inoue N., Distribution of tributyltin, dibutyltin and monobutyltin in the liver, brain and dat of rats: two-generation toxicity study of tributyltin chloride, Environ Sci, 11, 123-132, 2004.01.
63. Nakayama K, Oshima Y, Yamaguchi T, Tsuruda Y, Kang IJ, Kobayashi M, Imada N, Honjo T, Fertilization success and sexual behavior in male medaka, Oryzias latipes, exposed to tributyltin, Chemospheres, 10.1016/j.chemoshere.2003.11.050, 55, 10, 1331-1337, 55. 1331-1337, 2004.01.
64. Inoue S, Oshima Y, Nagai K, Yamamoto T, Go J, Hiramatsu J, Okada M, Imada N and Honjo T, Maternal effect of tributyltin on reproduction of pearl oyster, Pinctada fucata martensii, Environ Toxicol Chem, 23, 1276-1281, 2004.01.
65. Kang IJ, Yokota H, Oshima Y, Tsuruda Y, Hano T, Maeda M, Imada N, Tadokoro H and Honjo T, Effects of 4-nonylphenol on reproduction of japanese medaka (Oryzias latipes), Environ Toxicol Chem, 10.1897/02-225, 22, 10, 2438-2445, 22:2438-2445, 2003.01.
66. 井上 英,大嶋雄治,今田信良,本城凡夫, 北部九州とその周辺水域におけるトリブチルスズ汚染, 環境毒性学会誌, 5: 43-50, 2002.01.
67. Oshima Y, Kang IJ, Kobayashi M, Nakayama K, Imada N, Tadokoro H and Honjo T., Suppression of sexual behavior in male Japanese medaka (Oryzias latipes) exposed to 17_-estradiol, Chemospheres, 10.1016/S0045-6535(02)00494-0, 50, 3, 429-436, 50: 429-436, 2002.01.
68. Shimasaki Y, KitanoT, Oshima Y, Inoue S, Imada N and Honjo T., Tributyltin causes masculinization in fish, Environ Toxicol Chem, 10.1897/1551-5028(2003)022<0141:TCMIF>2.0.CO;2, 22, 1, 141-144, 22: 141-144, 2002.01.
69. Kang IJ, Yokota H, Oshima Y, Tsuruda Y, Yamaguchi T, Oe T, Imada N, Tadokoro H and Honjo T., Effects of bisphenol A on the reproduction of Japanese medaka (Oryzias latipes)., Environ Toxicol Chem, 10.1897/1551-5028(2002)021<2394:EOBAOT>2.0.CO;2, 21, 11, 2394-2400, 20:2394-2400, 2002.01.
70. Shimasaki Y, Oshima Y, Yokota Y, Kitano T, Nakao M, Kawabata S, Imada N and Honjo T., Purification and identification of a TBT-binding protein from serum of Japanese flounder, Paralichthys olivaceus., Environ Toxicol Chem, 10.1897/1551-5028(2002)021<1229:PAIOAT>2.0.CO;2, 21, 6, 1229-1235, 21: 1229-1235., 2002.01.
1. Nakamura A, JAE MAN LEE, takahiro kusakabe, Miki S, Nonaka S, Komatsu S, Yohei Shimasaki, Yuji Oshima, Binding of tributyltin to recombinant saxitoxin and tetrodotoxin binding protein from the puffer fish Takifugu rubupires., SETAC Asia Pacific 2012, 2012.11.
Educational Activities
Environmental and Ecological Science for Animal Production