Other

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092-642-2856

092-642-2856

Doctor (Agriculture)

Biological Chemistry and Bioorganic Chemistry

In drug discovery, it is common to have measured activity data for a set of compounds acting upon a particular protein but not to have knowledge of the three-dimensional structure of the protein active site. In the absence of such three-dimensional information, one can attempt to build a hypothetical model of the receptor site that can provide insight about receptor-site characteristics. Such analyses are known as a comparative receptor surface analysis (CoRSA) and a molecular-field analysis (MFA), which provide compact and quantitative descriptors which capture three-dimensional information about a putative receptor site. Meanwhile pharmacophore models are qualitative and capture information about the commonality of compounds that bind. Agonists for tyramine (TA) reseceptor were tested for inhibitory specificity observing calling behavior and using a modified radiochemical bioassay to monitor de novo pheromone production in Plodia interpunctella. A set of 70 agonists and a set of 20 antagonists for octopamine (OA) receptor 3 in locust nervous tissue and of a set of 40 agonists against OA receptor 2 in cockroach nervous tissue were selected as study sets. The result may imply that the process of these molecular modeling treat the structures reasonably. The molecular modeling could provide useful information in the characterization and differentiation of TA and OA receptors. They may help to point the way towards developing extremely potent and relatively specific TA and OA ligands, leading to potential insecticides, although further research on the comparison of the 3D molecular modeling is necessary.

Research Interests

• Clarification of stress reaction and drug design of ligands for octopamiine/tyramine receptors
  keyword : sex pheromone, stress, octopamine, tyramine, pharmacophore model. structure-activity relationship
  2000.01.

Academic Activities Membership in Academic Society

• the Entomological society of Korea
• The Science Advisory Board
• Japan Society for Bioscience, Biotechonolgy and Agrochemistry
• Pesticide Science Society of Japan

Awards

• For my valuable contribution and dedicated service in the peer review of manuscripts submitted to ACS journals
• 学外
• 学外