||Md. Nur Kabidul Azam, Md. Nasir Ahmed, Biswas, Nargis Ara, Md. Masuder Rahman, Akinori Hirashima and Md. Nazmul Hasan, A Review on Bioactivities of Honey Bee Venom, Annual Research & Review in Biology, 2019.01, The Honeybee (Apis mellifera) is one of the world’s most beneficial insects, as it plays a critical role in many terrestrial ecosystems. The use of honeybee products has been documented for thousands of years in many cultures for the treatment of human diseases, and their healing properties have been documented in many religious texts. The present study sets out to compile information on the history, chemical composition and scientific evidence concerning bee venom research. The promising bioactivities have the potential to provide practical directions for further investigation. PubMed database, Google Scholar Library, research articles, books, and relevant web pages have been accessed to accumulate data so that the updated information included in this study is as current as possible. At least 18 pharmacologically active components including various enzymes, peptides, and amines are present in bee venom. Medicinal use of bee venom therapy wields significant in vivo and in vitro outcomes to some extent mitigate the effects of Parkinson’s disease, Alzheimer’s disease, HIV, arthritis, liver fibrosis, cancer, tumors, fibrotic diseases, Lyme disease, etc. The effects of bee venom were the first documented in 1888 with the publication of a European clinical study conducted on its impact on rheumatism. According to a study published in the journal, bee venom has been used to treat various conditions for centuries. Such research activities confirm the therapeutic effectiveness of bee venom and as a potential future biomedicine..
||Hirashima A, Tyramine and ocopamine receptors as a source of biorational insecticides, Biorational Control of Arthropod Pests: Application and Resistance Managements, I. Ishaaya, A. R. Horowitz (eds) Springer Dordrecht Heidelberg London New York, 83-109, 2009.09.
||Akinori Hirashima , Regulation of bombykol production by tyramine and octopamine in Bombyx mori, J. Pestic. Sci. 33 (1), 21-23, 2008.02.
||Hirashima A, Involvement of tyramine and octopamine receptors in insect behaviour and metamorphosis, Current Topics in Biotechnology, 1, 133-138, 2004.12.
||Akinori Hirashima, Involvement of Tyramine and Octopamine Receptors in Insect Stress Reaction in Behaviour and Metamorphosis, Report of the Center of Advanced Instrumental Analysis Kyushu University, 22, 36-44 (2004).
||Hirashima A., R. Ueno, K. Oyama, I. Ishaaya and M. Eto, Effect of insecticidal cyclic phosphorothionates on cyclic adenosine 3',5'-monophosphate (cAMP) level and various enzyme systems of insects, Advances in Second Messenger and Phosphoprotein Research: The Biology and Medicine of Signal Transduction, Vol. 24, p. 590, 1990.07.
||Hirashima A., Y. Yoshii and M. Eto, Quantitative structure-activity relationships of insecticidal 2-methoxy-1,3,2-oxazaphospholidine 2-sulfides, The Fourth Kyushu International Symposium on Physical Organic Chemistry (KISPOC-IV), 134-139, 1991.10.
||Eto M., S. Tashiro, S. Tawata, S.-Y. Wu and A. Hirashima, L-Leucine and D-octopamine as insect neuroactive substances and leads for design of insecticidal chemicals, Frontiers and New Horizons in Amino Acid Research, 303-307, 1992.08.
||Hirashima A. and M. Eto, Octopamine and growth-behavior regulation in insects, Pesticides/Environment: Molecular Biological Approaches, 219-225, 1993.03.
||Akinori Hirashima, Involvement of octopamine in insect metamorphosis and molecular modelling of octopaminergic agonists, Resent Research Developments in Agricultural and Biological Chemistry, 2, 17-28, 1998.02.