Kyushu University Academic Staff Educational and Research Activities Database
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Toshiro Matsui Last modified date:2019.04.08

Professor / Food Science and Biotechnology
Department of Bioscience and Biotechnology
Faculty of Agriculture

Graduate School
Undergraduate School
Other Organization
Administration Post
Director of the Research and Development Center for Taste and Odor Sensing

Homepage for Research and Development Center for Five-Sense Devices .
Homepage for Lab. of Food Analysis, Division of Bioscience and Bioenvironmental Siceinces, Faculty of Agriculture .
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Food Analysis, Functional Food Science
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Outline Activities
Studies on a prophylaxis of life-related diseases such as hypertension and diabetes by bioactive food compounds, and on their bioavailability.
Preparation of antihypertensive food compounds from natural resources, and elucidation of antihypertensive mechanism towards the renin-angiotensin systems.
Preparation of antihyperglycemic food compounds from natural resources, and elucidation of their actions such as suppression of glucose absorption and promotion of glucose assumption via inhibition of polyol metabolism.
Development of analytical assay systems of food compounds responsible for sensory properties.
Research Interests
  • Evaluation of Bioavailability of bioactive compounds
    keyword : Bioactive compounds, Intestinal absorption, Bioavailability
    2000.04Subject: prophylaxis of life-related disease such as hypertension and diabetes by specific active food compounds. The antihypertensive action by these compounds, in particular active peptides from sardine proteins, is also investigated by in vitro or in vivo systems..
  • Prevention of lefe-style related diseases by bioactive food compounds
    keyword : prevention of lyfe-style related disease, hypertension, diabetes, bioactive compounds
    2000.04Subject: prophylaxis of life-related disease such as hypertension and diabetes by specific active food compounds. The antihypertensive action by these compounds, in particular active peptides from sardine proteins, is also investigated by in vitro or in vivo systems..
  • Sorption of flavor compounds into polymer films
    keyword : flavor, sorption, food packaging
    1987.04Study on sorption or desorption behavior of flavor into food packaging..
Academic Activities
1. Si Jing Chen, 松井 利郎, Natural Product Drug Discovery; Discovery and Development of Antidiabetic Natural Products-Part 1, Elsevier (UK), Chapter 1, 2016.05.
2. Ju Qiu, Norihiko Terahara, 松井 利郎, Natural Bioactive Molecules: Impacts and Prospects, Narosa Publishing House, 2014.05.
3. Matsui Toshiro, Z. Wang, Mitsuru Tanaka, Bioactive Natural Products: Opportunities & Challenges in Medicinal Chemistry , World Scientific Publishing, pp.201-221, 2012.10.
4. T.Hasegawa, K.Matsumoto, T.Matsui, Laser Scanning, Theory and Applications, INTECH Book, pp.365-388, 2011.07.
5. T.Matsui, M.Tanaka, Biologically Active Food Proteins and Peptides in Health- Fundamental and Clinical aspects-, Wiley Blackwell, pp.43-54, 2010.07.
6. Norihiko Terahara and Toshiro Matsui, Recent Progress in Studies on Bioavailability and Health Promotion Effects, Research Signpost, Anthocyanins as food factor, 2008.01.
7. T.Matsui, K.Matsumoto, Current Topics in Peptide & Protein Research Vol.4, Research Trends, Bioactive Peptides with Antihypertensive Potency Derived from Natural Protein pp.113-122, 2001.04.
8. Food Function-antihypertensive effect of food compounds..
1. Toshiro Matsui, Are Peptides Absorbable Compounds?, Journal of Agricultural and Food Chemistry, 10.1021/acs.jafc.7b05589, 2018.01.
2. Weilin Shen, Toshiro Matsui, Current knowledge of intestinal absorption of bioactive peptides, Food & Function, 8, 4306-4314, 2017.10.
3. 松井 利郎, Condensed catechins and their potential health-benefits, Eur. J. Pharm., 75, 495-502, 2015.10.
4. Antihypertensive effect of bioactive peptides.
5. Peptidic food and hypertension.
1. Anti-diabetic Effect of Acetic Acid-Free Red Vinegar in Spontaneously Diabetic Torii Rats.
2. Tatsuro Yamamoto, Chiyomi Sakamoto, Hiroaki Tachiwana, Mitsuru Kumabe, Toshiro Matsui, Tadatoshi Yamashita, Masatoshi Shinagawa, Koji Ochiai, Noriko Saitoh, Mitsuyoshi Nakao, Endocrine therapy-resistant breast cancer model cells are inhibited by soybean glyceollin I through Eleanor non-coding RNA, Scientific reports, 10.1038/s41598-018-33227-y, 8, 15202, 2018.10, Long-term estrogen deprivation (LTED) of an estrogen receptor (ER) α-positive breast cancer cell line recapitulates cancer cells that have acquired estrogen-independent cell proliferation and endocrine therapy resistance. Previously, we have shown that a cluster of non-coding RNAs, Eleanors (ESR1 locus enhancing and activating non-coding RNAs) formed RNA cloud and upregulated the ESR1 gene in the nuclei of LTED cells. Eleanors were inhibited by resveratrol through ER. Here we prepared another polyphenol, glyceollin I from stressed soybeans, and identified it as a major inhibitor of the Eleanor RNA cloud and ESR1 mRNA transcription. The inhibition was independent of ER, unlike one by resveratrol. This was consistent with a distinct tertiary structure of glyceollin I for ER binding. Glyceollin I preferentially inhibited the growth of LTED cells and induced apoptosis. Our results suggest that glyceollin I has a novel role in LTED cell inhibition through Eleanors. In other words, LTED cells or endocrine therapy-resistant breast cancer cells may be ready for apoptosis, which can be triggered with polyphenols both in ER-dependent and ER-independent manners..
3. Ayano Shimizu, Takakazu Mitani, Sachi Tanaka, Hiroshi Fujii, Motohiro Maebuchi, Yusuke Amiya, Mitsuru Tanaka, Toshiro Matsui, Soichiro Nakamura, Shigeru Katayama, Soybean-Derived Glycine-Arginine Dipeptide Administration Promotes Neurotrophic Factor Expression in the Mouse Brain, Journal of Agricultural and Food Chemistry, 10.1021/acs.jafc.8b01581, 66, 30, 7935-7941, 2018.08, Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays an important role in cognitive abilities, including memory and learning. We demonstrated that soybean protein hydrolysate (SPH) diet suppresses age-related cognitive decline via the upregulation of BDNF in a mouse model of senescence. Our purpose was to identify novel bioactive peptides in SPH, which enhance BDNF expression. We treated mouse primary astrocytes with SPH as well as with its positively charged chromatographic fraction. Significant increases in the expression of BDNF were observed in the treatment with positively charged fraction of SPH. Among the synthesized peptides, the dipeptide glycine-arginine (GR) increased BDNF expression in vitro, and LC-TOF-MS analysis showed the presence of GR in the SPH. Furthermore, its administration in vivo increased the expression of BDNF in the cerebral cortex and the number of neurons in hippocampus and cerebral cortex. These data indicate that GR might promote neurogenesis by upregulating BDNF levels..
4. Hsuan Chung, Akihiro Shimura, Toshiro Matsui, Discriminant and simultaneous HPLC analysis of reducing and nonreducing monosaccharides on a polyethyleneimine-attached hydrophilic interaction liquid chromatography column, Food Science and Technology Research, 10.3136/fstr.24.501, 24, 3, 501-508, 2018.06, The aim of this study was to develop an analytical method for the discrimination of reducing and non-reducing monosaccharides including rare sugars on a prototype hydrophilic interaction liquid chromatography (HILIC) column. The HILIC column was composed of a glycidyl methacrylate-ethylene glycol dimethacrylate copolymer attached to 8 wt% polyethyleneimine. Seven monosaccharides (reducing aldoses: D-xylose, D-allose, and D-glucose; non-reducing ketoses: D-fructose, D-psicose, D-sorbose, and D-tagatose) were targeted. In individual HPLC analysis of both aldoses and ketoses, elution with 90 v/v% acetonitrile permitted successful detection and separation only for the non-reducing ketoses. Besides, elution of a mixture of ketoses and aldoses with 85 v/v% acetonitrile containing 5 mmol/L sodium 1-octanesulfonate (OS) (pH 4.8) enabled the simultaneous separation of all seven monosaccharides within 40 min. The polyethyleneimine-attached HILIC column allowed discriminant HPLC analysis for non-reducing ketoses using elution with 90 v/v% acetonitrile, whereas elution with 85 v/v% acetonitrile containing 5 mmol/L OS simultaneously detected both ketoses and aldoses..
5. Ryoko Yamamoto, Hisanori Minami, Hiromi Matsusaki, Mami Sakashita, Naoki Morita, Osamu Nishimiya, Naonobu Tsutsumi, Masashi Hosokawa, Yutaka Itabashi, Toshiro Matsui, Kazuhiro Ura, Consumption of the edible sea urchin Mesocentrotus nudus attenuates body weight gain and hepatic lipid accumulation in mice, Journal of Functional Foods, 10.1016/j.jff.2018.04.063, 47, 40-47, 2018.04, The beneficial health effects of edible sea urchin consumption in mice fed a normal (ND) or high-fat diet (HFD) were investigated in this study. Notably, sea urchin-administered (250, 500, 1000 mg/kg) mice exhibited lower body, liver, and visceral fat weights, lower plasma levels of aspartate aminotransferase and alanine aminotransferase, and lower hepatic triacylglycerol levels than those fed carboxymethyl cellulose (CMC). Despite the high levels of cholesterol found in sea urchins, intake of these organisms had no effect on plasma cholesterol levels among the mice tested. Additionally, sea urchin consumption resulted in enhanced levels of arachidonic acid and docosahexaenoic acid within mouse livers. Lastly, mice fed HFD with sea urchin (500 mg/kg) exhibited increased mRNA expression of uncoupling protein-1 within brown adipose tissue, compared with those fed HFD with CMC. In conclusion, consumption of sea urchin might provide a protective effect against the development of obesity and/or nonalcoholic fatty liver disease..
6. Baorui Li, Yusuke Terazono, Naoto Hirasaki, Yuki Tatemichi, Emiko Kinoshita, Akio Obata, Toshiro Matsui, Inhibition of Glucose Transport by Tomatoside A, a Tomato Seed Steroidal Saponin, through the Suppression of GLUT2 Expression in Caco-2 Cells, Journal of Agricultural and Food Chemistry, 10.1021/acs.jafc.7b06078, 66, 6, 1428-1434, 2018.02, We investigated whether tomatoside A (5α-furostane-3β,22,26-triol-3-[O-β-d-glucopyranosyl (1→2)-β-d-glucopyranosyl (1→4)-β-d-galactopyranoside] 26-O-β-d-glucopyranoside), a tomato seed saponin, may play a role in the regulation of intestinal glucose transport in human intestinal Caco-2 cells. Tomatoside A could not penetrate through Caco-2 cell monolayers, as observed in the transport experiments using liquid chromatography-mass spectrometry. The treatment of cells with 10 μM tomatoside A for 3 h resulted in a 46.0% reduction in glucose transport as compared to untreated cells. Western blotting analyses revealed that tomatoside A significantly (p < 0.05) suppressed the expression of glucose transporter 2 (GLUT2) in Caco-2 cells, while no change in the expression of sodium-dependent glucose transporter 1 was observed. In glucose transport experiments, the reduced glucose transport by tomatoside A was ameliorated by a protein kinase C (PKC) inhibitor and a multidrug resistance-associated protein 2 (MRP2) inhibitor. The tomatoside A-induced reduction in glucose transport was restored in cells treated with apical sodium-dependent bile acid transporter (ASBT) siRNA or an ASBT antagonist. These findings demonstrated for the first time that the nontransportable tomato seed steroidal saponin, tomatoside A, suppressed GLUT2 expression via PKC signaling pathway during the ASBT-influx/MRP2-efflux process in Caco-2 cells..
7. Si Jing Chen, Chiwa Aikawa, Risa Yoshida, Tomoaki Kawaguchi, Toshiro Matsui, Anti-prediabetic effect of rose hip (Rosa canina) extract in spontaneously diabetic Torii rats, Journal of the Science of Food and Agriculture, 10.1002/jsfa.8254, 97, 12, 3923-3928, 2017.09, BACKGROUND: Prediabetes, a high-risk state for developing diabetes showing impaired glucose tolerance but a normal fasting blood glucose level, has an increasing prevalence worldwide. However, no study investigating the prevention of impaired glucose tolerance at the prediabetic stage by anti-diabetic functional foods has been reported. Thus, the present study aimed to evaluate the anti-prediabetic effect of rose hip in a prediabetic rat model. RESULTS: Spontaneously diabetic Torii (SDT) rats were supplemented with hot-water extract of rose hip at a dose of 100 mg kg–1 body weight day–1 for 12 weeks. The results obtained showed that the supplementation of rose hip extract improved impaired glucose tolerance, promoted insulin secretion, preserved pancreatic beta-cell function and suppressed plasma advanced glycation end-products formation of methylglyoxal-derived hydroimidazolone (MG-H1) residue and Nϵ-carboxymethyl-lysine residues (e.g. MG-H1, control: 465.5 ± 43.8 versus rose hip: 59.1 ± 13.0 pmol mg protein–1, P < 0.05) in SDT rats at the prediabetic stage (12–20 weeks old). CONCLUSION: The present study provides the first evidence showing that a hot-water extract of rose hip could exert an anti-prediabetic effect in a rat model..
8. Vu Thi Hanh, Weilin Shen, Mitsuru Tanaka, Aino Siltari, Riita Korpela, Toshiro Matsui, Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats, Journal of Agricultural and Food Chemistry, 10.1021/acs.jafc.7b01727, 65, 29, 5935-5943, 2017.07, In the present study, we aimed to evaluate the effect of aging on the absorption of small peptides in spontaneously hypertensive rats (SHRs). Three kinds of dipeptides, glycyl-sarcosine (Gly-Sar), Trp-His, and captopril (a dipeptidomimetic drug), a Gly-Sar-Sar tripeptide, a Gly-Sar-Sar-Sar tetrapeptide, and a Gly-Sar-Sar-Sar-Sar pentapeptide were administered at doses of 10 mg/kg each to 8- and 40-week-old SHRs. The peptides were all detected in their intact forms in the blood. There was a significantly promoted absorption of di/tripeptides in aged SHRs compared with young SHRs. In contrast, the absorption of tetra/pentapeptides was not affected by aging. PepT1 expression in the mid-jejunum was significantly increased in 40-week-old SHRs compared with 8-week-old SHRs, whereas aging did not alter the expression of claudin-1, a tight junction related protein. Thus, the present results suggest that SHR aging may enhance the absorption of di/tripeptides through the enhanced PepT1 transport route, although oligopeptides may be absorbed in an age-independent manner..
9. Gonzalo Miyagusuku-Cruzado, Naoki Morishita, Keiichi Fukui, Norihiko Terahara, Toshiro Matsui, Anti-prediabetic effect of 6-O-caffeoylsophorose in prediabetic rats and its stimulation of glucose uptake in L6 Myotubes, Food Sci. Technol. Res., 23, 3, 449-456, 2017.06.
10. Thanutchaporn Kumrungsee, Sayaka Akiyama, Jian Guo, Mitsuru Tanaka, Matsui Toshiro, Identification of peptides in wheat germ hydrolysate that demonstrate calmodulin-dependent protein kinase II inhibitory activity, FOOD CHEMISTRY, 10.1016/j.foodchem.2016.06.059, 213, 329-335, 2016.12.
11. THuu-Nghi Nguyen, Mitsuru Tanaka, Genki Komabayashi, Matsui Toshiro, The photobase generator nifedipine as a novel matrix for the detection of polyphenols in matrix-assisted laser desorption/ionization mass spectrometry, JOURNAL OF MASS SPECTROMETRY, 10.1002/jms.3805, 51, 10, 748-756, 2016.10.
12. Toshihiko Fukuda, Takanori Kuroda, Miki Kono, Mai Hyoguchi, Satoshi Tajiri, Mitsuru Tanaka, Yoshinori Mine, Matsui Toshiro, Adenine attenuates the Ca2+ contraction-signaling pathway via adenine receptor-mediated signaling in rat vascular smooth muscle cells, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 10.1007/s00210-016-1264-0, 389, 9, 999-1007, 2016.09.
13. Thanutchaporn Kumrungsee, Sayaka Akiyama, Tomomi Saiki, Mitsuru Tanaka, Masao Omae, Kazuhiro Hamasawa, Matsui Toshiro, Vasorelaxation effect of 5’-methylthioadenosine obtained from Candida utilis yeast extract though the suppression of intracellular Ca2+ concentration in rat isolated aorta, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 64, 17, 3362-3370, 2016.07.
14. Akiko Mizokami, DaGuang Wang, Genki Komabayashi, Mitsuru Tanaka, Jing Gao, Hiroshi Takeuchi, Matsui Toshiro, Hirata Masato, An extract from pork bones containing osteocalcin improves glucose metabolism in mice by oral administration., Bioscience, Biotechnology, and Biochemistry, 10.1080/09168451.2016.1214530, 80, 11, 2176-2183, 2016.07.
15. Toshihiko Fukuda, Kaustav Majumder, Hua Zhang, Patricia V Turner, Matsui Toshiro, Yoshinori Mine, Adenine Inhibits TNF-alpha Signaling in Intestinal Epithelial Cells and Reduces Mucosal Inflammation in a Dextran Sodium Sulfate-Induced Colitis Mouse Model, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 10.1021/acs.jafc.6b00665, 64, 21, 4227-4234, 2016.06.
16. Jian Guo, Naoto Hirasaki, Yuji Miyata, Kazunari Tanaka, TakashiTanaka, Xiao Wu, Yusuke Tahara, Kiyoshi Toko, Matsui Toshiro, Evaluating the Reduced Hydrophobic Taste Sensor Response of Dipeptides by Theasinensin A by Using NMR and Quantum Mechanical Analyses, PLOS ONE, 10.1371/journal.pone.0157315, 11, 6, e0157315, 2016.06, 重合カテキンであるテアシネンシンAが苦みペプチドである各種のトリプトファン含有ジペプチドの苦み応答を抑制し、かつ園現象は溶液内での両者の複合体形成であることをin vitroおよびin silico解析によって突き止めたこと。.
17. Hirosuke Inoue, Hisanori Nishio, Hidetoshi Takada, Etsuko Nanishi, Mitsuho Onimaru, Si Jing Chen, Matsui Toshiro, Toshiro Hara, Activation of Nod1 signaling induces fetal growth restriction and death through fetal and maternal vasculopathy, Journal of Immunology, 196, 2779-2787, 2016.05.
18. Seong-Min Hong, Mitsuru Tanaka, Riho Koyanagi, Weilin Shen, Matsui Toshiro, Structural Design of Oligopeptides for Intestinal Transport Model, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 10.1021/acs.jafc.6b00279, 64, 10, 2072-2079, 2016.03.
19. Vu Thi Hanh, Yutaro Kobayashi, Motohiro Maebuchi, Toshihiro Nakamori, Mitsuru Tanaka, Matsui Toshiro, Quantitative mass spectrometric analysis of dipeptides in protein hydrolysate by a TNBS derivatization-aided standard addition method, FOOD CHEMISTRY, 10.1016/j.foodchem.2015.05.053, 190, 345-350, 2016.01.
20. Yusuke Ushida, Boonyapichest Chutinan, Hiroyuki Suganuma, Mitsuru Tanaka, Matsui Toshiro, Paracellular Transport of Sulforaphane across Caco-2 Cell Monolayers, FOOD SCIENCE AND TECHNOLOGY RESEARCH, 10.3136/fstr.22.127, 22, 1, 127-134, 2016.01.
21. Jian Zhao, Aki Suyama, Hsuan Chung, Toshihiko Fukuda, Mitsuru Tanaka, Matsui Toshiro, Ferulic acid enhances nitric oxide production through up-regulation of argininosuccinate synthase in inflammatory human endothelial cells, LIFE SCIENCES, 10.1016/j.lfs.2015.12.044, 145, 224-232, 2016.01.
22. Toshihiko Fukuda, Takanori Kuroda, Miki Kono, Mai Hyoguchi, Mitsuru Tanaka, Matsui Toshiro, Augmentation of ferulic acid-induced vasorelaxation with aging and its structure importance in thoracic aorta of spontaneously hypertensive rats, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 10.1007/s00210-015-1171-9, 388, 10, 1113-1117, 2015.10.
23. Takashi Ichinose, Kazuki Moriyasu, Akane Nakahara, Mitsuru Tanaka, Matsui Toshiro, Shigeki Furuya, Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 10.1080/09168451.2015.1044932, 79, 9, 1542-1547, 2015.09.
24. Mitsuru Tanaka, Seong-Min Hong, Sayaka Akiyama, Qing-Qiang Hu, Matsui Toshiro, Visualized absorption of anti-atherosclerotic dipeptide, Trp-His, in Sprague-Dawley rats by LC-MS and MALDI-MS imaging analyses, MOLECULAR NUTRITION & FOOD RESEARCH, 10.1002/mnfr.201500075, 59, 8, 1541-1549, 2015.08.
25. Ruge Cao, Yutaro Kobayashi, Airi Nonaka, Yuji Miyata, Kazunari Tanaka, Takashi Tanaka, Matsui Toshiro, NMR Spectroscopic and Quantum Mechanical Analyses of Enhanced Solubilization of Hesperidin by Theasinensin A, PHARMACEUTICAL RESEARCH, 10.1007/s11095-015-1621-6, 32, 7, 2301-2309, 2015.07.
26. Si Jing Chen, Chiwa Aikawa, Risa Yoshida, Matsui Toshiro, Methylglyoxal-derived hydroimidazolone residue of plasma protein can behave as a predictor of pre-diabetes in Spontaneously Diabetic Torii rats, Physiological Reports, doi10.14814/phy2.12477, 3, 7, e12477, 2015.07.
27. Ruge Cao, Airi Nonaka, Fusae Komura, Matsui Toshiro, Application of diffusion ordered-H-1-nuclear magnetic resonance spectroscopy to quantify sucrose in beverages, FOOD CHEMISTRY, 10.1016/j.foodchem.2014.08.105, 171, 8-12, 2015.03.
28. Si Jing Chen, Chiwa Aikawa, Matsui Toshiro, Qantitative analysis of methylglyoxal, glyoxal and free advanced glycation end-products in plasma of Wistar rats during oral glucose tolerance test, Biological Pharmacology Bulletin, 38, 2, 336-339, 2015.02.
29. Ha-Young Park, Yuri Kunitake, Naoto Hirasaki, Mitsuru Tanaka, Matsui Toshiro, Theaflavins enhance intestinal barrier of Caco-2 Cell monolayers through the expression of AMP-activated protein kinase-mediated Occludin, Claudin-1, and ZO-1, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 10.1080/09168451.2014.951027, 79, 1, 130-137, 2015.01.
30. Jiang Guo, Tomomi Saiki, Kumrungsee Thanutchaporn, Wanying Liu, Akihiro Shimura, Matsui Toshiro, Elution Profile of Di-peptides on a Sulfonated Ethylstyrene-Divinylbenzene Copolymer Resin Column by High-performance Liquid Chromatography, ANALYTICAL SCIENCES, 31, 1, 45-50, 2015.01.
31. Soga Minoru, Ohashi Ayaka, Taniguchi Emi, Matsui Toshiro, Tsuda Takanori, The di-peptide Trp-His activates AMP-activated protein kinase and insulin-independently enhances glucose uptake in L6 myotubes, FEBS Open Bio, 4, 898-904, 2014.11.
32. Kumrungsee Thanutchaporn, Saiki Tomomi, Akiyama Sayaka, Nakashima Kentaro, Mitsuru Tanaka, Kobayashi Yutaro, Matsui Toshiro, Inhibition of calcium-calmodulin complex formation by vasorelaxant basic dipeptides demonstrated by in vitro and in silico analyses, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 10.1016/j.bbagen.2014.07.020, 1840, 10, 3073-3078, 2014.10.
33. Kovacs-Nolan Jennifer, Rupa Prithy, Matsui Toshiro, Mitsuru Tanaka, Konishi Toni, Sauchi Yusuke, Sato Kenji, Ono Shin, Mine Yoshinori, In Vitro and ex Vivo Uptake of Glutathione (GSH) across the Intestinal Epithelium and Fate of Oral GSH after in Vivo Supplementation, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 10.1021/jf503257w, 62, 39, 9499-9506, 2014.10.
34. Zhao Jian, Suyama Aki, Mitsuru Tanaka, Matsui Toshiro, Ferulic acid enhances the vasorelaxant effect of epigallocatechin gallate in tumor necrosis factor-alpha-induced inflammatory rat aorta, JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 10.1016/j.jnutbio.2014.03.013, 25, 7, 807-814, 2014.07.
35. Kumrungsee Thanutchaporn, Wang Zheng-Quan, Matsumura Shinya, Saiki Tomomi, Mitsuru Tanaka, Matsui Toshiro, Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells, FOOD CHEMISTRY, 10.1016/j.foodchem.2013.11.143, 152, 218-224, 2014.06.
36. Cao Ruge, Komura Fusae, Nonaka Airi, Kato Takeshi, Fukumashi Junji, Matsui Toshiro, Quantitative analysis of D-(+)-glucose in fruit juices using diffusion ordered-1H nuclear magnetic resonance spectroscopy, Analytical Sciences, 30, 3, 383-388, 2014.03.
37. Fukuda Toshihiko, Kuroda Takahiro, Kono Miki, Takahisa Miyamoto, Mitsuru Tanaka, Matsui Toshiro, Attenuation of L-Type Ca2+ Channel Expression and Vasomotor Response in the Aorta with Age in Both Wistar-Kyoto and Spontaneously Hypertensive Rats, PLOS ONE, 10.1371/journal.pone.0088975, 9, 2, e88975-e88983, 2014.02.
38. Qiu Ju, Maekawa Kanako, Kitamura Yuko, Miyata Yuji, Tanaka Kazunari, Tanaka Takashi, Soga Minoru, Tsuda Takanori, Matsui Toshiro, Stimulation of glucose uptake by theasinensins through the AMP-activated protein kinase pathway in rat skeletal muscle cells, BIOCHEMICAL PHARMACOLOGY, 10.1016/j.bcp.2013.10.029, 87, 2, 344-351, 2014.01.
39. Seong-Min Hong, Mitsuru Tanaka, Saori Yoshii, Yoshinori Mine, Matsui Toshiro, Enhanced visualization of small peptides absorbed in rat small intestine by phytic-acid-aided MALDI-imaging mass spectrometry, Anal. Chem, 85, 11, 10033-10039, 2013.11.
40. Eduardo M. N. Nakashima, Hu-Qiang Qing, Tanaka Mitsuru, Matsui Toshiro, Improvement of liquid chromatography-tandem mass spectrometric detection of di-peptides by 2,4,6-trinitrobenzene sulfonate derivatization, Biosci. Biotechnol. Biochem, 77, 10, 2094-2099, 2013.10.
41. Y.Miyata, S.Tamaru, K.Tamaya, Matsui Toshiro, Y.Nagata, K.Tanaka, Theflavins and theasinensin A derived from fermented tea have antihyperglycemic and hypotriacylglycerolemic effects in KK-Ay mice and Sprague-Dawley rats, J. Agric. Food Chem, 61, 10, 9366-9372, 2013.10.
42. Takeda, Junko, Park, Ha-Young, Kunitake, Yuri, Yoshiura, Keiko, Matsui Toshiro, Theaflavins, dimeric catechins, inhibit peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide transporter PEPT1, FOOD CHEMISTRY, 10.1016/j.foodchem.2012.12.026, 138, 4, 2140-2145, 2013.06.
43. Hoang Lan Phuong, Qiu, Ju, Matsui Toshiro, Kuwahara, Takashi, Fukui, Keiichi, Yoshiyama, Kayo, Matsugano, Kazusato, Terahara, Norihiko, Transepithelial transport of 6-O-caffeoylsophorose across Caco-2 cell monolayers, FOOD CHEMISTRY, 10.1016/j.foodchem.2012.10.137, 138, 1, 9048-9054, 2013.05.
44. Chihiro Hashimoto, Yuri Iwaihara, Si-Jing Chen, Tanaka Mitsuru, Toshiaki Watanabe, Matsui Toshiro, Highly-Sensitive Detection of Free Advanced Glycation End-Products by Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry with 2,4,6-Trinitrobenzene Sulfonate Derivatization, ANALYTICAL CHEMISTRY, 10.1021/ac400294q, 85, 9, 4289-4295, 2013.05, 生体内での糖化産物である各種AGEを高感度分析する新たなアッセイ法(LC-MS/MS-MRM-TNBS法)を提案した。.
45. Ha-Young Park, Yuri Kunitake, Matsui Toshiro, Benzotropolone moiety in theaflavins is responsible for inhibiting peptide-transport and activating AMP-activated protein kinase in Caco-2 cells., J. Functional Foods in Health and Disease, 3, 5, 111-121, 2013.05.
46. Mahmud Tareq Hassan Khan, Kenichi Dedachi, Matsui Toshiro, Noriyuki Kurita, Monica Borgatti, Ingebrigt Sylte, Dipeptide inhibitors of thermolysin and angiotensin I-converting enzyme., Current Topics in Medicinal Chemistry, 12, 16, 1748-1762, 2012.10.
47. Tanaka Mitsuru, Suyama Aki, J. Zhao, Matsui Toshiro, Epigallocatechin gallate enhances the endothelium-independent vasorelaxation of the anti-atherosclerotic Ca2+ channel blocking peptide Trp-His in thoracic aorta from Sprague-Dawley rats, J. Hypertens., eS 1, e279-e279, 2012.09.
48. Toshihiko Fukuda, Yutaro kobayashi, Tanaka Mitsuru, Matsui Toshiro, Vasorelaxant di-peptide, Trp-His, regulates Ca2+-signaling pathway by inhibiting the phosphorylation of voltage-dependent L-type Ca2+ channel in vascular smooth muscle cells, J. Hypertens., eS 1, e279-e279, 2012.09, 血管弛緩ペプチドであるTrp-Hisがラット平滑筋細胞においてカルシウムシグナル系抑制を介してL型カルシウムチャンネルのリン酸化を制御していることを証明した。.
49. Mitsuru Tanaka, Jian Zhao, Aki Suyama, Matsui Toshiro, Epigallocatechin gallate promotes the vasorelaxation power of the anti-atherosclerotic dipeptide Trp-His in contracted rat aorta, J. Agric. Food Chem, 60, 9048-9054, 2012.08.
50. Ju Qiu, Yoko Kitamura, Yuji Miyata, Shizuka Tamaru, Kazunari Tanaka, Takashi Tanaka, Matsui Toshiro, Transepithelial Transport of Theasinensins through Caco-2 Cell Monolayers and Their Absorption in Sprague-Dawley Rats after Oral Administration, J. Agric. Food Chem, 60, 8036-8043, 2012.07.
51. Jennifer Kovacs-Nolan, Hua Zhang, Masahisa Ibuki, Toshihiro Nakamori, Keiko Yoshiura, Patricia V Turner, Matsui Toshiro, Yoshinori Mine, The PepT1-transportable soy tripeptide VPY reduces intestinal inflammation, Biochim. Biophys. Acta-General Subjects, 1820, 1753-1763, 2012.06.
52. Eui-Baek Byun, Teruaki Ishikawa, Aki Suyama, Masaya Kono, Shohei Nakashima, Tomomasa Kanda, Miyamoto Takahisa, Matsui Toshiro, A procyanidin trimer, C1, promotes NO production in rat aortic endothelial cells via both hyperpolarization and PI3K/Akt pathways, Eur. J. Pharm, 10.1016/j.ejphar.2012.07.011, 692, 52-60, 2012.06.
53. S.Tokuda, T.Fukuda, Y.Kobayashi, Mitsuru Tanaka, Matsui Toshiro, Uncharged imidazolium moiety in adenine is responsible for endothelium-independent relaxation in contracted thoracic aorta of Sprague-Dawley rats, Biosci. Biotechnol. Biochem., 76, 4, 828-830, 2012.04.
54. Yutaro Kobayashi, T.Fukuda, Mitsuru Tanaka, Matsui Toshiro, The anti-atherosclerotic di-peptide, Trp-His, inhibits the phosphorylation of voltage-dependent L-type Ca2+ channels in rat vascular smooth muscle cells, FEBS Open Bio, 10.1016/j.fob.2012.04.005, 2, 83-88, 2012.04.
55. E.B.Byun, S.Korematsu, T.Ishikawa, T.Nishizuka, S.Ohshima, Matsui Toshiro, Apple procyanidins induce hyperpolarization of rat aorta endothelial cells via activation of K+ channels, J. Nutr. Biochem., 23, 3, 278-286, 2012.03.
56. Yuji Miyata, Takashi Tanaka, Kei Tamaya, Toshiro Matsui, Shizuka Tamaru and Kazunari Tanaka, Cholesterol-lowering effect of black tea polyphenols, theaflavins, Theasinensin A and thearubigins, in rats fed high fat diet, Food Sci. Technol. Res., 17, 6, 583-588, 2011.12.
57. T.Shii, T.Tanaka, S.Watarumi, Y.Matsuo, Y.Miyata, K.Tamaya, S.Tamaru, K.Tanaka, T.Matsui and I.Kouno, Polyphenol composition of a functional fermented tea obtained by tea-rolling processing of green tea and loquat leaves, J. Agric. Food Chem, 59, 13, 7253-7260, 2011.07.
58. J.Qiu, N.Saito, M.Noguchi, K.Fukui, K.Yoshiyama, K.Matsugano, N.Terahara and T.Matsui, Absorption of 6-O-caffeoylsophorose and its metabolites in Sprague-Dawley rats detected by ECD-HPLC and ESI-TOF-MS methods, J. Agric. Food Chem., 59, 11, 6299-6304, 2011.05.
59. E. M. N. Nakashima, A.Kudo, Y. Iwaihara, M. Tanaka, K. Matsumoto, T. Matsui, Application of 13C-stable-isotope labeling LC-MRM-MS/MS method for determining intact absorption of bioactive di-peptides in rats., Anal. Biochem., 10.1016/j.ab.2011.02.037, 414, 4, 109-116, 2011.04.
60. N. Inoue, K. Nagao, K.Sakata, N.Yamano, P.E.R.Gunawardena, S.Y.Han, T.Matsui, T.Nakamori, H.Furuta, K.Takamatsu and T.Yanagita, Screening of soy protein-derived hypotriglyceridemic di-peptides in vitro and in vivo, Lipids in Health and Disease, 10, 85-94, 2011.04.
61. T.Hasegawa, T.Matsui, K.Matsumoto, Effect of multi stratification and film depth on visualized dynamic sorption behavior of perylene in cellulose acetate film by confocal laser scanning microscope technique., J.Appl.Polymer Sci., 121, 3, 1780-1787, 2011.03.
62. Z.Wang, S.Watanabe, Y.Kobayashi, M.Tanaka, T.Matsui, Trp-His, a vasorelaxant di-peptide, can inhibit extracellular Ca2+ entry to rat vascular smooth muscle cells through blockade of dihydropyridine-like L-type Ca2+ channels, Peptides, 31, 2060-2066, 2010.10, 抗動脈硬化作用並びに血管弛緩作用を有するジペプチドTrp-Hisが血管平滑筋細胞膜に局在する電位依存性L型カルシウムチャンネルに結合し、降圧薬であるニフェジピンと同様に細胞内へのカルシウムイオンの流入を遮断させることを明らかにした。.
63. T.Matsui, A.Kudo, S.Tokuda, K.Matsumoto, H.Hosoyama, Identification of a new natural vasorelaxatant compound, (+)-osbeckic acid, from rutin-free tartary buckwheat extract, J. Agric. Food Chem., 58, 20, 10876-10879, 2010.10.
64. T.Hasegawa, T.Matsui, K.Matsumoto, Application of confocal laser scanning microscope technique to visualize dynamic sorption behavior of perylene in cellulose acetate film, J. Appl. Polymer Sci., 116, 5, 1552-1557, 2010.05.
65. T.Hasegawa, T.Matsui, K.Matsumoto, Comparative study of additives on visualized dynamic sorption behavior of perylene in cellucose acetate film by confocal laser scanning microscope technique, J. Appl. Polymer Sci., 116, 5, 1710-1717, 2010.05.
66. A.Toshima, T.Matsui, M.Noguchi, J.Qiu, K.Tamaya, Y.Miyata, T.Tanaka, K.Tanaka, Identification of α-glucosidase inhibitors from a new fermented tea obtained by tea-rolling processing of loquat (Eriobotrya japonica) and green tea leaves, J. Sci. Food Agr., 90, 1545-1550, 2010.05.
67. T.Matsui, X.L.Zhu, K.Shiraishi, T.Ueki, Y.Noda, K.Matsumoto, Antihypertensive effect of salt-free soy sauce, a new fermented seasoning, in spontaneously hypertensive rats, J.Food Sci., 75, 4, H129-H134, 2010.04.
68. T.Matsui, M.Sato, M.Tanaka, Y.Yamada, S.Watanabe, Y.Fujimoto, K.Imaizumi, K.Matsumoto, Vasodilating di-peptide Trp-His can prevent atherosclerosis in apolipoprotein E-deficient mice, Br. J. Nutr., 103, 3, 309-313, 2010.03.
69. K.Tamaya, T.Matsui, A.Toshima, M.Noguchi, J.Qiu, Y.Miyata, T.Tanaka, K.Tanaka, Suppression of blood glucose level by a new fermented tea obtained by tea-rolling processing of loquat (Eriobotrya japonica) and green tea leaves in disaccharides-loaded Sprague-Dawley rats, J. Sci. Food Agr., 90, 779-783, 2010.03.
70. R.Selyanchyn, S.Korposh, T.Matsui, H.Matsui, S.W.Lee, Purge and trap sampling coupled to curie point thermal desorption for the detection of parts per trillion 2,4,6-trichloroanisole in water, Chromatographia, 71, 317-321, 2010.01.
71. Toshiro Matsui, Sachiko Korematsu, Eui-Baek Byun, Taichi Nishizuka, Shunji Ohshima and Tomomasa Kanda, Apple Procyanidins Induce Vascular Relaxation in Isolated Rat Aorta through NO/cGMP Pathway in Combination with Hyperpolarization by Multiple K+ Channel Activations, Biosci. Biotechnol. Biochem., 73(10), 2246-2251, 2009.10.
72. Norihiko Terahara, Toshiro Matsui,Kanako Minoda, Kanae Nasu, Risa Kikuchi, Keiichi Fukui, Hiroshi Ono, and Kiyoshi Matsumoto, Functional new acylated sohoroses and deglucosylated anthocyanins in a fermented red vinegar, J. Agric. Food Chem, 57(18), 8331-8338 , 2009.10.
73. Takashi Tanaka, Yuji Miyata, Kei Tamaya, Rie Kusano, Yusuke Matsuo, Shizuka Tamaru, Kazunari Tanaka, Toshiro Matsui, Masamichi Maeda, Isao Kouno, Increase of theaflavin gallates and thearubigins by acceleration of catechin oxidation in a new fermented tea product obtained by tea-rolling processing of loquat (Eriobotrya japonica) and green tea leaves, J. Agric. Food Chem., 57(13), 5816-5822, 2009.09.
74. Mitsuru Tanaka, Shimpei Watanabe, Zhengquan Wang, Kiyoshi Matsumoto and Toshiro Matsui, His-Arg-Trp potently attenuates contracted tension of thoracic aorta of Sprague-Dawley rats through the suppression of extracellular Ca2+ influx, Peptides, 30, 1502-1507, 2009.06.
75. Toshiro Matsui, Mayu Shimada, Nozomi Saitoh and Kiyoshi Matsumoto, α-Glucosidase inhibition assay in an enzyme-immobilized amino-microplate, Anal.Sci. , 25(4), 559-562 (2009), 2009.04.
76. Masahiro Yoshiki, Keisuke Tsuge, Yumi Tsuruta, Takashi Yoshimura, Kazuyoshi Koganemaru, Toshihisa Sumi, Toshiro Matsui, Kiyoshi Matsumoto, Production of a new antioxidant compound from mycosporine-like amino acid, Porphyra-334, by heat treatment., Food Chem., 113, 1127-1132 , 2009.01.
77. Yusuke Ushida, Toshiro Matsui, Mitsuru Tanaka, Kiyoshi Matsumoto, Hirokazu Hosoyama, Atsuhiro Mitomi, Yuko Sagesaka, Takami Kakuda, Endothelium-dependent vasorelaxation effect of rutin-free tartary buckwheat extract in isolated rat thoracic aorta. , J. Nutr. Biochem., 19(10), 700-707, 2008.10.
78. Lieselot Vercruysse, Guy Smagghe, Toshiro Matsui, John Van Camp, Purification and Identification of an Angiotensin I-converting Enzyme (ACE) Inhibitory Peptide from the Gastrointestinal Hydrolysate of the Cotton Leafworm, Spodoptera Littoralis. , Process Biochem., 43, 900-904, 2008.10.
79. Tomoko Fujise, Norihiko Terahara, Keiichi Fukui, Koichi Sugita, Hideaki Ohta, Toshiro Matsui, Kiyoshi Matsumoto, Durable antihyperglycemic effect of 6-O-caffeoylsophorose with α-glucosidase inhibitory activity in rats., Food Sci. Technol. Res., 14(5), 477-484, 2008.10.
80. Mitsuru Tanaka, Shinpei Watanabe, Mai Tokuyasu, Toshiro Matsui, Kiyoshi Matsumoto, Structure-activity relationship between vasodilating di- and tri-peptides in thoracic aorta of Sprague-Dawley rats. , J. Hypertension, 26(suppl.1), S171, 2008.06.
81. Xiao-Lin Zhu, Keisuke Watanabe, Koso Shiraishi, Tatsuro Ueki, Yoshiharu Noda, Toshiro Matsui, Kiyoshi Matsumoto, Identification of ACE-inhibitory Peptides in Salt-free Soy Sauce that are Transportable across Caco-2 Cell Monolayers, Peptides, 29(3), 338-344 , 2008.03.
82. Xiao-Lin Zhu, Toshiro Matsui, Keisuke Watanabe, Koso Shiraishi, Tatsuro Ueki, Kiyoshi Matsumoto, Simultaneous determination of angiotensin I-converting enzyme inhibitory peptides in tryptic casein hydrolysate by high-performance liquid chromatography combined with a replicate heart-cut column-switching technique, J. Agric. Food Chem., 55(21), 8367-8374 , 2007.10.
83. Isiaka Ajani Ogunwande, Toshiro Matsui, Tomoko Fujise and Kiyoshi Matsumoto, α-Glucosidase Inhibitory Profile of Nigerian Medicinal Plants in Immobilized Assay System, Food Sci. Technol. Res., 13(2), 169-172, 2007.05.
84. Toshiro Matsui, Takashi Tanaka, Satomi Tamura, Asami Toshima, Kei Tamaya, Yuji Miyata, Kazunari Tanaka, and Kiyoshi Matsumoto, Alpha-Glucosidase Inhibitory Profile of Catechins and Theaflavins, J.Agric. Food Chem., 55(1), 99-105, 2007.01.
85. Mitsuru Tanaka, Toshiro Matsui, Yusuke Ushida and Kiyoshi Matsumoto, Vasodilating action of di-peptides in thoracic aortas from spontaneously hypertensive rats, Biosci. Biotechnol. Biochem., 70(9), 2292-2295, 2006.09.
86. Toshiro Matsui, Xiao Lin Zhu, Keisuke Watanabe, Keisuke Tanaka, Yoko Kusano, Kiyoshi Matsumoto, Combined administration of captopril with an antihypertensive Val-Tyr di-peptide to spontaneously hypertensive rats attenuates the blood pressure lowering effect, Life Sciences, 2006.08.
87. Toshiro Matsui, Isiaka Ogunwande, Kanthi J. M. Abesundara, and Kiyoshi Matsumoto, Anti-hyperglycemic Potential of Natural Products, Mini-Reviews in Medicinal Chemistry, 6(3), 109-120, 2006.02.
88. T.Matsui, T.Ueno, M.Tanaka, H.Oka, T.Miyamoto, K.Osajima, K.Matsumoto, Antiproliferative action of an angiotensin I-converting enzyme inhibitory peptide, Val-Tyr, via an L-type Ca2+ channel inhibition in cultured vascular smooth muscle cells, Hypertension Res., 10.1291/hypres.28.545, 28, 6, 545-552, 28(6), 545-552, 2005.06.
89. T.Matsui, S.Ebuchi, T.Fujise, K.J.M.Abesundara, S.Doi, H.Yamada, K.Matsumoto, Strong antihyperglycemic effects of water-soluble fraction of Brazilian propolis and its bioactive constituent, 3, 4, 5-tri-O-caffeoylquinic acid, Biol. Pharm. Bull., 10.1248/bpb.27.1797, 27, 11, 1797-1803, 27, 1797-1803, 2004.11.
90. K.Abesundara, T.Matsui, K.Matsumoto, a-Glucosidase inhibitory activity of some Sri Lanka plant extracts, One of which, Cassia auriculata, exerts a strong antihyperglycemic effect in rats comparable to the therapeutic drug acarbose, J.Agric. Food Chem., 10.1021/jf035330s, 52, 9, 2541-2545, 52, 2541-2544, 2004.05.
91. T.Matsui, M.Imamura, H.Oka, K.Osajima, K.Kimoto, T.Kawasaki, K.Matsumoto, Tissue distribution of antihypertensive dipeptide, Val-Tyr, after its single oral administration to spontaneously hypertensive rats, J.Peptide Sci., 10.1002/psc.568, 10, 9, 535-545, 10,535-545, 2004.01.
92. H.Oka, T.Matsui, T.Ueno, K.Matsumoto, T.Kawasaki, ACE inhibitory peptides can act as an inhibitor of vascular smooth muscle cell growth, J.Hypertension, 22, S68-S68, 22(suppl 1), S68, 2004.01.
93. T.Matsui, T.Kawasaki, Classification of natural ACE inhibitory peptides into C-/N-domain selective inhibitor, J.Hypertension, 22, S70-S70, 22(suppl. 1), S70, 2004.01.
94. Physiological function and preparation of antihypertensive peptide, SVY, from 7S globulin..
95. Antihypertensive effect of food containing sardine peptides in high-normal hypertensives amd hypertensives..
96. SOD-like activity of sardine muscle hydrolysate by alkaline protease..
97. Intestinal absorption behavior of bioactive peptides..
98. K.Nagao, N.Inoue, Y.-M.Wang. J.Hirata, Y.Shimada, T.Nagao, T.Matsui, and T.Yanagita, The 10trans,12cis isomer of conjugated linoleic acid suppress the development of hypertension in Otsuka Long-Evans Tokushima fatty rats, Biochem. Biophys. Res. Commun., 10.1016/S0006-291X(03)00929-X, 306, 1, 134-138, 306, 134-138, 2003.05.
99. T.Matsui, A.Hayashi, K.Tamaya, K.Matsumoto, T.Kawasaki, K.Murakami, and K.Kimoto, Depressor effect induced by dipeptide, Val-Tyr, in hypertensive transgenic mice is due, in part, to the suppression of human circulating renin-angiotensin system, Clin. Exp. Pharmacol. Physiol., 10.1046/j.1440-1681.2003.03824.x, 30, 4, 262-265, 30(4), 262-265, 2003.04.
100. N.Terahara, T.Matsui, K.Fukui, K.Matsugano, K.Sugita, and K.Matsumoto, Caffeoylsophorose in a red vinegar produced through fermentation with purple sweetpotato, J. Agric. Food Chem., 10.1021/jf026146u, 51, 9, 2539-2543, 51(9), 2539-2543, 2003.03.
101. K.Matsumoto, K.Takayama, J.M.Kanthi Abesundara, and T.Matsui, Assay of a-glucosidase inhibitory activity using flow-biosensor system, Anal. Chim. Acta, 10.1016/S0003-2670(02)01539-8, 479, 2, 135-141, 479, 135-141, 2003.02.
102. T.Matsui, S.Ebuchi, M.Kobayashi, K.Fukui, K.Sugita, N.Terahara, and K.Matsumoto, K.Matsumoto: Anti-hyperglycemic effect of diacylated anthocyanin derived from Ipomoea batatas cv. Ayamurasaki can be achieved through the a-glucosidase inhibitory action, J. Agric. Food Chem., 10.1021/jf025913m, 50, 25, 7244-7248, 50(25),7244-7248, 2002.12.
103. Safety and depressor effect of sardine peptide-drink in mild hypertensives, high-normal hypertensives, and normotensives..
104. T.Matsui, K.Tamaya, E.Seki, K.Osajima, K.Matsumoto, and T.Kawasaki, Absorption of Val-Tyr with in vitro angiotensin I-converting enzyme inhibitory activity into the circulating blood system of mild hypertensive subjects., Biol. Pharmacol. Bull., 10.1248/bpb.25.1228, 25, 9, 1228-1230, 25(9), 1228-1230, 2002.09.
105. T.Matsui, K.Tamaya, E.Seki, K.Osajima, K.Matsumoto, and T.Kawasaki, Circulatory and localized angiotensin I-converting enzyme inhibitory effects of the sardine peptide, Val-Tyr., J. Hypertension, 20, S241-S241, 22(suppl.4), S241, 2002.06.
106. M.Imamura, T.Matsui, E.Seki, K.Osajima, K.Matsumoto, and T.Kawasaki, The relationship between rat age and the antihypertensive effect of the sardine peptide, Val-Tyr., J. Hypertension, 20, S241-S241, 22(suppl.4), S241, 2002.06.
107. T.Kawasaki, Y.Fukushima, J.J.Chen, K.Kegai, E.Seki, K.Osajima, K.Itoh, T.Matsui, and K.Matsumoto, Antihypertensive effect of drink containing peptides derived from sardine protein hydrolysate in mild hypertensive blood pressure subjects., J. Hypertension, 20, S332-S332, 22(suppl.4), S332, 2002.06.
108. Chun-Hui Li, T. Matsui, K. Matsumoto, R. Yamasaki, and T. Kawasaki, Latent production of angiotensin I-converting enzyme inhibitors from buckwheat protein., J. Peptide Sci., 10.1002/psc.387, 8, 6, 267-274, 8, 267-274, 2002.05.
109. T.Matsui, A.Yukiyoshi, S.Doi, H.Sugimoto, H.Yamada, and K.Matsumoto, Gastrointestinal enzyme production of bioactive peptides from royal jelly protein and their antihypertensive ability in SHR., J. Nutr. Biochem., 10.1016/S0955-2863(01)00198-X, 13, 2, 80-86, 13(2), 80-86, 2002.04.
110. Depressor effect of sardine peptide-drink in mild hypertensives and normotensives..
111. T.Matsui, K.Tamaya, E.Seki, K.Osajima, K.Matsumoto, and T.Kawasaki, Val-Tyr as a natural antihypertensive dipeptide can be absorbed into human circulatory blood system., Clin. Exp. Pharmacol. Physiol., 10.1046/j.1440-1681.2002.03628.x, 29, 3, 204-208, 29(3), 204-208, 2002.03.
112. T.Matsui, M.Kobayashi, S.Hayashida, and K.Matsumoto, Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of a-glucosidase action., Biosci. Biotechnol. Biochem., 66, 3, 689-692, 66(3), 689-692, 2002.03.
113. Mahmud Tareq Hassan Khan, T.Matsui, K.Matsumoto, and Shaila Jabbar, In vitro antihypertensive studies of some Bangladeshi plant extracts., Die Pharmazie, 56(11), 902-903, 2001.11.
114. T.Matsui, T.Ueda, T.Oki, K.Sugita, N.Terahara, and K.Matsumoto, a-Glucosidase inhibitory action of natural acylated anthocyanins. 1. Survey of natural pigments with potent inhibitory activity., J. Agric. Food Chem., 10.1021/jf001251u, 49, 4, 1948-1951, 49(4), 1948-1951, 2001.04.
115. T.Matsui, T.Ueda, T.Oki, K.Sugita, N.Terahara, and K.Matsumoto, a-Glucosidase inhibitory action of natural acylated anthocyanins. 2. a-Glucosidase inhibition by isolated acylated anthocyanins., J. Agric. Food Chem., 10.1021/jf0012502, 49, 4, 1952-1956, 49(4), 1952-1956, 2001.04.
116. T.Oki, T.Matsui, and K. Matsumoto, Evaluation of a-glucosidase inhibition by using an immobilized assay system., Biol. Pharm. Bull., 23(9), 1084-1087, 2000.09.
117. Y-H.Hwang, T.Matsui, T.Hanada, M.Shimoda, K.Matsumoto, and Y.Osajima, Desorption behavior of sorbed flavor compounds from packaging films with ethanol solution., J. Agric. Food Chem., 10.1021/jf991082h, 48, 9, 4310-4313, 48(9), 427-431, 2000.09.
118. Deviation of desorption equation of flavors from plastic films by using compatibility theory..
119. T. Kawasaki, E. Seki, K. Osajima, M. Yoshida, K. Asada, T. Matsui, and Y. Osajima, Antihypertensive effect of Valyl-Tyrosine, a short chain peptide derived from sardine muscle hydrolyzate, on mild hypertensive subjects., J. Human Hypertens., 10.1038/sj.jhh.1001065, 14, 8, 519-523, 14, 519-523, 2000.08.
120. T.Matsui, K.Tamaya, K.Matsumoto, E.Seki, K.Osajima, and T.Kawasaki, The bioavailability of antihypertensive small peptide, Val-Tyr, in human., J. Hypertension, 18, S87-S87, 18(suppl.4), S87, 2000.08.
121. E.Seki, T.Kawasaki, K.Osajima, K.Tamaya, and T.Matsui, Antihypertensive effect of sardine peptide, Val-Tyr, in normotensive and hypertensive subjects., J. Hypertension, 18, S90-S90, 18(suppl.4), S90, 2000.08.
122. Antihypertensive effect of sardine peptides in mild hypertensives and high-normal hypertensives..
123. T.Matsui, Chun-Hui Li, T. Tanaka, T. Maki, Y. Osajima, and K. Matsumoto, Depressor effect of wheat germ hydrolysate and its novel angiotensin I-converting enzyme inhibitory peptide, Ile-Val-Tyr, and the metabolism in rat and human plasma., Biol. Pharm. Bull., 23, 4, 427-431, 23(4), 427-431, 2000.04.
124. Antihypertensive effect of sardine peptides and Val-Tyr - antihypertensive effect of the peptides in spontaneously hypertensive rats-.
125. T.Matsui, K.Tamaya, K.Matsumoto, Y.Osajima, K.Uezono, and T.Kawasaki, Plasma concentrations of angiotensin metabolites in young male normotensive and mild hypertensive subjects., Hypertens. Res., 10.1291/hypres.22.273, 22, 4, 273-277, 22(4), 273-277, 1999.08.
126. T.Matsui, K.Tamaya, T.Kawasaki, and Y.Osajima, Determination of angiotensin metabolites in human plasma by fluorimetric high-performance liquid chromatography using a heart-cut column-switching technique., J. Chromatogr.B, 10.1016/S0378-4347(99)00128-0, 729, 1-2, 89-95, 729, 89-95, 1999.07.
127. T.Matsui, C. -H. Li, and Y.Osajima, Preparation and characterization of novel bioactive peptides responsible for angiotensin I-converting enzyme inhibition from wheat germ., J. Peptide Sci., 10.1002/(SICI)1099-1387(199907)5:7<289::AID-PSC196>3.0.CO;2-6, 5, 7, 289-297, 5, 289-297, 1999.05.
128. P.Pfnuer, T.Matsui, W.Grosch, H.Guth, and P.Schieberle, Development of a stable isotope dilution assay for the quantification of 5-methyl-(E)-2-heptene-4-one: Application to hazelnut oils and hazelnuts., J. Agric. Food Chem., 10.1021/jf9810214, 47, 5, 2044-2047, 47(5), 2044-2047, 1999.05.
129. T.Matsui, T. Oki, and Y.Osajima, Isolation and identification of peptidic a-glucosidase inhibitors derived from sardine mucle hydrolyzate., Z. Naturforsch., 54, 3-4, 259-263, 54C, 259-263, 1999.02.
130. T.Oki, T.Matsui, and Y.Osajima, Inhibitory effect of a-glucosidase inhibitors varies according to its origin., J. Agric. Food Chem., 10.1021/jf980788t, 47, 2, 550-553, 47(2), 550-553, 1999.02.
131. T.Oki, K.Matsumoto, T.Matsui, and Y.Osajima, Change in catalytic property of trypsin immobilized on support activated with glutaraldehyde in lower protogenic solvent., Food Sci. Technol. Res., 5(1), 13-17, 1999.01.
132. T.Kawasaki, K.Osajima, E.Seki, M.Yoshida, K.Asada, T.Matsui, and Y.Osajima, Antihypertensive effect of Val-Tyr, a short chain peptide derived from sardine muscle hydrolyzate, on hypertensives., J. Hypertension, 16, S25-S25, 16(suppl.2), S25, 1998.06.
133. T.Matsui, Y.Osajima, K.Uezono, and T.Kawasaki, Metabolism of endogenous Val-Tyr with antihypertensive effect in human plasma., J. Hypertension, 16, S138-S138, 16(suppl.2), S138, 1998.06.
134. Antihypertensive effect of sardine peptides in mild hypertensive subjects..
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4. 鐘 璇,田尻聡史,俵口真衣,小柳里穂,志村昭弘,松井利郎, Simultaneous separation of catecholamine metabolites on a sulfonated mixed-mode copolymer column by liquid chromatography mass spectrometry, 第72回日本栄養・食糧学会大会, 2018.05.
5. 申 偉琳,田中 充,松井利郎, Simultaneous detection of angiotensin metabolites in rat plasma using LC-MS/MS method, 第72回日本栄養・食糧学会大会, 2018.05.
6. Ritsuko Sato, Risa Yoshida, Naoki Morishita, Toshiro Matsui, Koji Ochiai, Baorui Li, Yusuke Terazono, Naoto Hirasaki, Emiko Kinoshita, Akio Obata, Toshiro Matsui, Masatoshi Shinagawa, Identification of isoflavone-derived metabolites in soybean and their promoting effect on glucose uptake in L6 myotubes, 平成29年度日本食品科学工学会西日本支部および日本栄養・食糧学会九州・沖縄支部合同大会, 2017.10.
7. 松井 利郎, Effect of aging on vasorelaxation of small peptides on contracted rat aorta, ISNFF2017, 2017.10.
8. 田中 充、松井 利郎, Screening of synergic combination of food compounds to exert vasorelaxation effect in rat aorta, ISNFF2017, 2017.10, SDラット大動脈血管を用いて、フェルラ酸等のフェノール酸による血管弛緩を促進させる他の食品成分を明らかにし、その相乗作用について報告した。.
9. 大野直土、田端淳二、松井 利郎, Intestinal absorption of hesperidin and its metabolites in Sprague-Dawley rats, ISNFF2017, 2017.10.
10. 網屋祐輔、田中 充、松井 利郎, Optimization of MALDI-MS detection of bioactive peptides in rat plasma, ISNFF2017, 2017.10.
11. Baorui Li, Yusuke Terazono, Naoto Hirasaki, Emiko Kinoshita, Akio Obata, Toshiro Matsui, Tomatoside A inhibits glucose transport across Caco-2 cell monolayers, 第64回日本食品科学工学会大会, 2017.08.
12. Hsusan Chung, Akihiro Shimura, Toshiro Matsui, Simultaneous and discriminant HPLC analysis of reducing and non-reducing monosaccharides on a polyethylene-attached hydrophilic interaction liquid chromatography column, 日本食品分析学会平成29年度学術集会, 2017.08.
13. 松井 利郎, Absorption of peptides into rat blood: Effect of peptide-length and aging of rats on absorption, 108th AOCS Annual Meeting & Expo, 2017.05.
14. 松井 利郎, Small peptides: Anti-hypertensive and vasorelaxation actions, International Symposium on Bioactive Peptides, 2017.05, 低分子ペプチドの生理作用と吸収挙動について招待講演を行った。.
15. A. Siltari, W. Shen, R. Yoshida, T. Matsui, R. Korpela, H. Vapaatalo, Absorption of bioactive tripeptides across Caco-2 cell membrane and rat intestine in vitro., 5th International Conference on Food Digestion, 2017.04.
16. 松井 利郎, Vasorelaxation mechanism of small peptides in contracted aged aorta, 9th ISNFF, 2016.10.
17. Nguyen Huu Nghi, 田中 充, 松井 利郎, Enhanced matrix-assisted MALDI-MS detection of polyphenol by nifedipine a photobase generator, 日本分析化学会第65回年会, 2016.09.
18. 鐘 璇, Nguyen Thu Huong, 志村昭弘, 松井 利郎, Discriminant analysis of non-reducing and reducing rare sugars on a prototype hydrophilic interaction liquid chromatography (HILIC) column, 第2回日本食品分析学会, 2016.09.
19. Vu-Thi Hanh, 小林優多郎, 田中 充, 松井 利郎, Application of a standard addition method for quantitative mass spectrometry assay of dipeptides, 第63回日本食品科学工学会大会, 2016.08.
20. 郭 建, 平崎直人, 田中 隆, 松井 利郎, Interaction of theasinensin A with hydrophobic dipeptides in water by NMR analysis, 第70回日本栄養・食糧学会大会, 2016.05.
21. 松井 利郎, Design of oligopeptides for intestinal absorption model, 107th AOCS Annual Meeting & Expo, 2016.05.
22. 松井 利郎, Intestinal absorption of bioactive compounds, The 4th Nutrition Winter School, 2016.01.
23. 松井 利郎, Health-benefit of small peptides, Symposium of bioactive compounds, 2016.01.
24. Toshihiko Fukuda, 松井 利郎, Yoshinori Mine, Adenine, a vasorelaxant purine, reduces intestinal inflammation in colitis mouse model, The international Chemical Congress of Pacific Basin Societies, 2015.12.
25. 松井 利郎, Mechanism of vasorelaxation of small peptides via the suppression of intracellular Ca2+ signaling pathways, 8th Meeting of the International Society of Nutrition and Functional Foods (ISNFF), 2015.09.
26. Si Jing Chen, Chiwa Aikawa, 松井 利郎, Advanced glycation end-products in spontaneously diabetic Torii rats at pre-diabetic stage by liquid-chromatography-tandem mass spectrometry, 日本分析化学会第64年会, 2015.09.
27. Jiang Guo, Akihiro Shimura, 松井 利郎, Elution profile of di/tri-peptides on sulfonated ethylstylene-divinylbenzene copolymer resin column by high-performance liquid chromatography, 日本分析化学会第64年会, 2015.09.
28. 陳 思婧, 相川知和, 吉田理紗, 松井 利郎, High-sensitive detection of advanced glycation end-products and its application for the prevention of of pre-diabetic diseases, 第33回分析化学会九州分析若手の会夏季セミナー, 2015.07.
29. Mai Hyoguchi, Toshihiko Fukuda, Miki Kono, Mitsuru Tanaka, 松井 利郎, Age-related vasorelaxation of natural bioactive compounds, The 2nd Taiwan-Japan Food Science, Technology and Industry Symposium, 2015.05.
30. Naoto Hirasaki, Yuri Kunitake, Ha-Yong Park, Mitsuru Tanaka, 松井 利郎, Theaflavins can enhance the intestinal barrier in Caco-2 cells, The 2nd Taiwan-Japan Food Science, Technology and Industry Symposium, 2015.05.
31. Mitsuru Tanaka, Jian Zhao, Aki Suyama, 松井 利郎, Ferulic acid improves acetylcholine-induced nitric oxide production via up-regulation of argnitrosaccinate synthase in TNF-alpha-stimulated inflammatory human umbilical vein endothelium cells, 12th Asian Congress of Nutrition, 2015.05.
32. Shizuka Tamaru, Mimi Iha, Sayaka Shimamoto, Hisayuki Nakayama, Sadayuki Aramaki, Yuji Miyata, Takashi Tanaka, 松井 利郎, Yasuo Nagata, Kazunari Tanaka, Effect of mixed tea made with unripe citrus Unshu and third-crop green tea leaves on hepatic lipid accumulation in rats, 12th Asian Congress of Nutrition, 2015.05.
33. Kazuki Moriyasu, Takashi Ichinose, Akane Nakahara, Motohiro Maebuchi, Mitsuru Tanaka, 松井 利郎, 古屋 茂樹, The oral supplementation of soy protein-derived dipeptides accelerates the neurotransmitter metabolism, 12th Asian Congress of Nutrition, 2015.05.
34. Toshihiko Fukuda, Takanori Kuroda, miki Kono, Mai Hyoguchi, 松井 利郎, Inhibition of Ca2+/calmodulin signaling on adenine-induced vasorelaxation in vascular smooth muscle cells, 12th Asian Congress of Nutrition, 2015.05.
35. Si Jing Chen, Chiwa Aikawa, Mitsuru Tanaka, 松井 利郎, Plasma levels of advanced glycation end-products during pathogenic progress of diabetes in spontaneously diabetic Torii rats, 12th Asian Congress of Nutrition, 2015.05.
36. Gonzalo Miyagusuku, Masaya Kono, Kayo Yoshiyama, Keiichi Fukui, Norihiko Terahara, 松井 利郎, 6-O-Caffeolysophorose enhances glucose uptake in L6 cells by induced Glut4 translocation, 12th Asian Congress of Nutrition, 2015.05.
37. 松井 利郎, Intestinal absorption of bioactive peptides: detection and visualization, 106th AOCS Meeting, 2015.05.
38. 福田俊彦, 黒田高広, 河野美紀, 松井 利郎, Adenine, a vasorelaxant purine, regulates Ca2+ signialing through PLC/CaMKII/MLC pathway in vascular smooth muscle cells, 7th International Conference and Exhibition on Nutraceutical and Functional Foods (ISNFF), 2014.10.
39. Thanutchaporn Kumrungsee, 秋山紗綾香, 松井 利郎, In vivo and in silico analysis for calcium-calmodulin complex formation, 日本分析化学会第63年会, 2014.09.
40. Jian Guo, Thanutchaporn Kumrungsee, 佐伯知美, Wanying Liu, Akihiro Shimura, 松井 利郎, Application of cation-exchemgel reversed-phase mixed-mode HPLC column for the separation of small peptides, 日本分析化学会第63年会, 2014.09.
41. 朴 夏英, 國武友里, 松井 利郎, Enhancement of intestinal barrier by theaflavins through the expression of AMP-activated protein kinase mediated tight junction related proteins, The 36th ESPEN (The European society for clinical nutrition and metabolism), 2014.09.
42. 朴 夏英, 國武友里, 松井 利郎, Enhancement of intestinal barrier by theaflavins through increasing the expression of AMP-activated protein kinase mediated tight junction-related proteins occuludin, claudin-1 and ZO-1, The XXVⅡth International Conference on Polyphenols, 2014.09.
43. Gonzalo Miyagusuku, 幸野将也, 吉山かよ, 福井敬一, 寺原典彦, 松井 利郎, Enhanced glucose uptake in L6 cells by 6-O-Caffeoylsophorose, 第61回日本食品科学工学会大会, 2014.08.
44. Yoshinori Mine, Jennifer Kovacs-Nolan, 松井 利郎, 田中 充, Toru Konishi, Yusuke Sauchi, Transport of intact glutathione across human intestinal epithelial cell monolayers using Caco-2 and HT-29 models, 248th ACS National Meeting, 2014.08.
45. 曹 汝鴿, 野中愛理, 松井 利郎, The application of diffusion ordered-‘H-nuclear magnetic resonance spectroscopy to evaluate the food quality, 第32回分析化学会九州分析若手の会夏季セミナー, 2014.07.
46. 小林優多郎, Yoshinori Mine, 松井 利郎, Anti-inflammatory effect of the vasoprotective di-peptides in intestinal mucosa system, 105th AOCS Annual Meeting & Expo, 2014.05.
47. Matsui Toshiro, Vasoactivity of small peptides and high-sensitive detection of absorbed peptides, 2013 Int. Symposium of Functional Foods Research Center, 2013.11.
48. Matsui Toshiro, Physiological potentials of condensed polyphenols in intestine and muscle tissues, 2013 Int. Conference of the Korean Society of Food Science and Nutrition, 2013.11.
49. 朴 夏英, 國武友里, Matsui Toshiro, Theaflavins enhance the intestinal barrier through AMP-activated protein kinase-mediated expression of tight-junction-related proteins, 2013 Int. Conference of the Korean Society of Food Science and Nutrition, 2013.11.
50. 國武友里, 朴 夏英, Matsui Toshiro, Theaflavins inhibit peptide transport across Caco-2 cell monolayers via down-regulation of peptide transporter PEPT1, 2013 Int. Conference of the Korean Society of Food Science and Nutrition, 2013.11.
51. Matsui Toshiro, High-sensitive detection and visualization of vasoactive small peptides, 2013 Symposium on Analysis and Efficacy of Functional Foods in East Asia Region, 2013.10.
52. Gozalo Miyagusuku, 幸野将也, 橋本千尋, 福井敬一, 田中 充, 松井 利郎, 6-O-Caffeoylsophorose stimulates glucose uptake in L6 myotubes through IRS-PI3K activation, 平成25年度日本栄養・食糧学会九州・沖縄支部及び日本食品科学工学会西日本支部合同大会, 2013.10.
53. 趙 健, 須山 晶, 田中 充, 松井 利郎, Ferulic acid enhances vasorelaxation effect of epigallocatechin gallate in tumor necrosis factor-a-induced inflammatory rat aorta, 第60回日本食品科学工学会, 2013.08.
54. 陳 思婧, 橋本千尋, 相川知和, 松井 利郎, Improvement of advanced glycation end products detection by liquid-chromatography-tandem mass spectrometry with 2,4,6-trinitrobenzen sulfonate derivatization, Asianalysis XII, 2013.08.
55. 曹 汝鴿, 野中愛理, 小村英恵, 松井 利郎, Application of diffusion ordered-nuclear magnetic resonance spectroscopy to quantify glucose and sucrose in some beverages, Asianalysis XII, 2013.08.
56. T.Kumrungsee, 佐伯知美, 松井 利郎, Ca-CaM complex formation inhibitory activity of bioactive peptide, Trp-His, by in vitro and in silica analyses, Asianalysis XII, 2013.08.
57. 朴 夏英, 竹田隼子, 國武友里, 松井 利郎, Theaflavins enhance the intestinal barrier by increasing the expression of tight junction proteins via activation of AMP-activated protein kinase, 13th International Conference of FFC, 2013.05.
58. 國武友里, 朴 夏英, 松井 利郎, Theaflavins can close tight-junction via activation of AMP-activated protein kinase in Caco-2 cell monolayers, 2013 International Students Academic Conference, 2013.03.
59. 洪 性珉, 吉井沙織, 盛田裕太郞, Mitsuru Tanaka, 松井 利郎, Application of MALDI-MS imaging to visualize the tissue distribution of absorbable small peptides in rat intestine, 2013 International Students Academic Conference, 2013.03.
60. 福田俊彦, 徳田信二, 小林優多郎, Mitsuru Tanaka, 松井 利郎, Endothelium-independent vasorelaxation of adenine in contracted thoracic aorta of Sprague-Dawley rats, 2012 International Students Academic Conference, 2012.03.
61. 朴 夏英, 竹田 隼子, 松井 利郎, Theaflavins regulate the absorption activity and expression of the peptide transporter PEPT-1 in Caco-2 cells, 2012 International Students Academic Conference, 2012.03.
62. 松井 利郎, Functional Food Compounds : Vasorelaxation and Absorption, 2012 International Students Academic Conference, 2012.03.
63. Bioactive peptides and hypertension.
  • 学外
  • 学外
Educational Activities
Undergraduate School:
Analytical Chemistry, Engineering for Food Analysis, Scientific English I, and II, Food Science for G30, Applied Biological Science, Experiment for Fundamental Analytical Chemistry, Experiment for Food Analysis
Graduate School:
Seminar on Engineering Analysis, Food Science and technology I and II, Functional Food、Food Science and Food System, Food Science and Biotechnology
Other Educational Activities
  • 2019.03.
  • 2018.08.
  • 2017.08.
  • 2017.10.
  • 2016.08.
  • 2016.10.
  • 2015.08.
  • 2015.10.
  • 2013.10.
  • 2013.09.
  • 2013.08.
  • 2013.02.
  • 2010.08.
  • 2009.08.
  • 2008.11.
  • 2006.11.
  • 2004.08.
  • 2003.08.
  • 2003.03.
  • 2002.07.
Professional and Outreach Activities
2002- Guest researcher of Nagasaki Pref. Industry Center
2001-2002 Guest researcher of Hiroshima Pref. Food Industry Center
2016- Lecture at University of Helsinki.