Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Miki Nakao Last modified date:2019.09.08

Professor / Division of Molecular Bioscience / Department of Bioscience and Biotechnology / Faculty of Agriculture

1. Evolution of the complement system.
2. Evolution and phylogeny of the complement system and complementology.
3. Van Muiswinkel WB, Miki Nakao, A short history of research on immunity to infectious diseases in fish, Dev Comp Immunol. , doi: 10.1016/j.dci.2013.08.016, 2013.08, This review describes the history of research on immunity to infectious diseases of fish in the period between 1965 and today. Special attention is paid to those studies, which are dealing with the interaction between immune system and invading pathogens in bony fish. Moreover, additional biographic information will be provided of people involved. In the 1960s and 1970s the focus of most studies was on humoral (Ig, B-cell) responses. Thorough studies on specific cellular (T-cell) responses and innate immunity (lectins, lysozyme, interferon, phagocytic cells) became available later. In the period between 1980 and today an overwhelming amount of data on regulation (e.g. cell cooperation, cytokines) and cell surface receptors (e.g. T-cell receptor; MHC) was published. It became also clear, that innate responses were often interacting with the acquired immune responses. Fish turned out to be vertebrates like all others with a sophisticated immune system showing specificity and memory. These basic data on the immune system could be applied in vaccination or in selection of disease resistant fish. Successful vaccines against bacterial diseases became available in the 1970s and 1980s. Effective anti-viral vaccines appeared from the 1980s onwards. There is no doubt, that Fish Immunology has become a flourishing science by the end of the 20th century and has contributed to our understanding of fish diseases as well as the success of aquaculture..
4. Miki Nakao, Takahiko Horiuchi, H. Ohi, I. Ohsawa, T. Fujita, M. Matsushita, N. Okada, T. Seya, T. Yamamoto, Y. Endo, M. Hatanaka, N. Wakamiya, M. Mizuno, H. Okada, H. Tsukamoto, M. Matsumoto, N. Inoue, M. Nonaka, T. Kinoshita, Guideline for hereditary angioedema (HAE) 2010 by the Japanese Association for Complement Research - secondary publication., Allergology International, 2012.06, This guideline was provided by the Japanese Association for Complement Research targeting clinicians for making an accurate diagnosis of hereditary angioedema (HAE), and for prompt treatment of the HAE patient in Japan. This is a 2010 year version and will be updated according to any pertinent medical advancements..
5. Nakao M, Tsujikura M, Ichiki S, Vo TK, Somamoto T., The complement system in teleost fish: Progress of post-homolog-hunting researches., Dev Comp Immunol. , Epub, 2011.05.
6. Phylogeny and evolution of activation pathways of the complement system.
7. Nakao M, Kato-Unoki Y, Nakahara M, Mutsuro J and Somamoto T, Diversified components of bony fish complement system: More genes for robuster innate defense?, Advances in Experimental Medicine and Biology, 586: 121-138, 2006.03.
8. Nakao M, Mutsuro J, Nakahara M, Kato Y, Yano T, Expansion of genes encoding complement components in bony fish: biological implications of the complement diversity., Developmental and Comparative Immunology, 27: 749-762., 2003.01.
9. Nakao M, Mutsuro J, Yano T, The structural and functional diversity of complement components in carp, Cyprinus carpio, Fisheries Science, 68 suppl II, 1139-1142., 2002.01.
10. Protective effects of polysaccharides for infectious fish diseases..
11. A unique strategy of the immune system of bony fish based on diversity of complement components..
12. Bayne CJ, Nakao M, Clarifying complement complexity., Trends in Immunology, 22: 58-59..