九州大学 研究者情報
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佐藤 匡央(さとう まさお) データ更新日:2019.03.14

教授 /  農学研究院 生命機能科学部門 食料化学工学講座


主な研究テーマ
ヒトの血清脂肪酸組成と病態との関係解析
キーワード:脂肪酸組成、疫学
2005.04.
画期的米油原料用稲の育種・利用に向けた基盤的技術の開発
キーワード:米、米油、糠
2009.09.
脂質輸送に及ぼす食品成分の影響
キーワード:リンパ管、脂質吸収、小腸内皮細胞
1989.04.
肥満に及ぼす食事成分の影響
キーワード:メタボリックシンドローム、脂質代謝
2005.04.
エピジェネティクス系における食事の介入
キーワード:DNAのメチル化、メタボリックメモリー、エピジェネティクス
2003.04.
食餌による脂質及びリポタンパク質代謝の調節
キーワード:動脈硬化症、HDL,LDL
1984.04~1991.03.
病態モデル動物を用いた新規高コレステロール血症発症機構に関する研究
キーワード:外因性高コレステロールラット、連鎖解析
1984.04.
脂質代謝に及ぼす外因性および内因性酸化コレステロールの影響
キーワード:酸化コレステロール
2004.04.
脂質代謝・動脈硬化に及ぼす食事成分の影響
キーワード:脂質代謝,、動脈硬化
1997.04.
動脈硬化の進展に及ぼす食事の影響.
栄養素による遺伝子発現の調節
キーワード:遺伝子発現
1990.04.
従事しているプロジェクト研究
KEEP試験
2015.06~2015.03, 代表者:佐々木淳, 国際医療福祉大学, 日本老年医学会(日本).
EWTOPIA75-Kyushu
2015.06~2015.03, 代表者:佐々木淳, 国際医療福祉大学, 日本老年医学会(日本).
米油原料用イネの作出と利用 に関する研究・開発
2015.09~2017.03, 代表者:熊丸敏博, 九州大学, 農林水産技術会議(日本)
農林水産業・食品産業科学技術研究推進事業 発展融合ステージ.
難消化性澱粉構造と高水分吸収性を有する変異体米を用いた低カロリー食品の開発
2013.08~2015.03, 代表者:藤田直子, 秋田県立大学, 農林水産技術会議(日本)
農林水産業・食品産業科学技術研究推進事業 発展融合ステージ.
「農林水産物・食品の機能性等を解析・評価するための基盤技術の開発」米タンパク質の新規生体調節機能性の先導的開発と機構解析
2011.10~2013.03, 代表者:門脇 基二, 新潟大学大学院自然科学研究科, 農林水産省 農業技術会議(日本)
 本課題は我が国における「米は悪者」というネガティブイメージを払拭し、米の生産・消費を拡大に転じるための科学的根拠を提供するプロジェクトである。特に米の中のタンパク質に注目し、そのほとんど知られていない未知の生体調節機能性を発掘するものである。この組織的に実施する米タンパク質の新規機能性の発掘により、第3の植物性タンパク質として健康食品素材としての新市場を獲得し、また、米の価値の再認識による日本型食生活の発展、そして米消費量の拡大、高齢社会での健康の維持増進につながり、ひいては米生産の拡大、食料自給率の上昇につながる。さらには未利用資源である米糠タンパク質を高付加価値素材に転換することにより、新産業創出をも目的とする。.
EWTOPIA75-Kyushu
2009.05~2014.03, 代表者:佐々木淳, 国際医療福祉大学, 日本老年医学会(日本).
画期的米油原料用稲の育種・利用に向けた基盤的技術シーズの開発
2009.10~2013.03, 代表者:佐藤光, 九州大学, 生物系特定産業技術研究支援センター(日本).
研究業績
主要著書
主要原著論文
1. Takeyama, A., Nagata, Y., Shirouchi, B., Nonaka, C., Aoki, H., Haraguchi, T., Sato, M., Tamaya, K., Yamamoto, H., Tanaka, K., Dietary Sparassis crispa reduces body fat mass and hepatic lipid levels by enhancing energy expenditure and suppressing lipogenesis in rats, Journal of Oleo Science, 10.5650/jos.ess18043, 67, 9, 1137-1147, 2018.09, Accumulation of abdominal fat triggers metabolic syndrome, which is a cluster of metabolic abnormalities, such as dyslipidemia, glucose intolerance, insulin resistance or hyperinsulinemia, and hypertension, that leads to the development of diabetes and cardiovascular disease. Mushrooms have been used as a foodstuff and folk medicine worldwide. Among these mushrooms, Sparassis crispa (SC) is a relatively newly cultivated edible and medicinal mushroom, which has been reported to have anti-diabetic and anti-hypertensive properties. However, little is known about the anti-obesity and anti-hyperlipidemic properties of SC. In the present study, we investigated the effects of dietary SC on lipid metabolism and energy expenditure in Sprague-Dawley rats with diet-induced obesity and diabetes, and conducted respiratory gas analysis to determine how energy metabolism is altered by SC. After feeding periods of 3 and 7 weeks, dietary SC had significantly reduced hepatic triacylglycerol and cholesterol contents in a dose-dependent manner. These changes were attributable to suppression of fatty acid and cholesterol synthesis in the liver and increased insulin sensitivity in the body. In addition, after a feeding period of 6 weeks, dietary SC significantly increased energy expenditure through carbohydrate oxidation, reducing abdominal fat mass after 7 weeks. In conclusion, our results indicate that in addition to the previously reported anti-diabetic and anti-hypertensive activities, dietary SC exhibits anti-obesity and anti-hyperlipidemic activities that help protect against metabolic syndrome..
2. Shirouchi, B., Yamanaka, R., Tanaka, S., Kawatou, F., Hayashi, T., Takeyama, A., Nakao, A., Goromaru, R., Iwamoto, M., Sato, M., Quantities of phospholipid molecular classes in japanese meals and prediction of their sources by multiple regression analysis, Journal of Nutritional Science and Vitaminology, 10.3177/jnsv.64.215, 64, 3, 215-221, 2018.03, Dietary intake of total phospholipids (PLs) accounts for approximately 10% of total dietary lipids. Each PL molecular class has various beneficial effects on health. However, limited information is available regarding the intake of phosphatidylcholine (PC), phos-phatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), lysophos-phatidylcholine (LPC) and sphingomyelin (SM) among Japanese people, and the relevant food sources. In this study, we quantified the contents of PC, PE, PI, PS, LPC, and SM in 120 meal samples served in a Japanese company’s dormitory and cafeteria. Additionally, we measured the weight of each food group and estimated the contents of nutrients in these meals. Furthermore, we conducted a stepwise multiple regression analysis to identify pre-dictors (food groups) of each PL class intake. The contents of total PL, PC, PE, PI+PS, LPC, and SM (mean value) were 4.44, 2.17, 0.632, 0.123, 0.313, and 0.127 g/d, respectively. These values were considered as daily PL intake in accordance with data (three macronu-trients, vitamins, and minerals) from our study and the National Health and Nutrition Survey (NHNS) Japan, 2015. The content of eggs, meat, fish and shellfish, milk, pulses, fruits, mushrooms, cereals, and fats and oils in the meals predicted the PL and PC contents. The content of eggs, pulses, and mushrooms in the meals predicted the PE contents. Our results determined the daily intake of PL molecular classes among Japanese people and the food sources of PC and PE, and suggested that multiple regression analysis is useful for the prediction of food sources of bioactive components.
3. Kimura Y, Yasuda K, Kurotani K, Akter S, Kashino I, Hayabuchi H, Sato M, Mizoue T, Circulating ferritin concentrations are differentially associated with serum adipokine concentrations in Japanese men and premenopausal women., Eur J Nutr,, 10.1007/s00394-016-1285-y, 56, 8, 2497-2505, 2017.12, PURPOSE:
Increased iron storage, as measured by circulating ferritin, has been linked to an increased risk of various diseases including diabetes. We examined the association of circulating ferritin with serum adiponectin, leptin, resistin, plasminogen activator inhibitor-1 (PAI-1), and visfatin levels.
METHODS:
We conducted a cross-sectional study among 429 Japanese employees (284 men and 145 premenopausal women, mean age: 42.5 ± 10.5 years). Serum adipokines were measured using Luminex suspension bead-based multiplexed array, and serum ferritin was determined using a chemiluminescence immunoassay. Multivariable regression analysis was performed to calculate mean concentrations of adipokine according to the tertile of ferritin concentrations with adjustment for potential confounders.
RESULTS:
Leptin and visfatin concentrations increased with increasing ferritin concentrations in men after multivariable adjustment of physical activity, smoking, alcohol use, and body mass index (P for trend = 0.02 and 0.01 for leptin and visfatin, respectively). Serum ferritin concentrations were inversely and significantly associated with adiponectin in women (P for trend = 0.01). Resistin and PAI-1 were not appreciably associated with ferritin concentration.
CONCLUSIONS:
Increased iron storage may be associated with higher circulating concentrations of leptin and visfatin in men and with lower concentrations of adiponectin in women.
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4. Matsuoka R, Shirouchi B, Umegatani M, Fukuda M, Muto A, Masuda Y, Kunou M, Sato M, Dietary egg-white protein increases body protein mass and reduces body fat mass through an acceleration of hepatic β-oxidation in rats., Br J Nutr., 10.1017/S0007114517002306, 118, 6, 423-430, 2017.09, Egg-white protein (EWP) is known to reduce lymphatic TAG transport in rats. In this study, we investigated the effects of dietary EWP on body fat mass. Male rats, 4 weeks old, were fed diets containing either 20 % EWP or casein for 28 d. Carcass protein levels and gastrocnemius leg muscle weights in the EWP group were significantly higher than those in the casein group. In addition, carcass TAG levels and abdominal fat weights in the EWP group were significantly lower than those in the casein group; adipocyte size in abdominal fat in the EWP group was smaller than that in the casein group. To identify the involvement of dietary fat levels in the rats, one of two fat levels (5 or 10 %) was added to their diet along with the different protein sources (EWP and casein). Abdominal fat weight and serum and hepatic TAG levels were significantly lower in the EWP group than in the casein group. Moreover, significantly higher values of enzymatic activity related to β-oxidation in the liver were observed in the EWP group compared with the casein group. Finally, abdominal fat weight reduction in the EWP group with the 10 % fat diet was lower than that in the EWP group with the 5 % fat diet. In conclusion, our results indicate that, in addition to the inhibition of dietary TAG absorption reported previously, dietary EWP reduces body fat mass in rats through an increase of body protein mass and the acceleration of β-oxidation in the liver..
5. Akter, S., Email Author, Kurotani, K., Sato, M., Hayashi, T., Kuwahara, K., Matsushita, Y., Nakagawa, T., Konishi, M., Honda, T., Yamamoto, S., Hayashi, T., Noda, M., Mizoue, T., High serum phospholipid dihomo-γ-linoleic acid concentration and low Δ5-desaturase activity are associated with increased risk of type 2 diabetes among Japanese adults in the hitachi health study, J Nutri., 10.3945/jn.117.248997, 147, 8, 1558-1566, 2017.08, Background: The association between the circulating fatty acid (FA) composition and type 2 diabetes (T2D) has been reported in Western populations, but evidence is scarce among Asian populations, including Japanese, who consume large amounts of fish. Objective: The objective of the present study was to prospectively examine the association between circulating concentrations of individual FAs and T2D incidence among Japanese adults. Methods: We conducted a nested case-control study in a cohort of 4754 employees, aged 34-69 y, who attended a comprehensive health checkup in 2008-2009 and donated blood samples for the Hitachi Health Study. During 5 y of follow-up, diabetes was identified on the basis of plasma glucose, glycated hemoglobin, and self-report. Two controls matched to each case by sex, age, and date of checkup were randomly chosen by using density sampling, resulting in 336 cases and 678 controls with FA measurements. GC was used to measure the FA composition in serum phospholipids. Cox proportional hazards regression was used to estimate the HRs and 95% CIs after adjusting for potential confounders. We examined the association of T2D risk with 25 different individual and combinations of FAs. Results: T2D risk was positively associated with serum dihomo-γ-linoleic acid concentration (highest compared with the lowest quartile-HR: 1.49; 95% CI: 1.04, 2.11; P-trend = 0.02) and inversely associated with Δ5-desaturase activity (highest compared with the lowest quartile-HR: 0.72; 95% CI: 0.52, 0.99; P-trend = 0.02), independent of body mass index (BMI). There were also inverse associations between T2D risk with serum total n-6 (ω-6) polyunsaturated fatty acids (PUFAs), linoleic acid, and cis-vaccenic acid, but these were attenuated and became nonsignificant after adjustment for BMI. Serum n-3 (ω-3) PUFAs and saturated fatty acids (SFAs) were not associated with T2D risk. Conclusions: T2D risk was associated with circulating concentrations of the n-6 PUFA dihomo-γ-linoleic acid and Δ5-desaturase activity but not with n-3 PUFA or SFA concentrations in Japanese adults..
6. Hiraki E, Furuta S, Kuwahara R, Takemoto N, Nagata T, Akasaka T, Shirouchi B, Sato M, Ohnuki K, Shimizu K., Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds., J Nat Med, 10.1007/s11418-017-1075-8, 71, 3, 482-491, 2017.07, Hericium erinaceus (H. erinaceus) improves the symptoms of menopause. In this study, using ovariectomized mice as a model of menopause, we investigated the anti-obesity effect of this mushroom in menopause. Mice fed diets containing H. erinaceus powder showed significant decreases in the amounts of fat tissue, plasma levels of total cholesterol, and leptin. To determine the mechanism, groups of mice were respectively fed a diet containing H. erinaceus powder, a diet containing ethanol extract of H. erinaceus, and a diet containing a residue of the extract. As a result, H. erinaceus powder was found to increase fecal lipid levels in excreted matter. Further in vitro investigation showed that ethanol extract inhibited the activity of lipase, and four lipase-inhibitory compounds were isolated from the extract: hericenone C, hericenone D, hericenone F, and hericenone G. In short, we suggest that H. erinaceus has an anti-obesity effect during menopause because it decreases the ability to absorb lipids..
7. Bungo Shirouchi, Kentaro Kashima, Yasutaka Horiuchi, Yuki Nakamura, Yumiko Fujimoto, Li-Tao Tong, MASAO SATO, 27-Hydroxycholesterol suppresses lipid accumulation by down-regulating lipogenic and adipogenic gene expression in 3T3-L1 cells, Cytotechnology, 10.1007/s10616-016-9962-5, 69, 3, 485-492, 2017.06.
8. Kurotani K, Sato M, Yasuda K, Kashima K, Tanaka S, Hayashi T, Shirouchi B, Akter S, Kashino I, Hayabuchi H, Mizoue T., Even- and odd-chain saturated fatty acids in serum phospholipids are differentially associated with adipokines., PLoS One, 10.1371/journal.pone.0178192, 12, 5, e0178192, 2017.05, BACKGROUND:
Saturated fatty acids are generally thought to have detrimental effects on health. However, a recent study showed that even- and odd-chain saturated fatty acids had opposite associations with type 2 diabetes. Limited studies of Western populations examined the associations of circulating saturated fatty acids with adipokines, an important role in glucose metabolism.
OBJECTIVE:
We examined the associations of saturated fatty acids in serum phospholipids with circulating levels of adipokines among a Japanese population.
DESIGN:
A cross-sectional study was conducted among 484 Japanese employees (284 men and 200 women) aged 20-65 years. The serum fatty acid composition in the phospholipid fraction was measured by gas-chromatography. Serum leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), resistin, and visfatin were measured using a Luminex suspension bead-based multiplexed array. Multiple linear regression analysis was performed to assess the association between saturated fatty acids and adipokines, with adjustment for potential confounding variables.
RESULTS:
Even- and odd-chain saturated fatty acids were differentially associated with adipokines. Higher levels of even-chain saturated fatty acids (14:0 myristic, 16:0 palmitic, and 18:0 stearic acids) were associated with higher levels of resistin (P for trend = 0.048) and lower levels of adiponectin (P for trend = 0.003). By contrast, odd-chain saturated fatty acids (15:0 pentadecanoic and 17:0 heptadecanoic acids) showed inverse associations with leptin and PAI-1 (P for trend = 0.048 and 0.02, respectively). Visfatin was positively associated with both even- and odd-chain saturated fatty acids.
CONCLUSIONS:
The results suggest that even- and odd-chain saturated fatty acids are differentially associated with adipokine profile..
9. Michio Shimabukuro, Chinami Okawa, Shuhei Yanagi, Etsuko Uematsu, Noriko Sugasawa, Hirotsugu Kurobe, Yoichiro Hirata, Joo-ri Kim-Kaneyama, Xiao-Feng Lei, Shoichiro Takao, Yasutake Tanaka, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuya Kitagawa, Hiroaki Masuzaki, MASAO SATO, Masataka Sata, The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe, Journal of Nutritional Biochemistry, 10.1016/j.jnutbio.2016.05.010, 35, 1, 66-73, 2016.09, Oxidized cholesterols (oxycholesterols) in food have been recognized as strong atherogenic components, but their tissue distributions and roles in cardiovascular diseases remain unclear. To investigate whether accumulation of oxycholesterols is linked to cardiac morphology and function, and whether reduction of oxycholesterols can improve cardiac performance, domestic male swine were randomized to a control diet (C), high caloric diet (HCD) or HCD + Ezetimibe, an inhibitor of intestinal cholesterol absorption, group (HCD + E) and evaluated for: (1) distribution of oxycholesterol components in serum and tissues, (2) levels of oxycholesterol-related enzymes, (3) paracardial and epicardial coronary fat thickness, and (4) cardiac performance. Ezetimibe treatment for 8 weeks attenuated increases in oxycholesterols in the HCD group almost completely in liver, but reduced only levels of 4β-hydroxycholesterol in left ventricular (LV) myocardium. Ezetimibe treatment altered the expression of genes for cholesterol and fatty acid metabolism and decreased the expression of CYP3A46, which catabolizes cholesterol to 4β-hydroxycholesterol, strongly in liver. An increase in epicardial fat thickness and impaired cardiac performance in the HCD group were improved by ezetimibe treatment, and the improvement was closely related to the reduction in levels of 4β-hydroxycholesterol in LV myocardium. In conclusion, an increase in oxycholesterols in the HCD group was closely related to cardiac hypertrophy and dysfunction, as well as an increase in epicardial fat thickness. Ezetimibe may directly reduce oxycholesterol in liver and LV myocardium, and improve cardiac morphology and function..
10. Kazuo ERAMI, Yasutake TANAKA, Sayaka KAWAMURA, Motonori MIYAGO, Ai SAWAZAKI, katsumi imaizumi, MASAO SATO, Dietary Egg Yolk Supplementation Improves Low-Protein-Diet-Induced Fatty Liver in Rats, Journal of Nutritional Science and Vitaminology, 10.3177/jnsv.62.240, 62, 4, 240-248, 2016.08, [URL], Egg yolk is an important source of nutrients and contains different bioactive substances. In the present study, we studied the benefits of egg yolk in preventing low-protein-diet-induced fatty liver in rats. Rats were fed the following diets, which were based on the AIN-76 formula, for 2 wk: an adequate-protein diet containing 20% casein (C), a low-protein diet containing 5% casein (LP-C), a low-protein diet supplemented with 12.5% egg yolk (LP-EY), and a low-protein diet supplemented with 4.1% egg yolk oil (LP-EYO). The low-protein diets were adjusted to contain 4.13% protein and 4.7% lipids. The LP-C diet resulted in a greater increase in the liver trigriceride (TG) and the vacuolation and a greater decrease in the serum TG and free fatty acid (FFA) than did the C diet. These deviations in the serum and liver TG, serum FFA levels and the liver histopathology were corrected in rats fed the LP-EY diet but not in those fed the LP-EYO diet. Compared to rats fed the LP-C diet, although the activities of lipogenesis-related enzymes (fatty acid synthase, glucose-6-phosphate dehydrogenase, and malic enzyme) decreased in rats fed both of the LP-EY and LP-EYO diets, the level of the microsomal TG transfer protein (MTP) increased only in rats fed the LP-EY diet. Collectively, these results suggest that dietary egg yolk supplementation decreases the LP diet-induced accumulation of TG in the liver by increasing transport of TG in the liver, and egg yolk oil alone is not sufficient enough to bring about these benefits..
11. Bungo Shirouchi, Kouji Nagao, Minami Umegatani, Aya Shiraishi, Yukiko Morita, Shunichi Kai, Teruo Yanagita, Akihiro Ogawa, Yukio Kadooka, MASAO SATO,  Probiotic Lactobacillus gasseri SBT2055 improves glucose tolerance and reduces body weight gain in rats by stimulating energy expenditure., British Journal of Nutrition, 116, 451-458, 2016.05.
12. Ikuko Kashino, Akiko Nanri, Kayo Kurotani, Shamima Akter, Kazuki Yasuda, MASAO SATO, Hitomi Hayabuchi, Tetsuya Mizoue, Association of dietary patterns with serum adipokines among Japanese: a cross-sectional study
, Nutrition Journal, 10.1186/s12937-015-0046-8., 14, 58, 2015.08.
13. Ngoc Minh Phama, Akiko Nanri, Siyan Yi, Kayo Kurotani,, Shamima Akter, Leng Huat Foo, Nobuo Nishi, MASAO SATO, Hitomi Hayabuchi, Tetsuya Mizoue, Habitual consumption of coffee and green tea in relation to serum adipokines: a cross-sectional study, European Journal of Nutrition
, 10.1007/s00394-014-0701-4, 54, 2, 205-214, 2015.03, PURPOSE:Coffee and green tea consumption may be associated with circulating adipokines, but data are inconsistent, scarce or lacking. We examined the association of coffee and green tea consumption with serum adiponectin, leptin, visfatin, resistin and plasminogen activator inhibitor-1 (PAI-1) among a Japanese working population.
METHODS:
The authors analyzed data (n = 509) from a cross-sectional survey among Japanese workers aged 20-68 years. Serum adipokines were measured using a Luminex suspension bead-based multiplexed array. Coffee and green tea consumption was assessed using a validated diet history questionnaire, and caffeine consumption from these beverages was estimated. Multiple regression analysis was performed with adjustment for potential confounding variables.
RESULTS:
Coffee consumption was significantly, inversely associated with leptin and PAI-1 (P for trend = 0.007 and 0.02, respectively); compared with subjects consuming <1 cup per day, those consuming ≥4 cups per day had 13 and 10 % lower means of leptin and PAI-1, respectively. Similar associations were observed for caffeine consumption (P for trend = 0.02 for both leptin and PAI-1). Additionally, we noted a significant positive association between coffee consumption and adiponectin in men (P for trend = 0.046), but not in women (P for trend = 0.43, P for interaction = 0.11). Moreover, there was a positive association between coffee consumption and resistin in current male smokers (P for trend = 0.01), but not in male non-smokers (P for trend = 0.35, P for interaction = 0.11). Green tea consumption was not associated with any adipokine.
CONCLUSIONS:
Higher consumption of coffee and caffeine but not green tea was associated with lower serum levels of leptin and PAI-1 in Japanese adults.
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14. Ryousuke Matsuoka, Bungo Shirouchi, Masao Sato, Sayaka Kawamura, Sanae Baba, Sawako Shiratake, Kazuko Nagata, Katsumi Imaizumi, Dietary Egg White Protein Inhibits Lymphatic Lipid Transport in Thoracic Lymph Duct-Cannulated Rats, Journal of Agricultural and Food Chemistry, 10.1021/jf502741b, 62, 44, 10694-10700, 2014.11, Dietary egg white protein (EWP) decreases serum cholesterol levels. We previously showed that EWP decreased cholesterol absorption in the intestine. Rats subjected to permanent lymph duct cannulation were used to investigate the effects of dietary EWP on lipid transport. They were fed diets with 20% EWP and casein, and their lymph was collected to quantify lymphatic lipid levels. Dietary EWP decreased lymphatic cholesterol transport compared with casein. It was previously shown that EWP excluded cholesterol from bile acid micelles. Therefore, pepsin-hydrolyzed EWP and casein were prepared. EWP was not completely digested. Ovalbumin, which is the most abundant protein in EWP, showed resistance to digestion by pepsin. This study investigated the effects of EWP pepsin hydrolysate (EWP-ph) on cholesterol micellar solubility, cholesterol transfer from the micellar to the oil phase, water-holding capacity (WHC), settling volume in water (SV), and relative viscosity and compared them with the effects of casein pepsin hydrolysate (C-ph). EWP-ph significantly decreased the micellar solubility and transfer rate and increased the WHC, SV, and relative viscosity compared with C-ph. Moreover, the pepsin hydrolysate of ovalbumin, a major protein in EWP, played a role in decreasing cholesterol micellar solubility, leading to the inhibition of cholesterol absorption. In conclusion, dietary EWP decreased cholesterol intestinal absorption by exerting combined effects of these physicochemical properties in the gut..
15. Ai Hori, Hiroshi Kasai, Kazuaki Kawai, Akiko Nanri, MASAO SATO, Masanori Ohta, Tetsuya Mizoue, COFEE INTAKE IS ASSOCIATED WITH REDUCING OXIDATIVE DNA DAMAGE AND DECREASING BODY IRON STORAGE IN HEALTHY WOMEN, Nutrition and Cancer , 10.1080/01635581.2014.932398., 66, 6, 964-969, 2014.06, Habitual coffee drinking has been linked to a lower risk for some forms of cancer, but the mechanism remains elusive. Coffee may decrease oxidative DNA damage, an important pathway to carcinogenesis. We examined the association between coffee consumption and urinary 8-hydroxydeoxyguanosine (8-OHdG) concentrations, a biomarker of systemic oxidative DNA damage and repair, in 507 healthy subjects (298 men and 209 women aged 21-67 years) while adjusting for age, sex, smoking status, body mass index, job type, and fasting blood glucose in multivariable regression models. The association with green tea consumption was also assessed. Urinary 8-OHdG concentrations tended to decrease with coffee consumption (Trend P=0.068) only in women, with participants drinking 2-3 cups of coffee per day showing the lowest mean of urinary 8-OHdG concentrations. This association diminished after adjustment for serum ferritin concentrations, a marker of body iron storage (Trend P=0.87). Green tea consumption was not significantly associated with urinary 8-OHdG concentrations. Coffee drinking may be associated with decreased systemic oxidative DNA damage through decreasing body iron storage in women..
16. Hiroyuki Kikuchi, Akiko Nanri, Ai Hori, MASAO SATO, Kazuaki Kawai, Hiroshi Kasai, Tetsuya Mizoue, Lower serum levels of total cholesterol are associated with higher urinary levels of 8-hydroxydeoxyguanosine, Nutirition and Metabolism, 10.1186/10.1186/1743-7075-10-59, 10, Art. NO. 59, 2014.03, [URL], Background
Lower serum total (TC), high-density lipoprotein (HDL-C) and low-density lipoprotein cholesterols (LDL-C) have been linked to an increased risk of cancer in various sites, but its underlying mechanism remains unclear. In an attempt to clarify the association between cholesterol levels and oxidative DNA damage, we investigated the relationship between serum cholesterol and urinary 8-hydroxydeoxyguanosine levels in a Japanese working population.
Methods
The study subjects were 294 men and 209 women aged 21-66 years in two Japanese municipal offices. Urinary 8-hydroxydeoxyguanosine (8-OHdG) was measured using an automated high-pressure liquid chromatography. Linear regression analysis was used to examine the associations of urinary 8-OHdG with TC, HDL-C and LDL-C levels with adjustment for sex, age, smoking and body mass index. Subgroup analyses were conducted by smoking status in men and age in women. Analysis of covariance was employed to estimate adjusted means of urinary 8-OHdG across TC category.
Results
After multivariate adjustment, urinary 8-OHdG levels were inversely associated with serum TC levels (β = −0.0015, p < 0.05) and LDL-C levels (β = −0.0012, p = 0.07). The inverse association with TC was apparent among smoking men (β = −0.0017, p < 0.05) and among women aged less than 48 years (β = −0.0040, p < 0.01). 8-OHdG decreased as TC increased (up to 219 mg/dL); subjects with TC levels of <160 mg/dL had a 17.4% higher adjusted mean of 8-OHdG than did those with TC levels of 200–219 mg/dL.
Conclusion
Results suggest that circulating low TC levels are associated with higher oxidative DNA damage.
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17. Ngoc Minh Pham, Akiko Nanri, Takeshi Kochi, Keisuke Kuwahara, Hiroko Tsuruoka, Kayo Kurotani, Shamima Akter, Isamu Kabe, MASAO SATO, Hitomi Hayabuchi, Tetsuya Mizoue, Coffee and green tea consumption is associated with insulin resistance in Japanese adults, Metabolism - Clinical and Experimental, 10.1016/j.metabol.2013.11.008, 63, 3, 400-408, 2014.03, Objective. Higher coffee and green tea consumption has been suggested to decrease risk of type 2 diabetes, but their roles in insulin resistance (IR) and insulin secretion remain unclear. This study examined the association between habitual consumption of these beverages with markers of glucose metabolism in a Japanese working population.
Materials/Methods. Participants were 1,440 Japanese employees (1,151 men and 289 women) aged 18-69 years. Consumption of coffee and green tea was ascertained via a validated brief diet history questionnaire. Multilevel linear regression was used to estimate means and 95% confidence intervals of fasting insulin, fasting plasma glucose, homeostatic model assessment of IR (HOMA-IR), homeostatic model assessment of β-cell function (HOMA-β) and glycated hemoglobin (HbA1c) with adjustment for potential confounding variables. Stratified analyses by smoking and body mass index (BMI) were also performed.
Results. Coffee consumption was significantly, inversely associated with HOMA-IR (P for trend = .03), and the association appeared to be confined to overweight subjects (BMI ≥25kg/m2 ) (P for trend = .01, P for interaction = .08). Contrarily, there was a significant, positive association between green tea consumption and HOMA-IR (P for trend = .015), though dose response relationship among daily consumers of green tea was not observed. Neither coffee nor green tea consumption was associated with HOMA-β and HbA1c.
Conclusions. Our findings indicate that coffee consumption may be associated with decreased IR, but not with insulin secretion. The positive association between green tea consumption and IR warrants further investigation..
18. Kayo Kurotani, MASAO SATO, Yuko Ejima, Kentaro Kashima, Akiko Nanri, Ngoc Minh Pham, Keisuke Kuwahara, Tetsuya Mizoue, Serum alpha-linolenic and linoleic acids are inversely associated with depressive symptoms in adults, e-SPEN Journal, 10.1016/j.clnme.2013.12.003, 9, 1, e7-e12, 2014.02, Background & Aims: Fatty acid composition in diet and serum has been linked to depression, but the evidence on this issue is limited among Japanese, who consume large amounts of fish rich in n-3 polyunsaturated fatty acids. We examined the association between fatty acid composition in serum and depressive symptoms in Japanese men and women.
Methods: The subjects were 496 participants aged 21-67 years in a cross-sectional study. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Free, cholesterol ester, and phospholipid fatty acids in serum were measured by gas-liquid chromatography. Multiple logistic regression was used to assess the association between serum fatty acid and depressive symptoms.
Results: A higher free alpha-linolenic acid level was marginally significantly associated with a decreased prevalence of depressive symptoms (CES-D≥16) (P for trend = 0.07). When a cut-off of CES-D≥19 was used, the association was strengthened; the multivariable-adjusted odds ratios (95% confidence interval) of depressive symptoms for the lowest through highest tertile of alpha-linolenic acid levels were 1.00 (reference), 0.49 (0.29-0.84), and 0.47 (0.26-0.83), respectively (P for trend = 0.007). A higher n-6 PUFA in cholesterol esters and free linoleic acid were also significantly associated with a decreased prevalence of depressive symptoms (CES-D≥19) (P for trend = 0.03 and 0.048, respectively). The other polyunsaturated fatty acids including marine-derived n-3 PUFA were not associated with depressive symptoms.
Conclusions: Fatty acid composition with high levels of serum alpha-linolenic and linoleic acids might be protectively associated with depressive symptoms in Japanese adults.
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19. Yasutake Tanaka, Koji Nagao, Hideaki Nakagiri, Toshirou Nagaso, Yasue Iwasa, Haruhiko Mori, Makoto Asahina, katsumi imaizumi, MASAO SATO, Unavailability of liver triacylglycerol increases serum cholesterol concentration induced by dietary cholesterol in exogenously hypercholesterolemic (ExHC) rats, Lipids in Health and Disease, 10.1186/1476-511X-13-19, 13, 19-30, 2014.01, Background
Exogenously hypercholesterolemic (ExHC) rats develop hypercholesterolemia and low hepatic triacylglycerol (TAG) levels when dietary cholesterol is loaded. The responsible gene Smek2 was identified via linkage analysis using the original strain Sprague–Dawley (SD) rats. In this study, we compared SD and ExHC rats to investigate a relationship between hypercholesterolemia and the low hepatic TAG levels observed in ExHC rats.
Methods
Male 4-weeks-old ExHC and SD rats were fed a 1% cholesterol diet for 1 week. Serum and liver parameters were analyzed. Gene expression and enzyme activities related to TAG metabolism were also assessed.
Results
We reproducibly observed higher serum cholesterol and lower hepatic TAG levels in ExHC rats than in SD rats. Golgi apparatus in the livers of ExHC rats secreted β-very-low-density lipoprotein (β-VLDL) that had higher cholesterol ester (CE) and lower TAG content than those in the β-VLDL secreted by SD rats. Gene expression related to fatty acid and TAG synthesis in ExHC rats was lower than that in SD rats. Enzymatic activities for fatty acid synthesis were also relatively lower in ExHC rats. Moreover, the fatty acid composition of hepatic and serum CE in ExHC rats showed that these CEs were not modified after secretion from the liver despite the similar activities of serum lecithin-cholesterol acyltransferase (LCAT) in ExHC rats to those in SD rats.
Conclusions
Low production of liver TAG and secretion of CE-rich, TAG-poor β-VLDL without modification by LCAT in the circulation contributed to hypercholesterolemia induced by dietary cholesterol in ExHC rats.
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20. Yukio Kadooka, MASAO SATO, Akihiro Ogawa, Masaya Miyoshi, Hiroshi Uenishi, Hitomi Ogawa, Ken Ikuyama, Masatoyo Kagoshima, Takashi Tsuchida, Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomized controlled trial, British Journal of Nutrition, 10.1017/S0007114513001037, 110, 9, 1696-1703, PMID: 23614897, 2013.10, Consumption of fermented milk (FM) containing a probiotic, Lactobacillus gasseri SBT2055 (LG2055), previously showed a reduction in abdominal adiposity in a randomised controlled trial (RCT) using FM with 108 colony-forming units (cfu) of LG2055/g. However, whether the effectiveness is observed at lower concentrations, the recommended minimum or intermediate levels of probiotics (106 or 107cfu/g, respectively), remains to be examined. A multi-centre, double-blind, parallel-group RCT was conducted using 210 healthy Japanese adults with large visceral fat areas (80·2-187·8 cm2). They were balanced for their baseline characteristics and randomly assigned to three groups receiving FM containing 107, 106 or 0 (control) cfu LG2055/g of FM, and were asked to consume 200 g FM/d for 12 weeks. Abdominal visceral fat areas, which were determined by computed tomography, at week 12, changed from baseline by an average of - 8·5 % (95 % CI - 11·9, - 5·1; P< 0·01) in the 107 dose group, and by - 8·2 % (95 % CI - 10·8, - 5·7; P< 0·01) in the 106 dose group. Other measures including BMI, waist and hip circumferences, and body fat mass were also significantly decreased from baseline at week 12 in both groups; interestingly, the cessation of taking FM for 4 weeks attenuated these effects. In the control group, none of these parameters significantly decreased from baseline. These findings demonstrate that consumption of LG2055 at doses as low as the order of 108cfu/d exhibited a significant lowering effect on abdominal adiposity, and suggest that constant consumption might be needed to maintain the effect..
21. Ngoc Minh Pham, Shamima Akter, Kayo Kurotani, Akiko Nanri, Masao Sato, Hitomi Hayabuchi, Kazuki Yasuda, Tetsuya Mizoue, Green tea and coffee consumption is inversely associated with depressive symptoms in a Japanese working population, Public Health Nutrition, org/10.1016/j.psychres.2012.04.040, 9, 1, PMID: 23453038, Epub ahead of print, 2013.07, Although several studies have reported an association between blood folate concentrations and
depressive symptoms, few studies have prospectively examined the association. This study aimed to
investigate the cross-sectional and prospective associations between serum folate concentrations and
depressive symptoms among Japanese. We analysed data among 545 subjects who participated in a
health survey at the time of periodic check-up in 2009 for a cross-sectional association and among 272
subjects without depressive symptoms at baseline (in 2006) who responded to both baseline (2006)
and follow-up (2009) surveys for prospective association. Depressive symptoms were assessed using
the Center for Epidemiologic Studies Depression (CES-D) scale. In a cross-sectional analysis, serum
folate concentrations were significantly associated with a decreased prevalence of depressive symptoms
(CES-D scale of Z16). Moreover, serum folate concentrations at baseline were significantly
inversely associated with depressive symptoms after 3 years; the multivariate-adjusted odds ratios
(95% confidence intervals) of depressive symptoms for the lowest through highest tertile categories of
serum folate concentrations were 1.00 (reference), 0.66 (0.29–1.52) and 0.40 (0.16–0.99) (P for
trend¼0.047). Our findings suggest that a higher serum folate may be associated with decreased risk
of depressive symptoms in Japanese..
22. Ayami Kume, Kayo Kurotani, MASAO SATO, Yuko Ejima, Ngoc Minh Pham, Akiko Nanri, Keisuke Kuwahara, Tetsuya Mizoue, Polyunsaturated fatty acids in serum and homocysteine concentrations in Japanese men and women: a cross-sectional study, Nutrition & Metabolism, 10.1186/1743-7075-10-41, 10, 1, Article NO. 41, 2013.07, Background: Supplementation studies have suggested a role of n-3 polyunsaturated fatty acids
(PUFAs) in homocysteine metabolism, but the evidence is limited and inconsistent among studies
that measured blood levels of n-3 and n-6 PUFAs. We examined the association between blood
levels of PUFAs and homocysteine in Japanese men and women.
Methods: The subjects were 496 employees (290 men and 206 women) of 2 municipal offices in
Japan. Fatty acid composition in serum phospholipids and cholesterol ester (CE) was measured
using gas-liquid chromatography. Multiple regression was used to calculate means of homocysteine
concentrations according to PUFA tertile with adjustment for potential confounders.
Results: Serum homocysteine concentration decreased with increasing levels of total n-3 PUFA,
eicosapentaenoic acid and docosahexaenoic acid (DHA) in serum phospholipids and CE with
adjustment for age, sex and workplace. However, only DHA in serum phospholipids remained
statistically significant after additional adjustment for other potential confounders including serum
folate (P-trend = 0.04). N-6 PUFAs were not significantly associated with homocysteine
concentrations.
Conclusions: Higher proportion of DHA in serum phospholipids may be associated with lower
homocysteine concentrations in Japanese men and women..
23. Akiko Nanri, Minh N Pham, Kayo Kurotani, Ayami Kume, Keisuke Kuwahara, MASAO SATO, Hitomi Hayabuchi, Tetsuya Mizoue, Serum pyridoxal concentrations and depressive symptoms among Japanese adults: results from a prospective study, European Journal of Clinical Nutrition, 10.1038/ejcn.2013.115, PMID: 23801094, 2013.07, BACKGROUND/OBJECTIVE: Vitamin B6 is suggested to play a protective role against depression. However, the association between vitamin B6 intake and depression remains inconclusive, and few studies have examined the relationship between circulating vitamin B6 concentrations and depressive symptoms. Here, we investigated the cross-sectional and prospective associations between serum pyridoxal concentrations and depressive symptoms among Japanese workers.
SUBJECTS/METHODS: Participants were 422 municipal employees (aged 21-67 years) who participated in a baseline survey in 2006 for cross-sectional analysis, and 210 subjects without depressive symptoms at baseline (2006) who completed both baseline and follow-up (2009) surveys for prospective analysis. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regression analysis was used to estimate the odds ratio of depressive symptoms (CES-D scale of ≥19) according to tertile of serum pyridoxal with adjustment for potential confounding variables.
RESULTS: In the cross-sectional analysis, serum pyridoxal concentrations were significantly associated with a decreased prevalence of depressive symptoms (P for trend = 0.03); the multivariable-adjusted odds ratio of depressive symptoms for the highest tertile of pyridoxal was 0.54 (95% confidence interval 0.30-0.96) compared with the lowest tertile. In longitudinal analyses, higher serum pyridoxal concentrations at baseline were associated with a trend towards reduced depressive symptoms after three years; the multivariable-adjusted odds ratio of depressive symptoms for the highest versus the lowest tertile of pyridoxal concentration was 0.55 (95% confidence interval 0.13-2.32).
CONCLUSIONS: A higher vitamin B6 status may be associated with a decreased risk of depressive symptoms in Japanese..
24. Keisuke Kuwahara, Akiko Nanri, Minh N Pham, MASAO SATO, Kayo Kurotani, Kazuaki Kawai, Hiroshi Kasai, Tetsuya Mizoue, Serum vitamin B6, folate, and homocysteine concentrations and oxidative DNA damage in Japanese men and women
, Nutrition, 10.1016/j.nut.2013.03.014, 29, 10, 1219-1223, 2013.07.
25. Akter, S, Kurotani, K, Nanri, A., Pham, N.M, MASAO SATO, Hayabuchi, H., Mizoue, T, Dairy consumption is associated with decreased insulin resistance among the Japanese, Nutrition Research, 10.1016/j.nutres.2013.01.009, 33, 4, 286-292, 2013.04, Beneficial effects of dairy consumption in preventing obesity and metabolic syndrome have been suggested, but the association between dairy intake and insulin resistance (IR) is not clear. To test the hypothesis that higher dairy consumption is associated with lower insulin resistance, the authors investigated the association between dairy intake (taking fat content into consideration) and markers of IR in a Japanese working population. A cross-sectional study was conducted in 2009 among 496 subjects aged 20-68 years who participated in a health survey during a periodic checkup. Dairy consumption was assessed using a validated brief dietary history questionnaire. Multiple regression analysis was used to assess the association between fasting serum insulin, plasma glucose, and the homeostatic model assessment of IR (HOMA-IR) and dairy consumption with adjustment for potential confounding variables. The subjects in the highest quartile for total dairy intake showed the lowest mean IR markers compared to those in other categories, although the difference was not statistically significant. Intake of full-fat dairy products was inversely associated with HOMA-IR (P for trend = 0.02). The multivariable adjusted mean HOMA-IR values (with 95% confidence intervals) for the four groups, from those who consumed the fewest to those who consumed the most servings of full-fat dairy products, were 1.04 (0.96-1.12), 1.04 (0.96-1.13), 1.00 (0.91-1.08), and 0.86 (0.76-0.96), respectively. Low-fat dairy intake was not significantly associated with any IR markers. The results suggest that the consumption of full-fat dairy products may be associated with lower IR among Japanese adults..
26. Ngoc Minh Phama, Akiko Nanri, Siyan Yi, Kayo Kurotani,, Shamima Akter, Leng Huat Foo, Nobuo Nishi, MASAO SATO, Hitomi Hayabuchi, Tetsuya Mizoue, Serum ferritin is associated with markers of insulin resistance in Japanese men but not in women, Metabolism: Clinical and Experimental, 10.1016/j.metabol.2012.07.025 , 62, 4, 561-567, 2013.04, OBJECTIVE: Several epidemiological studies have reported that high concentrations of circulating ferritin, a marker of iron stores, are related to insulin resistance (IR); however, questions remain regarding inconsistent data between Asian men and women and the inadequate consideration of potential confounding effects on the relationship between ferritin and IR. Our aim was to examine the relationship between serum ferritin concentrations and IR markers in the Japanese population. MATERIALS/METHODS: We analyzed data (n=493) from a cross-sectional survey conducted in 2009 among a Japanese working population aged 20-68years. Fasting serum ferritin and insulin levels and fasting plasma glucose levels were determined, and the homeostatic model assessment of IR (HOMA-IR) was calculated. Multiple regression analysis was performed with adjustments for demographic and lifestyle factors, body mass index and serum C-reactive protein. RESULTS: Fasting insulin and HOMA-IR significantly increased with increasing levels of serum ferritin after adjustment for covariates in men (P for trend=.005 and .001, respectively). Compared with men in the lowest tertile of serum ferritin, those in the highest tertile had a 24% higher HOMA-IR score. Additional data suggested a positive association between iron intake and HOMA-IR (P for trend=.07) in men. Neither serum ferritin nor iron intake was related to IR markers in women, even in postmenopausal women. CONCLUSIONS: Serum ferritin concentrations were positively associated with fasting insulin and HOMA-IR in men but not in women, suggesting an important role of iron storage in the pathogenesis of IR in Japanese men..
27. Ngoc Minh Pham, Shamima Akter, Kayo Kurotani, Akiko Nanri, MASAO SATO, Hitomi Hayabuchi, Kazuki Yasuda, Tetsuya Mizoue, Serum 25-hydroxyvitamin D and markers of insulin resistance in a Japanese working population, European Journal of Clinical Nutrition, 10.1038/ejcn.2012.169, 66, 12, 1323-1328, PMID: 23093338, 2012.12, Background/Objectives:The association between vitamin D status and insulin resistance (IR) has been less studied among Asians, and it remains elusive whether calcium could modify such an association. We examined the association of serum 25-hydroxyvitamin D (25(OH)D) concentrations with IR markers and the potential effect modification by calcium intake among a Japanese population.
Subjects/Methods:The authors analyzed data (n=494) from a cross-sectional survey conducted in 2009 among a Japanese working population aged 20–68 years. Fasting serum 25(OH)D and insulin, as well as fasting plasma glucose were determined, and homeostatic model assessment of IR (HOMA-IR) was calculated. Calcium intake was assessed using a validated diet history questionnaire. Multiple linear regression was done with adjustment of potential confounding variables.
Results:Fasting insulin and HOMA-IR were significantly inversely associated with 25(OH)D concentration across quartiles of 25(OH)D after fully adjusting for covariates (Ptrend=0.04 and 0.02, respectively). Across clinically relevant categories of 25(OH)D, compared with participants in the vitamin D sufficiency group, those in the vitamin D insufficiency group had a 5% higher HOMA-IR score, and those in the hypovitaminosis D group had an 18% higher HOMA-IR score (Ptrend=0.01). In an analysis by calcium intake, the HOMA-IR score was highest among participants with both a low calcium intake and lowest 25(OH)D concentrations, with significant inverse trend being observed in the group with lower calcium intake (Ptrend=0.02).
Conclusions:Our findings suggest that low vitamin D status is associated with IR among Japanese adults..
28. Akiko Nanri, Hitomi Hayabuchi, Masanori Ohta, MASAO SATO, Norio Mishima, Tetsuya Mizoue, Serum folate and depressive symptoms among Japanese men and women: a cross-sectional and prospective study, Psychiatry Research, 10.1016/j.psychres.2012.04.040, 200, 2-3, 349-353, PubMed ID: 22682152, 2012.12, Although several studies have reported an association between blood folate concentrations and depressive symptoms, few studies have prospectively examined the association. This study aimed to investigate the cross-sectional and prospective associations between serum folate concentrations and depressive symptoms among Japanese. We analyzed data among 545 subjects who participated in a health survey at the time of periodic checkup in 2009 for cross-sectional association and among 272 subjects without depressive symptoms at baseline (in 2006) who responded to both baseline (2006) and follow-up (2009) surveys for prospective association. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. In a cross-sectional analysis, serum folate concentrations were significantly associated with a decreased prevalence of depressive symptoms (CES-D scale of ≥16). Moreover, serum folate concentrations at baseline were significantly inversely associated with depressive symptoms after three years; the multivariate-adjusted odds ratios (95% confidence intervals) of depressive symptoms for the lowest through highest tertile categories of serum folate concentrations were 1.00 (reference), 0.66 (0.29-1.52), and 0.40 (0.16-0.99) (P for trend = 0.047). Our findings suggest that higher serum folate may be associated with decreased risk of depressive symptoms in Japanese..
29. Bungo Shirouchi, Nakamura Y, Furukawa Y, Shiraishi A, Tomoyori H, katsumi imaizumi, MASAO SATO, Ezetimibe inhibits lymphatic transport of esterified cholesterol but not free cholesterol in thoracic lymph duct-cannulated rats., Cardiovascular Drugs and Therapy, 10.1007/s10557-012-6403-3, 26, 5, 427-431, 2012.10, [URL], Purpose Ezetimibe has been shown to inhibit dietary choles- terol absorption in animal models and humans, but studies on lymphatic lipid transport have not yet been performed. Rats subjected to permanent lymph duct cannulation were used to investigate the effects of ezetimibe on lipid transport. Methods Rats were fed diets with and without ezetimibe (5.0 mg/kg), and their lymph was collected after feeding to quantify lymphatic lipid levels. Total cholesterol content in the intestinal mucosa was also measured.
Results Rats that consumed ezetimibe had significantly lower lymphatic total cholesterol transport with the reduction of esterified cholesterol transport. According to the calculation based on cholesterol consumption, ezetimibe reduced the total cholesterol lymphatic recovery rate by 54 %. We also deter- mined that ezetimibe significantly reduced the total cholester- ol content in the intestinal mucosa.
Conclusion This is the first direct evidence that ezetimibe inhibits esterified but not free cholesterol lymphatic transport in thoracic duct-cannulated rats. The results also indicate that ezetimibe is not involved in the lymphatic transport of triacyl- glycerols, phospholipids, or α-tocopherol..
30. Masako Iwamoto, Katsumi Imai, Hideaki Ohta, Bungo Shirouch and Masao Sato, Supplementation of highly concentrated beta-cryptoxanthin in a satsuma mandarin beverage improves adipocytokine profiles in obese Japanese women, Lipids in Health and Disease, 10.1186/1476-511X-11-52, 11, 1, 52, 2012.09, Background: Serum β-cryptoxanthin levels are lower in overweight subjects than in normal subjects. Abnormalities of adipocytokine profiles in obesity subjects have been reported. There are several reports that serum β-cryptoxanthin levels in them were relatively lower than normal subjects.
Objective: We hypothesize that supplementation of highly concentrated β-cryptoxanthin improves serum adipocytokine profiles in obese subjects. This study tested the association between β-cryptoxanthin intake and serum adipocytokine levels.
Methods: An intervention study consisted of a 3-week long before-and-after controlled trial, where β-cryptoxanthin (4.7 mg/day) was given to 17 moderately obese postmenopausal women.
Results: The results indicated no significant changes in body weight or body mass index (BMI). Serum β-cryptoxanthin levels increased significantly by 4-fold. Serum high molecular weight (HMW)-adiponectin levels increased significantly, while serum plasminogen activator inhibitor (PAI)-1 levels decreased.
Conclusions: We concluded that increasing the intake of β-cryptoxanthin to approximately 4 mg per day for 3 weeks may have beneficial effects on the serum adipocytokine status and consequently alleviate progression of metabolic syndrome.
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31. Kayo Kurotani, MASAO SATO, Yuko Ejima, Nanri, A., Yi, S., Pham, N.M, Akter, S., Poudel-Tandukar, K., Kimura, Y., katsumi imaizumi, High levels of stearic acid, palmitoleic acid, and dihomo-gamma-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance, Nutrition Research, org/10.1016/j.nutres.2012.07.004, 32, 9, 669-675, 2012.07, The association of fatty acid composition with insulin resistance and type 2 diabetes has been reported in Western populations, but there is limited evidence of this association among the Japanese, whose populace consume large amounts of fish. To test the hypothesis that high palmitic, palmitoleic, and dihomo-gamma-linolenic acids and low linoleic and n-3 fatty acids are associated with higher insulin resistance among the Japanese, the authors investigated the relationship between serum fatty acid composition and serum C-peptide concentrations in 437 Japanese employees, aged 21-67 years, who participated in a workplace health examination. Serum cholesterol ester and phospholipid fatty acid compositions were measured by gas-liquid chromatography. Desaturase activity was estimated by fatty acid product-to-precursor ratios. A multiple regression was used to assess the association between fatty acid and C-peptide concentrations. C-peptide concentrations were associated inversely with linoleic acid levels in cholesterol ester and phospholipid (P for trend = 0.01 and 0.02, respectively) and positively with stearic and palmitoleic acids in cholesterol ester (P for trend = 0.02 and 0.006, respectively) and dihomo-gamma-linolenic acid in cholesterol ester and phospholipid (P for trend <0.0001 for both). C-peptide concentrations were not associated with n-3 polyunsaturated fatty acids. C-peptide concentrations significantly increased as delta-9-desaturase (16:1 n-7/16:0; D9D-16) and delta-6-desaturase (18:3 n-6/18:2 n-6; D6D) increased (P for trend = 0.01 and 0.03, respectively) and delta-5-desaturase (20:4 n-6/20:3 n-6; D5D) decreased (P for trend = 0.004). In conclusion, a fatty acid pattern with high levels of serum stearic, palmitoleic, or dihomo-gamma-linolenic acids; D9D-16 or D6D activities; and low levels of serum linoleic acid or D5D activity might be associated with higher insulin resistance in Japanese adults..
32. Yasumi Kimura, Masao Sato, Kayo Kurotani, Akiko Nanri, Kazuaki Kawai, Hiroshi Kasai, Katsumi Imaizumi, Tetsuya Mizoue, PUFAs in serum cholesterol ester and oxidative DNA damage in Japanese men and women, American Journal of Clinical Nutrition, 10.3945/ajcn.111.030817, 95, 1209-1214, 2012.05, Background: PUFAs are susceptible to lipid peroxidation and play a role in inflammation, both of which can induce oxidative stress. However, the relation of PUFA to oxidative DNA damage in humans is elusive.

Objective: We examined the association between concentrations of circulatory PUFAs and urinary 8-oxo-7,8-dihydroguanine (8-oxoGua) in Japanese men and women.

Design: The subjects were 495 participants (290 men and 205 women) in a cross-sectional study in 2 municipal offices in Japan. Serum cholesterol ester (CE) and phospholipid fatty acid composition were measured by gas-liquid chromatography. Urinary 8-oxoGua concentrations were measured by HPLC, and 8-oxoGua values for each tertile of PUFA after adjustment for covariates were calculated by multiple regression.
Results: Urinary 8-oxoGua concentrations increased with increasing concentrations of n–3 (omega-3) PUFAs, EPA, and DHA in serum CE (P-trend = 0.001, 0.01, and 0.009, respectively), whereas they decreased with increasing concentrations of n–6 PUFAs and linoleic acid (P-trend = 0.02 and 0.051, respectively).
Conclusion: Oxidative DNA damage may be greater with higher concentrations of long-chain n–3 PUFAs but lower with higher concentrations of n–6 (omega-6) PUFAs.
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33. 城内文吾、中村有理、古川裕美子、友寄博子、今泉勝己、佐藤匡央, 食事脂質のリンパ輸送に及ぼすコレステロール吸収阻害剤の影響, 脂質生化学研究, 54, 173-175, 2012.05.
34. 田中愛健、永尾晃治、佐藤匡央、今泉勝己, 食事誘導性高コレステロール血症モデルラットにおけるトリアシルグリセロール代謝, 脂質生化学研究, 54, 196-199, 2012.05.
35. Masaki KATO, Yusuke ITO, Yasutake TANAKA, Masao SATO, Katsumi IMAIZUMI, Nao INOUE, and Ikuo IKEDA, SHRSP/Izm and WKY/NCrlCrlj Rats Having Missense Mutation in Abcg5 Deposited Plant Sterols in the Body, But not Change Their Biliary Secretion and Lymphatic Absorption --- Comparison with Jcl:Wistar and WKY/Izm Rats , Bioscience, Biotechnology, and Biochemistry, 2012.03.
36. Tadateru HAMADA, Mariko KUDO, Masao SATO, Nao INOUE, Koji NAGAO, Katsumi IMAIZUMI and Ikuo IKEDA, Effect of a Liver X Receptor Agonist on Deposition and Lymphatic Absorption of Plant Sterols in Stroke-Prone Spontaneously Hypertensive Rats Having a Mutation in ATP-Binding Cassette Transporter G5, Bioscience, Biotechnology, and Biochemistry, 10.1271/bbb.110554, 75, 12, 2359-2363, 2012.03.
37. Kalpana Poudel-Tandukara, Masao Sato, Yuko Ejima, Akiko Nanric, Yumi Matsushitac, Katsumi Imaizumib, Tetsuya Mizoue, Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women, Atherosclerosis, 0.1016/j.atherosclerosis.2011.11.012 , 220, 2, 520-524, 2012.02, Background: Although fatty acid composition in serum and desaturase activity, which alters serum fatty acid composition, has been associated with C-reactive protein (CRP) concentration in Western populations, no study has been carried out in non-Western populations. We examined the association of serum fatty acids and estimated desaturase activity with CRP concentrations in Japanese men and women. Methods: Subjects were 489 Japanese municipal employees aged 21-67 years who participated in a survey at the time of a periodic health check-up. Serum high-sensitivity CRP concentrations were measured using the latex agglutination nephelometry method. Fatty acid composition was measured in serum cholesteryl esters and desaturase activities by fatty acid product-to-precursor ratios. Relationships were assessed using multiple regression. Results: Serum CRP concentration was positively associated with palmitic acid (P for trend = 0.002) and inversely with alpha-linolenic acid (P for trend = 0.01) in men, and positively with dihomo-gamma-linolenic acid (P for trend in men or women = 0.01) and inversely with delta-5-desaturase (20:4n-6/20:3n-6) (P for trend in men and women = 0.05 and 0.002, respectively) in men and women. Conclusions: Low-grade inflammation may be associated with a serum fatty acid pattern of high palmitic acid or low alpha-linolenic acid in men, and of high dihomo-gamma-linolenic acid or low delta-5-desaturase in both sexes..
38. Li-Tao Tong, Yumiko Fujimoto, Naoki Shimizu, Mariko Tsukino, Taiki Akasaka, Yukiko Kato, Wakako Iwamoto, Sawako Shiratake, Katsumi Imaizumi, Masao Sato, Rice α-globulin decreases serum cholesterol concentrations in rats fed a hypercholesterolemic diet and ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice, Food Chemistry, 10.1016/j.foodchem.2011.10.056, 132, 194-200, 2012.01.
39. 佐藤匡央、森田有紀子、白石彩、城内文吾, プロバイオティクスによる抗メタボリックシンドローム作用, 生物機能研究, 15, 39-43, 2011.11.
40. Bungo Shirouchi, Sayaka Kawamura, Ryosuke Matsuoka, Sanae Baba, Kazuko Nagata, Sawako Shiratake, Hiroko Tomoyori, Katsumi Imaizumi, and Masao Sato, Dietary guar gum reduces lymph flow and diminishes lipid transport in thoracic duct-cannulated rats, Lipids, DOI: 10.1007/s11745-011-3570-0, 46, 8, 789-793, 2011.08.
41. Masao Sato, Takatoshi Ueda , Kazuko Nagata , Sawako Shiratake , Hiroko Tomoyori , Mitsuo Kawakami , Yukio Ozaki , Hiroshi Okubo , Bungo Shirouchi , Katsumi Imaizumi, Dietary kakrol (Momordica dioica Roxb.) flesh inhibits triacylglycerol absorption and lowers the risk for development of fatty liver in rats, Experimental Biology and Medicine, 10.1258/ebm.2011.011037, 236, 1139-1146, 2011.05.
42. Yukio Kadooka, Akihiro Ogawa, Ken Ikuyama, Masao Sato, The probiotic Lactobacillus gasseri SBT2055 inhibits enlargement of visceral adipocytes and upregulation of serum soluble adhesion molecule (sICAM-1) in rats, International Dairy Journal, 10.1016/j.idairyj.2011.02.001, 2011.04.
43. 赤坂泰輝、山田耕路、佐藤匡央, 実験動物用X線CT装置による白色脂肪組織重量の測定, 生物機能研究, 14, 52-56, 2010.11.
44. A Nanri, Y Kimura, Y Matsushita, M Ohta, M Sato, N Mishima, S Sasaki, T Mizoue, Dietary patterns and depressive symptoms among Japanese men and women, European Journal of Clinical Nutrition, 64, 8, 832-839, 2010.08.
45. Yukio Kadooka, Masao Sato, Katsumi Imaizumi, Akihiro Ogawa, Ken Ikuyama, Yoshihito Akai, Masako Okano , Masatoyo Kagoshima, Takashi Tsuchida, Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial, European Journal of Clinical Nutrition, 64, 6, 636-643, 2010.06.
46. Makoto Asahina, Waka Haruyama, Yasuhiro Ichida, Mai Sakamoto, Masao Sato, Katsumi Imaizumi , Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats , Journal of Lipid Research, 50:41-46, 2009.01.
47. Ichiko Miyamoto, Jun Shiono, Jie Liu, Kuniyoshi Shimizu, Masao Sato, Akiko Kukita, Toshio Kukita, Ryuichiro Kondo, Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum, European Journal of Pharmacology , 6002(1), 1-7, 2009.01.
48. E. M. Hamad, M. Sato, K. Uzu, T. Yoshida, H. Kadooka, H. Kawakami, H. Matsuyama, I. A. A. El-Gawaqd, and K. Imaizumi, Milk fermented by Lactobacillus gasseri SBT2055 influences adipocyte size via inhibition of dietary fat absorption in Zucker rats, Br. J. Nutr., 1-9, 2008.08.
49. M. Sato, K. Uzu, T. Yoshida, E. M. Hamad, H. Kawakami, H. Matsuyama, I. A. A. El-Gawaqd, and K. Imaizumi, Effects of milk fermented by Lactobacillus gasseri SBT2055 on adipocyte size in rats,, Br. J. Nutr., 99, 1013-1017, 2007.12.
50. M. Sato, Y. Kawata· K. Erami,· I. Ikeda· K. Imaizumi, LXR agonist increases the lymph HDL transport in rats by promoting reciprocally intestinal ABCA1 and apo A-I mRNA levels, Lipids, 43 (2), 125-131, 2007.12.
51. M. Sato, H. Sato, A. Ogawa, R. Nomura, S. Takashima, H.-J. Bang, H. Matsuoka and K. Imaizumi, Antiatherogenic effect of isoflavones in ovariectomized apolipoprotein E-deficient mice, J. Agr. Food Chem., 55 (22), 8967–8971, 2007.09.
52. K. Shimizu, M. Yamanaka, M. Gyokusen, S. Kaneko, M. Tsutsui, J. Sato. M. Sato, R. Kondo, Estrogen-like Activity and Prevention Effect of Bone Loss in Calcium Deficient Ovariectomized Rats by the Extract of Pleurotus eryngii, Phytother. Res., 20,659-664, 2006.06.
53. M. Asahina, M. Sato , K. Imaizumi, Genetic analysis of diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats, Journal of Lipid Research, 10.1194/jlr.M5000257-JLR200, 46, 10, 2289-2294, 46: 2289-2294, 2005.10.
主要総説, 論評, 解説, 書評, 報告書等
1. 宮後 元徳、佐藤 匡央, コレステロールの生体内での役割, オレオサイエンス,  第17 巻第11 号, 2017.11.
2. 田中翔士, 佐藤 匡央, 酸化コレステロールの生体内の存在とその意義-分子各論-, 月刊バイオインダストリー , 2014.09.
3. 佐藤 匡央, 森田有紀子, プロバイオティクスの抗メタボリックシンドローム効果, The New Food Industry, 2013.05.
4. 佐藤匡央, 血中バイオマーカとしての脂肪酸組成, 第109回食用加工油技術研究会 会報, 2012.06.
5. 佐藤匡央、森田有紀子、白石彩、城内文吾, プロバイオティクスによる抗メタボリックシンドローム作用, 生物機能研究(Biological Function Research), 2011.11.
6. 佐藤匡央, 酸化コレステロール誘導性脂肪肝の食事卵黄による改善, 平成21年度研究報告概要集(財団法人旗影会), p63-69, 2010.11.
7. 今泉勝己、佐藤匡央, ステロール酸化物の吸収と病態への関与, 消化と吸収 Digestion & Absorption, Vol.32, No.2, p116-125, 2010.07.
8. 佐藤匡央, 特集 血管力をつける! 血管の健康を守る食品は何か?, 食生活 株式会社カザン, 104(2)、14-19, 2010.01.
9. 今泉勝己、佐藤匡央, Special Article ステロール酸化物の吸収・代謝と機能, Cardio-Lipidology, 3(3) 123-129, 2009.12.
10. 佐藤匡央, 連載 アンチエイジングと食品 血管のアンチエイジングと食品, Functional Food, 3, 67-71, 2009.07.
11. 佐藤匡央, ゲノム栄養学の進歩と生活習慣病, 週間 医学の歩み , 218,5,355-359, 2006.07.
主要学会発表等
1. 佐藤 匡央, 乳酸菌の抗肥満作用, 岐阜大学 平成29年度 食品分子機能学セミナー, 2017.11.
2. 佐藤 匡央, 血清奇数鎖脂肪酸のバイオマーカとしての可能性, 岩手大学農学部動物生理学特別セミナー, 2017.10.
3. 佐藤 匡央, コレステロール合成中間体を測定する, 愛媛大学農学部附属食品健康科学研究センター 第6回 食品健康科学セミナー, 2017.09.
4. 小野雅博、宮後元徳、鈴木隆久、田中愛健、城内文吾、佐藤匡央, 外因性高コレステロール血症(ExHC)ラットにおける糖代謝, 第54回化学関連支部合同九州大会, 2017.07.
5. 溝上拓哉、林拓也、田中愛健、城内文吾、石塚敏、名倉泰三、福島道広、佐藤匡央, ベタイン摂取がラットの脂質代謝に及ぼす影響, 日本農芸化学会2017年度大会, 2017.03.
6. 林拓也、城内文吾、佐藤匡央, 分枝鎖アミノ酸摂食がラットの奇数直鎖脂肪酸および分枝鎖脂肪酸代謝に及ぼす影響, 日本農芸化学会2017年度大会, 2017.03.
7. 佐藤 匡央, 病態における脂質代謝, 中村学園大学大学院栄養科学研究科博士後期 課程セミナー第3回, 2017.02, ほぼ全ての病態で、脂質代謝は変化する。その表現系としての物質変化は脂肪酸とステロイドの量の変化である。この量的変化は、疾病の発症予測的である可能性がある。おもに、血液中のステロイドの濃度と脂肪酸組成とそれぞれの病態について、測定方法および標的分子について解説する。.
8. 佐藤 匡央, 酸化コレステロールと病態, 島根大学生物資源科学部第3回分子細胞生物学研究室セミナー, 2016.12.
9. 佐藤 匡央, 〜食物繊維研究の基盤強化-タンパク質・脂質・糖質の最新の話題を学ぶ〜 多価不飽和脂肪酸摂取の血管病に対する有効性, 日本食物繊維学会 第21回学術集会, 2016.11.
10. 佐藤 匡央, 酸化コレステロールの生理的意義, 愛媛大学農学部附属食品健康科学研究センター 第5回 食品健康科学セミナー, 2016.09.
11. 城内 文吾, 加嶋健太郎, 堀内康孝, 佐藤 匡央, 27-Hydroxycholesterolは脂肪細胞の脂肪蓄積を抑制する, 日本過酸化脂質・抗酸化物質学会 第24回年会, 2016.08.
12. 澤﨑 愛, 加藤順一, 田中愛健, 髙橋清美, 藤田直子, 城内 文吾, 佐藤 匡央, 食後血糖上昇抑制米のインスリン分泌能亢進の作用機序に関する研究, 第53回化学関連支部合同九州大会, 2016.07.
13. 新保美里, 梅ヶ谷南, 城内 文吾, 佐藤 匡央, 炎症誘導による肝硬変モデルマウスの開発, 第53回化学関連支部合同九州大会, 2016.07.
14. 溝上拓哉, 林 拓也, 城内 文吾, 佐藤 匡央, ベタイン摂取が肝臓および血清の脂肪酸組成へ及ぼす影響, 第53回化学関連支部合同九州大会, 2016.07.
15. 宮後元徳, 鈴木隆久, 田中愛健, 城内 文吾, 佐藤 匡央, 外因性高コレステロール血症ラットの脳内コレステロール代謝, 第53回化学関連支部合同九州大会, 2016.07.
16. 城内 文吾, 梅ヶ谷南, 白石彩, 森田有紀子, 甲斐俊一, 永尾晃治, 柳田晃良, 小川哲弘, 門岡幸男, 佐藤 匡央, Lactobacillus gasseri SBT2055摂取がラットのエネルギー代謝および糖代謝に及ぼす影響, 第70回日本栄養・食糧学会大会, 2016.05.
17. 佐藤 匡央, 米α-グロブリンの脂質代謝改善作用, 第70回日本栄養・食糧学会大会, 2016.05.
18. 花井健人, 辻 美咲, 吉次玲香, 菊池慧大, 野勢琢馬, 多田幸司, 清水英寿, 萩尾真人, 城内 文吾, 佐藤匡央, 吹谷 智, 横田 篤, 原 博, 石塚 敏, コール酸誘導性脂肪肝発症に伴う脂質組成と遺伝子発現, BMB2015(第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会), 2015.12.
19. 城内 文吾, 河内明日香, 有馬優子, 佐藤匡央, ホスファチジルコリン摂取によるリンパ液中サイトカイン濃度変動およびその作用機構, 第6回機能油脂懇話会(第17回CLA懇話会), 2015.11.
20. 河東華均, 林 拓也, 城内 文吾, 佐藤匡央, 日本人動脈硬化症患者における血清コレステロール合成・吸収マーカー濃度, 平成27年度日本栄養・食糧学会九州・沖縄支部および日本食品科学工学会西日本支部 合同大会, 2015.10.
21. 梅ヶ谷南, 新保美里, 林 拓也, 福田愛梨, 小川哲弘, 門岡幸男, 城内 文吾, 佐藤匡央, Goto-KakizakiラットにおけるLactobacillus gasseri SBT2055の摂取が慢性炎症に及ぼす影響, 平成27年度日本栄養・食糧学会九州・沖縄支部および日本食品科学工学会西日本支部 合同大会, 2015.10.
22. 有馬優子, 城内 文吾, 林 拓也, 馬場龍栄, 永尾晃治, 柳田晃良, 佐藤匡央, レスベラトロールおよびそのアナログであるプテロスチルベンは異なる経路を介して動脈硬化症の進展を抑制する, 平成27年度日本栄養・食糧学会九州・沖縄支部および日本食品科学工学会西日本支部 合同大会, 2015.10.
23. 花井健人, 辻 美咲, 野勢琢馬, 多田幸司, 清水英寿, 萩尾真人, 城内 文吾, 佐藤匡央, 吹谷 智, 横田 篤, 原 博, 石塚 敏, コール酸誘導性脂肪肝における脂質代謝・炎症・線維化関連遺伝子の発現, 日本栄養・食糧学会東北支部会(第49回大会)北海道支部会(第45回大会)合同支部会, 2015.10.
24. 福田優美, 宮後元徳, 鈴木隆久, 田中愛健, 城内 文吾, 佐藤匡央, ラットにおける米α—グロブリンの抗肥満作用, 日本農芸化学会2015年度中四国・西日本支部合同大会, 2015.09.
25. 赤坂泰輝, 齋藤雄飛, 髙橋清美, 加藤順一, 城内 文吾, 田中愛健, 藤田直子, 熊丸 敏博, 佐藤 匡央, 炊飯時に高保水性かつ高RS含量を有する変異米の探索とラットに対する血糖上昇抑制効果, 日本応用糖質科学会平成27年度大会, 2015.09.
26. 佐藤 匡央, 実験動物を用いた食品によるメタボリックシンドローム改善の考え方, 愛媛大学農学部附属食品健康科学研究センター 第3回 食品健康科学セミナー, 2015.09.
27. 佐藤匡央, 酸化ステロールの生体機能, 日本脂質栄養学会第24回大会, 2015.08.
28. 佐藤匡央, ヒト血清脂肪酸組成と疾病, 平成27年度 日本農芸化学会北海道支部講演会, 2015.08.
29. 林 拓也, 河東華均, 田中翔士, 城内 文吾, 佐藤 匡央, 日本人における動脈硬化指標CAVIと血清脂肪酸組成の関係, 第52回化学関連支部合同九州大会, 2015.06.
30. 有馬優子, 河内明日香, 城内 文吾, 佐藤 匡央, レスベラトロール及びプテロスチルベンが食後の脂質吸収及び炎症ステータスに及ぼす影響, 第52回化学関連支部合同九州大会, 2015.06.
31. MASAO SATO, Physiological significance of oxidized cholesterols, ACN2015, a joint meeting with The 69th Annual Meeting of Japan Society of Nutrition and Food science, 2015.05.
32. Bungo Shirouchi, Asuka Kawauti, Yumiko Furukawa, Yuko Arima, MASAO SATO, Effects of dietary phosphatidylcholine on postprandial lymphatic inflammatory cytokine levels in rats, ACN2015, a joint meeting with The 69th Annual Meeting of Japan Society of Nutrition and Food science, 2015.05.
33. Yasutake Tanaka, Kiyomi Takahashi, Taiki Akasaka, Naoko Fujita, Yuhi Saito, Bungo Shirouchi, MASAO SATO, Screening of rice (Oryza sativa L.) grains with antidiabetic functionalities, ACN2015, a joint meeting with The 69th Annual Meeting of Japan Society of Nutrition and Food science, 2015.05.
34. 黒谷佳代, 佐藤 匡央, 田中翔士, 加嶋健太郎, 南里明子, 安田和基, 早渕仁美, 溝上哲也, Even- and odd-chain saturated fatty acids are differentially associated with adipokines, 第25回日本疫学会学術総会, 2015.01.
35. 田中翔士, 加嶋健太郎, 城内 文吾, 佐藤 匡央, 日本人成人における風邪引き回数と血清脂肪酸組成の関係, 日本食品科学工学会 平成26年度西日本支部大会, 2014.12.
36. 梅ヶ谷南, 森田有紀子, 小川哲弘, 門岡幸男, 城内 文吾, 佐藤 匡央, アポE欠損マウスにおいてLactobacillus gasseri SBT2055は動脈硬化プラークを安定化させる, 日本食品科学工学会 平成26年度西日本支部大会, 2014.12.
37. 河内明日香, 城内 文吾, 古川裕美子, 佐藤 匡央, ホスファチジルコリン摂取がリンパ脂質動態及びサイトカイン濃度に与える影響, 平成26年度日本栄養・食糧学会九州・沖縄支部大会, 2014.10.
38. 髙橋清美, 加藤順一, 赤坂泰輝, 藤田直子, 齊藤雄飛, 田中愛健, 城内 文吾, 佐藤 匡央, ラットを用いた血糖上昇抑制作用をもつ米品種の探索, 平成26年度日本栄養・食糧学会九州・沖縄支部大会, 2014.10.
39. 福田優美, 美濃部裕太郎, 田中愛健, 髙橋清美, 加藤順一, 城内 文吾, 佐藤 匡央, 高デンプン食を摂食させたラットにおける米グロブリンの脂質代謝に及ぼす影響, 平成26年度日本栄養・食糧学会九州・沖縄支部大会, 2014.10.
40. 岩田夏記, 田中翔士, 河東華均, 林拓也, 城内 文吾, 佐藤匡央, 糖尿病ラットの病態と酸化コレステロールの関係, 2014年度日本農芸化学会西日本支部大会, 2014.09.
41. 加藤順一, 髙橋清美, 美濃部裕太郎, 阪田光和, 吉村 淳, 熊丸 敏博, 佐藤匡央, 低脂肪酸含有米簡易測定技術の開発, 2014年度日本農芸化学会西日本支部大会, 2014.09.
42. Bungo Shirouchi, Asuka Kawauchi, Takuya Kato, Yumiko Furukawa, Yuko Arima, MASAO SATO, Dietary phosphatidylcholine reduces lymphatic inflammatory cytokine levels in thoracic lymph-duct cannulated rats, 1st Asian Conference on Oleo Science (ACOS2014), 2014.09.
43. Bungo Shirouchi, Ryuei Baba, Takuya Kato, Nagao K, MASAO SATO, Dietary Resveratrol Alleviates Atherosclerotic Lesions in ApoE-deficient Mice: Comparison with Pterostilbene, a Resveratrol Analog, 27th International Conference on Polyphenols & 8th Tannin Conference, 2014.09.
44. 加藤順一, 高橋清美, 美濃部裕太郎, 阪田光和, 吉村 淳, 佐藤 匡央, 低脂肪酸含有米スクリーニング技術の開発, 第51回化学関連支部合同九州大会, 2014.06.
45. 鈴木隆久, 田中愛健, 石田尽, 佐藤 匡央, 食事誘導性高コレステロール血症(ExHC)ラットの肝臓における糖質代謝, 第51回化学関連支部合同九州大会, 2014.06.
46. 岩田夏記, 田中翔士, 黒谷佳代, 佐藤 匡央, 動脈硬化症患者の血清中各種酸化コレステロール濃度, 第51回化学関連支部合同九州大会, 2014.06.
47. 田中翔士, 岩田夏記, 黒谷佳代, 佐藤 匡央, 動脈硬化症患者の血清中各種酸化コレステロール濃度, 第67回日本栄養・食糧学会大会, 2014.05.
48. Bungo Shirouchi, 松岡亮輔, 川村沙也佳, 馬場さなえ, 白武佐和子, 永田和子, 友寄博子, Katsumi Imaizumi, 佐藤 匡央, 卵白タンパク質摂取は腸管での物理化学的特性を介して食事脂質のリンパ輸送を低下させる, 第67回日本栄養・食糧学会大会, 2014.05.
49. 鈴木隆久, 田中愛健, 石田尽, 佐藤 匡央, 食事誘導性高コレステロール血症(ExHC)ラットにおける糖質代謝, 第67回日本栄養・食糧学会大会, 2014.05.
50. 小川哲弘, 門岡幸男, 加藤健, 中島肇, 城内 文吾, 佐藤 匡央, 半永久胸管リンパカニュレーションを施したラットにおける食事ステロイドのリンパ吸収及びリンパ液中サイトカイン濃度に対するエゼチミブの影響, 日本農芸化学会2014年度大会, 2014.03.
51. Akter S, Pham NM, 南里明子, 黒谷佳代, 桑原恵介, Jacka NF, 安田和基, 佐藤 匡央, 溝上哲也, Serum leptin and ghrelin are associated with depression in Japanese women but not in men, 第24回日本疫学会, 2014.01.
52. 馬場龍栄, 加藤拓也, 城内 文吾, 永尾晃治, 柳田晃良, 佐藤 匡央, レスベラトロールはアナログであるプテロスチルベンよりも動脈硬化症の進展を抑制する, 平成25年度日本食品科学工学会西日本支部および日本栄養・食糧学会九州・沖縄支部合同大会, 2013.10.
53. 古川裕美子, 城内 文吾, 河内明日香, 中村有理, 佐藤 匡央, 食事酸化コレステロールのリンパ吸収におけるコレステロール吸収阻害剤の影響, 平成25年度日本食品科学工学会西日本支部および日本栄養・食糧学会九州・沖縄支部合同大会, 2013.10.
54. 城内 文吾, 佐藤 匡央, 大豆サポニンはメタボリックシンドロームの発症リスクを低減する, 第34回日本肥満学会, 2013.10.
55. Tanaka Y, Nagao K, Nakagiri H, Nagaso T, Iwasa Y, Mori H, Asahina M, katsumi imaizumi, MASAO SATO, Increase of Serum Cholesterol Level Induced by Dietary Cholesterol Involves Secretion of Triacylglycerol from Liver in EXHC Rats, IUNS 20th International Congress of Nutrition, 2013.09.
56. 田中愛健, 河野通生, 山口千仁, 朝比奈誠, 佐藤 匡央, 食事性高コレステロール血症モデルラットにおけるホモシステイン代謝, 第 52 回日本油化学会年, 2013.09.
57. 城内 文吾, 古川裕美子, 河内明日香, 中村有理, 佐藤 匡央, 食事酸化コレステロールの吸収ならびに体内蓄積及ぼすエゼチミブ影響, 第 52 回日本油化学会年, 2013.09.
58. 城内 文吾, 馬場龍栄, 永尾晃治, 柳田晃良, 佐藤 匡央, レスベラトロールおよびそのアナログ摂取がアポリポタンパク質E欠損マウスの動脈硬化症に及ぼす影響, 第25回夏期油脂・コレステロール研究会, 2013.07.
59. 佐藤 匡央, 酸化コレステロールと動脈硬化症, 第45回日本動脈硬化学会総会・学術集会, 2013.07.
60. 佐藤 匡央, 食事酸化コレステロールの吸収, 第3回食後サイエンス懇話会, 2013.07.
61. 岩田夏記, 塩田将貴, 柳修平, 柳綾佳, 佐藤 匡央, 5α-hydroxy-6-ketocholestanolが肝臓の脂質蓄積に及ぼす影響, 第50回化学関連支部合同九州大会, 2013.07.
62. 石塚友里絵, 大澤徳子, 佐藤 匡央, 酸化コレステロールのLXRαに対する結合活性, 第50回化学関連支部合同九州大会, 2013.07.
63. 河内明日香, 古川裕美子, 城内 文吾, 佐藤 匡央, 脂質のリンパ輸送に対する卵黄ホスファチジルコリンの影響, 第50回化学関連支部合同九州大会, 2013.07.
64. 高橋清美, 中村勇貴, 福田優美, 美濃部裕太郎, 城内 文吾, 佐藤 匡央, 低リン脂質米選抜のための簡易分析法の開発, 第50回化学関連支部合同九州大会, 2013.07.
65. 福田優美, 美濃部裕太郎, 田中愛健, 城内 文吾, 佐藤 匡央, 米α-グロブリンの血清コレステロール濃度に及ぼす影響, 第50回化学関連支部合同九州大会, 2013.07.
66. 加嶋健太郎, 溝上哲也, 城内 文吾, 佐藤 匡央, 成人日本人における肥満と血清脂肪酸組成との関連, 第67回日本栄養・食糧学会大会, 2013.05.
67. 美濃部裕太郎, 福田優美, 田中愛健, 熊丸 敏博, 佐藤 匡央, ラットにおける高α-グロブリン米の血清コレステロール濃度低下作用, 第67回日本栄養・食糧学会大会, 2013.05.
68. 小川哲弘, 門岡幸男, 加藤健, 中島肇, 城内 文吾, 佐藤 匡央, Lactobacillus gasseri SBT2055(ガセリ菌SP株)が高トリアシルグリセロール血症を伴う過体重の日本人の食後脂質代謝に及ぼす影響, 日本農芸化学会2013年度大会, 2013.03.
69. Shimabukuro M, 大川知奈美, SATO MASAO, Higashida M, Sato H, Kurobe H, Takao S, Hirata Y, Nakayama T, Lei XF, Kim-Kaneyama JR, Fukuda D, Yamada H, Kitagawa T, Sata M, Effects of Ezetimibe on Oxidized Cholesterol and Fatty-acid Components in Epicardial fat and Myocardium: A Gas Chromatography-Mass Spectrometry Analysis, 第77回日本循環器学会学術集会, 2013.03, Background: Growing evidence suggest that epicardial adipose tissue (EAT) may contribute to the development of coronary artery disease (CAD). Proinflammatory cytokines/adipocytokines are expressed and secreted at a higher level in EAT of individuals with coronary artery disease (CAD) (Hirata et al, JACC 2011). Oxidized cholesterol and fatty acids in food serve as strong atherogenic components, but their distribution in EAT remain unclarified. Objective: We determined effects of ezetimibe on oxidized cholesterol and fatty-acid components in EAT and myocardium using gas chromatography-mass spectrometry analysis.Methods: Male guinea mini pigs were divided into 3 groups of control (80 kcal/kg/day), 1.5% cholesterol-containing high-fat diet (120 kcal/kg/day) (HFD), and HFD+
ezetimibe (0.3mg/kg/day) (Ezetimibe). Fourteen oxidized cholesterol and twenty fatty-acid components were measured by a gas chromatography-mass spectrometry analysis. Results: 1. Plasma levels of Α- and Β-epoxy-cholesterol were increased and 7-ketocholesterol was decreased in HFD group;Α- and Β-epoxy-cholesterol in EAT were decreased in HFD group;Α-epoxy-cholesterol in plasma and epicardial fat were decreased in Ezetimibe group as compared to HFD group, 2. Levels of arachidonic acids were increased comparably in HFD and Ezetimibe groups, 3. EAT volume and echocardiographic indices were comparable among three groups. Conclusion: Components of atherogenic oxidized cholesterol and fatty acids are altered in plasma and perivascular fat and ezetimibe ma
y be beneficial in regulating these components..
70. 南里明子, Pham Ngoc Min, 黒谷佳代, 久米絢弓, 桑原恵介, 佐藤 匡央, 早渕仁美, 溝上哲也, 血中ビタミンB6濃度と抑うつ症状との関連について, 第23回日本疫学会学術総会, 2013.01, 【目的】ビタミンB6は、ホモシステインやトリプトファンの代謝に関与していることから、うつに対する予防的役割が期待されている。しかしながら、ビタミンB6摂取とうつとの関連について一致した結果は得られておらず、また、血中ビタミンB6濃度との関連を検討した研究はほとんどない。本研究では、血清ピリドキサール濃度と抑うつ症状との断面および縦断的関連を明らかにする。
【方法】2006年の調査に参加した北部九州の2地域の公務員547名(21~67歳)のうち、抑うつ症状の評価を含む健康調査票に回答し、血清中ピリドキサール濃度を測定した422名を対象に断面的関連について分析した。さらに、2006年(ベースライン)の調査参加者のうち、ベースライン時に抑うつの評価に用いたCenter for Epidemiologic Studies Depression (CES-D)スケールが16点未満であり、かつ2009年の追跡調査に参加し、データ欠損のない210名について、ベースライン時のピリドキサールとその3年後の抑うつ症状との関連を分析した。
【結果】解析対象者のうち抑うつ症状のある者(CES-D 19点以上:日本人基準)は26%であった。血中ピリドキサール濃度が高い群で抑うつ症状のオッズ比は有意に低く、多変量調整オッズ比(95%信頼区間)は血中ビリドキサール濃度の最小三分位群から順に、1.00、0.54 (0.31-0.94)、0.54 (0.30-0.96)であった。さらに、ベースライン時の血中ピリドキサール濃度が高いほど3年後の抑うつ症状のオッズ比が低下する傾向がみられ、血中ピリドキサール濃度が最も低い群に対する最も高い群のオッズ比は0.55 (95%信頼区間0.13-2.32)であった。
【考察】日本人勤労者において、血中ピリドキサール高濃度は抑うつ症状低下と関連していた。これまで断面研究により血中ビタミンB6(pyridoxal 5’-phosphate)と抑うつ症状との負の関連が報告されており(Hvas et al., Psychother Psychosom 2004; Merete et al., J Am Coll Nutr 2008)、本研究により、さらにビタミンB6が将来の抑うつ症状に抑制的に働くことが示唆された。
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71. 木村安美, 南里明子, 安田和基, ファンゴクミン, 黒谷佳代, 桑原恵介, 久米絢弓, 佐藤 匡央, 早渕仁美, 溝上哲也, 成人期における体重増加とアディポカイン、CRP、HOMA-IRとの関連, 第23回日本疫学会学術総会, 2013.01, 【背景】 肥満は糖尿病、高血圧、心疾患、がんの重要な危険因子であり、生活習慣病対策における重要な課題である。肥満は脂肪細胞由来のアディポカインの産生・分泌を介して生活習慣病リスクを高めると考えられている。しかしながら、成人期における体重増加が現在の肥満度とは独立してアディポカイン、あるいは炎症やインスリン抵抗性に関連しているかは明らかではない。
【目的】 職域集団を対象に20歳からの体重増加とアディポカイン、CRP、HOMA-IRとの関連を検討する。
【方法】 解析対象は、北部九州の2地域の公務員567名(20~68歳)のうち、血清中アディポカインの測定値および20歳の体重データ(自己申告)がある427名(男性253名、女性174名)である。アディポネクチン、レプチン、レジスチン、PAI-1、ビスファチン、C-reactive protein (CRP)を測定し、さらにインスリン抵抗性指数 (HOMA-IR)を算出した。20歳から調査時までの体重増加カテゴリー (<5 kg, 5-9.9 kg, ≥10 kg) ごとに各測定値の幾何平均と95%信頼区間を算出し、あわせて傾向性を検定した。交絡要因として、性、年齢、職場、身体活動、喫煙状況、飲酒状況、糖尿病の家族歴、BMIを調整した。
【結果】 20歳からの体重増加が大きい群ほどレプチン濃度が高いという統計学的に有意な関連を認めた。アディポネクチンについても、解析対象者を40歳以上に限定した場合には有意な負の関連を認めた。CRP、HOMA-IRについては、体重が10キロ以上増加した群は5キロ未満の群に比べ有意に高い値を示したが、調査時のBMIを調整すると関連がなくなった。一方、レジスチン、PAI-1、ビスファチンと体重増加との関連は認めなかった。
【考察・結論】 成人期における体重増加は現在の肥満度とは独立してレプチン濃度に関連していた。また、20歳から中年期までの長期間の体重増加はアディポネクチン値に関連していることが示唆された。若年成人期における大幅な体重増加にともなう各種疾患のリスク増大には、レプチンの上昇とアディポネクチンの低下が関与しているのかもしれない。
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72. 小峰愛理 、八木香里 、八住香代子 、岩本昌子 、城内文吾 、 佐藤匡央, 社員食堂を利用した昼食介入における血清脂肪酸組成の変化, 平成24年度日本農芸化学会西日本支部および日本栄養・食糧学会九州・沖縄支部合同大会, 2012.09.
73. 山口千仁、河野道生、石田尽、壽山智也、田中愛健、城内文吾、今泉勝己、 佐藤匡央, 食事誘導性高コレステロール血症の責任遺伝子 Smek2 の機能解析, 平成24年度日本農芸化学会西日本支部および日本栄養・食糧学会九州・沖縄支部合同大会, 2012.09.
74. 大澤徳子、加藤拓也、河野通生、石塚友里絵、城内文吾、佐藤匡央, 酸化コレステロール含有人工リポタンパク質添加がヒト肝癌細胞の脂質合成に及ぼす影響, 平成24年度日本農芸化学会西日本支部および日本栄養・食糧学会九州・沖縄支部合同大会, 2012.09.
75. 田中愛健、石田尽、壽山智也、山口千仁、城内文吾、今泉勝己、佐藤匡央, 食事性高コレステロール血症ラットにおけるインスリン感受性の低下, 平成24年度日本農芸化学会西日本支部および日本栄養・食糧学会九州・沖縄支部合同大会, 2012.09.
76. 島袋充生、大川知奈美、東田真由子、佐藤寛美、黒部裕嗣、高尾正一郎、平田陽一郎、中山泰介、金山朱里、福田大受、山田博胤、佐藤匡央、北川哲也、佐田政隆, エゼチミブ投与によるブタ心臓周囲脂肪ならびに心筋組織の酸化コレステロール•脂肪酸分画の変動:GC/MS法による検討, 第60回日本心臓病学会学術集会, 2012.09, 【目的】血管および心臓周囲脂肪組織が心血管系に影響する可能性が指摘されている。我々は、血管外膜周囲脂肪組織の炎症がアディポネクチンの発現を抑制し血管リモデリングに関わること(Takaoka, Circ Res 2009)、血管内傷害で血管外膜周囲脂肪が炎症性アディポサイトカイン発現型へシフトし、新生内膜過形成を起こすことを報告した(Takaoka, ATVB 2010)。Payenらは、高脂肪食負荷ミニブタの外膜周囲脂肪で、レプチンシグナル異常と冠動脈内皮機能障害がみられたと報告した(ATVB 2010)。本研究では、高脂肪食および小腸コレステロールトランスポーターNPC1L1 阻害薬 エゼチミブの心臓周囲脂肪および心筋組織の酸化コレステロールおよび脂肪酸組成に及ぼす影響を検討した。【方法】ミニブタを通常食群(C 群), 1.5%コレステロール添加高脂肪食群 (H群), H群と同じ餌にezetimibeを添加したEzetimibe 投与群 (E 群)に分け、血清、左心室、心外膜脂肪の酸化コレステロール14分画, 脂肪酸20分画をガスクロマトグラフ質量分析(GC/MS)で測定した。【結果】1. H群では、血清でα-およびβ-epoxycholesterolが増加、7-ketocholesterolが減少していた。H群で心外膜脂肪のα-およびβ-epoxycholesterol が減少していた。E群ではH群と比較して、血清および心外膜脂肪組織のα-epoxycholesterol が減少していた。2. H群では、血清および左心室でアラキドン酸が増加したがE群で変化しなかった。3. H群とE群で心臓周囲脂肪量(CT測定)に差はなかった。【総括】高脂肪食負荷ブタでは、血清の酸化コレステロールα-およびβ-epoxycholesterolが増加し、エゼチミブ投与でα-epoxycholesterolが減少した。エゼチミブは、血中および心臓周囲脂肪の酸化コレステロール動態に影響する可能性がある。.
77. 中村勇貴・藤本由美子・美濃部祐太郎・白石彩・佟立涛・赤坂泰輝・城内文吾・佐藤匡央, 大豆サポニンによるメタボリックシンドロームのリスク低減効果, 第24回夏期油脂・コレステロール研究会, 2012.07.
78. 城内文吾・中村有理・古川裕美子・友寄博子・今泉勝己・佐藤匡央, エゼチミブが食事脂質吸収に及ぼす影響〜半永久胸管リンパカニュレーション法による評価〜, 第24回夏期油脂・コレステロール研究会, 2012.07.
79. 古川裕美子・中村有理・城内文吾・佐藤匡央, コレステロール阻害剤がラット生体内の酸化コレステロール蓄積へ与える影響, 第49回化学関連支部合同九州大会, 2012.06.
80. 馬場龍栄・加藤拓也・城内文吾・永尾晃治・柳田晃良・佐藤匡央, アポE欠損マウスにおける動脈硬化症に及ぼすプテロスチルベンおよびレスベラトロールの影響, 第49回化学関連支部合同九州大会, 2012.06.
81. 田中愛健・永尾晃治・佐藤匡央・今泉勝己, 食事誘導性高コレステロール血症モデルラットにおけるトリアシルグリセロール代謝, 第54回日本脂質生化学会, 2012.06.
82. 城内文吾・中村有理・古川裕美子・友寄博子・今泉勝己・佐藤匡央, 食事脂質のリンパ輸送に及ぼすコレステロール吸収阻害剤の影響, 第54回日本脂質生化学会, 2012.06.
83. 塩田将貴・柳修平・栁綾佳・城内文吾・佐藤匡央, 脂質合成に関与する酸化コレステロール分子種の同定, 第66回日本栄養・食糧学会大会, 2012.05.
84. 佐藤匡央, 酸化コレステロールと病態, アンチエイジングフェスタ2011:抗加齢医学の実践, 2011.12.
85. 柳修平・大川知奈美・古賀舞子・今泉勝己・城内文吾・佐藤匡央, 脂肪肝の発症を惹起する酸化コレステロール分子種の同定, 平成23年度日本栄養・食糧学会九州・沖縄支部および日本食品科学工学会西日本支部合同大会, 2011.09.
86. 白石彩・森田有紀子・甲斐俊一・永尾晃治・柳田晃良・門岡幸男・城内文吾・佐藤匡央, Lactobacillus gasseri SBT 2055による抗肥満作用機序の解明, 平成23年度日本栄養・食糧学会九州・沖縄支部および日本食品科学工学会西日本支部合同大会, 2011.09.
87. 城内文吾、川村沙也佳、松岡亮輔、馬場さなえ、永田和子、白武佐和子、友寄博子、今泉勝己、佐藤匡央, グアーガム摂取はリンパ流量低下を介して脂質輸送を低下させる, 第23回夏期油脂・コレステロール研究会, 2011.07.
88. 佐藤匡央, 21世紀の機能性食品研究―基礎と応用―
プロバイオティクスの体調調節作用, 帯広畜産大学食品科学研究部門主催公開セミナー, 2011.07.
89. 中村勇貴、白石彩、藤本由美子、佟立涛、赤坂泰輝、城内文吾、佐藤匡央, メタボリックシンドロームのリスクを大豆サポニンが低減する, 第48回化学関連支部合同九州大会, 2011.07.
90. 壽山智也、田中愛健、河野道生、朝比奈誠、城内文吾、佐藤匡央, 病態モデル動物における白色脂肪組織重量を規定する遺伝子の同定, 第48回化学関連支部合同九州大会, 2011.07.
91. 塩田将貴、堀内康孝、S. Olavanh、中村好徳、衛藤哲次、塩塚雄二、江原史雄、林恵介、後藤貴文、城内文吾、佐藤匡央, 和牛およびホルスタインの筋肉中脂肪酸組成における代謝的刷り込み効果の基礎研究, 第48回化学関連支部合同九州大会, 2011.07.
92. 小峰愛理、加藤拓也、高橋綾子、城内文吾、佐藤匡央, HepG2細胞におけるグルコースの栄養状態が脂質代謝関連遺伝子の代謝的刷り込み効果に与える影響, 第48回化学関連支部合同九州大会, 2011.07.
93. 大澤徳子、中村有理、筒井辰憲、城内文吾、佐藤匡央, 酸化コレステロール誘導性脂肪肝の発症機構に関する研究, 第48回化学関連支部合同九州大会, 2011.07.
94. 佐藤匡央, 酸化コレステロールの生理的意義「食品における動脈硬化抑制作用の新規ターゲット機構−ApoE欠損マウスのメタ解析結果より」, 徳島大学大学院ヘルスバイオサイエンス研究部心臓血管病態医学分野ならびに循環器内科学分野学内合同セミナー, 2011.05.
95. 城内文吾、堀内康孝、宮崎聖子、南里明子、溝江哲也、佐藤匡央, メタボリック症候群改善を反映する血清脂肪酸指標の探索, 第65回日本栄養・食糧学会大会, 2011.05.
96. 佐藤匡央, ラットにおける連鎖解析法を用いた新規コレステロール代謝遺伝子の探索, 第65回日本栄養・食糧学会大会, 2011.05.
97. 柳修平、古賀舞子、今泉勝己、城内文吾、佐藤匡央, 脂肪肝の発症を惹起する酸化コレステロール分子種の同定, 日本農芸化学会2011年度大会, 2011.03.
98. 森田有紀子、白石彩、小川哲弘、門岡幸男、城内文吾、佐藤匡央, 糖尿病ラットの糖代謝に及ぼすLactobacillus gasseri SBT2055の影響, 日本農芸化学会2012年度大会, 2011.03.
99. 佐藤匡央, 酸化コレステロールの生理的意義, Cholesterol Metabolism Conference (CMC), 2011.02.
100. 佟 立涛、佐藤匡央、佐藤 光, 染色法による米粒の脂質分析法の開発, 第31回種子生理生化学研究会年会, 2010.12.
101. Tanaka Y, Kawano M, Nakashima S, Sakamoto M, Asahina M, Imaizumi K, Sato M., Analysis of female-specific gene for responsiveness to dietary cholesterol in rats., The XVIIIth International Workshop on Genetic Systems in the Rat, 2010.12.
102. 高橋綾子、小峰愛理、加藤拓也、城内文吾、佐藤匡央, ヒト、ラットおよびマウスにおける脂肪酸合成酵素遺伝子プロモーター領域のメチル化が転写活性に与える影響, 平成22年度日本栄養・食糧学会九州・沖縄支部大会, 2010.09.
103. 佐藤 匡央, 食事酸化コレステロールの脂肪肝発症の可能性, 私立大学戦略的研究基盤形成事業主催 シンポジウム「酸化ストレスと健康」, 2010.09.
104. 佐藤 匡央, コレステロールと遺伝子発現, 油化学関連シンポジウム in SAGA, 2010.08.
105. 佐藤 匡央, 米油の栄養特性〜特に脂肪酸組成〜, 新品種産業化研究会/油糧米分科会 勉強会, 2010.07.
106. 中村 有理,筒井 辰憲,坂石 萌,伊藤 悠介,今泉 勝己,佐藤 匡央, SREBP-1c 遺伝子発現を誘導する酸化コレステロール分子種の探索, 第47回化学関連支部合同九州大会, 2010.07.
107. 加藤 拓也,高橋 綾子,加藤 史佳,城内 文吾,佐 藤 匡央, 脂肪酸合成酵素に対して代謝的刷り込み効果を与える新規物質の検討, 第47回化学関連支部合同九州大会, 2010.07.
108. 河野 通生,中島 早和子,春山 和佳,朝比奈 誠, 今泉 勝己,佐藤 匡央, ラット血清apoA-I濃度を規定する遺伝子の同定, 第47回化学関連支部合同九州大会, 2010.07.
109. 白石 彩,永田 和子,白武 佐和子,門岡 幸男,今 泉 勝己,佐藤 匡央, Lactobacillus gasseri SBT2055の脂肪細胞面積低下作用機序の解明, 第47回化学関連支部合同九州大会, 2010.07.
110. 堀内 康孝,宮崎 聖子,溝上 哲也,佐藤 匡央, 男性における血清中の脂肪酸組成とメタボリック症候群との関係, 第47回化学関連支部合同九州大会, 2010.07.
111. 柳 修平,坂石 萌,今泉 勝己,佐藤 匡央, 鶏卵黄摂取による酸化コレステロール誘導性脂肪肝発症の改善, 第47回化学関連支部合同九州大会, 2010.07.
112. 赤坂泰輝、白武佐和子、白石彩、佐藤 匡央、山田耕路, 実験動物用X線CT撮影装置の利用とラットにおける脂肪蓄積過程の解析, 生物機能研究会, 2010.06.
113. 筒井辰憲、伊藤悠介、中村友理、荒川千代、今泉 勝己、佐藤 匡央, 食事酸化コレステロールによる脂肪肝発症機構の解明, 第64回日本栄養・食糧学会大会, 2010.05.
114. Makoto Asahina, Waka Haruyama, Masao Sato, Katsumi Imaizumi, Machio Kawano, Sawako Nakashima, A genetic locus that regulates serum apo A-I levels on rat chromosome 3, Arteriosclerosis, Thrombosis, and Vascular Biology 2010 Scientific Sessions, 2010.04.
115. 佐藤 匡央、伊藤悠介、房賢貞、今泉 勝己, 脂質が変える、脂質が変わる -生体内脂質研究のダイナミズム-
LXRを介した食事酸化コレステロールの肝臓脂肪蓄積作用の解明, 日本農芸化学会2009年度大会, 2009.03.
116. M.Sato, S. Shiratake, S. Shimizu, Y.Kato, K.Imaizumi, Oral administration of globulin fraction in rice protein to rats decreases serum cholesterol concentration, The Second International Symposium on "Rice and Disease Prevention", 2008.10.
117. 朝比奈誠、春山和香、佐藤 匡央、今泉 勝己, Positional identification of a gene that regulates serum HDL cholesterol and apolipoprrotein A-I in rats and mice, 第40回日本動脈硬化学会総会・学術集会, 2008.07.
118. 朝比奈誠、佐藤 匡央、今泉 勝己, 連鎖解析による外因性高コレステロール血症ラットの原因遺伝子の同定, 第40回日本動脈硬化学会総会・学術集会, 2008.07.
119. 佐藤 匡央, Atherosclerosis protected by foods -beyond cholesterol- According to a meta-analysis of the reports in Apo E -/- mice-, 国際フードファクター学会(ICoFF 2007), 2007.11.
120. 上田孝俊、永田和子、松岡博美、佐藤 匡央、尾崎行生、大久保敬、今泉 勝己, ウリ科野菜カックロールの脂質代謝改善作用, 第62回日本栄養・食糧学会大会, 2007.05.
121. 朝比奈誠、春山和佳、坂本麻衣、市田康弘、佐藤 匡央、今泉 勝己, ExHCラットの食事コレステロール高感受性に関与する遺伝子座の限局, 第62回日本栄養・食糧学会大会, 2007.05.
122. 兼丸祐紀、井上崇、清水朋美、佐藤 匡央、今泉 勝己, 培養細胞においてメバロン酸が脂肪酸合成酵素発現に及ぼす刷り込み効果- DNAメチル化による発現調節-, 第62回日本栄養・食糧学会大会, 2007.05.
123. 朝比奈誠、市田康弘、春山和佳、佐藤匡央、今泉勝己, 近交系ラットを用いた血清apo A-I濃度を規定する遺伝子のポジショナルクローニング, 第23回 日本疾患モデル学会総会, 2006.11.
特許出願・取得
特許出願件数  1件
特許登録件数  3件
学会活動
所属学会名
食品科学工学学会
新品種産業化研究会
種子生理生化学研究会
植物油栄養懇話会
加工油脂研究会
日本動脈硬化学会
日本実験動物学会
日本脂質生化学会
油脂・コレステロール研究会
日本農芸化学会
日本栄養・食糧学会
学協会役員等への就任
2018.03~2020.03, 日本農芸化学会, 評議員.
2015.08~2016.06, 西日本機能性食品開発研究会実行委員会, 運営委員.
2015.05~2016.05, 日本栄養・食糧学会, 日本栄養・食糧学会用語解説委員.
2015.05~2016.05, 日本栄養・食糧学会, 中央選挙管理委員.
2014.05~2015.05, 日本栄養・食糧学会 九州・沖縄支部, 幹事.
2010.03~2019.05, 日本栄養・食糧学会, 評議員.
2014.12~2018.02, 日本食品科学工学会西日本支部, 評議員.
2014.08~2015.06, 西日本機能性食品開発研究会実行委員会, 運営委員.
2005.04~2015.03, 日本農芸化学会西日本支部, 評議員.
2009.08~2010.06, 西日本機能性食品開発研究会実行委員会, 運営委員.
2010.08~2011.06, 西日本機能性食品開発研究会実行委員会, 運営委員.
2011.08~2012.06, 西日本機能性食品開発研究会実行委員会, 運営委員.
2012.08~2013.06, 西日本機能性食品開発研究会実行委員会, 運営委員.
2010.05~2012.05, 油脂・コレステロール研究会, 監事.
2012.05~2017.09, 日本栄養・食糧学会, 本部代議委員.
2005.04~2012.03, 九州大学リサーチコア「食の安全と健康な生活の構築」, 幹事.
2005.11~2012.03, 京都大学大学院医学研究科ナショナルバイオリソースプロジェクト-ラット運営委員会, 運営委員.
2005.10, 日本栄養・食糧学会西日本支部, 参与.
2005.01, 日本農芸化学会西日本支部, 幹事.
2002.05~2010.05, コレステロール研究会, 幹事.
2000.10~2008.03, 日本栄養・食糧学会西日本支部, 幹事.
1997.05~1999.05, コレステロール研究会, 幹事.
学会大会・会議・シンポジウム等における役割
2018.06.22~2018.06.22, 第5回黒酢研究会, 座長(Chairmanship).
2018.05.11~2018.05.13, 第72回日本栄養・食糧学会大会, 座長(Chairmanship).
2017.06.23~2017.06.23, 第4回黒酢研究会, 座長(Chairmanship).
2017.05.20~2017.05.22, 第71回日本栄養・食糧学会大会, ランチョンセミナー担当委員.
2015.05.16~2015.05.18, 第26回食品産業創造展「機能性食品特別セミナー」, 座長(Chairmanship).
2015.03.26~2012.03.29, 日本農芸化学会2015年度大会, 座長(Chairmanship).
2015.03.17~2016.03.19, 日本農芸化学会2016年度大会, 座長(Chairmanship).
2014.05.30~2014.06.01, 第68回日本栄養・食糧学会大会, 座長(Chairmanship).
2012.06.07~2012.06.08, 第54回日本脂質生化学会(福岡大会), 大会実行委員.
2012.06.07~2012.06.08, 第54回日本脂質生化学会, 座長(Chairmanship).
2012.05.18~2012.05.20, 第66回日本栄養・食糧学会大会, 座長(Chairmanship).
2012.05.16~2012.05.18, 第22回食品産業創造展「機能性食品特別セミナー」, 座長(Chairmanship).
2012.03.23~2012.03.25, 日本農芸化学会2012年度大会, 座長(Chairmanship).
2012.02.03~2012.02.03, 第5回ラットリソースリサーチ研究会, 座長(Chairmanship).
2011.05.25~2011.05.27, 第21回食品産業創造展「機能性食品特別セミナー」, 座長(Chairmanship).
2010.11.30~2010.12.03, XVIIIth International Workshop on Genetic Systems in the Rat, Local Organizing Committee.
2010.05.21~2010.05.23, 日本栄養・食糧学会大会, 座長(Chairmanship).
2009.05.20~2009.05.22, 第63回日本栄養・食糧学会大会, プログラム委員.
2009.03.28~2009.03.30, 2009年度日本農芸化学会大会, 庶務幹事.
2009.03.26~2009.03.28, 日本農芸化学会2009年度大会, 座長(Chairmanship).
2009.01.24~2009.01.24, 日本農芸化学会西日本支部 支部奨励賞講演会, 座長(Chairmanship).
2008.11.01~2008.11.02, 日本栄養・食糧学会九州・沖縄支部大会, 座長(Chairmanship).
2008.09.13~2008.09.14, 日本農芸化学会西日本支部, 座長(Chairmanship).
2007.09.12~2007.09.13, 平成19年度日本栄養・食糧学会九州・沖縄支部大会, 座長(Chairmanship).
2007.05.12~2007.05.14, 日本栄養・食糧学会大会, 座長(Chairmanship).
2007.05.12~2007.05.14, 第61回日本栄養・食糧学会大会, 座長(Chairmanship).
2006.09.15~2006.09.15, 日本農芸化学会西日本支部、日本栄養・食糧学会九州・沖縄支部合同大会, 座長(Chairmanship).
2006.07.01~2006.07.01, 第43回化学関連支部合同九州大会, 座長(Chairmanship).
2006.06.04~2006.06.07, 第48回日本脂質生化学会, 座長(Chairmanship).
2006.05.16~2006.05.18, 平成18年度日本農芸化学会西日本支部例会, 座長(Chairmanship).
2006.05.12~2006.05.15, 日本栄養・食糧学会大会, 座長(Chairmanship).
2006.03.12~2006.03.15, 日本農芸化学会2006年度大会, 座長(Chairmanship).
2005.11.02~2005.11.02, 日本栄養・食糧学会西日本支部会, 座長(Chairmanship).
2005.05.11~2005.05.14, 日本栄養・食糧学会大会, 座長(Chairmanship).
2004.11.09~2004.11.11, 日本栄養・食糧学会西日本支部会, 座長(Chairmanship).
2004.10.08~2004.10.08, 日本農芸化学会西日本・北海道支部合同大会, 座長(Chairmanship).
2003.05.13~2003.05.15, 日本栄養食糧学会大会, 事務局幹事.
2003.03.28~2003.03.30, 日本農芸化学会大会, 座長(Chairmanship).
2002.11.08~2002.11.09, 日本栄養・食糧学会、日本食品科学会西日本支部合同大会, 座長(Chairmanship).
2002.09.12~2002.09.14, 日本農芸化学会西日本支部大会, 座長(Chairmanship).
2002.07.22~2002.07.25, 日本栄養・食糧学会大会, 座長(Chairmanship).
2000.10.12~2000.10.13, 日本農芸化学会、日本栄養・食糧学会、日本食品科学会西日本支部合同大会, 座長(Chairmanship).
1999.03.28~1999.03.30, 1999年度日本農芸化学会大会, プログラム編成.
学会誌・雑誌・著書の編集への参加状況
2017.05~2022.12, Journal of Nutritional Science and Vitaminology, 国際, 副編集員長.
2012.05~2022.12, Journal of Nutritional Science and Vitaminology, 国際, 編集委員.
2014.05~2015.05, Journal of Nutritional Science and Vitaminology/ ACN proceeding, 国際, 編集委員.
2016.01~2022.12, Journal of Nutritional Science and Vitaminology, 国際, 副編集員長.
学術論文等の審査
年度 外国語雑誌査読論文数 日本語雑誌査読論文数 国際会議録査読論文数 国内会議録査読論文数 合計
2017年度 24      24 
2016年度 18      19 
2015年度 22      23 
2014年度 21  15    36 
2013年度 16      17 
2012年度 10        10 
2011年度 12      13 
2010年度 13        13 
2009年度      
2008年度 12        12 
2007年度      
2006年度      
2005年度    
2004年度      
2003年度      
2002年度      
2001年度      
2000年度      
その他の研究活動
海外渡航状況, 海外での教育研究歴
ルイジアナ州立大学シュリープポート校医学部生理学科, UnitedStatesofAmerica, 1995.01~1996.03.
外国人研究者等の受入れ状況
2010.03~2010.05, 1ヶ月以上, kafrelsheikh大学(エジプト), Egypt, 日本学術振興会.
2006.07~2008.06, 1ヶ月以上, カイロ大学(エジプト), Egypt, 外国政府・外国研究機関・国際機関.
2000.01~2002.11, 1ヶ月以上, タンタ大学(エジプト), Egypt, 日本学術振興会.
受賞
食品免疫産業賞, 日本食品免疫学会, 2018.11.
栄養・食糧学会 技術賞, 公益社団法人 日本栄養・食糧学会, 2018.05.
第2回HK創造性開発賞最優秀賞, 九州大学農学部, 2010.03.
第43回三島海運記念財団学術奨励賞, 三島海運記念財団, 2005.06.
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2016年度~2018年度, 基盤研究(B), 代表, 食品中のステロイド化合物とその体内干渉の全体像の把握.
2015年度~2016年度, 挑戦的萌芽研究, 代表, 食事性高コレステロール血症ラットは認知症モデルになりうるか?.
2015年度~2015年度, 基盤研究(B), 分担, 勤労者における糖尿病発症に関するリスクスコアの開発と血中栄養成分の解明.
2014年度~2015年度, 基盤研究(B), 分担, アジア人種の食と腸内フローラと健康に関する調査研究.
2012年度~2014年度, 基盤研究(B), 代表, ラット系統を用いた脂質代謝異常の血中バイオマーカの探索と妥当性の検証.
2010年度~2012年度, 基盤研究(A), 分担, 生体調節ペプチドの科学的基盤構築.
2009年度~2011年度, 基盤研究(B), 分担, 連鎖解析法により同定された食事性高コレステロール血症原因遺伝子の機能解明.
2009年度~2012年度, 基盤研究(B), 分担, 脂肪酸組成が疾病早期バイオマーカー及び気管支ぜん息に及ぼす影響.
2009年度~2011年度, 基盤研究(C), 代表, 食事酸化コレステロール誘導性脂肪肝の発症機構の解明.
2007年度~2010年度, 基盤研究(A), 分担, 血管系疾患予防作用を有するペプチドの網羅的解明.
2006年度~2007年度, 基盤研究(B), 分担, エピジェネティクス系による動脈硬化の制御と食事による介入.
2006年度~2007年度, 基盤研究(C), 分担, 食事及び血清脂質の脂肪酸組成と抑うつに関する職域疫学研究.
2004年度~2005年度, 萌芽研究, 分担, 栄養環境によるエピゼネティックな状態の制御と食品栄養学への展開.
2004年度~2005年度, 基盤研究(B), 分担, 動脈硬化発症・進展の修飾に関与する食品成分の作用機作と予防食品の設計.
2004年度~2005年度, 基盤研究(C), 代表, 食事性高コレステロール血症の遺伝的背景に関する研究.
2002年度~2003年度, 若手研究(B), 代表, 新規脂肪酸Δ6不飽和化酵素分子種の単離・同定とその発現制御に関する研究.
2001年度~2002年度, 基盤研究(B), 分担, 脂質酸化物による動脈硬化発症の分子機構と食品成分による制御.
2000年度~2001年度, 奨励研究(A), 代表, 脂肪酸不飽和化酵素の発現を調節する中間代謝分子の検索.
1999年度~2000年度, 基盤研究(B), 分担, 動脈硬化の発症・進展と酸化ステロール分子種の解析.
1998年度~1999年度, 奨励研究(A), 代表, 食事スフィンゴミエリンによる加齢にともなう脂肪吸収環境の改善.
競争的資金(受託研究を含む)の採択状況
2015年度~2017年度, 平成27年度農林水産業・食品産業科学技術研究推進事業 [発展融合ステージ] 生物系特定産業技術研究支援センター, 分担, 米油原料用イネの作出と利用に関する研究・開発.
2013年度~2015年度, 平成25年度農林水産業・食品産業科学技術研究推進事業 [発展融合ステージ], 分担, 「難消化性澱粉構造と高水分吸収性を有する変異体米を用いた低カロリー食品の開発」.
2011年度~2013年度, 農林水産技術会議/平成23年度委託プロジェクト研究(農水産物・食品の機能性等を解析・評価するため の基盤技術の開発), 分担, 米タンパク質の新規生体調節機能性の先導的開発と機構解析.
2009年度~2010年度, 上原, 代表, FAS遺伝子発現のエピジェネティック制御.
2009年度~2013年度, 生物系特定産業技術研究支援センター, 分担, 画期的米油原料用稲の育種・利用に向けた基盤的技術シーズの開発.
2009年度~2009年度, 財団法人旗影会研究助成, 代表, 食事コレステロール酸化物誘導性脂肪肝の卵黄による改善.
2008年度~2008年度, 財団法人旗影会研究助成, 代表, 食事コレステロール酸化物による脂肪肝発症に関する研究.
2007年度~2007年度, 財団法人旗影会研究助成, 分担, 鶏卵黄摂取による脂肪肝の改善効果に関する研究.
2005年度~2005年度, 財団法人三島海運記念財団学術奨励金, 代表, 生活習慣病予防的な食環境形成への展開を目指した、脂質代謝における「刷り込み効果」発現機構の解明.
2005年度~2005年度, TSUNO研究ファンド, 代表, 米タンパク質中の血清コレステロール低下作用を有する成分の探索.
2003年度~2003年度, (社)全日本コーヒー協会 Human Healthに関する『コーヒーの効用』についての助成研究, 分担, コーヒーおよびその成分摂取が動脈硬化モデル動物の脂質代謝に及ぼす影響.
2002年度~2002年度, 財団法人 すかいらーくフードサイエンス研究所平成14年学術研究助成, 代表, 生活習慣病予防的な食環境形成への展開を目指した、脂質代謝における「刷り込み効果」発現機構の解明.
2002年度~2002年度, (社)全日本コーヒー協会 Human Healthに関する『コーヒーの効用』についての助成研究, 分担, コーヒーおよびその成分摂取が動脈硬化モデル動物の脂質代謝に及ぼす影響.
2001年度~2001年度, 財団法人 サッポロ生物科学振興財団 平成13年度(第17回)研究助成, 代表, 脂肪酸不飽和化酵素遺伝子の発現の調節を行う分子の探索.
2000年度~2000年度, 財団法人 森永奉仕会 平成12年度・研究奨励金, 代表, タンパク質のアミノ酸組成による血清コレステロール低下作用に関する研究.
1999年度~1999年度, (財)福岡県産業・科学技術振興財団 テーマ探索・シーズ発掘事業研究助成, 代表, 生活習慣病に関係するバイオマーカーの探索系の構築に関する研究.
1998年度~1998年度, ネスレ科学振興会1998年度一般公募研究助成, 代表, 小腸刷子縁膜と乳脂肪球皮膜との相互作用の解析と乳脂肪吸収促進に関与するこれら膜成分の分子クローニングに関する研究.
1998年度~1998年度, 1998年度(財)糧食研究会研究助成, 代表, 小腸刷子縁膜と乳脂肪球皮膜との相互作用の解析に基づく脂肪球脂質吸収特性の解明.
1996年度~1996年度, 新技術協会平成8年度科学技術特別研究員研究費, 代表, Differencial Dispay 法を用いた病態モデル動物における遺伝子の検索と、それら動物に対する食事の影響.
共同研究、受託研究(競争的資金を除く)の受入状況
2015.08~2016.03, 代表, 卵白タンパク質の抗肥満作用に関する研究.
2015.08~2016.07, 代表, 食事成分による高脂血症、脂肪肝の予防及び改善に関する研究.
2015.06~2016.03, 代表, ガゼリ菌SP株の抗炎症・抗酸化作用に関する研究.
2014.08~2015.03, 代表, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2014.06~2015.03, 代表, 米タンパク質の血清コレステロール濃度低下作用の解明.
2013.12~2014.03, 代表, 高LDLコレステロール血症を有するハイリスク高齢患者(75歳以上)に対するエゼチミブのコレステロール吸収・合成,炎症マーカー及び脳心血管イベント発症抑制効果に及ぼす影響(EWTOPIA75-Kyushu).
2013.08~2014.03, 代表, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2013.08~2014.03, 代表, ガセリ菌SP株の脂質代謝改善作用に関する共同研究.
2012.08~2013.03, 代表, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2012.05~2013.03, 代表, 新規澱粉構造を有する育種素材の選抜と米加工適性評価.
2011.11~2013.03, 代表, ガセリ菌SP株のメタボリックシンドローム改善作用に関する研究.
2011.08~2012.03, 代表, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2010.08~2011.03, 代表, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2009.07~2010.03, 代表, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2008.08~2009.03, 分担, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2008.06~2009.05, 代表, 脂質代謝を改善する鶏卵成分に関する研究.
2008.05~2009.03, 代表, 黒酢の健康機能評価研究.
寄附金の受入状況
2017年度, 雪印メグミルク株式会社, 農学研究院研究資金.
2016年度, 雪印メグミルク株式会社, 農学研究院研究資金.
2015年度, 雪印メグミルク株式会社, 農学研究院研究資金.
2014年度, 雪印メグミルク, ガセリ菌SP株の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2013年度, 雪印メグミルク, ガセリ菌SP株の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2012年度, 雪印メグミルク, ガセリ菌SP株の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2011年度, 雪印メグミルク, ガセリ菌SP株の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2010年度, HK創造性開発賞最優秀賞賞金, HK創造性開発研究資金.
2010年度, バイエル薬品, コレステロール吸収阻害剤の酸化コレステロール動態への影響.
2010年度, 雪印メグミルク株式会社, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2010年度, バイエル薬品, コレステロール吸収阻害剤の酸化コレステロール動態への影響.
2009年度, バイエル薬品, コレステロール吸収阻害剤の酸化コレステロール動態への影響.
2008年度, 旗影会, 食事コレステロール酸化物による脂肪肝発症に関する研究.
2008年度, バイエル薬品, コレステロール吸収阻害剤の酸化コレステロール動態への影響.
2007年度, ロッテ, カカオの香りと摂食行動.
2007年度, 築野食品, TUNOファンド.
学内資金・基金等への採択状況
2004年度~2004年度, 農学研究院教育研究特別経費, 分担, 食高齢性ホルモン疾患予防効果を有する「食」の開発.
2002年度~2002年度, 農学研究院教育研究特別経費, 分担, 食餌性機能因子が魚類の行動および脳内物質の挙動に与える影響.

九大関連コンテンツ

pure2017年10月2日から、「九州大学研究者情報」を補完するデータベースとして、Elsevier社の「Pure」による研究業績の公開を開始しました。
 
 
九州大学知的財産本部「九州大学Seeds集」