|佐藤 匡央（さとう まさお）||データ更新日：2019.06.24|
2015.06～2015.03, 代表者：佐々木淳, 国際医療福祉大学, 日本老年医学会（日本）.
2015.06～2015.03, 代表者：佐々木淳, 国際医療福祉大学, 日本老年医学会（日本）.
2015.06～2015.03, 代表者：佐々木淳, 国際医療福祉大学, 日本老年医学会（日本）.
2015.06～2015.03, 代表者：佐々木淳, 国際医療福祉大学, 日本老年医学会（日本）.
2015.09～2017.03, 代表者：熊丸敏博, 九州大学, 農林水産技術会議（日本）
2015.09～2017.03, 代表者：熊丸敏博, 九州大学, 農林水産技術会議（日本）
2013.08～2015.03, 代表者：藤田直子, 秋田県立大学, 農林水産技術会議（日本）
2013.08～2015.03, 代表者：藤田直子, 秋田県立大学, 農林水産技術会議（日本）
2011.10～2013.03, 代表者：門脇 基二, 新潟大学大学院自然科学研究科, 農林水産省 農業技術会議（日本）
2011.10～2013.03, 代表者：門脇 基二, 新潟大学大学院自然科学研究科, 農林水産省 農業技術会議（日本）
2009.05～2014.03, 代表者：佐々木淳, 国際医療福祉大学, 日本老年医学会（日本）.
2009.05～2014.03, 代表者：佐々木淳, 国際医療福祉大学, 日本老年医学会（日本）.
2009.10～2013.03, 代表者：佐藤光, 九州大学, 生物系特定産業技術研究支援センター（日本）.
2009.10～2013.03, 代表者：佐藤光, 九州大学, 生物系特定産業技術研究支援センター（日本）.
|1.||Shirouchi B, Furukawa Y, Nakamura Y, Kawauchi A, Imaizumi K, Oku H, Sato M., Inhibition of Niemann-Pick C1-Like 1 by Ezetimibe Reduces Dietary 5β,6β-Epoxycholesterol Absorption in Rats., Cardiovasc Drugs Ther, 10.1007/s10557-019-06854-4, 2019.05.|
|2.||Niibo, M., Shirouchi, B., Umegatani, M., Morita, Y., Ogawa, A., Sakai, F., Kadooka, Y., Sato, M, Probiotic Lactobacillus gasseri SBT2055 improves insulin secretion in a diabetic rat model, Journal of Dairy Science, 10.3168/jds.2018-15203, 102, 2, 997-1006, 2019.02.|
|3.||Takeyama, A., Nagata, Y., Shirouchi, B., Nonaka, C., Aoki, H., Haraguchi, T., Sato, M., Tamaya, K., Yamamoto, H., Tanaka, K., Dietary Sparassis crispa reduces body fat mass and hepatic lipid levels by enhancing energy expenditure and suppressing lipogenesis in rats, Journal of Oleo Science, 10.5650/jos.ess18043, 67, 9, 1137-1147, 2018.09, Accumulation of abdominal fat triggers metabolic syndrome, which is a cluster of metabolic abnormalities, such as dyslipidemia, glucose intolerance, insulin resistance or hyperinsulinemia, and hypertension, that leads to the development of diabetes and cardiovascular disease. Mushrooms have been used as a foodstuff and folk medicine worldwide. Among these mushrooms, Sparassis crispa (SC) is a relatively newly cultivated edible and medicinal mushroom, which has been reported to have anti-diabetic and anti-hypertensive properties. However, little is known about the anti-obesity and anti-hyperlipidemic properties of SC. In the present study, we investigated the effects of dietary SC on lipid metabolism and energy expenditure in Sprague-Dawley rats with diet-induced obesity and diabetes, and conducted respiratory gas analysis to determine how energy metabolism is altered by SC. After feeding periods of 3 and 7 weeks, dietary SC had significantly reduced hepatic triacylglycerol and cholesterol contents in a dose-dependent manner. These changes were attributable to suppression of fatty acid and cholesterol synthesis in the liver and increased insulin sensitivity in the body. In addition, after a feeding period of 6 weeks, dietary SC significantly increased energy expenditure through carbohydrate oxidation, reducing abdominal fat mass after 7 weeks. In conclusion, our results indicate that in addition to the previously reported anti-diabetic and anti-hypertensive activities, dietary SC exhibits anti-obesity and anti-hyperlipidemic activities that help protect against metabolic syndrome..|
|4.||Shirouchi, B., Yamanaka, R., Tanaka, S., Kawatou, F., Hayashi, T., Takeyama, A., Nakao, A., Goromaru, R., Iwamoto, M., Sato, M., Quantities of phospholipid molecular classes in japanese meals and prediction of their sources by multiple regression analysis, Journal of Nutritional Science and Vitaminology, 10.3177/jnsv.64.215, 64, 3, 215-221, 2018.05, Dietary intake of total phospholipids (PLs) accounts for approximately 10% of total dietary lipids. Each PL molecular class has various beneficial effects on health. However, limited information is available regarding the intake of phosphatidylcholine (PC), phos-phatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), lysophos-phatidylcholine (LPC) and sphingomyelin (SM) among Japanese people, and the relevant food sources. In this study, we quantified the contents of PC, PE, PI, PS, LPC, and SM in 120 meal samples served in a Japanese company’s dormitory and cafeteria. Additionally, we measured the weight of each food group and estimated the contents of nutrients in these meals. Furthermore, we conducted a stepwise multiple regression analysis to identify pre-dictors (food groups) of each PL class intake. The contents of total PL, PC, PE, PI+PS, LPC, and SM (mean value) were 4.44, 2.17, 0.632, 0.123, 0.313, and 0.127 g/d, respectively. These values were considered as daily PL intake in accordance with data (three macronu-trients, vitamins, and minerals) from our study and the National Health and Nutrition Survey (NHNS) Japan, 2015. The content of eggs, meat, fish and shellfish, milk, pulses, fruits, mushrooms, cereals, and fats and oils in the meals predicted the PL and PC contents. The content of eggs, pulses, and mushrooms in the meals predicted the PE contents. Our results determined the daily intake of PL molecular classes among Japanese people and the food sources of PC and PE, and suggested that multiple regression analysis is useful for the prediction of food sources of bioactive components.|
|5.||Kimura Y, Yasuda K, Kurotani K, Akter S, Kashino I, Hayabuchi H, Sato M, Mizoue T, Circulating ferritin concentrations are differentially associated with serum adipokine concentrations in Japanese men and premenopausal women., Eur J Nutr,, 10.1007/s00394-016-1285-y, 56, 8, 2497-2505, 2017.12, PURPOSE:
Increased iron storage, as measured by circulating ferritin, has been linked to an increased risk of various diseases including diabetes. We examined the association of circulating ferritin with serum adiponectin, leptin, resistin, plasminogen activator inhibitor-1 (PAI-1), and visfatin levels.
We conducted a cross-sectional study among 429 Japanese employees (284 men and 145 premenopausal women, mean age: 42.5 ± 10.5 years). Serum adipokines were measured using Luminex suspension bead-based multiplexed array, and serum ferritin was determined using a chemiluminescence immunoassay. Multivariable regression analysis was performed to calculate mean concentrations of adipokine according to the tertile of ferritin concentrations with adjustment for potential confounders.
Leptin and visfatin concentrations increased with increasing ferritin concentrations in men after multivariable adjustment of physical activity, smoking, alcohol use, and body mass index (P for trend = 0.02 and 0.01 for leptin and visfatin, respectively). Serum ferritin concentrations were inversely and significantly associated with adiponectin in women (P for trend = 0.01). Resistin and PAI-1 were not appreciably associated with ferritin concentration.
Increased iron storage may be associated with higher circulating concentrations of leptin and visfatin in men and with lower concentrations of adiponectin in women..
|6.||Matsuoka R, Shirouchi B, Umegatani M, Fukuda M, Muto A, Masuda Y, Kunou M, Sato M, Dietary egg-white protein increases body protein mass and reduces body fat mass through an acceleration of hepatic β-oxidation in rats., Br J Nutr., 10.1017/S0007114517002306, 118, 6, 423-430, 2017.09, Egg-white protein (EWP) is known to reduce lymphatic TAG transport in rats. In this study, we investigated the effects of dietary EWP on body fat mass. Male rats, 4 weeks old, were fed diets containing either 20 % EWP or casein for 28 d. Carcass protein levels and gastrocnemius leg muscle weights in the EWP group were significantly higher than those in the casein group. In addition, carcass TAG levels and abdominal fat weights in the EWP group were significantly lower than those in the casein group; adipocyte size in abdominal fat in the EWP group was smaller than that in the casein group. To identify the involvement of dietary fat levels in the rats, one of two fat levels (5 or 10 %) was added to their diet along with the different protein sources (EWP and casein). Abdominal fat weight and serum and hepatic TAG levels were significantly lower in the EWP group than in the casein group. Moreover, significantly higher values of enzymatic activity related to β-oxidation in the liver were observed in the EWP group compared with the casein group. Finally, abdominal fat weight reduction in the EWP group with the 10 % fat diet was lower than that in the EWP group with the 5 % fat diet. In conclusion, our results indicate that, in addition to the inhibition of dietary TAG absorption reported previously, dietary EWP reduces body fat mass in rats through an increase of body protein mass and the acceleration of β-oxidation in the liver..|
|7.||Akter, S., Email Author, Kurotani, K., Sato, M., Hayashi, T., Kuwahara, K., Matsushita, Y., Nakagawa, T., Konishi, M., Honda, T., Yamamoto, S., Hayashi, T., Noda, M., Mizoue, T., High serum phospholipid dihomo-γ-linoleic acid concentration and low Δ5-desaturase activity are associated with increased risk of type 2 diabetes among Japanese adults in the hitachi health study, J Nutri., 10.3945/jn.117.248997, 147, 8, 1558-1566, 2017.08, Background: The association between the circulating fatty acid (FA) composition and type 2 diabetes (T2D) has been reported in Western populations, but evidence is scarce among Asian populations, including Japanese, who consume large amounts of fish. Objective: The objective of the present study was to prospectively examine the association between circulating concentrations of individual FAs and T2D incidence among Japanese adults. Methods: We conducted a nested case-control study in a cohort of 4754 employees, aged 34-69 y, who attended a comprehensive health checkup in 2008-2009 and donated blood samples for the Hitachi Health Study. During 5 y of follow-up, diabetes was identified on the basis of plasma glucose, glycated hemoglobin, and self-report. Two controls matched to each case by sex, age, and date of checkup were randomly chosen by using density sampling, resulting in 336 cases and 678 controls with FA measurements. GC was used to measure the FA composition in serum phospholipids. Cox proportional hazards regression was used to estimate the HRs and 95% CIs after adjusting for potential confounders. We examined the association of T2D risk with 25 different individual and combinations of FAs. Results: T2D risk was positively associated with serum dihomo-γ-linoleic acid concentration (highest compared with the lowest quartile-HR: 1.49; 95% CI: 1.04, 2.11; P-trend = 0.02) and inversely associated with Δ5-desaturase activity (highest compared with the lowest quartile-HR: 0.72; 95% CI: 0.52, 0.99; P-trend = 0.02), independent of body mass index (BMI). There were also inverse associations between T2D risk with serum total n-6 (ω-6) polyunsaturated fatty acids (PUFAs), linoleic acid, and cis-vaccenic acid, but these were attenuated and became nonsignificant after adjustment for BMI. Serum n-3 (ω-3) PUFAs and saturated fatty acids (SFAs) were not associated with T2D risk. Conclusions: T2D risk was associated with circulating concentrations of the n-6 PUFA dihomo-γ-linoleic acid and Δ5-desaturase activity but not with n-3 PUFA or SFA concentrations in Japanese adults..|
|8.||Hiraki E, Furuta S, Kuwahara R, Takemoto N, Nagata T, Akasaka T, Shirouchi B, Sato M, Ohnuki K, Shimizu K., Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds., J Nat Med, 10.1007/s11418-017-1075-8, 71, 3, 482-491, 2017.07, Hericium erinaceus (H. erinaceus) improves the symptoms of menopause. In this study, using ovariectomized mice as a model of menopause, we investigated the anti-obesity effect of this mushroom in menopause. Mice fed diets containing H. erinaceus powder showed significant decreases in the amounts of fat tissue, plasma levels of total cholesterol, and leptin. To determine the mechanism, groups of mice were respectively fed a diet containing H. erinaceus powder, a diet containing ethanol extract of H. erinaceus, and a diet containing a residue of the extract. As a result, H. erinaceus powder was found to increase fecal lipid levels in excreted matter. Further in vitro investigation showed that ethanol extract inhibited the activity of lipase, and four lipase-inhibitory compounds were isolated from the extract: hericenone C, hericenone D, hericenone F, and hericenone G. In short, we suggest that H. erinaceus has an anti-obesity effect during menopause because it decreases the ability to absorb lipids..|
|9.||Bungo Shirouchi, Kentaro Kashima, Yasutaka Horiuchi, Yuki Nakamura, Yumiko Fujimoto, Li-Tao Tong, MASAO SATO, 27-Hydroxycholesterol suppresses lipid accumulation by down-regulating lipogenic and adipogenic gene expression in 3T3-L1 cells, Cytotechnology, 10.1007/s10616-016-9962-5, 69, 3, 485-492, 2017.06.|
|10.||Kurotani K, Sato M, Yasuda K, Kashima K, Tanaka S, Hayashi T, Shirouchi B, Akter S, Kashino I, Hayabuchi H, Mizoue T., Even- and odd-chain saturated fatty acids in serum phospholipids are differentially associated with adipokines., PLoS One, 10.1371/journal.pone.0178192, 12, 5, e0178192, 2017.05, BACKGROUND:
Saturated fatty acids are generally thought to have detrimental effects on health. However, a recent study showed that even- and odd-chain saturated fatty acids had opposite associations with type 2 diabetes. Limited studies of Western populations examined the associations of circulating saturated fatty acids with adipokines, an important role in glucose metabolism.
We examined the associations of saturated fatty acids in serum phospholipids with circulating levels of adipokines among a Japanese population.
A cross-sectional study was conducted among 484 Japanese employees (284 men and 200 women) aged 20-65 years. The serum fatty acid composition in the phospholipid fraction was measured by gas-chromatography. Serum leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), resistin, and visfatin were measured using a Luminex suspension bead-based multiplexed array. Multiple linear regression analysis was performed to assess the association between saturated fatty acids and adipokines, with adjustment for potential confounding variables.
Even- and odd-chain saturated fatty acids were differentially associated with adipokines. Higher levels of even-chain saturated fatty acids (14:0 myristic, 16:0 palmitic, and 18:0 stearic acids) were associated with higher levels of resistin (P for trend = 0.048) and lower levels of adiponectin (P for trend = 0.003). By contrast, odd-chain saturated fatty acids (15:0 pentadecanoic and 17:0 heptadecanoic acids) showed inverse associations with leptin and PAI-1 (P for trend = 0.048 and 0.02, respectively). Visfatin was positively associated with both even- and odd-chain saturated fatty acids.
The results suggest that even- and odd-chain saturated fatty acids are differentially associated with adipokine profile..
|11.||Michio Shimabukuro, Chinami Okawa, Shuhei Yanagi, Etsuko Uematsu, Noriko Sugasawa, Hirotsugu Kurobe, Yoichiro Hirata, Joo-ri Kim-Kaneyama, Xiao-Feng Lei, Shoichiro Takao, Yasutake Tanaka, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuya Kitagawa, Hiroaki Masuzaki, MASAO SATO, Masataka Sata, The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe, Journal of Nutritional Biochemistry, 10.1016/j.jnutbio.2016.05.010, 35, 1, 66-73, 2016.09, Oxidized cholesterols (oxycholesterols) in food have been recognized as strong atherogenic components, but their tissue distributions and roles in cardiovascular diseases remain unclear. To investigate whether accumulation of oxycholesterols is linked to cardiac morphology and function, and whether reduction of oxycholesterols can improve cardiac performance, domestic male swine were randomized to a control diet (C), high caloric diet (HCD) or HCD + Ezetimibe, an inhibitor of intestinal cholesterol absorption, group (HCD + E) and evaluated for: (1) distribution of oxycholesterol components in serum and tissues, (2) levels of oxycholesterol-related enzymes, (3) paracardial and epicardial coronary fat thickness, and (4) cardiac performance. Ezetimibe treatment for 8 weeks attenuated increases in oxycholesterols in the HCD group almost completely in liver, but reduced only levels of 4β-hydroxycholesterol in left ventricular (LV) myocardium. Ezetimibe treatment altered the expression of genes for cholesterol and fatty acid metabolism and decreased the expression of CYP3A46, which catabolizes cholesterol to 4β-hydroxycholesterol, strongly in liver. An increase in epicardial fat thickness and impaired cardiac performance in the HCD group were improved by ezetimibe treatment, and the improvement was closely related to the reduction in levels of 4β-hydroxycholesterol in LV myocardium. In conclusion, an increase in oxycholesterols in the HCD group was closely related to cardiac hypertrophy and dysfunction, as well as an increase in epicardial fat thickness. Ezetimibe may directly reduce oxycholesterol in liver and LV myocardium, and improve cardiac morphology and function..|
|12.||Kazuo ERAMI, Yasutake TANAKA, Sayaka KAWAMURA, Motonori MIYAGO, Ai SAWAZAKI, katsumi imaizumi, MASAO SATO, Dietary Egg Yolk Supplementation Improves Low-Protein-Diet-Induced Fatty Liver in Rats, Journal of Nutritional Science and Vitaminology, 10.3177/jnsv.62.240, 62, 4, 240-248, 2016.08, [URL], Egg yolk is an important source of nutrients and contains different bioactive substances. In the present study, we studied the benefits of egg yolk in preventing low-protein-diet-induced fatty liver in rats. Rats were fed the following diets, which were based on the AIN-76 formula, for 2 wk: an adequate-protein diet containing 20% casein (C), a low-protein diet containing 5% casein (LP-C), a low-protein diet supplemented with 12.5% egg yolk (LP-EY), and a low-protein diet supplemented with 4.1% egg yolk oil (LP-EYO). The low-protein diets were adjusted to contain 4.13% protein and 4.7% lipids. The LP-C diet resulted in a greater increase in the liver trigriceride (TG) and the vacuolation and a greater decrease in the serum TG and free fatty acid (FFA) than did the C diet. These deviations in the serum and liver TG, serum FFA levels and the liver histopathology were corrected in rats fed the LP-EY diet but not in those fed the LP-EYO diet. Compared to rats fed the LP-C diet, although the activities of lipogenesis-related enzymes (fatty acid synthase, glucose-6-phosphate dehydrogenase, and malic enzyme) decreased in rats fed both of the LP-EY and LP-EYO diets, the level of the microsomal TG transfer protein (MTP) increased only in rats fed the LP-EY diet. Collectively, these results suggest that dietary egg yolk supplementation decreases the LP diet-induced accumulation of TG in the liver by increasing transport of TG in the liver, and egg yolk oil alone is not sufficient enough to bring about these benefits..|
|13.||Bungo Shirouchi, Kouji Nagao, Minami Umegatani, Aya Shiraishi, Yukiko Morita, Shunichi Kai, Teruo Yanagita, Akihiro Ogawa, Yukio Kadooka, MASAO SATO, Probiotic Lactobacillus gasseri SBT2055 improves glucose tolerance and reduces body weight gain in rats by stimulating energy expenditure., British Journal of Nutrition, 116, 451-458, 2016.05.|
|14.||Ikuko Kashino, Akiko Nanri, Kayo Kurotani, Shamima Akter, Kazuki Yasuda, MASAO SATO, Hitomi Hayabuchi, Tetsuya Mizoue, Association of dietary patterns with serum adipokines among Japanese: a cross-sectional study
, Nutrition Journal, 10.1186/s12937-015-0046-8., 14, 58, 2015.08.
|15.||Ngoc Minh Phama, Akiko Nanri, Siyan Yi, Kayo Kurotani,, Shamima Akter, Leng Huat Foo, Nobuo Nishi, MASAO SATO, Hitomi Hayabuchi, Tetsuya Mizoue, Habitual consumption of coffee and green tea in relation to serum adipokines: a cross-sectional study, European Journal of Nutrition
, 10.1007/s00394-014-0701-4, 54, 2, 205-214, 2015.03, PURPOSE:Coffee and green tea consumption may be associated with circulating adipokines, but data are inconsistent, scarce or lacking. We examined the association of coffee and green tea consumption with serum adiponectin, leptin, visfatin, resistin and plasminogen activator inhibitor-1 (PAI-1) among a Japanese working population.
The authors analyzed data (n = 509) from a cross-sectional survey among Japanese workers aged 20-68 years. Serum adipokines were measured using a Luminex suspension bead-based multiplexed array. Coffee and green tea consumption was assessed using a validated diet history questionnaire, and caffeine consumption from these beverages was estimated. Multiple regression analysis was performed with adjustment for potential confounding variables.
Coffee consumption was significantly, inversely associated with leptin and PAI-1 (P for trend = 0.007 and 0.02, respectively); compared with subjects consuming <1 cup per day, those consuming ≥4 cups per day had 13 and 10 % lower means of leptin and PAI-1, respectively. Similar associations were observed for caffeine consumption (P for trend = 0.02 for both leptin and PAI-1). Additionally, we noted a significant positive association between coffee consumption and adiponectin in men (P for trend = 0.046), but not in women (P for trend = 0.43, P for interaction = 0.11). Moreover, there was a positive association between coffee consumption and resistin in current male smokers (P for trend = 0.01), but not in male non-smokers (P for trend = 0.35, P for interaction = 0.11). Green tea consumption was not associated with any adipokine.
Higher consumption of coffee and caffeine but not green tea was associated with lower serum levels of leptin and PAI-1 in Japanese adults.
|16.||Ryousuke Matsuoka, Bungo Shirouchi, Masao Sato, Sayaka Kawamura, Sanae Baba, Sawako Shiratake, Kazuko Nagata, Katsumi Imaizumi, Dietary Egg White Protein Inhibits Lymphatic Lipid Transport in Thoracic Lymph Duct-Cannulated Rats, Journal of Agricultural and Food Chemistry, 10.1021/jf502741b, 62, 44, 10694-10700, 2014.11, Dietary egg white protein (EWP) decreases serum cholesterol levels. We previously showed that EWP decreased cholesterol absorption in the intestine. Rats subjected to permanent lymph duct cannulation were used to investigate the effects of dietary EWP on lipid transport. They were fed diets with 20% EWP and casein, and their lymph was collected to quantify lymphatic lipid levels. Dietary EWP decreased lymphatic cholesterol transport compared with casein. It was previously shown that EWP excluded cholesterol from bile acid micelles. Therefore, pepsin-hydrolyzed EWP and casein were prepared. EWP was not completely digested. Ovalbumin, which is the most abundant protein in EWP, showed resistance to digestion by pepsin. This study investigated the effects of EWP pepsin hydrolysate (EWP-ph) on cholesterol micellar solubility, cholesterol transfer from the micellar to the oil phase, water-holding capacity (WHC), settling volume in water (SV), and relative viscosity and compared them with the effects of casein pepsin hydrolysate (C-ph). EWP-ph significantly decreased the micellar solubility and transfer rate and increased the WHC, SV, and relative viscosity compared with C-ph. Moreover, the pepsin hydrolysate of ovalbumin, a major protein in EWP, played a role in decreasing cholesterol micellar solubility, leading to the inhibition of cholesterol absorption. In conclusion, dietary EWP decreased cholesterol intestinal absorption by exerting combined effects of these physicochemical properties in the gut..|
|17.||Ai Hori, Hiroshi Kasai, Kazuaki Kawai, Akiko Nanri, MASAO SATO, Masanori Ohta, Tetsuya Mizoue, COFEE INTAKE IS ASSOCIATED WITH REDUCING OXIDATIVE DNA DAMAGE AND DECREASING BODY IRON STORAGE IN HEALTHY WOMEN, Nutrition and Cancer , 10.1080/01635581.2014.932398., 66, 6, 964-969, 2014.06, Habitual coffee drinking has been linked to a lower risk for some forms of cancer, but the mechanism remains elusive. Coffee may decrease oxidative DNA damage, an important pathway to carcinogenesis. We examined the association between coffee consumption and urinary 8-hydroxydeoxyguanosine (8-OHdG) concentrations, a biomarker of systemic oxidative DNA damage and repair, in 507 healthy subjects (298 men and 209 women aged 21-67 years) while adjusting for age, sex, smoking status, body mass index, job type, and fasting blood glucose in multivariable regression models. The association with green tea consumption was also assessed. Urinary 8-OHdG concentrations tended to decrease with coffee consumption (Trend P=0.068) only in women, with participants drinking 2-3 cups of coffee per day showing the lowest mean of urinary 8-OHdG concentrations. This association diminished after adjustment for serum ferritin concentrations, a marker of body iron storage (Trend P=0.87). Green tea consumption was not significantly associated with urinary 8-OHdG concentrations. Coffee drinking may be associated with decreased systemic oxidative DNA damage through decreasing body iron storage in women..|
|18.||Hiroyuki Kikuchi, Akiko Nanri, Ai Hori, MASAO SATO, Kazuaki Kawai, Hiroshi Kasai, Tetsuya Mizoue, Lower serum levels of total cholesterol are associated with higher urinary levels of 8-hydroxydeoxyguanosine, Nutirition and Metabolism, 10.1186/10.1186/1743-7075-10-59, 10, Art. NO. 59, 2014.03, [URL], Background
Lower serum total (TC), high-density lipoprotein (HDL-C) and low-density lipoprotein cholesterols (LDL-C) have been linked to an increased risk of cancer in various sites, but its underlying mechanism remains unclear. In an attempt to clarify the association between cholesterol levels and oxidative DNA damage, we investigated the relationship between serum cholesterol and urinary 8-hydroxydeoxyguanosine levels in a Japanese working population.
The study subjects were 294 men and 209 women aged 21-66 years in two Japanese municipal offices. Urinary 8-hydroxydeoxyguanosine (8-OHdG) was measured using an automated high-pressure liquid chromatography. Linear regression analysis was used to examine the associations of urinary 8-OHdG with TC, HDL-C and LDL-C levels with adjustment for sex, age, smoking and body mass index. Subgroup analyses were conducted by smoking status in men and age in women. Analysis of covariance was employed to estimate adjusted means of urinary 8-OHdG across TC category.
After multivariate adjustment, urinary 8-OHdG levels were inversely associated with serum TC levels (β = −0.0015, p < 0.05) and LDL-C levels (β = −0.0012, p = 0.07). The inverse association with TC was apparent among smoking men (β = −0.0017, p < 0.05) and among women aged less than 48 years (β = −0.0040, p < 0.01). 8-OHdG decreased as TC increased (up to 219 mg/dL); subjects with TC levels of <160 mg/dL had a 17.4% higher adjusted mean of 8-OHdG than did those with TC levels of 200–219 mg/dL.
Results suggest that circulating low TC levels are associated with higher oxidative DNA damage.
|19.||Ngoc Minh Pham, Akiko Nanri, Takeshi Kochi, Keisuke Kuwahara, Hiroko Tsuruoka, Kayo Kurotani, Shamima Akter, Isamu Kabe, MASAO SATO, Hitomi Hayabuchi, Tetsuya Mizoue, Coffee and green tea consumption is associated with insulin resistance in Japanese adults, Metabolism - Clinical and Experimental, 10.1016/j.metabol.2013.11.008, 63, 3, 400-408, 2014.03, Objective. Higher coffee and green tea consumption has been suggested to decrease risk of type 2 diabetes, but their roles in insulin resistance (IR) and insulin secretion remain unclear. This study examined the association between habitual consumption of these beverages with markers of glucose metabolism in a Japanese working population.
Materials/Methods. Participants were 1,440 Japanese employees (1,151 men and 289 women) aged 18-69 years. Consumption of coffee and green tea was ascertained via a validated brief diet history questionnaire. Multilevel linear regression was used to estimate means and 95% confidence intervals of fasting insulin, fasting plasma glucose, homeostatic model assessment of IR (HOMA-IR), homeostatic model assessment of β-cell function (HOMA-β) and glycated hemoglobin (HbA1c) with adjustment for potential confounding variables. Stratified analyses by smoking and body mass index (BMI) were also performed.
Results. Coffee consumption was significantly, inversely associated with HOMA-IR (P for trend = .03), and the association appeared to be confined to overweight subjects (BMI ≥25kg/m2 ) (P for trend = .01, P for interaction = .08). Contrarily, there was a significant, positive association between green tea consumption and HOMA-IR (P for trend = .015), though dose response relationship among daily consumers of green tea was not observed. Neither coffee nor green tea consumption was associated with HOMA-β and HbA1c.
Conclusions. Our findings indicate that coffee consumption may be associated with decreased IR, but not with insulin secretion. The positive association between green tea consumption and IR warrants further investigation..
|20.||Kayo Kurotani, MASAO SATO, Yuko Ejima, Kentaro Kashima, Akiko Nanri, Ngoc Minh Pham, Keisuke Kuwahara, Tetsuya Mizoue, Serum alpha-linolenic and linoleic acids are inversely associated with depressive symptoms in adults, e-SPEN Journal, 10.1016/j.clnme.2013.12.003, 9, 1, e7-e12, 2014.02, Background & Aims: Fatty acid composition in diet and serum has been linked to depression, but the evidence on this issue is limited among Japanese, who consume large amounts of fish rich in n-3 polyunsaturated fatty acids. We examined the association between fatty acid composition in serum and depressive symptoms in Japanese men and women.
Methods: The subjects were 496 participants aged 21-67 years in a cross-sectional study. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Free, cholesterol ester, and phospholipid fatty acids in serum were measured by gas-liquid chromatography. Multiple logistic regression was used to assess the association between serum fatty acid and depressive symptoms.
Results: A higher free alpha-linolenic acid level was marginally significantly associated with a decreased prevalence of depressive symptoms (CES-D≥16) (P for trend = 0.07). When a cut-off of CES-D≥19 was used, the association was strengthened; the multivariable-adjusted odds ratios (95% confidence interval) of depressive symptoms for the lowest through highest tertile of alpha-linolenic acid levels were 1.00 (reference), 0.49 (0.29-0.84), and 0.47 (0.26-0.83), respectively (P for trend = 0.007). A higher n-6 PUFA in cholesterol esters and free linoleic acid were also significantly associated with a decreased prevalence of depressive symptoms (CES-D≥19) (P for trend = 0.03 and 0.048, respectively). The other polyunsaturated fatty acids including marine-derived n-3 PUFA were not associated with depressive symptoms.
Conclusions: Fatty acid composition with high levels of serum alpha-linolenic and linoleic acids might be protectively associated with depressive symptoms in Japanese adults.
|21.||Yasutake Tanaka, Koji Nagao, Hideaki Nakagiri, Toshirou Nagaso, Yasue Iwasa, Haruhiko Mori, Makoto Asahina, katsumi imaizumi, MASAO SATO, Unavailability of liver triacylglycerol increases serum cholesterol concentration induced by dietary cholesterol in exogenously hypercholesterolemic (ExHC) rats, Lipids in Health and Disease, 10.1186/1476-511X-13-19, 13, 19-30, 2014.01, Background
Exogenously hypercholesterolemic (ExHC) rats develop hypercholesterolemia and low hepatic triacylglycerol (TAG) levels when dietary cholesterol is loaded. The responsible gene Smek2 was identified via linkage analysis using the original strain Sprague–Dawley (SD) rats. In this study, we compared SD and ExHC rats to investigate a relationship between hypercholesterolemia and the low hepatic TAG levels observed in ExHC rats.
Male 4-weeks-old ExHC and SD rats were fed a 1% cholesterol diet for 1 week. Serum and liver parameters were analyzed. Gene expression and enzyme activities related to TAG metabolism were also assessed.
We reproducibly observed higher serum cholesterol and lower hepatic TAG levels in ExHC rats than in SD rats. Golgi apparatus in the livers of ExHC rats secreted β-very-low-density lipoprotein (β-VLDL) that had higher cholesterol ester (CE) and lower TAG content than those in the β-VLDL secreted by SD rats. Gene expression related to fatty acid and TAG synthesis in ExHC rats was lower than that in SD rats. Enzymatic activities for fatty acid synthesis were also relatively lower in ExHC rats. Moreover, the fatty acid composition of hepatic and serum CE in ExHC rats showed that these CEs were not modified after secretion from the liver despite the similar activities of serum lecithin-cholesterol acyltransferase (LCAT) in ExHC rats to those in SD rats.
Low production of liver TAG and secretion of CE-rich, TAG-poor β-VLDL without modification by LCAT in the circulation contributed to hypercholesterolemia induced by dietary cholesterol in ExHC rats.
|22.||Yukio Kadooka, MASAO SATO, Akihiro Ogawa, Masaya Miyoshi, Hiroshi Uenishi, Hitomi Ogawa, Ken Ikuyama, Masatoyo Kagoshima, Takashi Tsuchida, Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomized controlled trial, British Journal of Nutrition, 10.1017/S0007114513001037, 110, 9, 1696-1703, PMID: 23614897, 2013.10, Consumption of fermented milk (FM) containing a probiotic, Lactobacillus gasseri SBT2055 (LG2055), previously showed a reduction in abdominal adiposity in a randomised controlled trial (RCT) using FM with 108 colony-forming units (cfu) of LG2055/g. However, whether the effectiveness is observed at lower concentrations, the recommended minimum or intermediate levels of probiotics (106 or 107cfu/g, respectively), remains to be examined. A multi-centre, double-blind, parallel-group RCT was conducted using 210 healthy Japanese adults with large visceral fat areas (80·2-187·8 cm2). They were balanced for their baseline characteristics and randomly assigned to three groups receiving FM containing 107, 106 or 0 (control) cfu LG2055/g of FM, and were asked to consume 200 g FM/d for 12 weeks. Abdominal visceral fat areas, which were determined by computed tomography, at week 12, changed from baseline by an average of - 8·5 % (95 % CI - 11·9, - 5·1; P< 0·01) in the 107 dose group, and by - 8·2 % (95 % CI - 10·8, - 5·7; P< 0·01) in the 106 dose group. Other measures including BMI, waist and hip circumferences, and body fat mass were also significantly decreased from baseline at week 12 in both groups; interestingly, the cessation of taking FM for 4 weeks attenuated these effects. In the control group, none of these parameters significantly decreased from baseline. These findings demonstrate that consumption of LG2055 at doses as low as the order of 108cfu/d exhibited a significant lowering effect on abdominal adiposity, and suggest that constant consumption might be needed to maintain the effect..|
|23.||Ngoc Minh Pham, Shamima Akter, Kayo Kurotani, Akiko Nanri, Masao Sato, Hitomi Hayabuchi, Kazuki Yasuda, Tetsuya Mizoue, Green tea and coffee consumption is inversely associated with depressive symptoms in a Japanese working population, Public Health Nutrition, org/10.1016/j.psychres.2012.04.040, 9, 1, PMID: 23453038, Epub ahead of print, 2013.07, Although several studies have reported an association between blood folate concentrations and
depressive symptoms, few studies have prospectively examined the association. This study aimed to
investigate the cross-sectional and prospective associations between serum folate concentrations and
depressive symptoms among Japanese. We analysed data among 545 subjects who participated in a
health survey at the time of periodic check-up in 2009 for a cross-sectional association and among 272
subjects without depressive symptoms at baseline (in 2006) who responded to both baseline (2006)
and follow-up (2009) surveys for prospective association. Depressive symptoms were assessed using
the Center for Epidemiologic Studies Depression (CES-D) scale. In a cross-sectional analysis, serum
folate concentrations were significantly associated with a decreased prevalence of depressive symptoms
(CES-D scale of Z16). Moreover, serum folate concentrations at baseline were significantly
inversely associated with depressive symptoms after 3 years; the multivariate-adjusted odds ratios
(95% confidence intervals) of depressive symptoms for the lowest through highest tertile categories of
serum folate concentrations were 1.00 (reference), 0.66 (0.29–1.52) and 0.40 (0.16–0.99) (P for
trend¼0.047). Our findings suggest that a higher serum folate may be associated with decreased risk
of depressive symptoms in Japanese..
|24.||Ayami Kume, Kayo Kurotani, MASAO SATO, Yuko Ejima, Ngoc Minh Pham, Akiko Nanri, Keisuke Kuwahara, Tetsuya Mizoue, Polyunsaturated fatty acids in serum and homocysteine concentrations in Japanese men and women: a cross-sectional study, Nutrition & Metabolism, 10.1186/1743-7075-10-41, 10, 1, Article NO. 41, 2013.07, Background: Supplementation studies have suggested a role of n-3 polyunsaturated fatty acids
(PUFAs) in homocysteine metabolism, but the evidence is limited and inconsistent among studies
that measured blood levels of n-3 and n-6 PUFAs. We examined the association between blood
levels of PUFAs and homocysteine in Japanese men and women.
Methods: The subjects were 496 employees (290 men and 206 women) of 2 municipal offices in
Japan. Fatty acid composition in serum phospholipids and cholesterol ester (CE) was measured
using gas-liquid chromatography. Multiple regression was used to calculate means of homocysteine
concentrations according to PUFA tertile with adjustment for potential confounders.
Results: Serum homocysteine concentration decreased with increasing levels of total n-3 PUFA,
eicosapentaenoic acid and docosahexaenoic acid (DHA) in serum phospholipids and CE with
adjustment for age, sex and workplace. However, only DHA in serum phospholipids remained
statistically significant after additional adjustment for other potential confounders including serum
folate (P-trend = 0.04). N-6 PUFAs were not significantly associated with homocysteine
Conclusions: Higher proportion of DHA in serum phospholipids may be associated with lower
homocysteine concentrations in Japanese men and women..
|25.||Akiko Nanri, Minh N Pham, Kayo Kurotani, Ayami Kume, Keisuke Kuwahara, MASAO SATO, Hitomi Hayabuchi, Tetsuya Mizoue, Serum pyridoxal concentrations and depressive symptoms among Japanese adults: results from a prospective study, European Journal of Clinical Nutrition, 10.1038/ejcn.2013.115, PMID: 23801094, 2013.07, BACKGROUND/OBJECTIVE: Vitamin B6 is suggested to play a protective role against depression. However, the association between vitamin B6 intake and depression remains inconclusive, and few studies have examined the relationship between circulating vitamin B6 concentrations and depressive symptoms. Here, we investigated the cross-sectional and prospective associations between serum pyridoxal concentrations and depressive symptoms among Japanese workers.
SUBJECTS/METHODS: Participants were 422 municipal employees (aged 21-67 years) who participated in a baseline survey in 2006 for cross-sectional analysis, and 210 subjects without depressive symptoms at baseline (2006) who completed both baseline and follow-up (2009) surveys for prospective analysis. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regression analysis was used to estimate the odds ratio of depressive symptoms (CES-D scale of ≥19) according to tertile of serum pyridoxal with adjustment for potential confounding variables.
RESULTS: In the cross-sectional analysis, serum pyridoxal concentrations were significantly associated with a decreased prevalence of depressive symptoms (P for trend = 0.03); the multivariable-adjusted odds ratio of depressive symptoms for the highest tertile of pyridoxal was 0.54 (95% confidence interval 0.30-0.96) compared with the lowest tertile. In longitudinal analyses, higher serum pyridoxal concentrations at baseline were associated with a trend towards reduced depressive symptoms after three years; the multivariable-adjusted odds ratio of depressive symptoms for the highest versus the lowest tertile of pyridoxal concentration was 0.55 (95% confidence interval 0.13-2.32).
CONCLUSIONS: A higher vitamin B6 status may be associated with a decreased risk of depressive symptoms in Japanese..
|26.||Keisuke Kuwahara, Akiko Nanri, Minh N Pham, MASAO SATO, Kayo Kurotani, Kazuaki Kawai, Hiroshi Kasai, Tetsuya Mizoue, Serum vitamin B6, folate, and homocysteine concentrations and oxidative DNA damage in Japanese men and women
, Nutrition, 10.1016/j.nut.2013.03.014, 29, 10, 1219-1223, 2013.07.
|27.||Akter, S, Kurotani, K, Nanri, A., Pham, N.M, MASAO SATO, Hayabuchi, H., Mizoue, T, Dairy consumption is associated with decreased insulin resistance among the Japanese, Nutrition Research, 10.1016/j.nutres.2013.01.009, 33, 4, 286-292, 2013.04, Beneficial effects of dairy consumption in preventing obesity and metabolic syndrome have been suggested, but the association between dairy intake and insulin resistance (IR) is not clear. To test the hypothesis that higher dairy consumption is associated with lower insulin resistance, the authors investigated the association between dairy intake (taking fat content into consideration) and markers of IR in a Japanese working population. A cross-sectional study was conducted in 2009 among 496 subjects aged 20-68 years who participated in a health survey during a periodic checkup. Dairy consumption was assessed using a validated brief dietary history questionnaire. Multiple regression analysis was used to assess the association between fasting serum insulin, plasma glucose, and the homeostatic model assessment of IR (HOMA-IR) and dairy consumption with adjustment for potential confounding variables. The subjects in the highest quartile for total dairy intake showed the lowest mean IR markers compared to those in other categories, although the difference was not statistically significant. Intake of full-fat dairy products was inversely associated with HOMA-IR (P for trend = 0.02). The multivariable adjusted mean HOMA-IR values (with 95% confidence intervals) for the four groups, from those who consumed the fewest to those who consumed the most servings of full-fat dairy products, were 1.04 (0.96-1.12), 1.04 (0.96-1.13), 1.00 (0.91-1.08), and 0.86 (0.76-0.96), respectively. Low-fat dairy intake was not significantly associated with any IR markers. The results suggest that the consumption of full-fat dairy products may be associated with lower IR among Japanese adults..|
|28.||Ngoc Minh Phama, Akiko Nanri, Siyan Yi, Kayo Kurotani,, Shamima Akter, Leng Huat Foo, Nobuo Nishi, MASAO SATO, Hitomi Hayabuchi, Tetsuya Mizoue, Serum ferritin is associated with markers of insulin resistance in Japanese men but not in women, Metabolism: Clinical and Experimental, 10.1016/j.metabol.2012.07.025 , 62, 4, 561-567, 2013.04, OBJECTIVE: Several epidemiological studies have reported that high concentrations of circulating ferritin, a marker of iron stores, are related to insulin resistance (IR); however, questions remain regarding inconsistent data between Asian men and women and the inadequate consideration of potential confounding effects on the relationship between ferritin and IR. Our aim was to examine the relationship between serum ferritin concentrations and IR markers in the Japanese population. MATERIALS/METHODS: We analyzed data (n=493) from a cross-sectional survey conducted in 2009 among a Japanese working population aged 20-68years. Fasting serum ferritin and insulin levels and fasting plasma glucose levels were determined, and the homeostatic model assessment of IR (HOMA-IR) was calculated. Multiple regression analysis was performed with adjustments for demographic and lifestyle factors, body mass index and serum C-reactive protein. RESULTS: Fasting insulin and HOMA-IR significantly increased with increasing levels of serum ferritin after adjustment for covariates in men (P for trend=.005 and .001, respectively). Compared with men in the lowest tertile of serum ferritin, those in the highest tertile had a 24% higher HOMA-IR score. Additional data suggested a positive association between iron intake and HOMA-IR (P for trend=.07) in men. Neither serum ferritin nor iron intake was related to IR markers in women, even in postmenopausal women. CONCLUSIONS: Serum ferritin concentrations were positively associated with fasting insulin and HOMA-IR in men but not in women, suggesting an important role of iron storage in the pathogenesis of IR in Japanese men..|
|29.||Ngoc Minh Pham, Shamima Akter, Kayo Kurotani, Akiko Nanri, MASAO SATO, Hitomi Hayabuchi, Kazuki Yasuda, Tetsuya Mizoue, Serum 25-hydroxyvitamin D and markers of insulin resistance in a Japanese working population, European Journal of Clinical Nutrition, 10.1038/ejcn.2012.169, 66, 12, 1323-1328, PMID: 23093338, 2012.12, Background/Objectives:The association between vitamin D status and insulin resistance (IR) has been less studied among Asians, and it remains elusive whether calcium could modify such an association. We examined the association of serum 25-hydroxyvitamin D (25(OH)D) concentrations with IR markers and the potential effect modification by calcium intake among a Japanese population.
Subjects/Methods:The authors analyzed data (n=494) from a cross-sectional survey conducted in 2009 among a Japanese working population aged 20–68 years. Fasting serum 25(OH)D and insulin, as well as fasting plasma glucose were determined, and homeostatic model assessment of IR (HOMA-IR) was calculated. Calcium intake was assessed using a validated diet history questionnaire. Multiple linear regression was done with adjustment of potential confounding variables.
Results:Fasting insulin and HOMA-IR were significantly inversely associated with 25(OH)D concentration across quartiles of 25(OH)D after fully adjusting for covariates (Ptrend=0.04 and 0.02, respectively). Across clinically relevant categories of 25(OH)D, compared with participants in the vitamin D sufficiency group, those in the vitamin D insufficiency group had a 5% higher HOMA-IR score, and those in the hypovitaminosis D group had an 18% higher HOMA-IR score (Ptrend=0.01). In an analysis by calcium intake, the HOMA-IR score was highest among participants with both a low calcium intake and lowest 25(OH)D concentrations, with significant inverse trend being observed in the group with lower calcium intake (Ptrend=0.02).
Conclusions:Our findings suggest that low vitamin D status is associated with IR among Japanese adults..
|30.||Akiko Nanri, Hitomi Hayabuchi, Masanori Ohta, MASAO SATO, Norio Mishima, Tetsuya Mizoue, Serum folate and depressive symptoms among Japanese men and women: a cross-sectional and prospective study, Psychiatry Research, 10.1016/j.psychres.2012.04.040, 200, 2-3, 349-353, PubMed ID: 22682152, 2012.12, Although several studies have reported an association between blood folate concentrations and depressive symptoms, few studies have prospectively examined the association. This study aimed to investigate the cross-sectional and prospective associations between serum folate concentrations and depressive symptoms among Japanese. We analyzed data among 545 subjects who participated in a health survey at the time of periodic checkup in 2009 for cross-sectional association and among 272 subjects without depressive symptoms at baseline (in 2006) who responded to both baseline (2006) and follow-up (2009) surveys for prospective association. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. In a cross-sectional analysis, serum folate concentrations were significantly associated with a decreased prevalence of depressive symptoms (CES-D scale of ≥16). Moreover, serum folate concentrations at baseline were significantly inversely associated with depressive symptoms after three years; the multivariate-adjusted odds ratios (95% confidence intervals) of depressive symptoms for the lowest through highest tertile categories of serum folate concentrations were 1.00 (reference), 0.66 (0.29-1.52), and 0.40 (0.16-0.99) (P for trend = 0.047). Our findings suggest that higher serum folate may be associated with decreased risk of depressive symptoms in Japanese..|
|31.||Bungo Shirouchi, Nakamura Y, Furukawa Y, Shiraishi A, Tomoyori H, katsumi imaizumi, MASAO SATO, Ezetimibe inhibits lymphatic transport of esterified cholesterol but not free cholesterol in thoracic lymph duct-cannulated rats., Cardiovascular Drugs and Therapy, 10.1007/s10557-012-6403-3, 26, 5, 427-431, 2012.10, [URL], Purpose Ezetimibe has been shown to inhibit dietary choles- terol absorption in animal models and humans, but studies on lymphatic lipid transport have not yet been performed. Rats subjected to permanent lymph duct cannulation were used to investigate the effects of ezetimibe on lipid transport. Methods Rats were fed diets with and without ezetimibe (5.0 mg/kg), and their lymph was collected after feeding to quantify lymphatic lipid levels. Total cholesterol content in the intestinal mucosa was also measured.
Results Rats that consumed ezetimibe had significantly lower lymphatic total cholesterol transport with the reduction of esterified cholesterol transport. According to the calculation based on cholesterol consumption, ezetimibe reduced the total cholesterol lymphatic recovery rate by 54 %. We also deter- mined that ezetimibe significantly reduced the total cholester- ol content in the intestinal mucosa.
Conclusion This is the first direct evidence that ezetimibe inhibits esterified but not free cholesterol lymphatic transport in thoracic duct-cannulated rats. The results also indicate that ezetimibe is not involved in the lymphatic transport of triacyl- glycerols, phospholipids, or α-tocopherol..
|32.||Masako Iwamoto, Katsumi Imai, Hideaki Ohta, Bungo Shirouch and Masao Sato, Supplementation of highly concentrated beta-cryptoxanthin in a satsuma mandarin beverage improves adipocytokine profiles in obese Japanese women, Lipids in Health and Disease, 10.1186/1476-511X-11-52, 11, 1, 52, 2012.09, Background: Serum β-cryptoxanthin levels are lower in overweight subjects than in normal subjects. Abnormalities of adipocytokine profiles in obesity subjects have been reported. There are several reports that serum β-cryptoxanthin levels in them were relatively lower than normal subjects.
Objective: We hypothesize that supplementation of highly concentrated β-cryptoxanthin improves serum adipocytokine profiles in obese subjects. This study tested the association between β-cryptoxanthin intake and serum adipocytokine levels.
Methods: An intervention study consisted of a 3-week long before-and-after controlled trial, where β-cryptoxanthin (4.7 mg/day) was given to 17 moderately obese postmenopausal women.
Results: The results indicated no significant changes in body weight or body mass index (BMI). Serum β-cryptoxanthin levels increased significantly by 4-fold. Serum high molecular weight (HMW)-adiponectin levels increased significantly, while serum plasminogen activator inhibitor (PAI)-1 levels decreased.
Conclusions: We concluded that increasing the intake of β-cryptoxanthin to approximately 4 mg per day for 3 weeks may have beneficial effects on the serum adipocytokine status and consequently alleviate progression of metabolic syndrome.
|33.||Kayo Kurotani, MASAO SATO, Yuko Ejima, Nanri, A., Yi, S., Pham, N.M, Akter, S., Poudel-Tandukar, K., Kimura, Y., katsumi imaizumi, High levels of stearic acid, palmitoleic acid, and dihomo-gamma-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance, Nutrition Research, org/10.1016/j.nutres.2012.07.004, 32, 9, 669-675, 2012.07, The association of fatty acid composition with insulin resistance and type 2 diabetes has been reported in Western populations, but there is limited evidence of this association among the Japanese, whose populace consume large amounts of fish. To test the hypothesis that high palmitic, palmitoleic, and dihomo-gamma-linolenic acids and low linoleic and n-3 fatty acids are associated with higher insulin resistance among the Japanese, the authors investigated the relationship between serum fatty acid composition and serum C-peptide concentrations in 437 Japanese employees, aged 21-67 years, who participated in a workplace health examination. Serum cholesterol ester and phospholipid fatty acid compositions were measured by gas-liquid chromatography. Desaturase activity was estimated by fatty acid product-to-precursor ratios. A multiple regression was used to assess the association between fatty acid and C-peptide concentrations. C-peptide concentrations were associated inversely with linoleic acid levels in cholesterol ester and phospholipid (P for trend = 0.01 and 0.02, respectively) and positively with stearic and palmitoleic acids in cholesterol ester (P for trend = 0.02 and 0.006, respectively) and dihomo-gamma-linolenic acid in cholesterol ester and phospholipid (P for trend <0.0001 for both). C-peptide concentrations were not associated with n-3 polyunsaturated fatty acids. C-peptide concentrations significantly increased as delta-9-desaturase (16:1 n-7/16:0; D9D-16) and delta-6-desaturase (18:3 n-6/18:2 n-6; D6D) increased (P for trend = 0.01 and 0.03, respectively) and delta-5-desaturase (20:4 n-6/20:3 n-6; D5D) decreased (P for trend = 0.004). In conclusion, a fatty acid pattern with high levels of serum stearic, palmitoleic, or dihomo-gamma-linolenic acids; D9D-16 or D6D activities; and low levels of serum linoleic acid or D5D activity might be associated with higher insulin resistance in Japanese adults..|
|34.||Yasumi Kimura, Masao Sato, Kayo Kurotani, Akiko Nanri, Kazuaki Kawai, Hiroshi Kasai, Katsumi Imaizumi, Tetsuya Mizoue, PUFAs in serum cholesterol ester and oxidative DNA damage in Japanese men and women, American Journal of Clinical Nutrition, 10.3945/ajcn.111.030817, 95, 1209-1214, 2012.05, Background: PUFAs are susceptible to lipid peroxidation and play a role in inflammation, both of which can induce oxidative stress. However, the relation of PUFA to oxidative DNA damage in humans is elusive.
Objective: We examined the association between concentrations of circulatory PUFAs and urinary 8-oxo-7,8-dihydroguanine (8-oxoGua) in Japanese men and women.
Design: The subjects were 495 participants (290 men and 205 women) in a cross-sectional study in 2 municipal offices in Japan. Serum cholesterol ester (CE) and phospholipid fatty acid composition were measured by gas-liquid chromatography. Urinary 8-oxoGua concentrations were measured by HPLC, and 8-oxoGua values for each tertile of PUFA after adjustment for covariates were calculated by multiple regression.
Results: Urinary 8-oxoGua concentrations increased with increasing concentrations of n–3 (omega-3) PUFAs, EPA, and DHA in serum CE (P-trend = 0.001, 0.01, and 0.009, respectively), whereas they decreased with increasing concentrations of n–6 PUFAs and linoleic acid (P-trend = 0.02 and 0.051, respectively).
Conclusion: Oxidative DNA damage may be greater with higher concentrations of long-chain n–3 PUFAs but lower with higher concentrations of n–6 (omega-6) PUFAs.
|35.||城内文吾、中村有理、古川裕美子、友寄博子、今泉勝己、佐藤匡央, 食事脂質のリンパ輸送に及ぼすコレステロール吸収阻害剤の影響, 脂質生化学研究, 54, 173-175, 2012.05.|
|36.||田中愛健、永尾晃治、佐藤匡央、今泉勝己, 食事誘導性高コレステロール血症モデルラットにおけるトリアシルグリセロール代謝, 脂質生化学研究, 54, 196-199, 2012.05.|
|37.||Masaki KATO, Yusuke ITO, Yasutake TANAKA, Masao SATO, Katsumi IMAIZUMI, Nao INOUE, and Ikuo IKEDA, SHRSP/Izm and WKY/NCrlCrlj Rats Having Missense Mutation in Abcg5 Deposited Plant Sterols in the Body, But not Change Their Biliary Secretion and Lymphatic Absorption --- Comparison with Jcl:Wistar and WKY/Izm Rats , Bioscience, Biotechnology, and Biochemistry, 2012.03.|
|38.||Tadateru HAMADA, Mariko KUDO, Masao SATO, Nao INOUE, Koji NAGAO, Katsumi IMAIZUMI and Ikuo IKEDA, Effect of a Liver X Receptor Agonist on Deposition and Lymphatic Absorption of Plant Sterols in Stroke-Prone Spontaneously Hypertensive Rats Having a Mutation in ATP-Binding Cassette Transporter G5, Bioscience, Biotechnology, and Biochemistry, 10.1271/bbb.110554, 75, 12, 2359-2363, 2012.03.|
|39.||Kalpana Poudel-Tandukara, Masao Sato, Yuko Ejima, Akiko Nanric, Yumi Matsushitac, Katsumi Imaizumib, Tetsuya Mizoue, Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women, Atherosclerosis, 0.1016/j.atherosclerosis.2011.11.012 , 220, 2, 520-524, 2012.02, Background: Although fatty acid composition in serum and desaturase activity, which alters serum fatty acid composition, has been associated with C-reactive protein (CRP) concentration in Western populations, no study has been carried out in non-Western populations. We examined the association of serum fatty acids and estimated desaturase activity with CRP concentrations in Japanese men and women. Methods: Subjects were 489 Japanese municipal employees aged 21-67 years who participated in a survey at the time of a periodic health check-up. Serum high-sensitivity CRP concentrations were measured using the latex agglutination nephelometry method. Fatty acid composition was measured in serum cholesteryl esters and desaturase activities by fatty acid product-to-precursor ratios. Relationships were assessed using multiple regression. Results: Serum CRP concentration was positively associated with palmitic acid (P for trend = 0.002) and inversely with alpha-linolenic acid (P for trend = 0.01) in men, and positively with dihomo-gamma-linolenic acid (P for trend in men or women = 0.01) and inversely with delta-5-desaturase (20:4n-6/20:3n-6) (P for trend in men and women = 0.05 and 0.002, respectively) in men and women. Conclusions: Low-grade inflammation may be associated with a serum fatty acid pattern of high palmitic acid or low alpha-linolenic acid in men, and of high dihomo-gamma-linolenic acid or low delta-5-desaturase in both sexes..|
|40.||Li-Tao Tong, Yumiko Fujimoto, Naoki Shimizu, Mariko Tsukino, Taiki Akasaka, Yukiko Kato, Wakako Iwamoto, Sawako Shiratake, Katsumi Imaizumi, Masao Sato, Rice α-globulin decreases serum cholesterol concentrations in rats fed a hypercholesterolemic diet and ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice, Food Chemistry, 10.1016/j.foodchem.2011.10.056, 132, 194-200, 2012.01.|
|41.||佐藤匡央、森田有紀子、白石彩、城内文吾, プロバイオティクスによる抗メタボリックシンドローム作用, 生物機能研究, 15, 39-43, 2011.11.|
|42.||Bungo Shirouchi, Sayaka Kawamura, Ryosuke Matsuoka, Sanae Baba, Kazuko Nagata, Sawako Shiratake, Hiroko Tomoyori, Katsumi Imaizumi, and Masao Sato, Dietary guar gum reduces lymph flow and diminishes lipid transport in thoracic duct-cannulated rats, Lipids, DOI: 10.1007/s11745-011-3570-0, 46, 8, 789-793, 2011.08.|
|43.||Masao Sato, Takatoshi Ueda , Kazuko Nagata , Sawako Shiratake , Hiroko Tomoyori , Mitsuo Kawakami , Yukio Ozaki , Hiroshi Okubo , Bungo Shirouchi , Katsumi Imaizumi, Dietary kakrol (Momordica dioica Roxb.) flesh inhibits triacylglycerol absorption and lowers the risk for development of fatty liver in rats, Experimental Biology and Medicine, 10.1258/ebm.2011.011037, 236, 1139-1146, 2011.05.|
|44.||Yukio Kadooka, Akihiro Ogawa, Ken Ikuyama, Masao Sato, The probiotic Lactobacillus gasseri SBT2055 inhibits enlargement of visceral adipocytes and upregulation of serum soluble adhesion molecule (sICAM-1) in rats, International Dairy Journal, 10.1016/j.idairyj.2011.02.001, 2011.04.|
|45.||赤坂泰輝、山田耕路、佐藤匡央, 実験動物用X線CT装置による白色脂肪組織重量の測定, 生物機能研究, 14, 52-56, 2010.11.|
|46.||A Nanri, Y Kimura, Y Matsushita, M Ohta, M Sato, N Mishima, S Sasaki, T Mizoue, Dietary patterns and depressive symptoms among Japanese men and women, European Journal of Clinical Nutrition, 64, 8, 832-839, 2010.08.|
|47.||Yukio Kadooka, Masao Sato, Katsumi Imaizumi, Akihiro Ogawa, Ken Ikuyama, Yoshihito Akai, Masako Okano , Masatoyo Kagoshima, Takashi Tsuchida, Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial, European Journal of Clinical Nutrition, 64, 6, 636-643, 2010.06.|
|48.||Makoto Asahina, Waka Haruyama, Yasuhiro Ichida, Mai Sakamoto, Masao Sato, Katsumi Imaizumi , Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats , Journal of Lipid Research, 50：41-46, 2009.01.|
|49.||Ichiko Miyamoto, Jun Shiono, Jie Liu, Kuniyoshi Shimizu, Masao Sato, Akiko Kukita, Toshio Kukita, Ryuichiro Kondo, Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum, European Journal of Pharmacology , 6002(1), 1-7, 2009.01.|
|50.||E. M. Hamad, M. Sato, K. Uzu, T. Yoshida, H. Kadooka, H. Kawakami, H. Matsuyama, I. A. A. El-Gawaqd, and K. Imaizumi, Milk fermented by Lactobacillus gasseri SBT2055 influences adipocyte size via inhibition of dietary fat absorption in Zucker rats, Br. J. Nutr., 1-9, 2008.08.|
|51.||M. Sato, K. Uzu, T. Yoshida, E. M. Hamad, H. Kawakami, H. Matsuyama, I. A. A. El-Gawaqd, and K. Imaizumi, Effects of milk fermented by Lactobacillus gasseri SBT2055 on adipocyte size in rats,, Br. J. Nutr., 99, 1013-1017, 2007.12.|
|52.||M. Sato, Y. Kawata· K. Erami,· I. Ikeda· K. Imaizumi, LXR agonist increases the lymph HDL transport in rats by promoting reciprocally intestinal ABCA1 and apo A-I mRNA levels, Lipids, 43 (2), 125-131, 2007.12.|
|53.||M. Sato, H. Sato, A. Ogawa, R. Nomura, S. Takashima, H.-J. Bang, H. Matsuoka and K. Imaizumi, Antiatherogenic effect of isoflavones in ovariectomized apolipoprotein E-deficient mice, J. Agr. Food Chem., 55 (22), 8967–8971, 2007.09.|
|54.||K. Shimizu, M. Yamanaka, M. Gyokusen, S. Kaneko, M. Tsutsui, J. Sato. M. Sato, R. Kondo, Estrogen-like Activity and Prevention Effect of Bone Loss in Calcium Deficient Ovariectomized Rats by the Extract of Pleurotus eryngii, Phytother. Res., 20,659-664, 2006.06.|
|55.||M. Asahina, M. Sato , K. Imaizumi, Genetic analysis of diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats, Journal of Lipid Research, 10.1194/jlr.M5000257-JLR200, 46, 10, 2289-2294, 46: 2289-2294, 2005.10.|
主要総説, 論評, 解説, 書評, 報告書等
2018.03～2020.03, 日本農芸化学会, 評議員.
2015.08～2016.06, 西日本機能性食品開発研究会実行委員会, 運営委員.
2015.05～2016.05, 日本栄養・食糧学会, 日本栄養・食糧学会用語解説委員.
2015.05～2016.05, 日本栄養・食糧学会, 中央選挙管理委員.
2014.05～2015.05, 日本栄養・食糧学会 九州･沖縄支部, 幹事.
2010.03～2019.05, 日本栄養・食糧学会, 評議員.
2014.12～2018.02, 日本食品科学工学会西日本支部, 評議員.
2014.08～2015.06, 西日本機能性食品開発研究会実行委員会, 運営委員.
2005.04～2015.03, 日本農芸化学会西日本支部, 評議員.
2009.08～2010.06, 西日本機能性食品開発研究会実行委員会, 運営委員.
2010.08～2011.06, 西日本機能性食品開発研究会実行委員会, 運営委員.
2011.08～2012.06, 西日本機能性食品開発研究会実行委員会, 運営委員.
2012.08～2013.06, 西日本機能性食品開発研究会実行委員会, 運営委員.
2010.05～2012.05, 油脂・コレステロール研究会, 監事.
2012.05～2017.09, 日本栄養・食糧学会, 本部代議委員.
2005.04～2012.03, 九州大学リサーチコア「食の安全と健康な生活の構築」, 幹事.
2005.11～2012.03, 京都大学大学院医学研究科ナショナルバイオリソースプロジェクト-ラット運営委員会, 運営委員.
2005.10, 日本栄養・食糧学会西日本支部, 参与.
2005.01, 日本農芸化学会西日本支部, 幹事.
2002.05～2010.05, コレステロール研究会, 幹事.
2000.10～2008.03, 日本栄養・食糧学会西日本支部, 幹事.
1997.05～1999.05, コレステロール研究会, 幹事.
2018.06.22～2018.06.22, 第5回黒酢研究会, 座長（Chairmanship）.
2018.05.11～2018.05.13, 第72回日本栄養・食糧学会大会, 座長（Chairmanship）.
2017.06.23～2017.06.23, 第4回黒酢研究会, 座長（Chairmanship）.
2017.05.20～2017.05.22, 第71回日本栄養・食糧学会大会, ランチョンセミナー担当委員.
2015.05.16～2015.05.18, 第26回食品産業創造展「機能性食品特別セミナー」, 座長（Chairmanship）.
2015.03.26～2012.03.29, 日本農芸化学会2015年度大会, 座長（Chairmanship）.
2015.03.17～2016.03.19, 日本農芸化学会2016年度大会, 座長（Chairmanship）.
2014.05.30～2014.06.01, 第68回日本栄養・食糧学会大会, 座長（Chairmanship）.
2012.06.07～2012.06.08, 第54回日本脂質生化学会（福岡大会）, 大会実行委員.
2012.06.07～2012.06.08, 第54回日本脂質生化学会, 座長（Chairmanship）.
2012.05.18～2012.05.20, 第66回日本栄養・食糧学会大会, 座長（Chairmanship）.
2012.05.16～2012.05.18, 第22回食品産業創造展「機能性食品特別セミナー」, 座長（Chairmanship）.
2012.03.23～2012.03.25, 日本農芸化学会2012年度大会, 座長（Chairmanship）.
2012.02.03～2012.02.03, 第5回ラットリソースリサーチ研究会, 座長（Chairmanship）.
2011.05.25～2011.05.27, 第21回食品産業創造展「機能性食品特別セミナー」, 座長（Chairmanship）.
2010.11.30～2010.12.03, XVIIIth International Workshop on Genetic Systems in the Rat, Local Organizing Committee.
2010.05.21～2010.05.23, 日本栄養・食糧学会大会, 座長（Chairmanship）.
2009.05.20～2009.05.22, 第63回日本栄養・食糧学会大会, プログラム委員.
2009.03.28～2009.03.30, 2009年度日本農芸化学会大会, 庶務幹事.
2009.03.26～2009.03.28, 日本農芸化学会2009年度大会, 座長（Chairmanship）.
2009.01.24～2009.01.24, 日本農芸化学会西日本支部 支部奨励賞講演会, 座長（Chairmanship）.
2008.11.01～2008.11.02, 日本栄養・食糧学会九州・沖縄支部大会, 座長（Chairmanship）.
2008.09.13～2008.09.14, 日本農芸化学会西日本支部, 座長（Chairmanship）.
2007.09.12～2007.09.13, 平成19年度日本栄養・食糧学会九州・沖縄支部大会, 座長（Chairmanship）.
2007.05.12～2007.05.14, 日本栄養・食糧学会大会, 座長（Chairmanship）.
2007.05.12～2007.05.14, 第61回日本栄養・食糧学会大会, 座長（Chairmanship）.
2006.09.15～2006.09.15, 日本農芸化学会西日本支部、日本栄養・食糧学会九州・沖縄支部合同大会, 座長（Chairmanship）.
2006.07.01～2006.07.01, 第43回化学関連支部合同九州大会, 座長（Chairmanship）.
2006.06.04～2006.06.07, 第48回日本脂質生化学会, 座長（Chairmanship）.
2006.05.16～2006.05.18, 平成18年度日本農芸化学会西日本支部例会, 座長（Chairmanship）.
2006.05.12～2006.05.15, 日本栄養・食糧学会大会, 座長（Chairmanship）.
2006.03.12～2006.03.15, 日本農芸化学会2006年度大会, 座長（Chairmanship）.
2005.11.02～2005.11.02, 日本栄養・食糧学会西日本支部会, 座長（Chairmanship）.
2005.05.11～2005.05.14, 日本栄養・食糧学会大会, 座長（Chairmanship）.
2004.11.09～2004.11.11, 日本栄養・食糧学会西日本支部会, 座長（Chairmanship）.
2004.10.08～2004.10.08, 日本農芸化学会西日本・北海道支部合同大会, 座長（Chairmanship）.
2003.05.13～2003.05.15, 日本栄養食糧学会大会, 事務局幹事.
2003.03.28～2003.03.30, 日本農芸化学会大会, 座長（Chairmanship）.
2002.11.08～2002.11.09, 日本栄養・食糧学会、日本食品科学会西日本支部合同大会, 座長（Chairmanship）.
2002.09.12～2002.09.14, 日本農芸化学会西日本支部大会, 座長（Chairmanship）.
2002.07.22～2002.07.25, 日本栄養・食糧学会大会, 座長（Chairmanship）.
2000.10.12～2000.10.13, 日本農芸化学会、日本栄養・食糧学会、日本食品科学会西日本支部合同大会, 座長（Chairmanship）.
1999.03.28～1999.03.30, 1999年度日本農芸化学会大会, プログラム編成.
2017.05～2022.12, Journal of Nutritional Science and Vitaminology, 国際, 編集委員.
2012.05～2022.12, Journal of Nutritional Science and Vitaminology, 国際, 編集委員.
2014.05～2015.05, Journal of Nutritional Science and Vitaminology/ ACN proceeding, 国際, 編集委員.
2016.01～2022.12, Journal of Nutritional Science and Vitaminology, 国際, 副編集員長.
2010.03～2010.05, 1ヶ月以上, kafrelsheikh大学（エジプト）, Egypt, 日本学術振興会.
2006.07～2008.06, 1ヶ月以上, カイロ大学（エジプト）, Egypt, 外国政府・外国研究機関・国際機関.
2000.01～2002.11, 1ヶ月以上, タンタ大学（エジプト）, Egypt, 日本学術振興会.
飯島藤十郎食品技術賞, 飯島藤十郎記念食品科学振興財団, 2019.04.
食品免疫産業賞, 日本食品免疫学会, 2018.11.
栄養・食糧学会 技術賞, 公益社団法人 日本栄養・食糧学会, 2018.05.
第2回ＨＫ創造性開発賞最優秀賞, 九州大学農学部, 2010.03.
第43回三島海運記念財団学術奨励賞, 三島海運記念財団, 2005.06.
2016年度～2018年度, 基盤研究(B), 代表, 食品中のステロイド化合物とその体内干渉の全体像の把握.
2015年度～2016年度, 挑戦的萌芽研究, 代表, 食事性高コレステロール血症ラットは認知症モデルになりうるか？.
2015年度～2015年度, 基盤研究(B), 分担, 勤労者における糖尿病発症に関するリスクスコアの開発と血中栄養成分の解明.
2014年度～2015年度, 基盤研究(B), 分担, アジア人種の食と腸内フローラと健康に関する調査研究.
2012年度～2014年度, 基盤研究(B), 代表, ラット系統を用いた脂質代謝異常の血中バイオマーカの探索と妥当性の検証.
2010年度～2012年度, 基盤研究(A), 分担, 生体調節ペプチドの科学的基盤構築.
2009年度～2011年度, 基盤研究(B), 分担, 連鎖解析法により同定された食事性高コレステロール血症原因遺伝子の機能解明.
2009年度～2012年度, 基盤研究(B), 分担, 脂肪酸組成が疾病早期バイオマーカー及び気管支ぜん息に及ぼす影響.
2009年度～2011年度, 基盤研究(C), 代表, 食事酸化コレステロール誘導性脂肪肝の発症機構の解明.
2007年度～2010年度, 基盤研究(A), 分担, 血管系疾患予防作用を有するペプチドの網羅的解明.
2006年度～2007年度, 基盤研究(B), 分担, エピジェネティクス系による動脈硬化の制御と食事による介入.
2006年度～2007年度, 基盤研究(C), 分担, 食事及び血清脂質の脂肪酸組成と抑うつに関する職域疫学研究.
2004年度～2005年度, 萌芽研究, 分担, 栄養環境によるエピゼネティックな状態の制御と食品栄養学への展開.
2004年度～2005年度, 基盤研究(B), 分担, 動脈硬化発症・進展の修飾に関与する食品成分の作用機作と予防食品の設計.
2004年度～2005年度, 基盤研究(C), 代表, 食事性高コレステロール血症の遺伝的背景に関する研究.
2002年度～2003年度, 若手研究(B), 代表, 新規脂肪酸Δ6不飽和化酵素分子種の単離・同定とその発現制御に関する研究.
2001年度～2002年度, 基盤研究(B), 分担, 脂質酸化物による動脈硬化発症の分子機構と食品成分による制御.
2000年度～2001年度, 奨励研究(A), 代表, 脂肪酸不飽和化酵素の発現を調節する中間代謝分子の検索.
1999年度～2000年度, 基盤研究(B), 分担, 動脈硬化の発症・進展と酸化ステロール分子種の解析.
1998年度～1999年度, 奨励研究(A), 代表, 食事スフィンゴミエリンによる加齢にともなう脂肪吸収環境の改善.
2015年度～2017年度, 平成27年度農林水産業・食品産業科学技術研究推進事業 [発展融合ステージ] 生物系特定産業技術研究支援センター, 分担, 米油原料用イネの作出と利用に関する研究・開発.
2013年度～2015年度, 平成25年度農林水産業・食品産業科学技術研究推進事業 [発展融合ステージ], 分担, 「難消化性澱粉構造と高水分吸収性を有する変異体米を用いた低カロリー食品の開発」.
2011年度～2013年度, 農林水産技術会議／平成23年度委託プロジェクト研究（農水産物・食品の機能性等を解析・評価するため の基盤技術の開発）, 分担, 米タンパク質の新規生体調節機能性の先導的開発と機構解析.
2009年度～2010年度, 上原, 代表, FAS遺伝子発現のエピジェネティック制御.
2009年度～2013年度, 生物系特定産業技術研究支援センター, 分担, 画期的米油原料用稲の育種・利用に向けた基盤的技術シーズの開発.
2009年度～2009年度, 財団法人旗影会研究助成, 代表, 食事コレステロール酸化物誘導性脂肪肝の卵黄による改善.
2008年度～2008年度, 財団法人旗影会研究助成, 代表, 食事コレステロール酸化物による脂肪肝発症に関する研究.
2007年度～2007年度, 財団法人旗影会研究助成, 分担, 鶏卵黄摂取による脂肪肝の改善効果に関する研究.
2005年度～2005年度, 財団法人三島海運記念財団学術奨励金, 代表, 生活習慣病予防的な食環境形成への展開を目指した、脂質代謝における「刷り込み効果」発現機構の解明.
2005年度～2005年度, TSUNO研究ファンド, 代表, 米タンパク質中の血清コレステロール低下作用を有する成分の探索.
2003年度～2003年度, （社）全日本コーヒー協会 Human Healthに関する『コーヒーの効用』についての助成研究, 分担, コーヒーおよびその成分摂取が動脈硬化モデル動物の脂質代謝に及ぼす影響.
2002年度～2002年度, 財団法人 すかいらーくフードサイエンス研究所平成14年学術研究助成, 代表, 生活習慣病予防的な食環境形成への展開を目指した、脂質代謝における「刷り込み効果」発現機構の解明.
2002年度～2002年度, （社）全日本コーヒー協会 Human Healthに関する『コーヒーの効用』についての助成研究, 分担, コーヒーおよびその成分摂取が動脈硬化モデル動物の脂質代謝に及ぼす影響.
2001年度～2001年度, 財団法人 サッポロ生物科学振興財団 平成13年度（第17回）研究助成, 代表, 脂肪酸不飽和化酵素遺伝子の発現の調節を行う分子の探索.
2000年度～2000年度, 財団法人 森永奉仕会 平成12年度・研究奨励金, 代表, タンパク質のアミノ酸組成による血清コレステロール低下作用に関する研究.
1999年度～1999年度, （財）福岡県産業・科学技術振興財団 テーマ探索・シーズ発掘事業研究助成, 代表, 生活習慣病に関係するバイオマーカーの探索系の構築に関する研究.
1998年度～1998年度, ネスレ科学振興会1998年度一般公募研究助成, 代表, 小腸刷子縁膜と乳脂肪球皮膜との相互作用の解析と乳脂肪吸収促進に関与するこれら膜成分の分子クローニングに関する研究.
1998年度～1998年度, 1998年度（財）糧食研究会研究助成, 代表, 小腸刷子縁膜と乳脂肪球皮膜との相互作用の解析に基づく脂肪球脂質吸収特性の解明.
1996年度～1996年度, 新技術協会平成8年度科学技術特別研究員研究費, 代表, Differencial Dispay 法を用いた病態モデル動物における遺伝子の検索と、それら動物に対する食事の影響.
2015.08～2016.03, 代表, 卵白タンパク質の抗肥満作用に関する研究.
2015.08～2016.07, 代表, 食事成分による高脂血症、脂肪肝の予防及び改善に関する研究.
2015.06～2016.03, 代表, ガゼリ菌SP株の抗炎症･抗酸化作用に関する研究.
2014.08～2015.03, 代表, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2014.06～2015.03, 代表, 米タンパク質の血清コレステロール濃度低下作用の解明.
2013.12～2014.03, 代表, 高LDLコレステロール血症を有するハイリスク高齢患者（75歳以上）に対するエゼチミブのコレステロール吸収・合成，炎症マーカー及び脳心血管イベント発症抑制効果に及ぼす影響(EWTOPIA75-Kyushu).
2013.08～2014.03, 代表, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2013.08～2014.03, 代表, ガセリ菌ＳＰ株の脂質代謝改善作用に関する共同研究.
2012.08～2013.03, 代表, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2012.05～2013.03, 代表, 新規澱粉構造を有する育種素材の選抜と米加工適性評価.
2011.11～2013.03, 代表, ガセリ菌SP株のメタボリックシンドローム改善作用に関する研究.
2011.08～2012.03, 代表, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2010.08～2011.03, 代表, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2009.07～2010.03, 代表, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2008.08～2009.03, 分担, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2008.06～2009.05, 代表, 脂質代謝を改善する鶏卵成分に関する研究.
2008.05～2009.03, 代表, 黒酢の健康機能評価研究.
2018年度, 雪印メグミルク株式会社, 農学研究院研究資金.
2017年度, 雪印メグミルク株式会社, 農学研究院研究資金.
2016年度, 雪印メグミルク株式会社, 農学研究院研究資金.
2015年度, 雪印メグミルク株式会社, 農学研究院研究資金.
2014年度, 雪印メグミルク, ガセリ菌SP株の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2013年度, 雪印メグミルク, ガセリ菌SP株の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2012年度, 雪印メグミルク, ガセリ菌SP株の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2011年度, 雪印メグミルク, ガセリ菌SP株の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2010年度, ＨＫ創造性開発賞最優秀賞賞金, HK創造性開発研究資金.
2010年度, バイエル薬品, コレステロール吸収阻害剤の酸化コレステロール動態への影響.
2010年度, 雪印メグミルク株式会社, L.gasseri菌の内臓脂肪蓄積抑制作用の発現機構に関する研究.
2010年度, バイエル薬品, コレステロール吸収阻害剤の酸化コレステロール動態への影響.
2009年度, バイエル薬品, コレステロール吸収阻害剤の酸化コレステロール動態への影響.
2008年度, 旗影会, 食事コレステロール酸化物による脂肪肝発症に関する研究.
2008年度, バイエル薬品, コレステロール吸収阻害剤の酸化コレステロール動態への影響.
2007年度, ロッテ, カカオの香りと摂食行動.
2007年度, 築野食品, TUNOファンド.