Kyushu University Academic Staff Educational and Research Activities Database
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toshihiro - ona Last modified date:2019.06.09

Associate Professor / Sustainable Resources Science
Department of Agro-environmental Sciences
Faculty of Agriculture


Graduate School
Undergraduate School


E-Mail
Homepage
hhtp://ffpsc.agr.kyushu-u.ac.jp/chem
forest chemistry and biochemistry .
Phone
092-802-4663
Fax
092-802-4663
Academic Degree
phD in engineering
Country of degree conferring institution (Overseas)
No
Field of Specialization
biological resources chemistry
Total Priod of education and research career in the foreign country
00years00months
Outline Activities
Recycling waste paper (pulp fiber) is equally as important as recycling forest resources. Interest in environmental issues such as conserving energy and cutting carbon dioxide emissions has increased in recent years, as has demand for a higher proportion of waste paper (pulp fiber) to be collected and re-used. Many pulp and paper companies have responded to this demand in various ways including increasing the proportion of waste paper used. However, the paper manufacturing process degrades the pulp fiber, so that after repeated recycling, problems such as paper brightness and strength arise. These factors present an obstacle to increasing the proportion of waste paper used. Large quantities of agents are added to increase the strength of the paper and for other purposes during paper processing to solve these problems, but such agents also have their limits and adding chemicals is environmentally unsound. Under these circumstances, it is essential to drastically change the raw materials used and to produce (plant) and utilize forest resources more capable of withstanding recycling. Such actions would unite the recycling of forest with the recycling of waste paper and would establish the recycling of raw materials and a society with resource recycling systems.We established selection techniques for trees with high performance for paper recycling using a Raman spectroscopical method. The materials were measured by a Raman spectrometer. Multivariate analysis of these results, the data of the anatomical features of wood fibers, and the chemical composition and strength of the paper after it had been recycled a specific number of times.
A rapid and pathway-based screening method is desired for the evaluation of therapeutic potentials and mechanisms of the anticancer drugs even designed using genomics because of the complexities of cancer cell and time-consuming conventional cell survival measurement providing no mechanism. We develop the non-label quantitative screening method and instrumentation of apoptosis via mitochondrial pathway for anticancer drugs of cell membrane mediating types by the cell reaction analysis of living pancreatic cancer cell cultured on a sensor chip using a surface plasmon resonance (SPR) sensor.
Research
Research Interests
  • Developement of cancer discrimination adn cancer drug efficacy evaluation aiming personal cancer therapy
    keyword : cancer
    2006.10The objectives of the project is the development of high sensitivity method and instrumentation for personal therapy of cancer cure, which will provide the selection of cancer drugs by the direct measurement of personal cancer cells with drug efficacy. Because cancer drug efficacy is significantly different among patients. We developed the method and prototype of instrumentation for cancer drug selection by living pancreatic cancer cells. In this project, we will construct the data base using various cancer cells for the practical instrumentation. Furthermore, our final targets are the development of product level prototype for cancer therapeutic efficacy prediction including cancer discrimination for practical use..
  • Developement of high sensitivity combined device aiming cancer therapy
    keyword : cancer
    2002.01A rapid and pathway-based screening method is desired for the evaluation of therapeutic potentials and mechanisms of the anticancer drugs even designed using genomics because of the complexities of cancer cell and time-consuming conventional cell survival measurement providing no mechanism. We develop the non-label quantitative screening method and instrumentation of apoptosis via mitochondrial pathway for anticancer drugs of cell membrane mediating types by the cell reaction analysis of living pancreatic cancer cell cultured on a sensor chip using a surface plasmon resonance (SPR) sensor..
  • Developement of forest resources possessing high paper reclability
    keyword : resource recycling, forest, CO2, pulp and paper
    1998.12Recycling waste paper (pulp fiber) is equally as important as recycling forest resources. Interest in environmental issues such as conserving energy and cutting carbon dioxide emissions has increased in recent years, as has demand for a higher proportion of waste paper (pulp fiber) to be collected and re-used. Many pulp and paper companies have responded to this demand in various ways including increasing the proportion of waste paper used. However, the paper manufacturing process degrades the pulp fiber, so that after repeated recycling, problems such as paper brightness and strength arise. These factors present an obstacle to increasing the proportion of waste paper used. Large quantities of agents are added to increase the strength of the paper and for other purposes during paper processing to solve these problems, but such agents also have their limits and adding chemicals is environmentally unsound. Under these circumstances, it is essential to drastically change the raw materials used and to produce (plant) and utilize forest resources more capable of withstanding recycling. Such actions would unite the recycling of forest with the recycling of waste paper and would establish the recycling of raw materials and a society with resource recycling systems.We established selection techniques for trees with high performance for paper recycling using a Raman spectroscopical method. The materials were measured by a Raman spectrometer. Multivariate analysis of these results, the data of the anatomical features of wood fibers, and the chemical composition and strength of the paper after it had been recycled a specific number of times..
Current and Past Project
  • The objectives of the project is the development of high sensitivity method and instrumentation for personal therapy of cancer cure, which will provide the selection of cancer drugs by the direct measurement of personal cancer cells with drug efficacy. Because cancer drug efficacy is significantly different among patients. We developed the method and prototype of instrumentation for cancer drug selection by living pancreatic cancer cells. In this project, we will construct the data base using various cancer cells for the practical instrumentation. Furthermore, our final targets are the development of product level prototype for cancer therapeutic efficacy prediction including cancer discrimination for practical use.
  • A rapid and pathway-based screening method is desired for the evaluation of therapeutic potentials and mechanisms of the anticancer drugs even designed using genomics because of the complexities of cancer cell and time-consuming conventional cell survival measurement providing no mechanism. We develop the non-label quantitative screening method and instrumentation of apoptosis via mitochondrial pathway for anticancer drugs of cell membrane mediating types by the cell reaction analysis of living pancreatic cancer cell cultured on a sensor chip using a surface plasmon resonance (SPR) sensor.
  • The first objectives is to establish a new resource recycling sysytem to construct an effective carbon loop by liquidation of forest wastes using reactive pyrolysis. Forest wastes contain high content of water and usually requires drying samples before pyrolysis to increase oil yield. In this research, aquous agents were examined as efficeint reactive agents in pyrolysis for the wet samples. On the other hand, the sample containing significant amount of lignin as forest wastes, the formation of char during pyrolysis is occured. However, we certified that both the formation of char could be minimized using reactive-pyrolysis and formed pyrolyzates species could be controled. The femt puls laser and ESR is combined with miniture pyrolyzer to controle the formed oil species as the second objectives.
  • Recycling waste paper (pulp fiber) is equally as important as recycling forest resources. Interest in environmental issues such as conserving energy and cutting carbon dioxide emissions has increased in recent years, as has demand for a higher proportion of waste paper (pulp fiber) to be collected and re-used. Many pulp and paper companies have responded to this demand in various ways including increasing the proportion of waste paper used. However, the paper manufacturing process degrades the pulp fiber, so that after repeated recycling, problems such as paper brightness and strength arise. These factors present an obstacle to increasing the proportion of waste paper used. Large quantities of agents are added to increase the strength of the paper and for other purposes during paper processing to solve these problems, but such agents also have their limits and adding chemicals is environmentally unsound. Under these circumstances, it is essential to drastically change the raw materials used and to produce (plant) and utilize forest resources more capable of withstanding recycling. Such actions would unite the recycling of forest with the recycling of waste paper and would establish the recycling of raw materials and a society with resource recycling systems.We established selection techniques for trees with high performance for paper recycling using a Raman spectroscopical method. The materials were measured by a Raman spectrometer. Multivariate analysis of these results, the data of the anatomical features of wood fibers, and the chemical composition and strength of the paper after it had been recycled a specific number of times.
Academic Activities
Membership in Academic Society
  • Japanese Society of Anti-Aging Medicine
  • International Congress on Nutrition and Integrative Medicine
  • The Japanese Pharmacological Society
  • Japanese Society for Alternatives to Animal Experiments
  • Japanese Society for Food Science and Technology
  • Japanese Cancer Association
  • The Japan Society for Analytical Chemistry
Awards
  • Hot Article Award
    Johzuka, J., Ona, T. and Nomura, M.
    One Hour in vivo-like phenotypic screening system for anti-cancer drugs using a high precision surface plasmon resonance device.
    Analytical Sciences, Vol. 34 (10): 1189-1194 (2018).
  • Award for contribution to inhibit animal tests.
  • Hot Article Award
    Nishijima, H., Kosaihira, A., Shibata, J. and Ona, T.
    Development of signaling echo method for cell-based quantitative efficacy evaluation of anti-cancer drugs in apoptosis without drug presence using high-precision surface plasmon resonance sensing
    Analytical Science, Vol. 26 (5): 529-534 (2010).
Educational
Educational Activities
Graduation Thesis Research
Forest Life Chemistry
Tutorials on Sustainable Bioresources Science
Tutorials Excercies on Sustainable Bioresources Science