Kyushu University Academic Staff Educational and Research Activities Database
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kuniyoshi shimizu Last modified date:2018.06.15

Associate Professor / Systematic Forest and Forest Products Science
Department of Agro-environmental Sciences
Faculty of Agriculture


Graduate School


E-Mail
Homepage
http://ffpsc.agr.kyushu-u.ac.jp/sffps/   
Homepage of Laboratory of Systematic Forest and Forest Products Sciences.
http://shinrinken.main.jp/ .
Phone
092-642-3002
Fax
092-642-3002
Academic Degree
PhD
Country of degree conferring institution (Overseas)
No
Field of Specialization
Natural Products Bioorganic Chemistry
Total Priod of education and research career in the foreign country
00years00months
Outline Activities
The investigation of LOHAS-oriented biological activity of forest products and their applications

Forest has been known to have healing power for mind and body. Our group deals with LOHAS (Life Of Health And Sustainability) oriented biological aspects of forest products and their mode of action. In most cases this involves investigating the biological activity of extractives of mushroom , woods and plant etc, such as anti-androgenic activity, prevention effect of bone loss in calcium deficient ovariectomized rats of mushroom, healing aroma, and melanin biosynthesis inhibitory activity of wood extractives. Our research cover several practical fields such as cosmetics, aroma, functional food, living environment, toiletry etc.

1, Search for biologically active substance from plants.
2, Search for biologically active substance from mushrooms.
3, Studies on the mode of action of bioactive natural substances and their structural criteria.
4, The physiological and psychological effect of aroma (natural volatiles) on human.
5, Development of bioactive substances and extracts for practical use (cosmetics, aroma, functional food, toiletry and living environment.)
Research
Research Interests
  • Functional components isolated from Olive
    keyword : Olive
    2013.04.
  • Comparison of the physiological and psychological response of the component profile and human essential oil aroma prepared from cedar leaves and wood parts
    keyword : Cryptomeria japonica essential oil
    2013.04~2015.02.
  • Wild Mushroom in Nepal: Some potential Candidates as Antioxidant and ACE Inhibition Sources
    keyword : Wild Mushroom in Nepal
    2013.04.
  • Comparative Biological Study of Roots, Stems, Leaves, and Seeds of
    Angelica shikokiana Makino

    keyword : Angelica shikokiana
    2013.04.
  • Search for bioactive compound from the waste of Ejyptian plants
    keyword : Medicinal Plants from Ejypt
    2013.04.
  • HMGCoA reductase inhibitors from natural resources
    keyword : HMGCoA reductase inhibitor
    2008.05~2010.03.
  • Search for hair growth agents from natural products
    keyword : hair growth
    2008.05~2010.03.
  • Functional components isolated from Eriobotrya japonica
    keyword : Eriobotrya japonica
    2008.05.
  • Search for bioactive compounds from the bamboo and the skin of bamboo shoot
    keyword : bamboo shoot, biological activity
    2007.05.
  • Volatile compounds emitted from woods and their functions
    keyword : terpene, volatile
    2006.04.
  • The physiological and psychological effects of volatiles emitted from natural resources on human
    keyword : natural product, volatile, aroma, essential oil
    2005.04.
  • The aldose reductase inhibitors from Ganoderma lucidum
    keyword : aldose reductase, Ganoderma lucidum
    2004.04The inhibitory activity of the ethanol extract of Ganoderma lucidum on aldose reductase..
  • Search for the preventive compounds from mushroom on benign prostate hyperplasia
    keyword : Ganoderma lucidum, fruiting body, antiandrogen, 5a-reductase
    2001.04Screening of the inhibitors of benign prostatic hyperplasia from edible and medicinal mushrooms..
  • Search for the compound with estrogenic activity from mushrooms
    keyword : fruiting body, estrogenic activity, Pleurotus eryngii, Ganoderma lucidum
    2002.04Screening of the prophylactic compounds for osteoporosis from edible and medicinal mushrooms..
Academic Activities
Books
1. I. Kubo, T. J. Ha, K. Shimizu, Molecular Design of Soybean Lipoxygenase Inhibitors Based on Natural Products, A Comprehensive Survey of International Soybean Research - Genetics, Physiology, Agronomy and Nitrogen Relationships, InTech, James E. Board (Ed.)
DOI: 10.5772/52703., 2013.03, [URL].
2. N. Masuoka, K. Shimizu, I. Kubo, Antioxidant Activity of Anacardic Acids
In: Antioxidants and Biocides from Latin American Plants;
, CABI Publishing (UK), C.L. Cespedes, D.A. Sampietro, D.S. Seigler, Ed., 2012.11.
3. I. Kubo, K. Fujita, K. Shimizu, Anti-Salmonella Agents from Tanacetum Balsamita, A Brazilian Medicinal Plant, and their Application
In: Antioxidants and Biocides from Latin American Plants
, CABI Publishing (UK), C.L. Cespedes, D.A. Sampietro, D.S. Seigler, Ed., 2012.11.
4. I. Kubo, K. Shimizu, K. Nihei, MANICOBA, A quercetin rich Amazonian dish
In: Quercetin: Dietary Sources, Functions and Health Benefits
, Nova Science Publishers, Inc., 2012.11.
5. I. Kubo, K. Shimizu, K. Fujita, Naturally Occurring Antifungal Agents and Their Modes of Action.
Fungicides for Plant and Animal Diseases
, InTech, D. Dhanasekaran, N. Thajuddin and A. Panneerselvam (Ed.), 2012.11, [URL].
Reports
1. Amira Mira, kuniyoshi shimizu, An Update on Antitumor Activity of Angelica Species, Medicinal Plants - Recent Advances in Research and Development, pp 363-371, 2016.10.
2. I. Kubo, T. J. Ha, K. Shimizu, Molecular Design of Soybean Lipoxygenase Inhibitors Based on Natural Products, A Comprehensive Survey of International Soybean Research - Genetics, Physiology, Agronomy and Nitrogen Relationships, James E. Board (Ed.), ISBN: 978-953-51-0876-4, InTech, DOI: 10.5772/52703., 2013.01.
3. I. Kubo, K. Shimizu, K. Fujita, Naturally Occurring Antifungal Agents and Their Modes of Action., In : Fungicides Volume I; D. Dhanasekaran, N. Thajuddin, A. Panneerselvam, Ed., InTech - Open Access Publisher, 2012.02.
4. I. Kubo, K. Shimizu, K. Nihei, MANICOBA, A quercetin rich Amazonian dish, In: Quercetin: Dietary Sources, Functions and Health Benefits- Nova Science Publishers, Inc., 2012.02.
5. I. Kubo, K. Fujita, K. Shimizu, Anti-Salmonella Agents from Tanacetum Balsamita, A Brazilian Medicinal Plant, and their Application, In: Antioxidants and Biocides from Latin American Plants; C.L. Cespedes, D.A. Sampietro, D.S. Seigler, Ed., CABI Publishing (UK), 2012.02.
6. N. Masuoka, K. Shimizu, I. Kubo, Antioxidant Activity of Anacardic Acids
, In: Antioxidants and Biocides from Latin American Plants; C.L. Cespedes, D.A. Sampietro, D.S. Seigler, Ed., CABI Publishing (UK)(2012), In: Antioxidants and Biocides from Latin American Plants;
C.L. Cespedes, D.A. Sampietro, D.S. Seigler, Ed., CABI Publishing (UK)(2012), 2012.02.
7. I. Kubo, N. Masuoka, T. J. Ha, K. Shimizu, K. Nihei, Multifunctional Antioxidant Activities of Alkyl Gallates, The Open Bioactive Compounds Journal, 3, 1-11(2010), 2010.06.
8. I. Kubo, T. J. Ha, T. Nitoda, K. Shimizu, A. Kubo, Multifunctional Acne Control Agents , Current Topics in Phytochemistry, 9, 95-102 (2008) , 2008.06.
9. K. Shimizu, Tyrosinase and 5a-Reductase Inhibitory Components from Artocarpus incisus, Bull. Kyushu Univ. For., 82, p21-63, 2001.01.
10. K. Shimizu, R. Kondo, K. Sakai, Tyrosinase inhibitors from Artocarpus incisus., Research Advances in Phytochemistry, 1, p19-34, 2000.01.
Papers
1. Khuong, L.D., Kondo, R., Leon, R.D., Anh, T.K., Shimizu, K., Kamei, I., Effect of chemical factors on integrated fungal fermentation of sugarcane bagasse for
ethanol production by a white-rot fungus, Phlebia sp. MG-60, Bioresource Technology, 167, 33-40, 2014.09.
2. Ha, T.J., Shimizu, K., Kubo, I., Lipoxygenase inhibitory activity of alkyl protocatechuates, Food Chemistry, 159, 15, 471-476, 2014.09.
3. Bang, T.H., Yamamoto, A., Matsumoto, S., Ito, H., Igami, K., Miyazaki, T., Kondo, R., Shimizu, K., Hypotensive effects of Reishi (Ganoderma lingzhi)’s auto-digested extract and its potent peptides for Angiotensin-Converting Enzyme inhibition, Molecules, doi:10.3390/molecules190913473, 19, 13473-13485, 2014.08.
4. Ashour, A., EI-Sharkawy, S., Amer, M., Marzouk, A., Kishikawa, A., Ohzono, M., Kondo, R., Shimizu, K., Production of citric acid from corncobs with its biological evaluation
, Journal of Cosmetics, Dermatological Sciences and Applications, 4, 3, 141-149, 2014.06.
5. Purnomo, A.S., Putri, E.M.M., Nawfa, R., Putra, S.R., Shimizu, K., Kondo, R., Biodegradation of heptachlor-contaminated soil by white-rot fungal inocula, Environmental Science and Pollution Research, 2014.05.
6. L. D. Khuong, R. Kondo, R. D. Leon, T. K. Anh, K. Shimizu, I. Kamei, Bioethanol production from alkaline-pretreated sugarcane bagasse by consolidated bioprocessing using Phlebia sp. MG-60, International Biodeterioration & Biodegradation, 88, 3, 62-68, 2014.03.
7. T. Hui, S. Furuta, T. Nagata, K. Ohnuki, T. Akasaka, B. Shirouchi, M. Sato, R. Kondo, K. Shimizu, The Inhibitory Effect of Loquat Leaves (Eriobotrya japonica) on Ovariectomy-induced Bone Loss and Osteoclast Differentiation, Journal of Agricultural and Food Chemistry, doi: 10.1021/jf402735u, 62, 4, 836-41, 2014.01.
8. A. Ashour, S. El-Sharkawy, M. Amer, B. F. Abdel, Y. Katakura, T. Miyamoto, N. Toyota, T. H. Bang, R. Kondo, K. Shimizu, Rational design and synthesis of topoisomerase I and II inhibitors based on oleanolic acid moiety for new anti-cancer drugs., Bioorg Med Chem., doi: 10.1016/j.bmc.2013.11.034., 22, 1, 211-20, 2014.01.
9. E. T. Arung, H. Kuspradini, I. W. Kusuma, T. H. Bang, S. Yamashita, Y. Katakura, K. Shimizu, Effects of isolated compound from Sonneratia caseolaris leaf : a validation of traditional utilization by melanin biosynthesis and antioxidant assays, submitted, 2013.12.
10. S. Fatmawati, R. Kondo, K. Shimizu, Structure-activity relationships of lanostane-type triterpenoids from Ganoderma lingzhi as α-glucosidase inhibitors., Bioorg Med Chem Lett., 23, 21, 5900-5903, 2013.11.
11. A. Ashour, M. Amer, A. Marzouk, K. Shimizu, R. Kondo, S. El-Sharkawy, Corncobs as a potential source of functional chemicals., Molecules, doi:10.3390/molecules181113823, 18, 11, 13823-13830, 2013.11.
12. T. H. Bang, A. Yamamoto, S. Matsumoto, H. Ito, K. Igami, T. Miyazaki, R. Kondo, K. Shimizu, Hypotensive effects of Reishi (Ganoderma lingzhi)’s auto-digested extract and its potent peptides for Angiotensin-Converting Enzyme inhibition., submitted, 2013.09.
13. T. H. Bang, H. Suhara, K. Doi, H. Ishikawa, K. Fukami, G. P. Parajuli, Y. Katakura, S. Yamashita, K. Watanabe, M. K. Adhikari, H. K. Manandhar, R. Kondo, K. Shimizu, Wild Mushroom in Nepal: Some potential Candidates as Antioxidant and ACE Inhibition Sources, Evidence-Based Complementary and Alternative Medicine, Volume 2014 (2014), Article ID 195305, 11 pages http://dx.doi.org/10.1155/2014/195305, 2014, 2013.08.
14. A. Mira, A. Tanaka, Y. Tateyama, R. Kondo, K. Shimizu, Comparative Biological Study of Roots, Stems, Leaves, and Seeds of Angelica shikokiana Makino, J Ethnopharmacol, 148, 980-987, 2013.08.
15. A. Ashour, S. El-Sharkawy, M. Amer, F.A. Bar, A. Mera, T. Nagata, R. Kondo, K. Shimizu, Biotransformation of Khellin to Khellol by Aspergillus niger and the Evaluation of their Biological Activities., The Open Bioactive Compounds Journal, 4, 1-3, 2013.08.
16. A. Ashour, M. Amer, A. Marzouk, K. Shimizu, R. Kondo, S. El-Sharkawy, A new lignan from corncobs, a potential source of functional chemicals, 2013.08.
17. J. Liu, K. Shimizu, A. Tanaka, W. Shinobu, K. Ohnuki, T. Nakamura, R. Kondo, A protocol for isolation of target proteins of natural compound, Protocol Exchange, doi:10.1038/protex.2013.051, 2013.05.
18. K. Shimizu, Antibacterial compounds from shoot skins of moso bamboo (Phyllostachys pubescens), Journal of Wood Science, 10.1007/s10086-012-1310-6, 59, 2, 155-159, 2013.04.
19. A. Ashour, S. El-Sharkawy, M. Amer, F. A.l Bar, R. Kondo, K. Shimizu, Melanin Biosynthesis Inhibitory Activity of Compounds Isolated from unused parts of Ammi visinaga, Journal of Cosmetics, Dermatological Sciences and Applications, 3, 40-43, 2013.03.
20. J. Liu, K. Shimizu, A. Tanaka, W. Shinobu, K. Ohnuki, T. Nakamura, R. Kondo., Target proteins of ganoderic acid DM provides clues to various pharmacological mechanisms, Sci. Rep. 2, 905, 2012.11, 霊芝には、古来よりガンを初め、様々な疾病に関する効能が伝承されている。その効能を裏付けようと多くの基礎研究が実施されており、霊芝の薬理活性に関する研究は、近年、劇的に増大している。その薬理活性は、含有されるβ-グルカンに代表される多糖類と、特徴的な構造を有するラノスタン型トリテルペノイド類に由来すると言われている。候補者は、霊芝の前立腺肥大症や骨粗鬆症に関する改善効果を見いだし、その活性成分の一つとして、ラノスタン型トリテルペノイド類に属するganoderic acid DMを単離した。本化合物は、5α-リダクターゼ阻害活性、男性ホルモン受容体結合活性、破骨細胞分化抑制効果、ガン細胞増殖抑制効果を示した。本化合物の作用機構の本質に迫るべく、細胞培養系での挙動並びに、構造活性相関を検討し、本知見を元に、ganoderic acid DM結合磁性プローブを用いて標的タンパク質の探索を行ったところ、微小管形成において重要な役割を担うタンパク質であるチューブリンと特異的に相互作用することを見いだした。さらに、同化合物は、チューブリンの重合を促進させ、微小管を不安定化させることにより、細胞の増殖・機能に影響を与えることを明らかにした。以上、霊芝由来トリテルペノイドの生理活性発現に関する新規メカニズムを提案した。.
21. Tukiran, S. S. Cahyasari, K. Shimizu, An ester of 4-methoxy cynnamic acid isolated from Xylocarpus moluccencis (Lamk) M. Roem (Meliaceae), Indonesian Journal of chemistry, 12, 2, 184-188, 2012.07.
22. T.X. Meng, C.-F. Zhang, T. Miyamoto, H. Ishikawa, K. Shimizu, S Ohga, R. Kondo, The melanin biosynthesis stimulating compounds isolated from the fruiting bodies of Pleurotus citrinopileatus, Journal of Cosmetics, Dermatological Sciences and Applications, 2, 151-157, 2012.07.
23. S. Yokoyama, T. H. Bang, K. Shimizu, R. Kondo, Osteoclastogenesis inhibitory effect of ergosterol peroxide isolated from Pleurotus eryngii, Natural Products Communications, 7, 9, 1163-1164, 2012.07.
24. E. T. Arung, S. Furuta, K. Sugamoto, K. Shimizu, H. Ishikawa, Y. Matsushita, R. Kondo, The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells, Natural Products Communications, 7, 8, 1007-1010, 2012.07.
25. E. T. Arung, H. Kuspradini I. W. Kusuma, K. Shimizu, R. Kondo, Validation of Eupatorium triplinerve Vahl leaves, a skin care herbal from East Kalimantan in melanin biosynthesis assay, Journal of Acupuncture and Meridian Studies, 5, 2, 87-92, 2012.07.
26. E. Matsubara, K. Shimizu, M. Fukagawa, Y. Ishizi, C. Kakoi, T. Hatayama, J. Nagano, T. Okamoto, K. Ohnuki, R. Kondo, Volatiles emitted from the roots of Vetiveria zizanioides suppress the decline in attention during a visual display terminal task, Biomedical Research, 35, 5, 299-308, 2012.07.
27. E. T. Arung, I. W. Kusuma, Y.-U. Kim, K. Shimizu, R. Kondo, Antioxidantive compounds from leaves of Tahongai (Klienhovia hospita), Journal of Wood Science,58(1)77-80, 58, 1, 77-80, 2012.04.
28. T. X. Meng, H. Ishikawa, K. Shimizu, S. Ohga, R. Kondo, A glucosylceramide with antimicrobial activity from the edible mushroom Pleurotus citrinopileatus, Journal of Wood Science, 58, 1, 81-86, 2012.02.
29. J. Liu, K.i Kurashiki, A. Fukuta, S.i Kaneko, Y. Suimi, K. Shimizu, R. Kondo, Quantitative determination of the representative triterpenoids in the extracts of Ganoderma lucidum with different growth stages using high-performance liquid chromatography for evaluation of their 5α-reductase inhibitory properties, Food Chemistry, 133, 1034-1038, 2012.02.
30. S. Fatmawati, K. Shimizu, R. Kondo, Structure-activity relationships of ganoderma acids from Ganoderma lucidum as aldose reductase inhibitors, Bioorganic & Medicinal Chemistry Letters, 21(24), 7295-7297, 2011.12.
31. I. Kubo, S. H. Lee, K. Shimizu, Combination effect of miconazole with polygodial against Candida albicans, Open Journal of Medical Microbiology, 1, 7-11, 2011.12.
32. A. Tanaka, H. J. Kim, S. Oda, K. Shimizu, R. Kondo, Antibacterial activity of moso bamboo shoot skin (Phyllostachys pubescens) against Staphylococcus aureus., Journal of Wood Science, 57, 6, 542-544, 2011.10.
33. E. T. Arung, K. Shimizu, Antioxidant activity of compounds from wood of Artocarpus heterophyllus, Indonesian Journal of Pharmaceutical Sciences, 9, 2, 72-77, 2011.09.
34. T.X. Meng, S. Furuta, S. Fukamizu, R. Yamamoto, H. Ishikawa, E.T. Arung, K. Shimizu, S. Ohga, R. Kondo, Evaluation of biological activities of extracts from the fruiting body of Pleurotus citrinopileatus for skin cosmetics, Journal of Wood Science, 57, 5, 452-458, 2011.05.
35. S. Fatmawati, K. Shimizu, R. Kondo , Ganoderol B: a potent alpha-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum, Phytomedicine, 18, 12, 1053-1055, 2011.02.
36. E. T. Arung, K. Shimizu, I. W. Kusuma, R. Kondo., Tyrosinase inhibitory effect of quercetin 4'-O-b-glucopyranoside from dried skin of Red Onion (Allium cepa)
, Natural Product Research, 25, 3, 256-263, 2011.02.
37. E. T. Arung, E. Matsubara, I. W. Kusuma, E. Sukaton, K. Shimizu, R. Kondo, Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells, Fitoterapia, 82, 2, 198-202(2011), 2011.02.
38. E. Matsubara, M. Fukagawa, T. Okamoto, K. Ohnuki, K. Shimizu, R. Kondo, (-)-Bornyl acetate induces autonomic relaxation and reduces arousal level after visual display terminal work without any influences of task performance in low-dose condition, Biomedical Research, 32, 2, 151-157, 2011.02.
39. E. Matsubara, M. Fukagawa, T. Okamoto, K. Ohnuki, K. Shimizu, R. Kondo, The essential oil of Abies sibirica (Pinaceae) reduces arousal levels after visual display terminal work, Flavour and Fragrance Journal, 26, 3, 204-210, 2011.02.
40. E. Matsubara, M. Fukagawa, T. Okamoto, A. Fukuda, C. Hayashi, K. Ohnuki, K. Shimizu, R. Kondo, Volatiles emitted from the leaves of Laurus nobilis L. improve vigilance performance in visual discrimination task, Biomedical Research, 32, 1, 19-28, in press, 2011.02, 月桂樹(Laurus nobilis L.)の葉を乾燥させたものは、香辛料として広く使用されている。また、葉から水蒸気蒸留により得られた精油も、食品の香り付けや薬、化粧品などにも使われる。月桂樹葉は、抗けいれん作用や抗炎症作用、抗菌活性、抗酸化活性など多岐にわたる生理活性を有することが知られている。さらにリウマチや神経痛、疥癬に効くとされ、ゴキブリ忌避作用や鎮静、麻酔作用なども知られている。本研究では、月桂樹葉揮発成分によるビジランス作業効率への影響について検討した。月桂樹葉の供試量を二段階(低濃度群と高濃度群)に設定し、清浄空気を対照とした三条件で、作業効率と生理心理学的な効果について比較した。低濃度の月桂樹葉揮発成分を吸入することによって、正答率の低下抑制に寄与することが分かった。さらに高濃度群では、吸入によりネガティブ感情を引き起こす可能性が示唆された。低濃度と高濃度群ではともに、心血管系循環促進が示唆され、覚醒状態は維持されていたことが分かった。これらの知見から、低濃度の月桂樹葉揮発成分には、感情への負の影響を引き起こすことなく、生理学的な覚醒状態の維持に寄与し、正答率の低下抑制というビジランス維持の機能を持つことが示唆された。.
41. S. Fatmawati, K. Shimizu, R. Kondo, Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum, Planta Med, 76, 15, 1691-1693, 2010.11.
42. E. T. Arung, B. D. Wicaksono, Y. A. Handoko, I. W. Kusuma, K. Shimizu, D. Yulia, F. Sandra, Cytotoxic effect of artocarpin on T47D cells, J. Nat. Med. , 64, 4, 423-429, 2010.10.
43. S. Fatmawati, K. Shimizu, R. Kondo, Ganoderic acid Df, a new triterpenoid with aldose reductase activity from the fruiting body of Ganoderma lucidum , Fitoterapia., 81, 8, 1033-1036, 2010.09.
44. J. Liu, K. Shimizu, R. Kondo, The effects of ganoderma alcohols isolated from Ganoderma lucidum on the androgen receptor binding and the growth of LNCaP cells, Fitoterapia., 81, 8, 1067-1072, 2010.09.
45. J. Liu, K. Shimizu, H. Yu,C. Zhang, F. Jin, R. Kondo, Stereospecificity of hydroxyl group at C-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells, Fitoterapia., 81, 7, 902-905, 2010.09.
46. E. T. Arung, S. Furuta, H. Ishikawa, I. W. Kusuma, K. Shimizu, R. Kondo, Anti-melanogenesis properties of quercetin- and its derivative-rich extract from Allium cepa, Food Chemistry, 124, 3, 1024-1028, 2010.09.
47. T.J. Ha, K. Shimizu, T. Ogura, I. Kubo, Inhibition mode of soybean lipoxygenase-1 by quercetin, Chem. Biodiversity, 7, 8, 1893-1903, 2010.08.
48. M. Nagano, K. Shimizu, R. Kondo, C. Hayashi, D. Sato, K. Kitagawa, K. Ohnuki, Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake, Biomedical Research, 31, 4, 231-237, 2010.08, Hericium erinaceumはサンゴハリタケ科のキノコであり、日本では、その形状から、ヤマブシタケ(山伏茸)と呼ばれている。本キノコは、抗ガン活性、脂質低減活性、細胞毒性活性、抗菌活性、抗酸化活性、小胞体ストレス抑制活性、神経成長因子(NGF)合成促進活性など多岐にわたる生理活性を有することが知られている。我々は、ヤマブシタケの新たな機能性の探索のために、中年女性における不定愁訴改善効果の検証を、無作為化二重盲検比較試験にて、クッパーマン更年期障害指数、CES-Dうつ病自己評価尺度、ピッツバーグ睡眠質問票、不定愁訴アンケートを用いて行った。その結果、4週間のヤマブシタケ含有食品摂取(1日ヤマブシタケ乾燥粉末4グラム)によって、様々な不定愁訴の有意な改善が認められた。.
49. I. W. Kusuma, E. T. Arung, E. Rosamah, S. Purwatiningsih, H. Kuspradini, Syafrizal, J. Astuti, Y-U, Kim, K. Shimizu, Antidermatophyte and antimelanogenesis compound from Eleutherine americana growing in Indonesia, J. Nat. Med., 64, 2, 223-226, 2010.07.
50. E. T. Arung, K. Shimizu, H. Tanaka, R. Kondo, 3-Prenyl luteolin, a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus, Fitoterapia., 81, 6, 640-643, 2010.06.
51. S. Yokoyama, S. Takeno, T. Nagata, K. Shimizu, R. Kondo, Screening of extracts of Japanese medicinal plants for HMG-CoA reductase inhibition, Bulletin of the Kagoshima University Forest, 37, 37-41, 2010.05.
52. J. Liu, J. Shiono, K. Shimizu, R. Kondo, Ganoderic acids from Ganoderma lucidum. Inhibitory activity of osteoclastic differentiation and structural criteria, Planta Med., 76, 137-139, 2010.05.
53. I. Kubo, T.J. Ha, K. Shimizu, Lipoxygenase inhibitory activity of 6-pentqadecanylsalicylic acid without prooxidant effect, Natural Product Communications , 5, 1, 85-90, 2010.05.
54. E. T. Arung, K. Shimizu, H. Tanaka, R. Kondo, Melanin biosynthesis inhibitors from wood of Artocarpus heterophyllus: The effect of isoprenoid substituent of flavone with 4-substituted resorcinol moiety at B ring, Lett. Drug Des. Discovery, 7, 8, 602-605, 2010.05.
55. E. T. Arung, K. Yoshikawa, K. Shimizu, R. Kondo, Isoprenoid-substituted flavonoids from wood of Artocarpus heterophyllus on B16 melanoma cell -Cytotoxicity and structural criteria-, Fitoterapia , 81, 120-123, 2010.04.
56. E. T. Arung, I. W. Kusuma, E. O. Christy, K. Shimizu, R. Kondo, Evaluation of medicinal plants from Central Kalimantan for anti melanogenesis, J. Nat. Med. , 63, 473-480, 2009.12.
57. Z. Huang, K. Hashida, R. Makino, F. Kawamura, K. Shimizu, R. Kondo, S. Ohara, Evaluation of biological activities of extracts from 22 African tropical wood species, J. Wood Sci, 55, 3, 225-229, 2009.05.
58. M. Hasegawa, R. Wakimoto, E. Yoshida, K. Shimizu, R. Kondo, A. Widyatmoko, A. Nirsatmanto, S. Shiraishi , Provenance variation in growth and wood properties of A. mangium and A. auriculiformis in Central Java, Indonesia : selecting potential hybrid parents for good performance, Bull. Kyushu Univ. For. , 90, 25-37, 2009.05.
59. J. Liu, J. Shiono, Y. Tsuji, K. Shimizu, R. Kondo, Methyl ganoderic acid DM: a selective potent osteoclastgenesis inhibitor, The Open Bioactive Compounds Journal, 2, 37-42, 2009.05.
60. J. Liu, J. Shiono, K. Shimizu, H. Yu,C. Zhang, F. Jin, R. Kondo, 20(R)-Ginsenoside Rh2, not 20(S), is a selective osteoclastgenesis inhibitor without any cytotoxicity, Bioorg. Med. Chem. Lett., 19, 3320-3323, 2009.05.
61. J. Liu, J. Shiono, K. Shimizu, A. Kukita, T. Kukita, R. Kondo, Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor, Bioorg. Med. Chem. Lett., 19, 2154-2157, 2009.05.
62. E.T. Arung, I.W. Kusuma, S. Purwatiningsih, S.-S. Roh, C.H. Yang, S. Jeon, Y.-U. Kim, E. Sukaton, J. Susilo, Y. Astuti, B.D. Wicaksono, F. Sandra, K. Shimizu, R. Kondo, Antioxidant Activity and Cytotoxicity of the Traditional Indonesian Medicine Tahongai (Kleinhovia hospita L.) Extract, JAMS Journal of Acupuncture and Meridian Studies, 2, 4, 306-308 , 2009.05.
63. K. Shimizu, I. Miyamoto, J. Liu, F. Konishi, S. Kumamoto, R. Kondo, Estrogen-like activity of ethanol extract of Ganoderma lucidum, J. Wood Sci., 55, 53-39 , 2009.04.
64. J. Liu, S. Tamura, K. Kurashiki, K. Shimizu, K. Noda, F. Konishi, S. Kumamoto, R. Kondo, Anti-androgen effects of extracts and compounds from Ganoderma lucidum, Chem. Biodiversity, 6, 231-243, 2009.04.
65. J. Liu, K. Shimizu, R. Kondo, Anti-androgenic activity of fatty acids, Chemistry&Biodiversity, 6, 4, 503-512, 2009.04.
66. J. Liu, K. Shimizu, R. Kondo, Anti-androgenic activity of fatty acids, Chemistry&Biodiversity, 6, 503-512, 2009.04.
67. I. Miyamoto, J. Liu, K. Shimizu, A. Kukita, T. Kukita, M. Sato, R. Kondo, Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum, Eur. J. Pharmacol., 602, 1, 1-7, 2009.04.
68. S. Fatmawatia, K. Kurashiki, S. Takeno, Y. Kim, K. Shimizu, M. Sato, K. Imaizumi, K. Takahashi, S. Kamiya, S. Kaneko, R. Kondo , The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum , Phytotherapy Research, 23, 28-32, 2009.03.
69. M. Noguchi, K. Tomiyasu, M, Nakiri, K. Matsuoka, T. Kakuma, F. Konishi, S. Kumamoto, K. Shimizu, R. Kondo, An extract of ganoderma lucidum in men with lower urinary tract symptoms: A double-blind, placebo-controlled randomized and dose-ranging study, Nishinihon Journal of Urology, 70, 9, 466-472, 2008.04.
70. K. Shimizu, M. Gyokusen, S. Kitamura,T. Kawabe, T. Kozaki, K. Ishibashi, R. Izumi, W. Mizunoya, K. Ohnuki, R. Kondo, Essential Oil of Lavender Inhibited the Decrement of Attention in the Long-term Task in Human, Bioscience, Biotechnology, and Biochemistry, 72, 7, 1944-1947, 72(7), 1944-1947 , 2008.04.
71. E. T. Arung, S. Muladi, E. Sukaton, K. Shimizu, R. Kondo, Artocarpin, a promising compound as whitening agent and skin cancer, Journal of Wood Science and Technology, 6, 33-36, 2008.04.
72. M. Noguchi, T. Kakuma, K. Tomiyasu, Y. Kurita, H. Kukihara, F. Konishi, S. Kumamoto, K. Shimizu, R. Kondo, K. Matsuoka , The effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: A double-blaind, placebo-controlled randomized and dose-ranging study, Asian Journal of Andrology, 10, 4, 651-658, 2008.03.
73. M. Noguchi, T. Kakuma, K. Tomiyasu, A. Yamada, K. Itoh, F. Konishi, S. Kumamoto, K. Shimizu, R. Kondo, K. Matsuoka , A randamized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms, Asian Journal of Andrology, 10, 5, 777-785, 2008.03.
74. J. Liu, R. Ando, K. Shimizu, K. Hashida, R. Makino, S. Ohara, R. Kondo, Steroid 5α-reductase inhibitory activity of condensed tannins from woody plants , J. Wood Sci , 54, 1, 68-75, 2008.03.
75. K. Shimizu, S. Fukunaga, K. Yoshikawa, R. Kondo, Screening of extracts of Japanese woods for melanin biosynthesis inhibition, J. Wood Sci., 53, 153-160, 2007.10.
76. Y. Kim, J. Han, S. S. Lee, K. Shimizu, Y. Tsutsumi, R. Kondo , Steroid 9a-hydroxylation during testosterone degradation by resting Rhodococcus equi Cells, Arch. Pharm. Chem. Life Sci.., 340, 209-214, 2007.07.
77. J. Liu, K. Shimizu, F. Konishi, K. Noda, S. Kumamoto, K. Kurashiki, R. Kondo, Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum , Food Chem. , 100, 1691-1696, 2007.06.
78. J. Liu, K. Shimizu, F. Konishi, S. Kumamoto, R. Kondo, The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum, Bioorg. Med. Chem. , 15, 14, 4966-4972, 2007.03.
79. Enos T. Arung, K. Shimizu, R. Kondo , Isoprenoid-substituted polyphenols from Artocarpus heterophyllus -Melanin biosynthesis inhibitory activity and structural criteria-, Chemistry & Biodiversity , 4, 2166-2171, 2007.03.
80. Y. Kim, J. Han, S. S. Lee, K. Shimizu, Y. Tsutsumi, R. Kondo, Steroid 9a-hydroxylation during testosterone degradation by resting Rhodococcus equi Cells, Arch. Pharm. Chem. Life Sci, 340, 209-214 (2007), 2007.01.
81. J. Liu, K. Kurashiki, K. Shimizu,R. Kondo, Structure activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum, Bioorg. Med. Chem., 14, 24, 8654-60, 2006.12.
82. Tukiran, Saidah, Suyatno, Nurul Hidayati, K Shimizu, Briononic acid from the hexane extract of Sandoricum koetjape Merr. stem bark (Meliaceae), Indo. J. Chem. , 6, 3, 304-306, in press, 2006.11.
83. Tukiran, K. Sakai, K. Shimizu, S.A. Achmad, Hemsleyanoside F, an oligoresveratrol glucoside from the stem bark of Shorea parvistipulata F. Heim., Bull. Soc. Nat. Prod. Chem. (Indonesia), 6, 7-12, 2006.11.
84. K. Shimizu, M. Yamanaka, M. Gyokusen, S. Kaneko, M. Tsutsui, J. Sato, I. Sato, M. Sato, R. Kondo, Estrogen-like activity and prevention effect of bone loss in calcium deficient ovariectomized rats by the extract of Pleurotus eryngii., Phytotherapy Research, 20, 659-664, 2006.01.
85. J. Liu, K. Shimizu, R. Kondo, Ganoderic acid TR, a new lanostanoid with 5a-reductase inhibitory activity from the fruiting body of Ganodema lucidum., Natural Product Communications, 1, 5, 345-350, 2006.01.
86. J. Liu, K. Kurashiki, K. Shimizu, R. Kondo, 5a-reductase inhibitory effects of triterpenoids isolated from Ganoderma lucidum., Biol. Pharm. Bull., 29, 392-395, 2006.01.
87. Enos T. Arung, K. Shimizu, R. Kondo, Inhibitory Effect of Isoprenoid-substituted Flavonoids Isolated from Artocarpus heterophyllus on Melanin Biosynthesis, Planta Med, 72, 847-850, 2006.01.
88. Enos T. Arung, K. Shimizu, R. Kondo, Inhibitory effect of Artocarpanone from Artocarpus heterophyllus on melanin biosynthesis, Biol Pharm. Bull., 29, 1966-1969, 2006.01.
89. Tukiran, S.A. Achmad, E.H. Hakim, Y.M. Syah, L. Makmur, L.D. Juliawaty, K. Shimizu, and K. Sakai., Oligostilbenoids from the stem bark of Shorea selanica Blume (Dipterocarpaceae), Malaysian Journal of Science (MJS),, 24, 1, 27-35, 2005.01.
90. Tukiran, S.A. Achmad, E.H. Hakim, L. Makmur, K. Sakai, K. Shimizu, and Y.M. Syah, Oligostilbenoids from Shorea balangeran., Biochemical systematic and Ecology (BSE),, 10.1016/j.bse.2004.10.016, 33, 6, 631-634, 2005.01.
91. J. Liu, R. Fujita, M. Sato, K. Shimizu, F. Konishi, K. Noda, S. Kumamoto, C. Ueda, H. Tajiri, S. Kaneko, Y. Suimi, R. Kondo, The effect of strain, growth stage and cultivationg condition of Ganoderma lucidum on 5a-reductase inhibition, J. Wood Sci, 10.1007/s10086-004-0645-z, 51, 2, 189-192, 2005.01.
92. Enos T. Arung, K. Yoshikawa., K. Shimizu, R. Kondo, The effect of chlorophorin and its derivatives on melanin biosynthesis., Holzforschung, 10.1515/HF.2005.085, 59, 5, 514-518, 2005.01.
93. Enos T. Arung, Irawan W. Kusuma, Yetti M. Iskandar, S. Yasutake, K. Shimizu, R. Kondo, Screening of Indonesian plants for tyrosinase inhibitory activity, J. Wood Sci.., 10.1007/s10086-004-0690-7, 51, 5, 520-525, 2005.01.
94. Tukiran, Sjamsul A. Achmad, Euis H. Hakim, Yana M. Syah, Lukman Makmur, Lia D. Juliawaty, K. Shimizu, K. Sakai, Resveratrol oligomers from the stem bark of Hopea bancana (Dipterocarpaceae), Bull. Soc. Nat. Prod. Chem. (Indonesia), 4, 17-22, 2004.01.
95. K. Fukuhara, K. Shimizu, I. Kubo, Arudonine, an allelopathic steroidal glycoalkaloid from the root bark of Solanum arundo Mattei, Phytochemistry, 65, 9, 1283-1286, 2004.01.
96. I. Kubo, Y Xu, K Shimizu, Antibacterial activity of ent-kaurene diterpenoids from Rabdosia rosthornii., Phytother Res., 18, 2, 180-183, 2004.01.
97. I kubo, K. Nihei,K. Shimizu, Oxidation products of quercetin catalyzed by mushroom tyrosinase, Bioorg. Med. Chem., 12, 5343-5347, 2004.01.
98. I. Kubo, K. Shimizu, Y.L. Xu, entIsopimarane diterpenoids of the leaves from Rabdosia forrestii, Fitoterapia, 74, 7-8, 649-9, 2003.01.
99. K. Towatari, K. Yoshida, N. Mori, K. Shimizu, R. Kondo, K. Sakai, Polyphenols from the heartwood of Cercidiphyllum japonicum and their effects on proliferation of mouse hair epithelial cells, Planta Med., 10.1055/s-2002-35657, 68, 11, 995-998, 2002.03.
100. K. Shimizu, R. Kondo, K. Sakai, N. Takeda, T. Nagahata, The skin-lightening effects of artocarpin on UVB -induced pigmentation., Planta Med. , 10.1055/s-2002-20057, 68, 1, 79-81, 2002.03.
101. K. Shimizu, R. Kondo, K. Sakai, Antioxidant activity of heartwood extracts of Papua New Guinean woods., J. Wood. Sci., 10.1007/BF00770708, 48, 5, 446-450, 2002.03.
102. K. Shimizu, R. Kondo, K. Sakai, N. Takeda, T. Nagahata, T. Oniki, Novel vitamin E derivative with 4-substituted resorcinol moiety has both antioxidant and tyrosinase inhibitory properties., Lipids, 10.1007/s11745-001-0847-9, 36, 12, 1321-1326, 2001.03.
103. K. Shimizu, R. Kondo, K. Sakai, A geranylated chalcone with 5α-reductase inhibitory properties from Artocarpus incisus., Phytochemistry, 10.1016/S0031-9422(00)00187-4, 54, 8, 737-739, 2001.03.
104. K. Shimizu, R. Kondo, K. Sakai, Y. Shoyama, H. Sato, T. Ueno, The 5α-reductase inhibitory activity and hair regrowth effects of extract from Boehmeria nipononivea., Biosci. Biotechnol. Biochem., 64, 875-877, 2000.03.
105. K. Shimizu, R. Kondo, K. Sakai , S. Buabarn, U. Dilokkunanant, The 5α-reductase inhibitory component from leaves of Artocarpus altilis., J. Wood. Sci., 46, 385-389, 2000.03.
106. K. Shimizu, R. Kondo and K. Sakai, Inhibition of tyrosinase by flavonoids, stilbenes and related 4-substituted resorcinols: Structure-activity investigations., Planta Med., 10.1055/s-2000-11113, 66, 1, 11-15, 2000.03.
107. K. Shimizu, M. Fukuda, R. Kondo, K. Sakai, The 5α-reductase inhibitiory components from heartwood of Artocarpus incisus: Structure-activity investigations., Planta Med., 10.1055/s-2000-11114, 66, 1, 16-19, 2000.03.
108. K. Shimizu, R. Kondo, K. Sakai, S.-H. Lee, H. Sato, The Inhibitory Components from Artocarpus incisus on Melanin Biosynthesis., Planta Med., 10.1055/s-2006-957470, 64, 5, 408-412, 1998.03.
109. K. Shimizu, R. Kondo, K. Sakai, A Stilbene Derivative from Artocarpus incisus., Phytochemistry, 10.1016/S0031-9422(97)00143-X, 45, 6, 1297-1298, 1997.03.
110. C. Pilotti, R. Kondo, K. Shimizu, K. Sakai, An Examination of the Anti-fungal Components in the Heartwood Extracts of Pterocarpus indicus., Mokuzai gakkaishi, 41, 6, 593-597, 1995.03.
111. Bang, T.H., Shimizu, K., Potent Angiotensin-Converting Enzyme Inhibitory Tripeptides identified by a Computer-based Approach, Journal of Molecular Graphics and Modeling.
112. Arung, E.T., Suwinarti, W., Supomo, M.H., Kusuma, I.W., Puteri, D.C.N., Eroglu, H.A., Kim, Y-U., Shimizu, K., Ishikawa, H., Antioxidant and anti-melanogenesis activities of an extract of the Indonesian Lai fruit (Durio kutejensis), Tropical Journal of Pharmaceutical Research.
113. Tanaka, A., Zhu, Q., Tan, H., Horiba, H., Ohnuki, K., Mori, Y., Yamauchi, R., Ishikawa, H., Iwamoto, A., Kawahara, H., Shimizu, K., Various biological activities of extracts from different parts of bamboo (Phyllostachys pubescens), Molecules.
114. Arung, E.T., Kuspradini, H., Kusuma, I.W., Bang, T.H., Yamashita, S., Katakura, Y., Shimizu, K., Effects of isolated compound from Sonneratia caseolaris leaf : a validation of traditional utilization by melanin biosynthesis and antioxidant assays, submitted.
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