Kyushu University Academic Staff Educational and Research Activities Database
Researcher information
Yoshinori Fukui Last modified date:2014.6.14



Graduate School


E-Mail
Homepage
[URL].
Phone
092-642-6828
Fax
092-642-6829
Academic Degree
Doctor of Medical Science
Field of Specialization
Immunogenetics, Molecular Immunology, Cell Biology
Outline Activities
Remodeling of the actin cytoskeleton is a fundamental biological response that regulates various cellular functions in the immune system. The aim of my research is to elucidate the mechanism by which remodeling of the actin cytoskeleton is induced in lymphoid and myeloid cells downstream of various receptors, and to define its relevance to cellular functions. This accomplishment will lead to the development of new therapeutics for intractable diseases such as autoimmune diseases, graft rejection and infectious diseases.
Research
Research Interests
  • Remodeling of the actin cytoskeleton in the immune system
    keyword : cytoskeleton, cell migration, antigen recognition, development of the immune system, G proteins
    2001.01.
Academic Activities
Papers
1. Kana Ogawa, Yoshihiko Tanaka, Takehito Uruno, DUAN XUEFENG, Yosuke Harada, Fumiyuki Sanematsu, Kazuhiko Yamamura, 寺澤 公男, Akihiko Nishikimi, JF Côté, Yoshinori Fukui,DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation,J. Exp.Med.,Vol.in press,2014.07.
2. Damoulakis G, Gambardella L, Rossman K, Lawson C, Anderson K, Yoshinori Fukui, Welch H, Der C, Stephens L, Hawkins P,P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.,J. Cell Sci.,Vol.127,2014.06.
3. Laurin M, Dumouchel A, Yoshinori Fukui, Côté JF,The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo.,Small GTPases ,Vol.4,2013.12.
4. Le Floc’h A, Yoshihiko Tanaka, Bantilan BS, Voisinne G, Altan-Bonnet G, Yoshinori Fukui, Huse M,Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse. ,J. Exp. Med.,Vol.210,2013.11.
5. Akihiko Nishikimi, M Kukimoto-Niino, S Yokoyama, Yoshinori Fukui,Immune regulatory functions DOCK family proteins in health and disease.,Exp.Cell.Res.,Vol.319,No.15,2013.09.
6. Sachiko Kamakura, Masatoshi Nomura, Jyunya Hayase, Y Iwakiri, Akihiko Nishikimi, Ryoichi Takayanagi, Yoshinori Fukui, Hideki Sumimoto,The cell polarity protein mlnsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway.,Dev. Cell.,Vol.26,No.3,2013.08.
7. Yusuke Sakai, Yoshihiko Tanaka, Tohoshi Yanagihara, Mayuki Watanabe, DUAN XUEFENG, 寺澤 公男, Akihiko Nishikimi, Fumiyuki Sanematsu, Yoshinori Fukui,The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation.,Blood,Vol.122,No.3,2013.05.
8. M Laurin, J Huber, A Pelletier, T Houalla, M Park, Yoshinori Fukui, B Haibe-Kains, WJ Muller, JF Côté,Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.,Proc.Natl.Acad.Sci.USA,Vol.110,No.18,2013.03.
9. Fumiyuki Sanematsu, Akihiko Nishikimi, Mayuki Watanabe, T Hongu, Yoshihiko Tanaka, Y Kanaho, JF Côté, Yoshinori Fukui,Phosphatidic acid-dependent recruitment and function of the Rat activator DOCK1 during dorsal ruffle formation,J. Biol. Chem.,Vol.288,pp.8092-8100,2013.01.
10. Unoki M, Masuda A, Dohmae N, Arita K, Yoshimatsu M, Iwai Y, Fukui Y, Ueda K, Hamamoto R, Shirakawa M, Sasaki H, Nakamura Y,Lysyl 5-Hydroxylation, a novel histone modification, by jumonji domain containing 6(JMJD6),J. Biol. Chem.,Vol.in press,pp.1-5,2013.01.
11. Cimino PJ, Yang Y, Li X, Hemingway JF, Cherne MK, Khademi SB, Fukui Y, Montine KS, Montine TJ, Keene CD,Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of alzheimer's disease,Exp. Mol. Pathol.,Vol.in press,pp.1-5,2013.01.
12. Shigeo Fujimori, Naoya Hirai, Hiroyuki Ohashi, Kazuyo Masuoka, Akihiko Nishikimi, Yoshinori Fukui, Takanori Washio, Tomohiro Oshikubo, Tatsuhiro Yamashita, Etsuko Miyamoto-Sato,Next-generation sequencing coupled with a cell-free display technology for high-throughput production of reliable interactome data,Scientific Reports,Vol.2:691,pp.1-5,2012.10.
13. Masao Terasawa, Takehito Uruno, Sayako Mori, Mutsuko Kukimoto-Niino, Akihiko Nishikimi, Fumiyuki Sanematsu, Yoshihiko Tanaka, Shigeyuki Yokoyama, Yoshinori Fukui,Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration,PLoS One,2012.09.
14. Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh N, Sakaoka S, Du Y, Suenaga A, Kukimoto-NIino M, Miyano K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, Fukui Y,Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.,Chem. Biol.,Vol.19,pp.488-497,2012.04.
15. Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T, Hanawa-Suetsugu K, Kukimoto-Niino M, Nishizaki T, Shirousu M, Duan X, Uruno T, Nishikimi A, Sanematsu F, Yokoyama S, Stein JV, Kinashi T, Fukui Y ,DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses,Blood,Vol.119,pp.4451-4461,2012.03.
16. Hanawa-Suetugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinishi T, Kohda D, Fukui Y, Yokoyama S,Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.,Proc. Natl. Acad. Sci. USA,Vol.109,No.9,pp.3305-3310,2012.02.
17. Ippagunta SK, Subbarao Malireddi RK, Shaw PJ, Neal GA, Walle LV, Green DR, Fukui Y, Lamkanfi M, Kanneganti T-D,The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization.,Nature Immunology,2011.09.
18. Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Côté JF, Nagasawa T, Fukui Y,DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.,Circ. Res.,107:1102-1105,2010.10.
19. Gotoh K, Tanaka Y, Nishikimi A, Nakamura R, Yamada H, Maeda N, Ishikawa T, Hoshino K, Uruno T, Cao Q, Higashi S, Kawaguchi Y, Enjoji M, Takayanagi R, Kaisho T, Yoshikai Y, Fukui Y,Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation,J. Exp. Med.,207: 721-730,2010.04.
20. Gollmer K, Asperti-Boursin F, Tanaka Y, Okkenhaug K, Vanhaesebroeck B, Peterson JR, Fukui Y, Donnadieu E, Stein JV,CCL21 mediates CD4+ T cell costimulation via a DOCK2/Rac-dependent pathway,Blood,114(3) : 580-588,2009.03.
21. Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y, ,Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis,Science,324:384-387,2009.04.
22. Gotoh K, Tanaka Y, Nishikimi A, Inayoshi A, Enjoji M, Takayanagi R, Sasazuki T, Fukui Y,Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells,Blood,111(6), 2973-2976,2008.03.
23. Tanaka Y, Hamano S, Gotoh K, Murata Y, Kunisaki Y, Nishikimi A, Takii R, Kawaguchi M, Inayoshi A, Masuko S, Himeno K, Sasazuki T, Fukui Y,T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock2.,Nature Immunol.,8,1067-1075,2007.09.
24. Nombela-Arrieta C, Mempel TR, Soriano SF, Mazo I, Wymann MP, Hirsch E, Martínez-A C, Fukui Y, von Andrian UH, Stein JV,A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediatsd egress,J. Exp. Med.,9: 121-128,2007.03.
25. Handa Y, Suzuki M, Ohya K, Iwai H, Ishijima N, Koleske AJ, Fukui Y, Sasakawa C,Shignella IpgB1 promotes bacterial entry through the ELMO-Dock180 machinery.,Nature Cell Biology,9: 121-128,2007.01.
26. García-Bernal D, Sotillo-Mallo E, Nombela-Arrieta C, Samaniego R, Fukui Y, Stein JV, Teixidó J,DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin alpha4beta1.,J. Immunol.,177: 5215-5225,2006.10.
27. Shulman Z, Pasvolsky R, Woolf E, Grabovsky V, Feigelson SW, Erez N, Fukui Y, Alon R,DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration.,Blood,108: 2150-2158,2006.04.
28. Kunisaki Y, Tanaka Y, Sanui T, Inayoshi A, Noda M, Nakayama T, Harada M, Taniguchi M, Sasazuki T, Fukui Y,DOCK2 is required in T cell precursors for development of Valpha14 natural killer T (NKT) cells.,J. Immunol.,176: 4640-4645,2006.04.
29. Kunisaki Y, Nishikimi A, Tanaka Y, Takii R, Noda M, Inayoshi A, Watanabe K, Sanematsu F, Sasazuki T, Sasaki T, Fukui Y,DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis.,J. Cell Biol.,174: 647-652,2006.04.
30. Jiang H, Pan F, Erickson LM, Jang MS, Sanui T, Kunisaki Y, Sasazuki T, Fukui Y,Deletion of DOCK2, a regulator of the actin cytoskeleton in lymphocytes, suppresses cardiac allograft rejection,J. Exp. Med,Vol.202,No.8,202: 1121-1130,2005.10.
31. Nombela-Arrieta C, Lacalle RA, Montoya M, Kunisaki Y, Megilas D, Marques M, Carrera AC, Manes S, Fukui Y, Martines-A C, Stein JV,Differential requirements of DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing,Immunity,Vol.21,No.3,21: 429-441,2004.09.
32. Kunisaki T, Masuko S, Noda M, Inayoshi A, Sanui T, Harada M, Sasazuki T, Fukui Y.,Defective fetal liver erythropoiesis and T-lymphopoiesis in mice lacking phosphatidylserine receptor,Blood,Vol.103,No.9,103:119-129,2004.05.
33. Sanui T, Inayoshi A, Noda M, Iwata E, Stein JV, Sasazuki T, Fukui Y,DOCK2 regulates Rac activation and cytoskeletal reorganization through the interaction with ELMO1,Blood,Vol.102,No.8,102: 2948-2950,2003.01.
34. Sanui T, Inayoshi A, Noda M, Iwata E, Oike M, Sasazuki T, Fukui Y,DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-q and LFA-1, in T cells,Immunity,Vol.19,No.1,19:119-129,2003.01.
35. Oono T, Fukui Y, Masuko S, Hashimoto O, Ueno T, Sanui T, Inayoshi A, Noda M, Sata M, Sasazuki T,Organ-specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptide.,J. Clin. Invest,Vol.108,No.11,108: 1589-1596,2001.01.
36. Fukui Y, Hashimoto O, Sanui T, Oono T, Koga H, Abe M, Inayoshi A, Noda M, Oike M, Shirai T, Sasazuki T,Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration,Nature,Vol.412,No.6849,412: 826-831,2001.01.
37. Fukui Y, Oono T, Cabaniols JP, Nakao K, Hirokawa K, Inayoshi A, Sanui T, Kanellopoulos J, Iwata E, Noda M, Katsuki M, Kourilsky P, Sasazuki T,Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor-contact.,Proc. Natl. Acad. Sci. USA,Vol.97,No.25,97:13760-13765,2000.01.
38. Gapin L, Fukui Y, Kanellopoulos J, Sano T, Casrouge A, Malier V, Beaudoing E, Gautheret D, Claverie JM, Sasazuki T, Kourilsky P,Quantitative analysis of the T-cell repertoire by a single peptide/MHC complex,J. Exp. Med.,187: 1871-1883,1998.01.
39. Fukui Y, Hashimoto O, Inayoshi A, Gyotoku T, Sano T, Koga T, Gushima T, Sasazuki T,Highly restricted T cell repertoire shaped by a single major histocompatibility complex-peptide ligand in the presence of a single rearranged T cell receptor b chain.,J. Exp. Med.,Vol.188,No.5,188:897-907,1998.01.
40. Fukui Y, Ishimoto T, Utsuyama M, Gyotoku T, Koga T, Nakao K, Hirokawa K, Katsuki M, Sasazuki,,Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus,Immunity,Vol.6,No.4,6: 401-410,1997.01.
41. Yamamoto K, Fukui Y, Esaki Y, Inamitsu T, Sudo T, Yamane K, Kamikawaji N, Kimura A, Sasazuki T,Functional interaction between human histocompatibility leukocyte antigen (HLA) class II and mouse CD4 molecule in antigen recognition by T cells in HLA-DR and DQ transgenic mice.,J. Exp. Med.,Vol.180,No.1,180: 165-171,1994.01.
42. Todd JA, Fukui Y, Kitagawa T, Sasazuki T,The A3 allele of the HLA-DQA1 locus in associated with susceptibility to type 1 diabetes in Japanese. ,Proc.Natl. Acad. Sci.,Vol.87,No.3,87:1094-1098,1990.01.
Educational
Educational Activities
Classes: Genetics, Immunology