Kyushu University Academic Staff Educational and Research Activities Database
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Hiroshi Takamatsu Last modified date:2018.07.26



Graduate School
Undergraduate School
Other Organization
Administration Post
Vice President


E-Mail
Homepage
http://www.mech.kyushu-u.ac.jp/~hmt/HMT_lb_en.html
Phone
092-802-3123
Fax
092-802-3123
Academic Degree
Doctor of Engineering
Country of degree conferring institution (Overseas)
No
Field of Specialization
Thermal Engineering, Bioengineering, Bio Heat and Mass Transfer
Total Priod of education and research career in the foreign country
00years10months
Outline Activities
Field of research and education: Thermal engineering, Heat and mass transfer in bioengineering and medicine

Research topics: (1) MEMS sensor for measurement of thermal conductivity of fluids and its application; (2) Irreversible electroporation; (3) Thermal transport properties of biopolymer materials; (4) Intracellular delivery of macromolecules; (5) Freezing of cells and tissues.

Education: (1) Heat transfer; (2) Thermal energy conversion; (3) Heat and mass transfer; (4) Biothermal engineering
Research
Research Interests
  • Noninvasive visualization of thermal properties of body using laser scanning thermography
    keyword : Laser scanning thermography, Visualization, Thermal transport property, Noninvasive technique
    2014.10.
  • Intracellular delivery of macromolecules
    keyword : Inracellular delivery, Gene transfer, Macromolecule
    2013.04.
  • Thermal transport properties of biopolymer materials
    keyword : Biopolymer, Thermal conductivity, Functional material, Fiber
    2017.05.
  • A new technique to measure the in-plane thermal conductivity of thin films using a MEMS sensor
    keyword : Thin film, Thermophysical properties, Thermal conductivity, MEMS, Measuring technique
    2012.04~2016.03Measurement of fluid thermal conductivity with infinitesimal samples using a MEMS sensor.
  • Study on irreversible electroporation
    keyword : Irreversible electroporation, Minimally invasive treatment, Bio Heat and Mass Transfer, Electric field
    2009.10.
  • Mechanical injury of cells by deformation and related cell biomechanics
    keyword : Cell deformation, Cell survival, Mechanical stress, Cytoskeleton, Plasma membrane
    1999.01~2005.03Mechanical injury of cells by deformation and related cell biomechanics.
  • A new technique to measure the thermal conductivity of fluids with a MEMS sensor
    keyword : Thermophysical properties, Thermal conductivity, MEMS, Measuring technique, Infinitesimal sample
    2008.04Measurement of fluid thermal conductivity with infinitesimal samples using a MEMS sensor.
  • Noninvasive technique to measure thermal transport properties of biological materials
    keyword : Thermal conductivity, Thermal diffusivity, Biologiacal material, Tissue, Noninvasive measurement, Laser, Infrared thermometry
    2001.04~2014.03Noninvasive measurement of thermal transport properties of biological materials.
  • Measurement of thermal transport properties of solids and soft materials.
    keyword : Thermal conductivity, Thermal diffusivity, Measurement technique, Solid, Soft material
    2007.04~2015.03Measurement of thermal transport properties of solids and soft materials.
  • Osmotic response and injury of cells
    keyword : Osmotic stress, Cell dehydration, Solution effects, Cytoskeleton, Plasma membrane, Hydraulic conductivity, Cell injury
    2000.04~2007.03Osmotic response and injury of cells.
  • In-situ harvesting of cultured cells by using thermoresponsive polymers
    keyword : Thermoresponsive polymer, Cell culture, Cell harvesting, In-situ observation
    2001.04~2008.03In-situ harvesting of cultured cells by using thermoresponsive polymers.
  • Freezing of Cells and Tissues

    keyword : Mechanism of freezing injury, Cryopreservation, Cryosurgery, Osmotic stress, Simulation of freezing process
    1999.01Freezing of cells and tissues.
  • Experimental and theoretical modeling of freezing during cryosurgery
    keyword : Cryosurgery, Simulation, Cryoprobe, Modeling
    2007.04Experimental and theoretical modeling of freezing during cryosurgery.
  • Boiling heat transfer from a surface with micro and nano structures for the application to the cooling of electronic devices
    keyword : LSI chip, Micro-configured surface, Boiling, Dielectric liquid, Heat transfer enhancement
    1996.04~2004.03Boiling heat transfer from a surface with micro and nano structures for the application to the cooling of electronic devices.
  • Heat and mass transfer in a vertical in-tube absorber
    keyword : Air-cooled absorber, In-tube absorption, Falling liquid film, LiBr, Heat and mass transfer
    1998.09~2004.05Heat and mass transfer in a vertical in-tube absorber..
Academic Activities
Books
1. JSME Texbook Series; Problems in Heat Transfer.
2. Bioengineering and Biomedical Engineering.
3. JSME Texbook Series; Heat Transfer.
Papers
1. Hiroshi Takamatsu, Haidong Wang, Takanobu Fukunaga, Kosaku Kurata, Measurement of fluid thermal conductivity using a micro-beam MEMS sensor, International Journal of Heat and Mass Transfer, 10.1016/j.ijheatmasstransfer.2017.09.117, 117, 30-35, 2018.01, A new method for measuring thermal conductivities of gases and liquids was established by demonstrating the measurement of five kinds of liquid and air. It uses a sensor named “micro-beam sensor” that is a ∼10-μm-long free-standing platinum membrane suspended across a trench on a silicon substrate and heated in a sample by DC. This method is unique in that it is a steady-state measurement but free from the effect of natural convection owing to the micrometer size of the sensor. Improving the method for precisely determining the temperature of the sensor and modifying the device from those used in our previous feasibility study, we successfully measured the thermal conductivity ranging from ∼0.03 to ∼0.6 W/(m⋅K) within 4% error..
2. Kosaku Kurata, Takashi Yoshii, Yoshihiro Deguchi, Hiroshi Takamatsu, Raman microspectroscopic detection of thermal denaturation associated with irreversible electroporation, International Journal of Heat and Mass Transfer, 111, 163-170, 2017.08.
3. Mohammed Shurrab, Haidong Wang, Noriaki Kubo, Takanobu Fukunaga, Kosaku Kurata, Hiroshi Takamatsu, The cooling performance of a cryoprobe: Establishing guidelines for the safety margins in cryosurgery, International Journal of Refrigeration, 67, 308-318, 2016.07.
4. Haidong Wang, Kosaku Kurata, Takanobu Fukunaga, Hiroki Ago, Hiroshi Takamatsu, Xing Zhang, Tatsuya Ikuta, Koji Takahashi, Takashi Nishiyama, Yasuyuki Takata, Simultaneous measurement of electrical and thermal conductivities of suspended monolayer graphene, Journal of Applied Physics, 119, 244306 (6 pages), 2016.06.
5. Kazuhiro Nishimura, DONG HAI WANG, Takanobu Fukunaga, Kosaku Kurata, Hiroshi Takamatsu, Measurement of in-plane thermal and electrical conductivities of thin film using a micro-beam sensor: A feasibility study using gold film, International Journal of Heat and Mass Transfer, 95, 727-734, 2016.04, A new method was proposed for measuring the in-plane thermal conductivity of thin films using a free-standing “micro-beam” metallic sensor. The sensor is heated in a vacuum with a direct current to induce temperature rise, which is determined from the electrical resistance of the sensor. The method consists of two protocols: measurement of a bare sensor and that after deposition of a sample film on its top surface. Based on the principle that the temperature rises of the sensor with and without a deposited film is different from each other because of the difference in the in-plane thermal conductance, the thermal conductivity of the sample film is determined by comparing the measured temperature rise with that obtained by a numerical analysis. In the present study, measurement of a 20-nm thick gold film was demonstrated by fabricating two platinum sensors that have different widths. The measured thermal conductivities of the platinum sensor and the gold film were significantly smaller than those of bulk materials. The relation between the thermal conductivity and the electrical conductivity was also discussed..
6. Mohammed Shurrab, Haidong Wang, Noriaki Kubo, Takanobu Fukunaga, Kosaku Kurata, Hiroshi Takamatsu, A Reference for Cryosurgery using Two Parallel Cryoprobes: Simulation and Experiment using a Tissue Phantom, 低温医学, 41, 2, 69-74, 2016.03.
7. Haidong Wang, Kosaku Kurata, Takanobu Fukunaga, Hiroshi Takamatsu, Xing Zhang, Tatsuya Ikuta, Koji Takahashi, Takashi Nishiyama, Hiroki Ago, Yasuyuki Takata, In-situ measurement of the heat transport in defect- engineered free-standing single-layer grapheme, Scientific Reports, 6, 21823, 2016.02.
8. Hiroshi Takamatsu, Kosaku Kurata, Engineering approach to irreversible electroporation, Proceedings of the 15th International Heat Transfer Conference, IHTC15-KN05, 18, 2014.08, 本論文では,著者が過去数年にわたって行って来た不可逆エレクトロポレーションに関する研究のレビューを行った.不可逆エレクトロポレーションとは高電圧パルスを組織に印加し,細胞膜のみを破壊する新しい治療法である.この治療法に関して,通電に起因した組織の温度上昇の検出とシミュレーションによる温度上昇の予測,電圧印加条件に依存した細胞壊死範囲の実験による特定とシミュレーションとの比較など,工学的な見地からの検討を行った..
9. Hiroshi Takamatsu, Takanobu Fukunaga, Yuki Tanaka, Kosaku Kurata, Koji Takahashi, Micro-beam sensor for detection of thermal conductivity of gases and liquids, Sensors and Actuators A, 10.1016/j.sna.2013.11.019, 206, 10-16, 2014.02, 本論文は,新しく提案したビーム型のMEMSセンサを用いて液体及び気体試料の熱伝導率を測定する方法に関するものである.このセンサを用いると,原理的にはわずか1マイクロリットルの試料の熱伝導率を1ミリ秒程度で簡単に測定できる.本論文では,実際にセンサを試作して,測定が可能であることを実証した..
10. Kosaku Kurata, Ryo Ueno, Masahiro Matsushita, Takanobu Fukunaga, Hiroshi Takamatsu, Experimental and Analytical Studies on Contact Irreversible Electroporation for Superficial Tumor Treatment, Journal of Biomechanical Science and Engineering, 8, 4, 306-318, 2013.12, 本論文は,新しい低侵襲治療法である非熱的不可逆エレクトロポレーションを表在組織に適用する為の実験的,解析的研究である.不可逆エレクトロポレーションは,組織に穿刺した電極間に高電圧パルスを印加して細胞膜のみを破壊する治療法であるが,本研究では穿刺電極を使わない接触式エレクトロポレーションを提案し,数値解析とともに三次元培養モデル組織を用いた実験によりその実現可能性を示した..
11. Kosaku Kurata, Takashi Yoshii, Satoru Uchida, Takanobu Fukunaga, Hiroshi Takamatsu, Visualization of electroporation-induced temperature rise using temperature-sensitive ink, International Journal of Heat and Mass Transfer, 10.1016/j.ijheatmasstransfer.2012.07.038, 55, 23-24, 7207-7212, 2012.11, 本論文は,不可逆エレクトロポレーションで生じる可能性のある組織の瞬間的な温度上昇を初めて実験的に捉えた研究である.高電圧パルス印加による温度上昇は数十マイクロ秒程度であるため,通常の温度測定法では測定不可能である.そこで,本研究では,感温性のインクを使って温度上昇を検知する方法を開発し,生体ファントムの温度上昇の測定に成功した..
12. H. Takamatsu, K. Inada, S. Uchida, K. Takahashi, M. Fujii, Feasibility Study of a Novel Technique for Measurement of Liquid Thermal Conductivity with a Micro Beam Sensor, International Journal of Thermophysics, 31.0, 41734.0, 888-899, 2010.05.
13. T. Yoshimori, H. Takamatsu, 3-D measurement of osmotic dehydration of isolated and adhered PC-3 cells, Cryobiology, Vol. 58, No. 1, pp.52-61, 2009.02.
14. H. Takamatsu, S. Zawlodzka, Contribution of Extracellular Ice Formation and the Solution Effects to the Freezing Injury of PC-3 Cells Suspended in NaCl Solutions, Cryobiology, 53, 1, 1-11, 2006.08.
15. S. Zawlodzka, H. Takamatsu, Osmotic Injury of PC-3 Cells by Hypertonic NaCl Solutions at Temperatures above 0°C, Cryobiology, 10.1016/j.cryobiol.2004.10.004, 50.0, 1.0, 50, 1, 58-70, 2005.02.
16. H. Takamatsu, R. Takeya, S. Naito, H. Sumimoto, On the Mechanism of Cell Lysis by Deformation, J. Biomech., 10.1016/j.jbiomech.2004.03.011, 38.0, 1.0, 38, 1, 117-124, 2005.01.
17. H. Takamatsu, Y. Komori, S. Zawlodzka, M. Fujii, Quantitative Examination of a Perfusion Microscope for the Study of Osmotic Response of Cells, J. Biomech. Eng., 10.1115/1.1784474, 126.0, 4.0, 126, 4, 402-409, 2004.08.
18. H. Takamatsu, N. Kumagae, Survival of Biological Cells Deformed in a Narrow Gap, J. Biomech. Eng., 10.1115/1.1516197, 124.0, 6.0, 124, 6, 780-783, 2002.12.
19. H. Takamatsu, M. Fujii, H. Honda, H. Uchiyama, Stability of Annular Liquid Film in Microgravity, Microgravity Science and Technology, 12.0, 1.0, 12, 1, 2-8, 1999.12.
20. H. Takamatsu, B. Rubinsky, Viability of Deformed Cells, Cryobiology, 10.1006/cryo.1999.2207, 39.0, 3.0, 39, 3, 243-251, 1999.11.
21. H. Honda, H. Yamashiro, H. Takamatsu, Stability of Vapor Film in Subcooled Film Boiling on a Sphere, Therm. Sci. Eng..
22. H. Takamatsu, H. Kubo, H. Honda, Immersion Cooling of a Simulated Microelectronic Chip with Artificial Re-entrant Cavities, Trans. JSME, Ser. B.
Presentations
1. Hiroshi Takamatsu, Kosaku Kurata, Engineering approach to irreversible electroporation, The 15th International Heat Transfer Conference, 2014.08.
2. H. Takamatsu, Freezing of Cells; Role of Ice and Solutes in Cell Damage, 2007 ASME-JSME Thermal Engineering Summer Heat Transfer Conference, 2007..
Membership in Academic Society
  • The Engineering Academy of Japan
  • Japan Society of Engineering Education
  • Kyushu Society of Engineering Education
  • Society for Cryobiology
  • The Japan Society of Mechanical Engineers
  • Heat Transfer Society of Japan
  • The Japan Society for Low Temperature Medicine
  • Japan Society of Refrigerating and Air Conditioning Engineers
  • Japan Society of Thermophysical Properties
  • Japanese Society for Cryobiology and Cryotechnology
Awards
  • JSME Medal for Outstanding Paper, The Japan Society of Mechanical Engineers
  • Best Paper Award from Heat Transfer Society of Japan, 2001
Educational
Educational Activities
Graduate School of Engineering, Department of Mechanical Engineering Science
1. Heat and Mass Transfer
2. Biomechanical Engineering
3. Bioengineering

Undergraduate School of Engineering, Department of Mechanical and Aerospace Engineering
1. Heat Transfer
2. Heat Transfer for Global Course