Kyushu University Academic Staff Educational and Research Activities Database
Keyword Search Method of using the search function
Keyword
Search Criteria
 
Detailed Search

Researcher information
Seiho Nagafuchi Last modified date：2012.9.14

Professor / Medical Science and Technology, Department of Health Sciences, Graduate School of Medical Sciences
Department of Health Sciences
Faculty of Medical Sciences


Graduate School
Department of Health Sciences
Graduate School of Medical Sciences
Undergraduate School
Medical Sciences and Technology
School of Medicine


Homepage
http://www.shs.kyushu-u.ac.jp/nagafuchi/
Laboratory of Viral and Molecular Immunology of Diabetes (Nagafuchi Lab.).
Phone
092-642-6731
Fax
092-642-6731
Academic Degree
Medical Doctor and Doctor of Philosophy, (M.D., Ph.D.)
Field of Specialization
Internal Medicine, Diabetology, Immunology, Virology
Outline Activities
Research
1. The role of AIRE gene in the regulation of immune responses
2. Pathogenesis of autoimmune (type 1) diabetes: virus-induced diabetes and autoimmune mechanisms
3. NOD-ES cell studies
4. Clinical significance of herpesvirus infections

Education and Social Activities
1. Educate intenal medicine, focusing on the diabetology, immunology and virology
2. Clinica practice of Diabetes
Research
Research Interests
  • Virus-induced Diabetes
    keyword : Diabetes, Virus, Immunoregulation, Susceptibility genes
    2000.05.
  • The regulatory mechanisms of AIRE gene expression and identification of target genes regulated by AIRE gene.
  • type 1 diabetes susceptibility genes
Academic Activities
Books
 Show All Books >>
1. Handbook for Diabetes Therapy.
Reports
 Show All Reports >>
1. Nagafuchi S, Katsuta H, Anzai K,Rituximab, B-lymphocyte Depletion, Beta-cell Function,New England Journal of Medicine,2010.02.
Papers
 Show All Papers >>
1. Nagafuchi S, Katsuta H, Anzai K.,Rituximab, B-Lympocyte depletion, and beta-cell function. ,Engl J Med 362(8):761, 2010,Vol.362,No.8,pp.761,2010.02.
2. Kounoue E, Izumi K, Ogawa S, Kondo S, Katsuta H, Akashi T, Niho Y, Harada M, Tamiya S, Kurisaki H, Nagafuchi S. ,The significance of T cells, B cells, antibodies and macrophages against encephalomyocarditis (EMC)-D virus-induced diabetes in mice,Archives of Virology,1223-1231,2008.07.
3. Nagafuchi S, Umene K, Yamanaka F, Oohashi S, Shindo M, Kurisaki H, Kudoh J, Shimizu N, Hara T, Harada M.,Recurrent herpes simplex virus (HSV) infection in a patient with autoimmune Polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator (AIRE) gene mutations.,Journal of Internal Medicine,261:605-610,2007.06.
4. Nagafuchi S, Katsuta H, Koyanagi-Katsuta R, Yamasaki S, Inoue Y, Shimoda K, Ikeda Y, Shindo M, Yoshida E, Matsuo T, Ohno Y, Kogawa k, Anzai K, Kurisaki H, Kudoh J, Harada M, Shimizu N.,Autoimmune regulator (AIRE) gene is expressed in human activated CD4+ T-cells and regulated by mitogen-activated protein kinase pathway,Microbiology and Immunology,50:979-987,2006.12.
5. Nagafuchi S, Katsuta H, Ohno Y, et al.,Mitogen activated protein kinase pathway controls autoimmune regulator gene expression in granulo-monocyte colony stimulating factor (GM-CSF) stimulated myelomonocytic leukemia OTC-4 cells,Immunology Letters,99: 130-135,2005.04.
6. Cavadini P, Vermi W, Facchetti F, Fontana S, Nagafuchi S, Mazzolari E, Sediva A, Marrella V, Villa A, Fischer A, Notarangelo LD, Badolato R.,AIRE deficiency in thymus of two patiens with Omenn syndrome.,Journal of Clinical Investigation,115(3):728-732, 2005,2005.03.
7. Kogawa K, Kudoh J, Nagafuchi S, Ohga S, Katsuta H, 1, Kudoh J, Ishibashi H, Harada M, Hara T, Shimizu N.,Distinct clinical phenotype and imjunoreactivity in Japanese siblings with atuoimmune polygalndular syndrome type 1 (APS-1) associated with compound heterozygous novel AIRE gene mutations.,Clinical Immunology,103:277-283,2002.01.
8. Kogawa K, Nagafuchi S, Katsuta H, Kudoh J, Tamiya S, Sakai Y, Shimizu N, Harada M.,Expression of AIRE gene in periperal monocyte/dendritic cell lineage.,Immunology Letters,80:195-198,2002.03.
9. Nagafuchi S, Oda H, Mori R, and Taniguchi T,Mechanism of acquired resistance to herpes simplex virus infection as studied in nude mice,Jouranal of General Virology,44:715-723,1979.01.
10. Nagafuchi S, Hayashida I, Higa K, Wada T, Mori R,Role of Lyt-1 positive immune T cells in recovery from herpes simplex virus infection in mice.,Microbiology and Immunology,26 : 359-362,,1982.01.
11. Hayashida I, Nagafuchi S, Hayashi Y, Kino Y, Mori R, Oda H, Ohtomo N, Tashiro A,Mechanism of antibody mediated protection against herpes simplex virus infection in mice : Requirement of Fc portion of antibody.,Microbiology and Immunology,26 : 497-509,1982,1982.01.
12. Akashi T, Nagafuchi S, Anzai K, Kondo s, Kitamura D, Wakana S, Ono J, Kikuchi M, Niho Y, Watanabe T,Direct evidence for the contribution of B cells to the progression of insulitis and the development of diabetes in non-obese diabetic mice,International Immunology,9:1159-1164,1997.01.
13. Nagafuchi S, Katsuta H, Kogawa K, Akashi T, Kondo S, Sakai Y, Tsukiyama T,Kitamura D, Niho Y, Watanabe T,Establishment of an embryonic stem (ES) cell line derived from a non-obese diabetic (NOD) mouse: In vivo differentiation into lymphocytes and potential for germ line transmission.,FEBS Letters,455: 101-104,1999.01.
14. Kounoue E, Nagafuchi S, Nakamura M, Nakano S, Koga T, Nakayama M, Mituyama M, Niho Y, Takaki R,Encephalomyocarditis (EMC) virus-induced diabetes mellitus prevented by Corynebacterium parvum in mice.,Experientia,43 : 430-431,1987.01.
15. Nagafuchi S, Kashiwagi S, Okada K, Anzai K, Nakamura M, Nishimura Y, Sasazuki T, and Niho Y,Reversal of Nonresponders and Postexposure Prophylaxis by Intradermal Hepatitis B Vaccination in Japanese Medical Personnel,JAMA (Journal of American Medical Association),265 : 2679-2683,1991.01.
16. Nagafuchi S, Kashiwagi S,Reversal by intradermal hepatitis B vaccination of unresponsiveness to HBsAg,Lancet,II : 1522-1523,1987.01.
17. Nagafuchi S, Tokiyama K, Kashiwagi S, Hayashi S, Imayama S, Niho Y,Eosinophilia after intradermal hepatitis B vaccination,Lancet,342: 998,1993.01.
18. Fujisaki T, Nagafuchi S, Niho Y, Tsuneyoshi M, Oshima K, and Kikuchi M,Malignant histiocytosis in a patient with chronic active Epstein-Barr virus infection,Lancet,340:1168-1169,1982.01.
19. Sugihara J, Imamura T, Nagafuchi S, Bonavantura J, Bonaventura D, and Cashon R,Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site : functional consequences of the alteration and effects of,Journal of Clinical Investigation,76:1169-1173,1985.01.
20. Iwata I, Nagafuchi S, Nakashima H, Kondo S, Koga T, Yokogawa Y, Akashi T, Shibuya T, Umeno Y, Okeda T, Shibata S, Kono S, Yasunami M, Ohkubo H, Niho Y,Association of polymorphism in the NeuroD/BETA2 gene with type 1 diabetes in the Japanese.,Diabetes,48:416-419,1999.01.
Presentations
 Show All Presentations >>
1. New Methods for the Diagnosis of Infectious Diseases.
Educational
Other Educational Activities
  • 2009.10,Diabetes Therapy Handbook (Medical Publishing company).


The fact that no permission it reprints contents of this data base is prohibitted.

Copyright © 2006, Kyushu University. All right reserved.