Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Shozo Tobimatsu Last modified date:2020.01.30

Professor / Science for Biological Information / Department of Basic Medicine / Faculty of Medical Sciences

1. Hayato Une, Dai Matsuse, Taira Uehara, Yoshikazu Kikuchi, Saeko Inamizu, Ryo Yamasaki, Shozo Tobimatsu, Hiroshi Shibasaki, Jun ichi Kira, Branchial myorhythmia in a case of systemic lupus erythematosus, Journal of the Neurological Sciences, 10.1016/j.jns.2019.116501, 408, 2020.01.
2. Katsuya Ogata, Hisato Nakazono, Taira Uehara, Shozo Tobimatsu, Prestimulus cortical EEG oscillations can predict the excitability of the primary motor cortex, Brain Stimulation, 10.1016/j.brs.2019.06.013, 12, 6, 1508-1516, 2019.11, Background: The motor evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS) vary considerably at rest, but the mechanism underlying this amplitude variation is largely unknown. We hypothesized that prestimulus EEG oscillations modulate the subsequent MEPs in a state-dependent manner. Objective: We studied the relationship between prestimulus alpha/beta oscillations and MEPs during eyes open (EO)/closed (EC) conditions, and then modulated TMS intensity in the EO condition. Furthermore, we developed an EEG-triggered TMS system (“informed open-loop”) to verify our hypothesis. Methods: TMS was applied to the left motor cortex. We first compared EEG power differences between high- and low-amplitude MEP epochs in the EO and EC conditions when using a high TMS intensity. Next, we evaluated the effects of varying TMS intensities (high vs. low) on the EEG–MEP relationship. Finally, we used EEG-triggered TMS to determine whether prestimulus EEG oscillations predicted MEP amplitudes. Results: Prestimulus higher-power alpha/low-beta bands produced larger MEPs only in the high-intensity EO condition. A positive relationship between EEG power and MEP amplitude was observed at C3 and left frontal electrodes. This relationship was obscured when using the lower TMS intensity but was observed in the high-intensity condition at the C3 electrode. EEG-triggered TMS demonstrated that higher alpha power predicted higher MEP amplitudes, but beta power at around 20 Hz did not. Conclusions: A causal relationship between alpha/low-beta oscillations and MEP amplitudes at rest requires high TMS intensity delivered when eyes are open. This association may allow us to develop a new informed open-loop TMS protocol..
3. Hiroyuki Mitsudo, Naruhito Hironaga, Katsuya Ogata, Shozo Tobimatsu, Vertical size disparity induces enhanced neural responses in good stereo observers, Vision Research, 10.1016/j.visres.2019.08.009, 164, 24-33, 2019.11, Stereoscopic three-dimensional vision requires cortical processing for horizontal binocular disparity between the two eyes’ retinal images. Behavioral and theoretical studies suggest that vertical size disparity is used to recover the viewing geometry and to generate the slant of a large surface. However, unlike horizontal disparity, the relation between stereopsis and neural responses to vertical disparity remains controversial. To determine the role of cortical processing for vertical size disparity in stereopsis, we measured neuromagnetic responses to disparities in people with good and poor stereopsis, using magnetoencephalography (MEG). Healthy adult participants viewed stereograms with a horizontal or vertical size disparity, and judged the perceived slant of the pattern. We assessed neural activity in response to disparities in the visual cortex and the phase locking of oscillatory responses including the alpha frequency range using MEG. For participants with good stereopsis, activity in the visual areas was significantly higher in response to vertical size disparity than to horizontal size disparity. The time–frequency analysis revealed that early neural responses to vertical size disparity were more phase-locked in good stereo participants than in poor stereo participants. These results provide neuromagnetic evidence that vertical-size disparity processing plays a role in good stereo vision..
4. Takao Yamasaki, Toshihiko Aso, Yumiko Kaseda, Yasuyo Mimori, Hikaru Doi, Naoki Matsuoka, Naomi Takamiya, Tsuyoshi Torii, Tetsuya Takahashi, Tomohiko Ohshita, Hiroshi Yamashita, Hitoka Doi, Saeko Inamizu, Hiroshi Chatani, Shozo Tobimatsu, Decreased stimulus-driven connectivity of the primary visual cortex during visual motion stimulation in amnestic mild cognitive impairment
An fMRI study, Neuroscience Letters, 10.1016/j.neulet.2019.134402, 711, 2019.10, Motion perceptual deficits are common in Alzheimer's disease (AD). Although the posterior parietal cortex is thought to play a critical role in these deficits, it is currently unclear whether the primary visual cortex (V1) contributes to these deficits in AD. To elucidate this issue, we investigated the net activity or connectivity within V1 in 17 amnestic mild cognitive impairment (aMCI) patients, 17 AD patients and 17 normal controls (NC) using functional magnetic resonance imaging (fMRI). fMRI was recorded under two conditions: visual motion stimulation and resting-state. The net activity or connectivity within V1 extracted by independent component analysis (ICA) was significantly increased during visual motion stimuli compared with that of the resting-state condition in NC, but not in aMCI or AD patients. These findings suggest the alteration of the net activity or connectivity within V1, which may contribute to the previously reported motion perceptual deficits in aMCI and AD. Therefore, the decreased net V1 activity measured as the strength of the ICA component may provide a new disease biomarker for early detection of AD..
5. Kazuhiko Goto, Takenao Sugi, Hiroki Fukuda, Takao Yamasaki, Shozo Tobimatsu, Yoshinobu Goto, The effect of stimulus pattern, color combination and flicker frequency on steady-state visual evoked potentials topography, International Journal of Innovative Computing, Information and Control, 10.24507/ijicic.15.04.1521, 15, 4, 1521-1530, 2019.08, We investigated color/luminance characteristics and flicker frequency characteristics from steady-state visual evoked potentials (SSVEPs) topography on sinusoidal patterns and square wave patterns using black-and-white flicker stimulus and isoluminant color combination stimulus. Flicker frequencies of 6-18 Hz to black-and-white flicker stimuli and isoluminant color combination stimuli (red/blue, red/green) were adopted. Each of the stimuli and stimulus patterns were sinusoidal and square wave patterns. The study subjects were 20 healthy, young adult males (9 for monochrome and 11 for colors). Their topographical characteristics were evaluated by the maximum amplitude, central point coordinates, and the ratio of the activated area from the VEP averaged waveform in each recorded area. No significant difference in any of the characteristic parameters between stimulus patterns existed. The isoluminant color combination stimuli had a significantly smaller maximum amplitude compared with the black-and-white flicker stimulus; the central point coordinates and the ratio of the activated area changed considerably. Significant changes in characteristic parameters were also seen between stimulus frequencies. It is suggested that the position and distribution of the neuronal population in the active primary visual cortex differ according to color, luminance, and flicker frequency. However, it is considered that even if the stimulus patterns are different, the active primary visual cortex neuronal population does not change..
6. Ryutaro Hayashi, Katsuya Ogata, Hisato Nakazono, Shozo Tobimatsu, Modified ischaemic nerve block of the forearm
use for the induction of cortical plasticity in distal hand muscles, Journal of Physiology, 10.1113/JP277639, 597, 13, 3457-3471, 2019.07, Key points: Ischaemic nerve block (INB) of the forearm rapidly reduces somatosensory input to a part of the body, which leads to the functional reorganization of the temporarily deafferented primary motor cortex (M1). We applied a novel modified INB (mINB) to the forearm, maintaining mean blood pressure, to assess cortical plasticity in the primary somatosensory cortex (S1) and the M1 regions associated with small hand muscles. S1 excitability was measured by median nerve somatosensory-evoked potentials (SEPs), while M1 excitability was evaluated by motor-evoked potentials (MEPS), using transcranial magnetic stimulation. The finding that S1 excitability increased and M1 excitability decreased after the mINB was removed reflects the differential short-term cortical plasticity of the S1 and M1 regions. These opposite effects observed for the S1 and M1 regions following the mINB may indicate a possible intra-hemispheric interaction between the S1 and M1 regions. Abstract: Ischaemic nerve block (INB) causes short-term sensory deprivation, leading to functional reorganization in the deafferented motor cortex (M1). We used a modified INB (mINB) to evaluate cortical plasticity in the somatosensory cortex (S1) and M1 region associated with small hand muscles, because INB strongly inhibits muscles distal to the tourniquet. Thirty-three healthy adults participated in different combinations of four experiments. A pneumatic tourniquet was placed just below the right elbow and inflated to induce a mINB. We recorded the median nerve somatosensory- and motor-evoked potentials (SEPs and MEPs) before, during and after mINB placement and assessed spinal cord excitability using F-wave measurements. SEPs at Erb's point (N9) were abolished during the mINB; those at cortical N20 were suppressed. After removing the mINB, N20 amplitudes increased significantly, while those at N9 did not fully recover. P14 amplitudes after tourniquet deflation immediately recovered to baseline levels. M1-MEP amplitudes decreased during the mINB, and Erb-MEPs were suppressed. After the mINB was removed, M1-MEPs remained suppressed, while Erb-MEPs fully recovered. F-waves were not affected by the intervention. Therefore, sensory, but not motor, nerve function was affected by the mINB. S1 excitability was enhanced after the mINB was removed, indicating that S1 and M1 excitability were modulated in opposing directions after deflation. These after-effects may reflect isolated effects or interactions between the S1 and M1 regions. Our findings may facilitate improved understanding of the sensorimotor modulations that occur distal to the tourniquet due to temporal deafferentation and lead to development of novel neuromodulation protocols..
7. Hisato Nakazono, Katsuya Ogata, Akinori Takeda, Emi Yamada, Takahiro Kimura, Shozo Tobimatsu, Transcranial alternating current stimulation of α but not β frequency sharpens multiple visual functions, Brain Stimulation, 10.1016/j.brs.2019.10.022, 2019.01, Background: Transcranial alternating current stimulation (tACS) can entrain and enhance cortical oscillatory activity in a frequency-dependent manner. In our previous study (Nakazono et al., 2016), 20 Hz (β) tACS significantly increased excitability of primary motor cortex compared with 10 Hz (α) tACS. α oscillations are a prominent feature of the primary visual cortex (V1) in a resting electroencephalogram. Hence, we investigated whether α and β tACS can differentially influence multiple visual functions. Methods: Firstly, we evaluated the after-effects of α and β tACS on pattern-reversal (PR) and focal-flash (FF) visual evoked potentials (VEPs). Secondly, we determined the relationship between resting α oscillations and PR-VEPs modulated by tACS. Thirdly, the behavioral effects of tACS were assessed by contrast sensitivity. Results: α tACS modulated the amplitudes of PR-VEPs, compared with β tACS, but did not modulate the FF-VEPs. Time-frequency analysis revealed that α tACS facilitated event-related α phase synchronizations without increasing power, which consequently increased the PR-VEP amplitudes. There was a significant positive correlation between PR-VEP amplitudes and resting α oscillations. These findings suggested that α tACS modulated α oscillations, and affected visual functions of contrast and spatial frequency. Indeed, α tACS also improved subjects’ contrast sensitivity at the behavioral level. Conversely, β tACS increased posterior α activity, but did not change VEP amplitudes. Conclusions: α tACS can influence different neuronal populations from those influenced by β tACS. Thus, our results provide evidence that α tACS sharpens multiple visual functions by modulating α oscillations in V1..
8. Ela Austria Barcelon, Takahiko Mukaino, Jun Yokoyama, Taira Uehara, Katsuya Ogata, Jun ichi Kira, Shozo Tobimatsu, Grand Total EEG score can differentiate Parkinson's disease from Parkinson-related disorders, Frontiers in Neurology, 10.3389/fneur.2019.00398, 10, APR, 2019.01, Background: Semi-quantitative electroencephalogram (EEG) analysis is easy to perform and has been used to differentiate dementias, as well as idiopathic and vascular Parkinson's disease. Purpose: To study whether a semi-quantitative EEG analysis can aid in distinguishing idiopathic Parkinson's disease (IPD) from atypical parkinsonian disorders (APDs), and furthermore, whether it can help to distinguish between APDs. Materials and Methods: A comprehensive retrospective review of charts was performed to include patients with parkinsonian disorders who had at least one EEG recording available. A modified grand total EEG (GTE) score evaluating the posterior background activity, and diffuse and focal slow wave activities was used in further analyses. Results: We analyzed data from 76 patients with a final diagnosis of either IPD, probable corticobasal degeneration (CBD), multiple system atrophy (MSA), or progressive supra-nuclear palsy (PSP). IPD patients had the lowest mean GTE score, followed those with CBD or MSA, while PSP patients scored the highest. However, none of these differences were statistically significant. A GTE score of ≤9 distinguished IPD patients from those with APD (p < 0.01) with a sensitivity of 100% and a specificity of 33.3%. Conclusion: The modified GTE score can distinguish patients with IPD from those with CBD, PSP or MSA at a cut-off score of 9 with excellent sensitivity but poor specificity. However, this score is not able to distinguish a particular form of APD from other forms of the disorder..
9. Takao Yamasaki, Shozo Tobimatsu, Driving ability in Alzheimer disease spectrum
Neural basis, assessment, and potential use of optic flow event-related potentials, Frontiers in Neurology, 10.3389/fneur.2018.00750, 9, SEP, 2018.09, Driving requires multiple cognitive functions including visuospatial perception and recruits widespread brain networks. Recently, traffic accidents in dementia, particularly in Alzheimer disease spectrum (ADS), have increased and become an urgent social problem. Therefore, it is necessary to develop the objective and reliable biomarkers for driving ability in patients with ADS. Interestingly, even in the early stage of the disease, patients with ADS are characterized by the impairment of visuospatial function such as radial optic flow (OF) perception related to self-motion perception. For the last decade, we have studied the feasibility of event-related potentials (ERPs) in response to radial OF in ADS and proposed that OF-ERPs provided an additional information on the alteration of visuospatial perception in ADS (1, 2). Hence, we hypothesized that OF-ERPs can be a possible predictive biomarker of driving ability in ADS. In this review, the recent concept of neural substrates of driving in healthy humans are firstly outlined. Second, we mention the alterations of driving performance and its brain network in ADS. Third, the current status of assessment tools for driving ability is stated. Fourth, we describe ERP studies related to driving ability in ADS. Further, the neural basis of OF processing and OF-ERPs in healthy humans are mentioned. Finally, the application of OF-ERPs to ADS is described. The aim of this review was to introduce the potential use of OF-ERPs for assessment of driving ability in ADS..
10. Teppei Matsubara, Katsuya Ogata, Naruhito Hironaga, Yosikazu Kikuchi, Taira Uehara, Hiroshi Chatani, Takako Mitsudo, Hiroshi Shigeto, Shozo Tobimatsu, Altered neural synchronization to pure tone stimulation in patients with mesial temporal lobe epilepsy
An MEG study, Epilepsy and Behavior, 10.1016/j.yebeh.2018.08.036, 88, 96-105, 2018.11, Objective: Our previous study of monaural auditory evoked magnetic fields (AEFs) demonstrated that hippocampal sclerosis significantly modulated auditory processing in patients with mesial temporal lobe epilepsy (mTLE). However, the small sample size (n = 17) and focus on the M100 response were insufficient to elucidate the lateralization of the epileptic focus. Therefore, we increased the number of patients with mTLE (n = 39) to examine whether neural synchronization induced by monaural pure tone stimulation provides useful diagnostic information about epileptic foci in patients with unilateral mTLE. Methods: Twenty-five patients with left mTLE, 14 patients with right mTLE, and 32 healthy controls (HCs) were recruited. Auditory stimuli of 500-Hz tone burst were monaurally presented to subjects. The AEF data were analyzed with source estimation of M100 responses in bilateral auditory cortices (ACs). Neural synchronization within ACs and between ACs was evaluated with phase-locking factor (PLF) and phase-locking value (PLV), respectively. Linear discriminant analysis was performed for diagnosis and lateralization of epileptic focus. Results: The M100 amplitude revealed that patients with right mTLE exhibited smaller M100 amplitude than patients with left mTLE and HCs. Interestingly, PLF was able to differentiate the groups with mTLE, with decreased PLFs in the alpha band observed in patients with right mTLE compared with those (PLFs) in patients with left mTLE. Right hemispheric predominance was confirmed in both HCs and patients with left mTLE while patients with right mTLE showed a lack of right hemispheric predominance. Functional connectivity between bilateral ACs (PLV) was reduced in both patients with right and left mTLE compared with that of HCs. The accuracy of diagnosis and lateralization was 80%–90%. Conclusion: Auditory cortex subnormal function was more pronounced in patients with right mTLE compared with that in patients with left mTLE as well as HCs. Monaural AEFs can be used to reveal the pathophysiology of mTLE. Overall, our results indicate that altered neural synchronization may provide useful information about possible functional deterioration in patients with unilateral mTLE..
11. Teppei Matsubara, Katsuya Ogata, Naruhito Hironaga, Taira Uehara, Takako Mitsudo, Hiroshi Shigeto, Toshihiko Maekawa, Shozo Tobimatsu, Monaural 40-Hz auditory steady-state magnetic responses can be useful for identifying epileptic focus in mesial temporal lobe epilepsy, Clinical Neurophysiology, 10.1016/j.clinph.2018.11.026, 130, 3, 341-351, 2019.03, Objective: Patients with mesial temporal lobe epilepsy (mTLE) often exhibit central auditory processing (CAP) dysfunction. Monaural 40-Hz auditory steady-state magnetic responses (ASSRs) were recorded to explore the pathophysiology of mTLE. Methods: Eighteen left mTLE patients, 11 right mTLE patients and 16 healthy controls (HCs) were examined. Monaural clicks were presented at a rate of 40 Hz. Phase-locking factor (PLF) and power values were analyzed within bilateral Heschl's gyri. Results: Monaural 40-Hz ASSR demonstrated temporal frequency dynamics in both PLF and power data. Symmetrical hemispheric contralaterality was revealed in HCs. However, predominant contralaterality was absent in mTLE patients. Specifically, right mTLE patients exhibited a lack of contralaterality in response to left ear but not right ear stimulation, and vice versa in left mTLE patients. Conclusion: This is the first study to use monaural 40-Hz ASSR with unilateral mTLE patients to clarify the relationship between CAP and epileptic focus. CAP dysfunction was characterized by a lack of contralaterality corresponding to epileptic focus. Significance: Monaural 40-Hz ASSR can provide useful information for localizing epileptic focus in mTLE patients..
12. Hironaga N, Mitsudo T, Hayamizu M, Nakajima Y, Takeichi H, Tobimatsu S, Spatiotemporal brain dynamics of auditory temporal assimilation., Sci Rep, 2017 Sep 12;7(1):11400., DOI:10.1038/s41598-017-11631-0, 2017.02.
13. Takao Yamasaki, Toshihiko Maekawa, Yuka Miyanaga, Kenji Takahashi, Naomi Takamiya, Katsuya Ogata, Shozo Tobimatsu, Enhanced fine-form perception does not contribute to gestalt face perception in autism spectrum disorder, PLoS ONE, 10.1371/journal.pone.0170239, 12, 2, 2017.02.
14. Takefumi Ohki, Atsuko Gunji, Yuichi Takei, Hidetoshi Takahashi, Yuu Kaneko, Yosuke Kita, Naruhito Hironaga, Shozo Tobimatsu, Yoko Kamio, Takashi Hanakawa, Masumi Ikenaga, Kazuo Hiraki, Neural oscillations in the temporal pole for a temporally congruent audio-visual speech detection task, SCIENTIFIC REPORTS, 10.1038/srep37973, 6, 2016.11.
15. Yoshikazu Kikuchi, Yoshikazu Kikuchi, Tsuyoshi Okamoto, Katsuya Ogata, Koichi Hagiwara, Toshiro Umezaki, Masamutsu Kenjo, Takashi Nakagawa, Shozo Tobimatsu, Katsuya Ogata, Koichi Hagiwara, Toshiro Umezaki, Kenjo Masamutsu, Takashi Nakagawa, Shozo Tobimatsu, Abnormal auditory synchronization in stuttering: A magnetoencephalographic study, HEARING RESEARCH, 10.1016/j.heares.2016.10.027, 344, 82-89, 2017.02.
16. Hisato Nakazono, Tsuyoshi Kuroda, Katsuya Ogata, Shozo Tobimatsu, Phase and Frequency-Dependent Effects of Transcranial Alternating Current Stimulation on Motor Cortical Excitability, PLOS ONE, 10.1371/journal.pone.0162521, 11, 9, 2016.09.
17. Atsushi Nagaike, Takako Mitsudo, Yoshitaka NAKAJIMA, Katsuya Ogata, Takao Yamasaki, Yoshinobu Goto, Shozo Tobimatsu, ‘Time-shrinking perception’in the visual system: A psychophysical and high-density ERP study., Experimental Brain Research, 10.1007/s00221-016-4726-1, 234, 11, 3279-3290, 2016.07.
18. Tsuyoshi Kuroda, Simon Grondin, Katsuya Ogata, Shozo Tobimatsu, The kappa effect with only two visual markers., Multisensory Research, 10.1163/22134808-00002533, 2016.04.
19. Yamasaki T, Horie S, Ohyagi Y, Tanaka E, Nakamura N, Goto Y, Kanba S, Kira J-I, Tobimatsu S, A potential VEP biomarker for mild cognitive impairment: Evidence from selective deficit of higher-level dorsal pathway, Journal of Alzheimer’s Disease, 2016.02.
20. Yuko Kume, Toshihiko Maekawa, Tomokazu Urakawa, Naruhito Hironaga, Katsuya Ogata, Maki Shigyo, Shozo Tobimatsu, Neuromagnetic evidence that the right fusiform face area is essential for human face awareness: An intermittent binocular rivalry study., Neuroscience Research, 10.1016/j.neures.2016.02.004, 2016.02.
21. Mariko Hayamizu, Koichi Hagiwara, Naruhito Hironaga, Katsuya Ogata, Sumio Hoka, Shozo Tobimatsu, A spatiotemporal signature of cortical pain relief by tactile stimulation: An MEG study., NeuroImage, 10.1016/j.neuroimage.2016.01.065, 130, 175-183, 2016.04.
22. Yuichi Takei, Kazuyuki Fujihara, Minami Tagawa, Naruhito Hironaga, Jamie Near, Masato Kasagi, Yumiko Takahashi, Tomokazu Motegi, Yusuke Suzuki, Yoshiyuki Aoyama, Noriko Sakurai, Miho Yamaguchi, Shozo Tobimatsu, Koichi Ujita, Yoshito Tsushima, Kosuke Narita, Masato Fukuda, The inhibition/excitation ratio related to task-induced oscillatory modulations during a working memory task: A multimodal-imaging study using MEG and MRS, NeuroImage, 10.1016/j.neuroimage.2015.12.057, 128, 302-315, 2016.03.
23. Hiroshi Chatani, Koichi Hagiwara, Naruhito Hironaga, Katsuya Ogata, Hiroshi Shigeto, Takato Morioka, Ayumi Sakata, Kimiaki Hashiguthi, Nobuya Murakami, Taira Uehara, Jun-ichi Kira, Shozo Tobimatsu, Neuromagnetic evidence for hippocampal modulation of auditory processing., NeuroImage, 10.1016/j.neuroimage.2015.09.006, 124, 1, 256-266, 2016.01.
24. Tomokazu Urakawa, Katsuya Ogata, Takehiro Ki,mura, Yuko Kume, Shozo Tobimatsu, Temporal dynamics of the knowledge-mediated visual disambiguation process in humans: An MEG study, Europian Journal of Neuroscience, 41, 2, 232-242, 2015.02.
25. Koichi Hagiwara, Katsuya Ogata, Tsuyoshi Okamoto, Shozo Tobimatsu, Age-related changes across the primary and secondary somatosensory areas: An analysis of neuromagnetic oscillatory activities, CLINICAL NEUROPHYSIOLOGY, 10.1016/j.clinph.2013.10.005, 125, 5, 1021-1029, 2014.05.
26. Takahiro Kimura, Katsuya Ogata, Shozo Tobimatsu, Repetitive Paired-pulse Transcranial Magnetic Stimulation Over the Visual Cortex Selectively Inhibits Focal Flash VEPs, BRAIN STIMULATION, 10.1016/j.brs.2013.12.010, 7, 2, 275-280, 2014.03.
27. Hideaki Miyaji, Koichi Hagiwara, Katsuya Ogata, Shozo Tobimatsu, Shizuo Komune, Neuromagnetic detection of the laryngeal area: Sensory-evoked fields to air-puff stimulation, NEUROIMAGE, 10.1016/j.neuroimage.2013.11.008, 88, 162-169, 2014.03.
28. Takao Yamasaki, Katsuya Ogata, Toshihiko Maekawa, Shozo Tobimatsu, Rapid maturation of voice and linguistic processing systems in preschool children: A near-infrared spectroscopic study, EXPERIMENTAL NEUROLOGY, 10.1016/j.expneurol.2013.10.005, 250, 313-320, 2013.12.
29. Toshihiko Maekawa, Toshiaki Onitsuka, Katsuya Ogata, Shozo Tobimatsu, Altered visual information processing systems in bipolar disorder: evidence from visual MMN and P3, FRONTIERS IN HUMAN NEUROSCIENCE, 10.3389/fnhum.2013.00403, 7, 2013.07.
30. Takako Fujita, Yoko Kamio, Takao Yamasaki, Sawa Yasumoto, Shinichi Hirose, Shozo Tobimatsu, Altered automatic face processing in individuals with high-functioning autism spectrum disorders: Evidence from visual evoked potentials, Res Autism Spectr Disord, 7, 6, 710-720, 2013.06.
31. Takayuki Taniwaki, Takashi Yoshiura, Katsuya Ogata, Jun-ichi Kira, Shozo Tobimatsu, Disrupted connectivity of motor loops in Parkinson's disease during self-initiated but not externally-triggered movements, BRAIN RESEARCH, 10.1016/j.brainres.2013.03.027, 1512, 45-59, 2013.05.
32. Kanamori Y, Hiroshi Shigeto, Shozo Tobimatsu, Jun-ichi Kira, Multimodality evoked potentials for discrimination of atopic myelitis and multiple sclerosis, Clin Exp Neuroimmunol, 4, 1, 29-35, 2013.04.
33. Takao Yamasaki, Jun-ichi Kira, Shigenobu Kanba, Shozo Tobimatsu, Selective impairment of optic flow perception in amnestic mild cognitive impairment: evidence from event-related potentials, J Alzheimers Dis, 28, 3, 695-708, 2012.03.
34. Takehiro Kimura, Katsuya Ogata, Shozo Tobimatsu, Repetitive paired-pulse transcranial magnetic stimulation over the visual cortex alters visual recovery function, Brain Stim, 6, 3, 298-305, 2012.03.
35. Shizuka Horie, Takao Yamasaki, Tshuyoshi Okamoto, Shigeyuki Kan, Katsuya Ogata, Satoru Miyauchi, Shozo Tobimatsu, Distinct role of spatial frequency in dissociative reading of ideograms and phonograms: An fMRI study, Neuroimage, 979-988, 2012.02.
36. Horie S, Yamasaki T, Okamoto T, Nakashima T, Ogata K, Tobimatsu S, Differential roles of spatial frequency on reading processes for ideograms and phonograms: A high-density ERP study, Neurosci Res, 72, 1, 68-78, 2012.01.
37. Shozo Tobimatsu, A Neural Decoding Approach to Auditory Temporal Assimilation, Neural Comput Appl, 20, 7, 965-973, 2011.06.
38. Mistudo T, Kamio Y, Goto Y, Nakashima T, Tobimatsu S, Neural responses in the occipital cortex to unrecognizable faces, Clin Neurophysiol, 122, 4, 718-728, 2011.04.
39. Kirimoto H, Ogata K, Onishi H, Oyama M, Goto Y, Tobimatsu S, Transcranial direct current stimulation over the motor association cortex induces plastic changes in ipsilateral primary motor and somatosensory cortices, Clin Neurophysiol, 122, 4, 777-783, 2011.04.
40. Kikuchi Y, Ogata K, Umesaki T, Yoshiura T, Kenjo M, Hirano Y, Okamoto T, Komune S, Tobimatsu S, Spatiotemporal signatures of an abnormal auditory system in stuttering, Neuroimage, 55, 3, 891-899, 2011.03.
41. Maekawa T, Tobimatsu S, Inada N, Oribe N, Onitsuka T, Kanba S, Kamio Y, Top-down and bottom-up visual information processing of non-social stimuli in high-functioning autism spectrum disorder, Res Autism Spectr Disord, 5, 1, 201-209, 2011.01.
42. Fujita T, Yamasaki T, Kamio Y, Hirose S, Tobimatsu S, Parvocellular pathway impairment in autism spectrum disorder: Evidence from visual evoked potentials, Res Autism Spectr Disord, 5, 1, 277-285, 2011.01.
43. Yamasaki T, Fujita T, Ogata K, Goto Y, Munetsuna S, Kamio Y, Tobimatsu S, Electrophysiological evidence for selective impairment of optic flow perception in autism spectrum disorder, Res Autism Spectr Disord, 5, 1, 400-407, 2011.01.
44. Noriuchi M, Kikuchi Y, Yoshiura T, Kira R, Shigeto H, Hara T, Tobimatsu S, Kamio Y, Altered white matter functional anisotropy and social impairment in children with autism spectrum disorder, Brain Res, 1362, 1, 141-149, 2010.10.
45. Takeichi H, Mitsudo T, Nakajima Y, Remijn GB, Goto Y, Tobimatsu S, A Neural Decoding Approach to Auditory Temporal Assimilation, Neural Comput Appl, Epub June 15, 2010., 2010.06.
46. Kai N, Kawajiri M, Seki N, Takano N, Kira J-I, Tobimatsu S, Naito S, Efficacy of high-frequency magnetic stimulation of the sacral root in patients with urinary incontinence following a radical prostectomy, Lower Urinary Tract Symposiums, 2, 1, 1-5, 2010.06.
47. Hagiwara K, Okamoto T, Shigeto H, Ogata K, Somehara Y, Matsushita T, Kira JI, Tobimatsu S, Oscillatory gamma synchronization binds the primary and secondary somatosensory areas in humans, Neuroimage, 51, 1, 412-420, 2010.01.
48. Obayashi C, Nakashima T, Onitsuka T, Maekawa T, Hirano Y, Hirano S, Oribe N, Kaneko K, Kanba S, Tobimatsu S, Decreased spatial frequency sensitivities for processing faces in male patients with chronic schizophrenia, Clin Nerurophysiol, 120 (8): 1525-1533, 2009.08.
49. Maekawa T, Tobimatsu S, Ogata K, Onitsuka T, Kanba S, Preattentive visual change detection as reflected by the mismatch negativity (MMN) – evidence for a memory-based process. , Neurosci Res, 65 (1): 107-112, 2009.07.
50. Ogata K, Okamoto T, Yamasaki T, Shigeto H, Tobimatsu S, Premovement gating of somatosensory evoked potentials by self-initiated movements: the effect of aging and its implication., Clin Neurophysiol, 120(6): 1143-1148, 2009.06.
51. Mitsudo T, Nakajima Y, Remijn GB, Takeichi H, Goto Y, Tobimatsu S, Electrophysiological evidence of auditory temporal perception related to the assimilation between neighboring two time intervals., NeuroQuantology, 7:114-127, 2009.06.
52. Nakashima T, Kaneko K, Goto Y, Abe T, Mitsudo T, Ogata K, Makinouchi A, Tobimatsu, S, Early ERP components differentially extract facial features: Evidence for spatial frequency-and-contrast detectors., Neurosci Res, 62 (4): 225-235, 2008., 2009.04.
53. Miyagi Y, Tsuyoshi Okamoto T, Morioka T, Tobimatsu S, Nakanishi Y, Aihara K, Hashiguchi K, Murakami N, Yoshida F, Samura K, Nagata S, Sasaki T, Spectral analysis of field potential recordings by DBS electrode for localization of subthalamic nucleus in patients with Parkinson’s disease. , Stereot Funct Neuros, 87(4):211-218, 2009.04.
54. Watanabe A, Matsushita T, Doi H, Matsuoka T, Shigeto H, Isobe N, Kawano Y, Tobimatsu S, Kira J, Multimodality-evoked potential study of anti-aquaporin-4 antibody-positive and –negative multiple sclerosis patients., J Neurol Sci, 281 (1): 34-40., 2009.01.
55. Oishi A, Tobimatsu S, Ogata, K, Taniwaki T, Kinukawa N, Toyoshiba H, Kira J-I, Differential contributions of spinal and cortical motoneurons to input-output properties of human small hand muscle. , Neurol Res, Neurol Res, 30 (12): 1106-1113., 2008.12.
56. Miyazaki M, Ikeda Y, Yonemitsu Y, Goto Y, Kohno R, Murakami Y, Inoue M, Ueda Y, Hasegawa M, Tobimatsu S, Sueishi K, Ishibashi T, Synergistic neuroprotective effect via simian lentiviral vector-mediated simultaneous gene transfer of human pigment epithelium-derived factor and human fibroblast growth factor-2 in rodent models of retinitis pigmentosa., J Gene Med, 10(12): 1273-1281, 2008.12.
57. Yamasaki T, Goto Y, Kinukawa N, Tobimatsu S, Neural basis of photo/chromatic sensitivity in adolescence. , Epilepsia , 49 (9): 1611-1618., 2008.09.
58. Nakashima T, Goto Y, Abe T, Kaneko K, Saito T, Makinouchi A, Tobimatsu, S, Electrophysiological evidence for sequential discrimination of positive and negative facial expressions., Clin Neurophysiol, 119 (8): 1803-1811, 2008.08.
59. Tsurusawa R, Goto Y, Mitsudome A, Nakashima T, Tobimatsu S, Different perceptual sensitivities for Chernoff’s face between children and adults. , Neurosci Res, 60 (2): 176-183, 2008.02.
60. Kurokawa-Kuroda T, Ogata K, Suga R, Goto Y, Taniwaki T, Kira J-I, Tobimatsu S, Altered soleus responses to magnetic simulation in pure cerebellar ataxia., Clin Neurophysiol, 118: 1198-1203, 2007.06.
61. Taniwaki T, Okayama A, Yoshiura T, Togao O, Nakamura Y, Yamasaki T, Ogata K, Shigeto H, Ohyagi Y, Kira J-I, Tobimatsu S, Age-related alterations of the functional interaction within the basal ganglia and cerebellar motor loops in vivo., Neuroimage, 36(4):1263-1276, 2007.04.
62. Tashiro K, Ogata K, Yamasaki T, Kuroda T, Goto Y, Munetsuna S, Kinukawa N, Kira J- I, Tobimatsu S, Repetitive transcranial magnetic stimulation alters optic flow perception. , Neuroreport, 18, 229-233, 2007.03.
63. Pineda AAM, Ogata K, Osoegawa M, Murai H, Shigeto H, Yoshiura T, Tobimatsu S, Kira J-I, A distinct subgroup of chronic inflammatory demyelinating polyneuropathy with CNS demyelination and a favorable response to immunotherapy., J Neurol Sci, 255: 1-6, 2007.01.
64. Tashiro K, Ogata K, Goto Y, Taniwaki T, Okayama A, Kira J, Tobimatsu S, EEG findings in early-stage corticobasal degeneration and progressive supranuclear palsy: A retrospective study and literature review., Clin Neurophysiol, 117: 2236-2242, 2006.10.
65. Taniwaki T, Okayama A, Yoshiura T, Togao O, Nakamura Y, Yamasaki T, Ogata K, Shigeto H, Ohyagi Y, Kira J, Tobimatsu S, Functional network of the basal ganglia and cerebellar motor loops in vivo: Different activation patterns between self-initiated and externally-triggered movements, Neuroimage, 31: 745-753, 2006.02.
66. Maekawa T, Goto Y, Kinukawa N, Taniwaki T, Kanba S, Tobimatsu S, Functional characterization of mismatch negativity to a visual stimulus, Clin Neurophysiol, 10.1016/j.clinph.2005.07.006, 116, 10, 2392-2402, 116: 2392-2402, 2005.10.
67. Oishi A, Tobimatsu S, Arakawa K, Taniwaki T, Kira J, Ocular dominancy in conjugate eye movements at reading distance., Neurosci Res, 10.1016/j.neures.2005.03.013, 52, 3, 263-268, 52:263-268, 2005.03.
68. Goto Y, Kinoe H, Nakashima T, Tobimatsu S, Familiarity facilitates the cortico-cortical processing of face perception, Neuroreport, 10.1097/, 16, 12, 1329-1334, 6(12): 1329-1334, 2005.01.
69. Kiyoshima A, Kudo K, Goto Y, Tobimatsu S, Ikeda N, Cerebral concentrations of myo-inositol in rats with induced brain death., Legal Med, 7(2):110-112, 2005.01.
70. Yamasaki T, Goto Y, Taniwaki T, Kira J, Tobimatsu S., Left hemisphere specialization for rapid temporal processing: A study with auditory 40 Hz steady-state responses., Clin Neurophysiol, 10.1016/j.clinph.2004.08.005, 116, 2, 393-400, 116(2):393-400, 2005.01.
71. Tobimatsu S, Goto Y, Yamasaki T, Tsurusawa R, Taniwaki T, Non-invasive evaluation of face and motion perception in humans., J Physiol Anthropol Appl Human Sci, 23(6): 273-276, 2004.01.
72. Kumagai-Eto R, Kaseda Y, Tobimatsu S, Uozumi T, Tsuji S, Nakamura S., Subclinical cranial nerve involvement in hereditary motor and sensory
neuropathy: A combined electrical and magnetic stimulation study., Clin Neurophysiol, 10.1016/j.clinph.2004.02.026, 115, 7, 1689-1696, 115(7): 1689-1696, 2004.01.
73. Goto Y, Taniwaki T, Kinukawa N, Tobimatsu S., Interhemispheric functional synchronization at the first step of visual
Information processing in humans., Clin Neurophysiol, 10.1016/.clinph.2004.01.013, 115, 6, 1409-1416, 115(6): 1409-1416, 2004.01.
74. Kiyoshima A, Kudo K, Goto Y, Tobimatsu S, Ikeda N, Changes of the cerebral mannitol concentrations in the course of brain death of a rodent model., Legal Med, 6(2): 117-124, 2004.01.
75. Murai H, Arahata H, Osoegawa M, Ochi H, Minohara M, Taniwaki T, Tobimatsu S, Minohara F, Tsuruta Y, Inaba S, Kira J, Effect of immunotherapy in myelitis with atopic diathesis., J Neurol Sci, 10.1016/j.jns.2004.08.001, 227, 1, 39-47, 227(1): 39-47, 2004.01.
76. Goto, Y., Taniwaki, T., Shigematsu, J. and Tobimatsu, S., The long-term effects of autiepileptic drugs on the visual system in rats: Electrophysiological and histopathologicalstudies., Clinical Neurophysiology, 10.1016/S1388-2457(03)00128-7, 114, 8, 1395-1402, 114(8):1395-1402, 2003.01.
77. Miyazaki, M., Ikeda, Y., Yonemitsu, Y., Goto, Y., Sakamoto, T., Tabata, T., Ueda, Y., Hasegawa, M., Tobimatsu, S., Ishibashi, T. and Sueishi, K., Simian lentiviral vector-mediated retinal gene transfer of pigment epithelium-derived factor protects retinal degeneration and electrical defect in Royal College of Surgeons rats, Gene Therapy, 10.1038/, 10, 17, 1503-1511, 10:1503-1511, 2003.01.
78. Taniwaki, T., Okayama, A., Yoshiura, T., Nakamura, Y., Goto, Y., Kira, J. and Tobimatsu, S., Reappraisal of the motor role of basal ganglia: A functional magnetic resonance image study, The Journal of Neuroscience, 23, 8, 3432-3438, 23(8):3432-3438, 2003.01.
79. Arakara, K., Tomi, H., Tobimatsu, S. and Kira, J., Middle latency auditory-evoked potentials in myotonic dystrophy: relation to the size of the CTG trinucleotide repeat and intelligent quotient, Journal of the Neurological Sciences, 10.1016/S0022-510X(02)00354-4, 207, 1-2, 31-36, 207:31-36, 2003.01.
80. Goto, Y., Taniwaki, T., Yamashita, K., Kinukawa, N. and Tobimatsu, S., Interhemispheric functional desynchronization in the human vibratory system, Brain Research, 10.1016/S0006-8993(03)02985-8, 980, 2, 249-254, 980:249-254, 2003.01.