Kyushu University Academic Staff Educational and Research Activities Database
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Jun-ichi Kira Last modified date:2019.07.03

Professor / Department of Neurology, Neurological Institute, Graduate school of Medical Sciences
Department of Clinical Medicine
Faculty of Medical Sciences

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Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Homepage .
Academic Degree
MD (Kyushu University) 1979, PhD (Kyushu University) 1986
Country of degree conferring institution (Overseas)
Field of Specialization
Immunological and immunogenetical studies of multiple sclerosis, Clinical and immunological studies of atopic myelitis, Genetical and immunological studies of motor neuron diseases
Total Priod of education and research career in the foreign country
Research Interests
  • Functional analysis of autoantibody in neuropathic pain patients and development of new biomarkers and therapeutic options
    keyword : neuropathic pain, auto-antibody, PlexinD1
  • Neuroimmunological research on multiple sclerosis
    keyword : Multiple sclerosis, genetic polymorphism, MRI, C-MS, OS-MS, Neuromyelitis optica, Balo disease
    1987.04In this study, multiple sclerosis (MS) in Japanese is clinically classified as opticospinal type (OS-MS) and conventional type (C-MS) and the difference between the two subtype is analyzed by neurological examination, MRI, immunoloilinical examination, and genetical examaination. We have disclosed that OS-MS preferentially found in Asian is distinct from C-MS..
  • Cell biological research on motor neuron diseases
    keyword : moter neuron disease, ALS, cytokine, growth factors, G-CSF
    1997.10The aim of theis study is to clarify cytokine and growth factor changes in motor neuron disease. We simultaneously measured 27 cytokines, chemokines and growth factors in cerebrospinal fluid of patients with motor neuron disease and found that granulocyte-colony stimulating factor (G-CSF) and monocyte chemoattractant protein-1 were significantly elevated, protein-1 were significantly elevated, compared with patients with other non-inflammatory neurologic diseases. Moreover, we disclosed that G-CSF had a neuroprotective effects for motor neurons in vivo and in vitro..
Current and Past Project
  • In this project, intractable neuroimmunological disorders, such as multiple sclerosis, myasthenia gravis, Guillain-Barre syndrome, Fisher syndrome, chronic inflammatory demyelinating polyradiculoneuropathy, Lewis-Sumner syndrome, Crow-Fukase syndrome, HTLV-1-associated myelopathy, paraneoplastic neurologic syndrome, and atopic myelitis, are investigated clinically and immunologically by a nation-wide survey team.
Academic Activities
1. Kira J, Neuromyelitis optica and opticospinal multiple sclerosis, Pathophysiology 18: 69-79, 2011, 2011.02.
1. Osoegawa M*, Kira J*, Fukazawa K, Kikuchi S, Kohriyama T, Sobue G, Yamamura T, Itoyama Y, Saida T, Sakata K, Ochi H, Matsuoka T(Equal contribution), Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese: nationwide survey results over 30 years, Multiple Sclerosis, 15: 159-173, 2009, 2009.01.
2. Kira J, Isobe N, Kawano Y, Osoegawa M, Ohyagi Y, Mihara F, Murai H, Atopic myelitis with focal amyotrophy: A possible link to Hopkins syndrome., Neurol Sci., 269(1-2):143-51., 2008.01.
Membership in Academic Society
  • Japan Society for Dementia Research
  • Japanese Headache Society
  • Neuroinfection
  • Japanese Society of Neurological Therapeutics
  • The Japan Stroke Society
  • The Japanese Society of Internal Medicine
  • Japanese Peripheral Nerve Society
  • Japanese Society for Neuroimmunology
  • Japan Society of Neurovegetative Research
  • Japanese Society of Neurology
Other Educational Activities
  • 2000.04.