Kyushu University Academic Staff Educational and Research Activities Database
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Masaki Mori Last modified date:2019.07.24

Professor / Department of Surgery and Science
Department of Clinical Medicine
Faculty of Medical Sciences


Graduate School
Other Organization


E-Mail
Phone
092-642-5461
Fax
092-642-5482
Academic Degree
Adenosquamous cell carcinoma of the stomach
Country of degree conferring institution (Overseas)
No
Field of Specialization
surgery, oncology, moleccular biology, surgical pathology
Total Priod of education and research career in the foreign country
00years00months
Outline Activities
We are doing research works that are originated from clinical problems. Based on the background of surgery and molecular biology, the following projects are on-going.

1. Genetic diagnosis of cancer
1) Identification of genes that are associated with grades of malignancy
2) Analysis of a correlation between gene polymorphism and canccer susceptibility
3) Molecular detection of circulating cancer cells in the blood
4) cDNA microarray analysis of genes that are associated with invasion and metastasis
2. Development of non-invasive diagnosis of breast cancer
3. Analysis of stress reactions during operation
4. Cancer immunotherapy
Tumor specific immunotherapy with dendritic cells pulsed with MAGE peptides
5. Study of gene therapy for cancers
6. Identificcation of cancer stem cells and their specific markers
Research
Research Interests
  • Identification of cancer stem cells and its application to cancer treatment
    keyword : cancer stem cell, gastrointestinal cancers, chemoresistance, recurrence of cancer
    2004.04~2006.12To identify cancer stem cells to develop novel diagnosis and treatment of cancers.
  • Analysis of colon cancer via epidemiology, genetic polymorphism and gene expression pattern
    keyword : colon cancer, epidemiology, life pattern, gene polymorphism, gene expression
    2004.04~2006.12To evaluate Japanese colorectal cancer from the view-points of epidemiological and molecular biological analyses.
  • Development of cancer specific immunotherapy
    keyword : cancer, immunotherapy, dendritic cells, cancer specific antigen
    2003.04~2006.12To develop cancer specific immunotherapy. To identify cancer specific molecule by using laser microdissection and cDNA microarray in the clinical samples..
  • Analysis of genes that specify heterogeneity of cancers of digestive organs
    keyword : DNA microarray, digestive organ cancers, heterogeneity of cancer
    2000.04~2003.12Genetic and Expression Polymorphism in Gastrointestinal Carcinomas.
Current and Past Project
  • To identify the characteristics of Japanese colorectal cancer with epidemiology and molecular biology
  • To identify the characteristics of Japanese esophageal cancer with epidemiology and molecular biology
  • Development of cancer specific immunotherapy
  • 1)Gene expression profiles of gastrointestinal carcinogenesis
    2)Chronic liver disease and its gene expression profiles
    3)Rat chemical carcinogenesis and gene expression profiles
  • Comparative genome wide analysis of fragile sites. #
Academic Activities
Papers
1. Mashino K, Sadanaga N, Yamaguchi H, Tanaka F, Ohta M, Shibuta K, Inoue H, Mori M, Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma, CANCER RES, 2003.05.
2. Inoue H, Matsuyama A, Mimori K, Ueo H, Mori M, Prognostic score of gastric cancer determined by cDNA microarray, CANCER RES, 2002.11.
3. Mimori K, Inoue H, Shiraishi T, Ueo H, Mafune K, Tanaka Y, Mori M, A single-nucleotide polymorphism of SMARCB1 in human breast cancers, GENOMICS, 2002.09.
Educational
Educational Activities
1. Cancer Research of Gastrointestinal Cancers and Breast Cancers
2. Development of surgical treatment of gastrointestinal cancers
3. Cancer stem cells