| Yoshitaka Hirooka | Last modified date：2011.9.30 |
Professor /
Department of Advanced Cardiovascular Regulation and Therapeutics, Kyushu University Graduate School of Medical Sciences
Faculty of Medical Sciences
Faculty of Medical Sciences
Graduate School
Undergraduate School
Other Organization
Administration Post
Others
E-Mail
Homepage
http://www.med.kyushu-u.ac.jp/cardiol/.
Phone
092-642-5360
Fax
092-642-5374
Academic Degree
Effects of alpha-human atrial natriuretic prptide on the interrelationship of arterial pressure, aortic nerve activity, and aortic diameter
Field of Specialization
Cardiovascular Medicine, Neural Control of Circulation, Hypertension, Heart Failure
Outline Activities
Research: 1. Neural control of circulation in physiological and pathophysiological states (hypertension, heart failure). 2. Role of vasoactive factors in heart failure and hypertension.
Education: Cardiovascular medicine (bedside teaching and lecture).
Clinical work.
Education: Cardiovascular medicine (bedside teaching and lecture).
Clinical work.
Research
Research Interests
Membership in Academic Society
- Peripheral Circulation in Hypertension and Heart Failure
keyword : hypertension, heart failure, forearm blood flow
1986.06. - Neural Contol of Circulation in Cardiovascular Diseases
keyword : blood pressure, sympathetic nervous system, brain, hypertension, heart failure
1986.06.
- Oxidative stress increases in hypertension. The aim of this study was to determine whether reactive oxygen species (ROS) are increased in the rostral ventrolateral medulla (RVLM) in the brainstem, where the vasomotor center is located, in stroke-prone spontaneously hypertensive rats (SHRSP), and, if so, to determine whether the increased ROS contribute to neural mechanisms of hypertension in SHRSP. We measured ROS levels in the RVLM of SHRSP and compared them with those in Wistar-Kyoto rats (WKY). Thiobarbituric acid-reactive substances were increased in SHRSP compared with WKY. ROS were also measured by electron spin resonance (ESR) spectroscopy. The ESR signal decay rate in the RVLM of SHRSP was significantly increased compared with that in WKY, and this increase was abolished by dimethylthiourea (a hydroxyl radical scavenger). The increased ESR signal decay was reduced to the same extent in the presence of desferrioxamine, catalase, and Tiron, indicating that hydroxyl radicals are derived from superoxide anions and hydrogen peroxide. In addition, total superoxide dismutase (SOD) activity in the RVLM decreased blood pressure in SHRSP but not in WKY, and MnSOD overexpression in the RVLM of SHRSP decreased blood pressure and inhibited sympathetic nerve activity. These results suggest that superoxide anions in the RVLM, which generate hydroxyl radicals, are increased in SHRSP and contribute to the neural mechanisms of hypertension in SHRSP. We also examined the role of inducible nitric oxide synthase (iNOS) in the RVLM in the control of blood pressure and sympathetic nerve activity. We fond that overexpression of iNOS in the RVLM increases blood pressure via activation of the sympathetic nervous system, which is mediated by an increase in oxidative stress.
Books
| 1. | 廣岡 良隆,AHA Highlights 2006,Epidemiology-Inflammatory/Subclinical CVD 篠山 重威編集，協和企画，2007.,2007.10. |
| 2. | 廣岡 良隆,Heart Disease 1, 2006 ISH HIGHLIGHTS,松岡 博昭編集，メディカルジャーナル社，pp18-21, 2007.,2007.10. |
| 3. | Hirooka Y,Central Mechanisms of Cardiovascular Regulation:,Role of nitric oxide and oxidative stress in the brainstem in cardiovascular regulation. Edited by Kubo T, Research Signport, Kerala, India, p139-152, 2007.,2007.10. |
| 4. | Ito K, Hirooka Y,Role of Rho/Rho-kinase in the brainstem in cardiovascular regulation via the sympathetic nervous system in "Sympathetic Nervous System Research Developments",Nova Science Publishers, Inc.,93-110,2007.10. |
| 5. | Hirooka Y,Central Mechanisms of Cardiovascular Regulation: Role of nitric oxide and oxidative stress in the brainstem in cardiovascular regulation,Transworld Research Network,in press,2007.08. |
| 6. | Antioxidant action and sympatho-inhibitory effect of ARB. |
Reports
| 1. | Hirooka Y,Brain perivascular macrophages and central sympathetic activation after myocardial infarction: heart and brain interaction.,Hypertension,2010.03. |
| 2. | Hirooka Y, Sagara Y, Kishi T, Sunagawa K.,Oxidative stress and central cardiovascular regulation: pathogenesis of hypertension and therapeutic aspects.,Circ J,2010.05. |
| 3. | Hirooka Y. ,Role of reactive oxygen species in brainstem in neural mechanisms of hypertension. ,Auton Neurosci,2008.10. |
| 4. | Hirooka Y,Localized gene transfer and its application for the study of central cardiovascular control.,126-127: 120-129,Auton Neurosci,2006.01. |
| 5. | Hirooka Y,Localized gene transfer and its application for the study of central cardiovascular control.,Autonomic Neuroscience: Basic and Clinical,2006.08. |
Papers
| 1. | Kishi T, Hirooka Y, Konno S, Ogawa K, Sunagawa K.,Angiotensin type 1receptor-activated caspase-3 through ras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats.,Hypertension,Vol.55,No.2,pp.291-297,2010.02. |
| 2. | Araki S, Hirooka Y, Kishi T, Yasukawa K, Utsumi H, Sunagawa K.,Olmesartan reduces oxidative stress in the brain of stroke-prone spontaneously hypertensive rats assessed by an in vivo ESR method.,Hypertens Res,Vol.32,No.12,pp.1091-1096,2009.12. |
| 3. | Ito K, Hirooka Y, Sunagawa K.,Acqusition of brain Na sensitivity contributes to salt-induced symapthoexcitation and cardiac dysfunction in mice with pressure overlord.,Circ Res,104: 1004-1011,2009.04. |
| 4. | Nozoe M, Hirooka Y, Koga Y, Araki S, Konno S, Kishi T, Ide T, Sunagawa K.,Mitochondria-derived reactive oxygen species mediate sympathoexcitation induced by angiotensin II in the rostral ventrolateral medulla.,Journal of Hypertension,26: 2176-2184,2008.11. |
| 5. | Hirooka Y, Kimura Y, Sagara Y, Ito K, Sunagawa K.,Effects of valsartan or amlodipine on endothelial function and oxidative stress after one year follow-up in patients with essential hypertension.,Clin Exp Hypertens,30: 267-276,2008.04. |
| 6. | Kishi T, Hirooka Y, Shimokawa H, Takeshita A, Sunagawa K. ,Atorvastatin reduces oxidative stress in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.,Clin Exp Hypertens,30: 3-11,2008.01. |
| 7. | Nozoe M, Hirooka Y, Koga Y, Sagara Y, Kishi T, Engelhardt JF, Sunagawa K,Inhibition of Rac1-derived reactive oxygen species in nucleus tractus solitarius decreases blood pressure and heart rate in stroke-prone sponatneously hypertensive rats.,Hypertension,50: 62-68,2007.07. |
| 8. | Fukumoto Y, Mohri M, Inokuchi K, Ito A, Hirakawa Y, Masumoto A, Hirooka Y, Takeshita A, Shimokawa H.,Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina.,J Cardiovasc Pharmacol,49: 117-121,2007.03. |
| 9. | Kimura Y, Hirooka Y, Sagara Y, Sunagawa K.,Long-acting calcium channel blocker, azelnidipine, increases endothelial nitric oxide synthase in the brain and inhibits sympathetic nerve activity.,Clin Exp Hypertens,29: 13-21, 2007.,2007.02. |
| 10. | Sagara Y, Hirooka Y, Nozoe M, Ito K, Kimura Y, Sunagawa K,Pressor response induced by central angiotensin II is mediated by activation of Rho/Rho-kinase pathway via AT1 receptors.,Journal of Hypertension,25: 399-406,2007.02. |
| 11. | Ito K, Hirooka Y, Kimura Y, Sagara Y, Sunagawa K.,Ovariectomy augments hypertension through Rho-kinase activation in the brain stem in female spontaneously hypertensive rats.,Hypertension,48: 651-657,2006.10. |
| 12. | Hirooka Y, Kimura Y, Nozoe M, Sagara Y, Ito K, Sunagawa K.,Amlodipine-induced reduction of oxidative stress in the brain is associated with sympatho-inhibitory effects in stroke-prone spontaneously hypertensive rats,Hypertens Res,29: 49-56, 2006.,2006.01. |
| 13. | Kishi T, Hirooka Y, Masumoto A, Ito K, Kimura Y, Inokuchi K, Shimokawa H, Takeshita A, Sunagawa K.,Rho-kinase inhibior improves increased vascular resistance and impaired vasodilation in patients with heart failure.,Circulation.,111: 2741-2747,2005.05. |
| 14. | Kimura Y, Hirooka Y, Sagara Y, Ito K, Kishi T, Shimokawa H, Takeshita A, Sunagawa K.,Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress.,Circ Res.,2005.02. |
| 15. | Kishi T, Hirooka Y, Kimura Y, Ito K, Shimokawa H, Takeshita A.,Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats.,Circulation.,2004.05. |
| 16. | Inokuchi K, Hirooka Y, Shimokawa H, Skai K, Kishi T, Ito K, Kimura Y, Takeshita A,Role of endothelium-derived hyperpolarizing factor in human forearm circulation.,Hypertension,42: 919-924,2003.11. |
| 17. | Ito K, Hirooka Y, Sakai K, Kishi T, Kaibuchi K, Shimokawa H, Takeshita A,Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension.,Circ. Res.,92: 1337-1343,2003.06. |
| 18. | Masumoto H, Hirooka Y, Shimokawa H, Hironaga K, Setoguchi S, Takeshita A,Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans.,Hypertension,38: 1307-1310,2001.12. |
| 19. | Kishi T, Hirooka Y, Sakai K, Shigematsu H, Shimokawa H, Takeshita A,Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release.,Hypertension,38: 896-901,2001.10. |
| 20. | Sakai K, Hirooka Y, Matsuo I, Eshima K, Shigematsu H, Shimokawa H, Takeshita A,Overexpression of eNOS in NTS causes hypotension and bradycardia in vivo,Hypertension,Vol.36,pp.1023-1028,2000.12. |
| 21. | Eshima K, Hirooka Y, Shigematsu H, Matsuo I, Koike G, Sakai K, Takeshita A,Angiotensin in the nucleus tractus solitarii contributes to neurogenic hypertension caused by chronic nitric oxide synthase inhibition,Hypertension,Vol.36,pp.259-263,2000.01. |
| 22. | Hirooka Y, Dampney RAL,Endogenous angiotensin within the rostral ventrolateral medulla facilitates the somatosympathetic reflex.,J. Hypertens.,Vol.13,pp.747-754,1995.01. |
| 23. | Hirooka Y, Imaizumi T, Tagawa T, Shiramoto M, Endo T, Ando S-I, Takeshita A,Effects of L-arginine on impaired acetylcholine-induced and ischemic vasodilation of the forearm in patients with heart failure.,Circulation,Vol.90,pp.658-668,1994.01. |
| 24. | Hirooka Y, Imaizumi T, Masaki H, Ando S, Harada S, Momohara M, Takeshita A,Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients.,Hypertension,Vol.20,pp.175-180,1992.01. |
| 25. | Hirooka Y, Takeshita A, Imaizumi T, Nakamura N, Tomoike H, Nakamura M,Effects of a-human atrial natriuretic peptide on the interrelationship of arterial pressure, aortic nerve activity, and aortic diameter,Circ Res,Vol.63,pp.987-996,1988.12. |
- American Heart Association
- International Society of Hypertension
- American Physiological Society
- Japanese Circulation Society
- Japanese Society of Hypertension
- Japanese College of Cardiology
- Amlodipine-induced reduction of oxidative stress in the brain is associated with sympatho-inhibitory effects in stroke-prone spontaneously hypertensive rats.
Educational
Educational Activities
Teaching (lecture and clinical practice) for students in Medical School etc.
Other Educational Activities
- 2009.04,I am teaching imporatnce and interest in cardiovascular medicine for students at the Department of Medicine and Pharmacy.
I am teaching how to do research for students at the Graduate School of Medical Sciences..
The fact that no permission it reprints contents of this data base is prohibitted.