Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Yasuharu Nakashima Last modified date:2019.08.02

Professor / Department of Orthopaedic Surgery / Department of Clinical Medicine / Faculty of Medical Sciences

1. Fukuda N, Kanazawa M, Tsuru K, Tsuchiya A, Sunarso, Toita R, Mori Y, Nakashima Y, Ishikawa K, Synergistic effect of surface phosphorylation and micro-roughness on enhanced osseointegration ability of poly(ether ether ketone) in the rabbit tibia., Sci Rep, 8, 1, 16887, 2019.06.
2. Fujii M, Nakamura T, Hara T, Nakashima Y, Can the hip joint center be estimated from pelvic dimensions in dysplastic hips?, J Orthop Sc, 22, 6, 1089-1095, 2017.06.
3. Kuwashima U, Mizu-Uchi H, Okazaki K, Hamai S, Akasaki Y, Murakami K, Nakashima Y, Three-dimensional analysis of accuracy of patient-matched instrumentation in total knee arthroplasty: Evaluation of intraoperative techniques and postoperative alignmen, J Orthop Sci, 22, 6, 1077-1083, 2017.06.
4. Yamada Y, Kinoshita I, Kohashi K, Yamamoto H, Iwasaki T, Otsuka H, Yoshimoto M, Ishihara S, Toda Y, Kuma Y, Setsu N, Koga Y, Honda Y, Inoue T, Yanai H, Yamashita K, Ito I, Takahashi M, Ohga S, Furue M, Nakashima Y, Oda Y, Histopathological and Genetic Review of Phosphaturic Mesenchymal Tumours, Mixed Connective Tissue Variant, Histopathology, 72, 3, 460-471, 2018.06.
5. Matsumoto Y, Baba S, Endo M, Setsu N, Iida K, Fukushi JI, Kawaguchi K, Okada S, Bekki H, Isoda T, Kitamura Y, Honda H, Nakashima Y , Metabolic Tumor Volume by 18F-FDG PET/CT Can Predict the Clinical Outcome of Primary Malignant Spine/Spinal Tumors, Biomed Res Int, 8132676, 2017.06.
6. Takeuchi N, Mae T, Fukushi JI, Tsukamoto N, Mizu-Uchi H, Momii K, Nakashima Y, Management of Intra-Articular Calcaneal Fractures: Clinical Results of Reduction
Technique Using a Bone Spreader
, J Foot Ankle Surg, 56, 5, 1025-1030, 2018.06.
7. Matsumoto Y, Shinoto M, Endo M, Setsu N, Iida K, Fukushi JI, Kawaguchi K, Okada S, Bekki H, Imai R, Kamada T, Shioyama Y, Nakashima Y , Evaluation of Risk Factors for Vertebral Compression Fracture after Carbon-Ion Radiotherapy for Primary Spinal and Paraspinal Sarcoma, Biomed Res Int, 9467402, 2017.06.
8. Kozono N, Okada T, Takeuchi N, Shimoto T, Higaki H, Nakashima Y, A Biomechanical Comparison Between Asymmetric Pennington Technique and Conventional Core Suture Techniques: 6-Strand Flexor Tendon Repair, J Hand Surg Am, 43, 1, e1-79-e8, 2018.06.
9. Tsuru K, Yoshimoto A, Kanazawa M, Sugiura Y, Nakashima Y, Ishikawa K, Fabrication of Carbonate Apatite Block through a Dissolution-Precipitation Reaction Using Calcium Hydrogen Phosphate Dihydrate Block as a Precursor, Materials (Basel), 31, 10(4), 2017.06.
10. Hara M, Kobayakawa K, Ohkawa Y, Kumamaru H, Yokota K, Saito T, Kijima K, YoshizakiS, Harimaya K, Nakashima Y, Okada S , Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation
through the integrin-N-cadherin pathway after spinal cord injury
, Nat Med, 23, 7, 818-828, 2017.06.
11. Hara D, Hamai S, Fukushi JI, Kawaguchi KI, Motomura G, Ikemura S, Komiyama K, Nakashima Y, Does Participation in Sports Affect Osteoarthritic Progression After Periacetabular Osteotomy?, Am J Sports Med, 45, 11, 2468-2475, 2017.06.
12. Kubo Y, Motomura G, Ikemura S, Sonoda K, Yamamoto T, Nakashima Y, Effect of collapse on the deformity of the femoral head-neck junction in osteonecrosis of the femoral head, Arch Orthop Trauma Surg, 137, 7, 933-938, 2017.06.
13. Utsunomiya T, Motomura G, Ikemura S, Hamai S, Fukushi JI, Nakashima Y, The Results of Total Hip Arthroplasty After Sugioka Transtrochanteric Anterior Rotational Osteotomy for Osteonecrosis, J Arthroplasty, 32, 9, 2768-2773, 2017.06.
14. Kanazawa M, Tsuru K, Fukuda N, Sakemi Y, Nakashima Y, Ishikawa K, Evaluation of carbonate apatite blocks fabricated from dicalcium phosphate dihydrate blocks for reconstruction of rabbit femoral and tibial defects., J Mater Sci Mater Med, 28, 6, 85, 2017.06.
15. Goto N, Okazaki K, Akasaki Y, Ishihara K, Murakami K, Koyano K, Ayukawa Y, Yasunami N, Masuzaki T, Nakashima Y, Single intra-articular injection of fluvastatin-PLGA microspheres reduces cartilage degradation in rabbits with experimental osteoarthritis, J Orthop Res, 10.1002/jor.23562. 2017 , 2017.06.
16. 67. Fujii M, Nakashima Y, Nakamura T, Ito Y, Hara T, Minimum Lateral Bone Coverage Required for Securing Fixation of Cementless Acetabular Components in Hip Dysplasia, Biomed Res Int, 4937151, 2017.06.
17. Kozono N, Okada T, Takeuchi N, Shimoto T, Higaki H, Nakashima Y, Effect of the Optimal Asymmetry on the Strength of Six-Strand Tendon Repair: An Ex Vivo Biomechanical Study, J Hand Surg Am, 42, 4, 250-256, 2017.06.
18. Sonoda K, Motomura G, Kawanami S, Takayama Y, Honda H, Yamamoto T, Nakashima Y, Degeneration of articular cartilage in osteonecrosis of the femoral head begins at the necrotic region after collapse: a preliminary study using T1 rho MRI
, Skeletal Radiol, 46, 4, 463-467, 2017.06.
19. Saito T, Yokota K, Kobayakawa K, Hara M, Kubota K, Harimaya K, Kawaguchi K, Hayashida M, Matsumoto Y, Doi T, Shiba K, Nakashima Y, Okada S, Experimental Mouse Model of Lumbar Ligamentum Flavum Hypertrophy, PLoS One, 12, 1, e0169717, 2017.06.
20. Hara D, Hamai S, Komiyama K, Motomura G, Shiomoto K, Nakashima Y, Sports Participation in Patients After Total Hip Arthroplasty vs Periacetabular Osteotomy: A Propensity Score-Matched Asian Cohort Study, 33, 2, 423-430, 2018.02.
21. Iwamoto M, Nakashima Y, Nakamura T, Kohno Y, Yamaguchi R, Takamura K, Clinical outcomes of conservative treatment with a non-weight-bearing abduction brace for Legg-Calvé-Perthes disease., J Orthop Sci, 23, 1, 156-160, 2018.01.
22. Oyamada A, Matsumoto Y, Wakata Y, Kimura A, Ikuta K, Tsuchiya K, Tayama N, Tomari S, Miyahara H, Mae T, Shiraishi H, Saito T, Arizono T, Kaji K, Mawatari T, Fujiwara M, Sakimura R, Shin K, Ninomiya K, Nakaie K, Antoku Y, Tokunaga S, Nakashima N, Iwamoto Y, Nakashima Y , Characteristics of patients with fragility hip fractures in the northern Kyushu district in Japan: a multicenter prospective registry based on an electronic data capture system., J Bone Miner Metab, doi: 10.1007/s00774-017-0869-9. 2017, 2017.06.
23. Iida K, Matsumoto Y, Setsu N, Harimaya K, Kawaguchi K, Hayashida M, Okada S, Nakashima Y, The neurological outcome of radiotherapy versus surgery in patients with metastatic spinal cord compression presenting with myelopathy., Arch Orthop Trauma Surg, 138, 1, 7-12, 2019.01, PURPOSE:

While radiotherapy is generally an acceptable treatment for metastatic spinal cord compression, surgical intervention is controversial due to the invasiveness and diversity of diseases in the patients being considered. The ideal treatment, therefore, depends on the situation, and the most acute treatment possible is necessary in patients presenting with myelopathy. We compared the neurological outcomes between radiotherapy and surgery in patients with metastatic spinal cord compression presenting with myelopathy.


A total 54 patients with metastatic spinal cord compression presenting with myelopathy treated in our institution between 2006 and 2016 were analyzed retrospectively. Twenty patients were selected by radiotherapy alone (radiation group), and 36 patients were selected by decompression and stabilization surgery with or without radiotherapy (surgery group). The neurological outcomes and complications were compared between the two treatment groups.


Seven patients initially in the radiation group underwent surgery because of a substantial decline in their motor strength during radiotherapy. One of the remaining 13 patients (8%) in the radiation group and 30 of the 34 patients (88%) in the surgery group showed improvement in their neurological symptoms (P < 0.01). One patient (8%) in the radiation group and 21 patients (62%) in the surgery group were ambulatory after treatment (P < 0.01). There were no major complications related to radiotherapy, but surgery-related complications occurred in 9 of 34 (26%) patients, and 6 (18%) patients needed reoperation.


Surgical decompression and stabilization may be required to improve the neurological function in patients with metastatic spinal cord compression presenting with myelopathy. However, the high rate of complications associated with surgery should be taken into consideration..
24. Yasuharu Nakashima, Re-dislocation after revision total hip arthroplasty for recurrent dislocation: a multicentre study., Int Orthop, 41, 2, 253-258, 2017.02.
25. Yasuharu Nakashima, Impact of methotrexate dose on efficacy of adalimumab in Japanese patients with rheumatoid arthritis: Results from registered data analyses., Mod Rheumatol, 27, 1, 15-21, 2017.01.
26. Yasuharu Nakashima, Is the timing of surgery associated with avascular necrosis after unstable slipped capital femoral epiphysis? A multicenter study., J Orthop Sci, 22, 1, 112-115, 2017.01.
27. Yasuharu Nakashima, Minimum 10-year results of cementless total hip arthroplasty in patients with rheumatoid arthritis., Mod Rheumatol, 15, 1-7, 2016.12.
28. Yasuharu Nakashima, Transtrochanteric rotational osteotomy for avascular necrosis of the femoral head after unstable slipped capital femoral epiphysis: 10-year clinical results., J Orthop Sci, 21, 6, 831-835, 2016.11.
29. Yasuharu Nakashima, Does High Hip Center Decrease Range of Motion in Total Hip Arthroplasty? A Computer Simulation Study., J Arthroplasty, 31, 10, 2342-2347, 2016.10.
30. Yasuharu Nakashima, High prevalence of cam deformity in dysplastic hips: A three-dimensional CT study., J Orthop Res, 34, 9, 1613-1619, 2016.09.
31. Yasuharu Nakashima, Quantification of pelvic tilt and rotation by width/height ratio of obturator foramina on anteroposterior radiographs., Hip Int, 26, 5, 462-467, 2016.09.
32. Yasuharu Nakashima, Cementless total hip arthroplasty for patients previously treated with femoral osteotomy for hip dysplasia: the incidence of periprosthetic fracture., Int Orthop, 40, 8, 1601-1606, 2016.08.
33. Yasuharu Nakashima, Dislocation and its recurrence after revision total hip arthroplasty., Int Orthop, 40, 8, 1625-1630, 2016.08.
34. Yasuharu Nakashima, Factors Associated With Severity of Intra-articular Lesions in Patients With Severe Hip Dysplasia., Arthroscopy, 32, 8, 1581-1589, 2016.08.
35. Yasuharu Nakashima, Dynamic Hip Kinematics During the Golf Swing After Total Hip Arthroplasty., Am J Sports Med, 44, 7, 1801-1809, 2016.07.
36. Yasuharu Nakashima, The Absence of Hydroxyapatite Coating on Cementless Acetabular Components Does Not Affect Long-Term Survivorship in Total Hip Arthroplasty., J Arthroplasty, 31, 6, 1228-1232, 2016.06.
37. Yasuharu Nakashima, Comparison of 10-year clinical wear of annealed and remelted highly cross-linked polyethylene: A propensity-matched cohort study., J Mech Behav Biomed Mater, 59, 99-107, 2016.06.
38. Yasuharu Nakashima, Is a Stem Version on the Crosstable Lateral Radiograph Accurate in Total Hip Arthroplasty?, J Arthroplasty, 31, 6, 1356-1360, 2016.06.
39. Yasuharu Nakashima, Late Anterior Dislocation Due to Posterior Pelvic Tilt in Total Hip Arthroplasty., Open Orthop, 22, 10, 206-212, 2016.06.
40. Yasuharu Nakashima, Impact of methotrexate dose on efficacy of adalimumab in Japanese patients with rheumatoid arthritis: results from prospectively registered data analyses., Mod Rheumatol, 2016.05.
41. Yasuharu Nakashima, Delayed diagnosis of ankylosing spondylitis in a Japanese population., Mod Rheumatol, 2016.05.
42. Yasuharu Nakashima, A novel type II collagen gene mutation in a family with spondyloepiphyseal dysplasia showing wide intra-familial phenotypic diversity, Human Genome Variation, 2016.05.
43. Yasuharu Nakashima, Tumor-induced osteomalacia caused by a massive phosphaturic mesenchymal tumor of the acetabulum: A case report., Mod Rheumatol, 4, 1-5, 2016.05.
44. Yasuharu Nakashima, Outcome of Joint-Preserving Arthroplasty for Rheumatoid Forefoot Deformities.

, Foot Ankle Int, 37, 3, 262-268, 2016.03.
45. Yasuharu Nakashima, Effects of dioxin-related compounds on bone mineral density in patients affected by the Yusho incident., Chemosphere, 145, 25-33, 2016.02.
46. Yasuharu Nakashima, Bone bonding strength of diamond-structured porous titanium-alloy implants manufactured using the electron beam-melting technique., Clin Biomech (Bristol, Avon), 32, 1047-1052, 2016.02.
47. Yasuharu Nakashima, Optimal anterior femoral offset for functional range of motion in total hip arthroplasty-a computer simulation study, INTERNATIONAL ORTHOPAEDICS, 10.1007/s00264-014-2538-0, 39, 4, 645-651, 2015.04.
48. Yasuharu Nakashima, Mid-Term Clinical and Radiographic Outcomes of Porous Tantalum Modular Acetabular Components for Hip Dysplasia, JOURNAL OF ARTHROPLASTY, 10.1016/j.arth.2014.11.007, 30, 4, 607-610, 2015.04.
49. Yasuharu Nakashima, Successful In Vitro Culture of Rheumatoid Arthritis Synovial Tissue Explants at the Air-Liquid Interface, ARTHRITIS & RHEUMATOLOGY, 10.1002/art.39019, 67, 4, 887-892, 2015.04.
50. Yasuharu Nakashima, Ischio-pubic stress fracture after peri-acetabular osteotomy in patients with hip dysplasia, INTERNATIONAL ORTHOPAEDICS, 10.1007/s00264-014-2375-1, 38, 10, 2051-2056, 2014.10.
51. Yasuharu Nakashima, Scintigraphic assessments of the reparative process in osteonecrosis of the femoral head using SPECT/CT with Tc-99m hydroxymethylene diphosphonate, NUCLEAR MEDICINE COMMUNICATIONS, 10.1097/MNM.0000000000000166, 35, 10, 1047-1051, 2014.10.
52. Yasuharu Nakashima, Remission in patients with active rheumatoid arthritis by tocilizumab treatment in routine clinical practice: results from 3 years of prospectively registered data, MODERN RHEUMATOLOGY, 10.3109/14397595.2013.854069, 24, 2, 258-264, 2014.03.
53. Yasuharu Nakashima, Combined anteversion technique reduced the dislocation in cementless total hip arthroplasty, INTERNATIONAL ORTHOPAEDICS, 10.1007/s00264-013-2091-2, 38, 1, 27-32, 2014.01.
54. Yasuharu Nakashima, Results at a minimum of 10 years of follow-up for AMS and PerFix HA-coated cementless total hip arthroplasty: impact of cross-linked polyethylene on implant longevity, JOURNAL OF ORTHOPAEDIC SCIENCE, 10.1007/s00776-013-0456-4, 18, 6, 962-68, 2013.11.
55. Yasuharu Nakashima, Effects of posterior pelvic tilt on anterior instability in total hip arthroplasty: A parametric experimental modeling evaluation, CLINICAL BIOMECHANICS, 10.1016/j.clinbiomech.2012.12.011, 28, 2, 178-181, 2013.02.
56. Hamasaki M, Yasuharu Nakashima, Era Takumi, Pathogenic mutation of ALK2 inhibits induced pluripotent stem cell reprogramming and maintenance: mechanisms of reprogramming and strategy for drug identification., 30, 11, 2437-2449, 2012.10.
57. 153) Nakashima Y, Mashima N, Imai H, Mitsugi N, Taki N, Mochida Y, Owan I, Arakaki K, Yamamoto T, Mawatari T, Motomura G, Ohishi M, Doi T, Kanazawa M, Iwamoto Y. , Clinical and radiographic evaluation of total hip arthroplasties using porous tantalum modular acetabular components: 5-year follow-up of clinical trial., Mod Rheumatol, Epub ahead of print 2012, 2012.07.
58. Kawahara S, Yasuharu Nakashima, Yukihide Iwamoto, High prevalence of acetabular retroversion in both affected and unaffected hips after Legg-Calvé-Perthes disease, 17, 3, 226-232, 2012.06.
59. Masanori Fujii, Yasuharu Nakashima, Yukihide Iwamoto, Acetabular Tilt Correlates with Acetabular Version and Coverage in Hip Dysplasia, 470, 2827-2835, 2012.06.
60. Yasuharu Nakashima, Taishi Sato, Yukihide Iwamoto, Wear resistant performance of highly crosslinked and annealed ultra-high molecular weight polyethylene against ceramic femoral heads in total hip arthroplasty, 30, 2031-2037, 2012.06, The purpose of this study was to examine the effects of ceramic femoral head material, size, and implantation periods on the wear of annealed, cross-linked ultra-high molecular weight polyethylene (UHMWPE) (XLPE) in total hip arthroplasty compared to non-cross-linked conventional UHMWPE (CPE). XLPE was fabricated by cross-linking with 60 kGy irradiation and annealing. Femoral heads made from zirconia and alumina ceramics and cobalt-chrome (CoCr) of 22 or 26 mm diameter were used. In this retrospective cohort study, the femoral head penetration into the cup was measured digitally on radiographs of 367 hips with XLPE and 64 hips with CPE. The average follow-up periods were 6.3 and 11.9 years, respectively. Both XLPE creep and wear rates were significantly lower than those of CPE (0.19 mm vs. 0.44 mm, 0.0001 mm/year vs. 0.09 mm/year, respectively). Zirconia displayed increased wear rates compared to alumina in CPE; however, there was no difference among head materials in XLPE (0.0008, 0.00007, and -0.009 mm/year for zirconia, alumina, and CoCr, respectively). Neither head size or implantation period impacted XLPE wear. In contrast to CPE, XLPE displayed low wear rates surpassing the effects of varying femoral head material, size, implantation period, and patient demographics. Further follow-up is required to determine the long-term clinical performance of the annealed XLPE..
61. Akiyama Mio, Yasuharu Nakashima, Yukihide Iwamoto, Femoral anteversion is correlated with acetabular version and coverage in Asian women with anterior and global deficient subgroups of hip dysplasia: a CT study , 41, 11, 1411-1418, 2012.03.
62. Yasuharu Nakashima, Clinical Features of Pustulotic Arthro-Osteitis, ARTHRITIS AND RHEUMATISM, 63, 10, S207-S207, 2011.10.
63. Yasuharu Nakashima, Preferential Accumulation of Activated Th1 Cells Not Only in Rheumatoid Arthritis But Also in Osteoarthritis Joints, JOURNAL OF RHEUMATOLOGY, 10.3899/jrheum.101355, 38, 8, 1569-1575, 2011.08.
64. Yasuharu Nakashima, Pelvic Deformity Influences Acetabular Version and Coverage in Hip Dysplasia, CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 10.1007/s11999-010-1746-1, 469, 6, 1735-1742, 2011.06.
65. Yasuharu Nakashima, Transtrochanteric rotational osteotomy for the late onset Legg-Calve-Perthes disease, J Pediatr Orthop, 31, 2, 223-228, 2011.06.
66. Fujii M, Nakashima Y, Yamamoto T, Mawatari T, Motomura G, Matsushita A, Matsuda S, Jingushi S, Iwamoto Y, Acetabular retroversion in developmental dysplasia of the hip, J Bone Joint Surg Am, 2010.03.
67. Matsushita A, Nakashima Y, Fujii M, Sato T, Iwamoto Y, Modular Necks Improve the Range of Hip Motion in Cases with Excessively Anteverted or Retroverted Femurs in THA, Clin Orthop Relat Res, 2010.03.
68. Nakashima Y, Kondo M, Harada H, Horiuchi T, Ishinishi T, Jojima H, Kuroda K, Miyahara H, Nagamine R, Nakashima H, Otsuka T, Saikawa I, Shono E, Suematsu E, Tsuru T, Wada K, Iwamoto Y, Clinical evaluation of tocilizumab for patients with active rheumatoid arthritis refractory to anti-TNF biologics: tocilizumab in combination with methotrexate., Mod Rheumatol, 2010.03.
69. Kaibara N, Yamada H, Shuto T, Nakashima Y, Okazaki K, Miyahara H, Esaki Y, Hirata G, Iwamoto Y, Comparative histopathological analysis between tenosynovitis and joint synovitis in rheumatoid arthritis., Histopathology 52(7):856-864, 2008, Histopathology 52(7):856-864, 2008, 2009.05.
70. Mawatari T, Miura H, Hamai S, Shuto T, Nakashima Y, Okazaki K, Kinukawa N, Sakai S, Hoffmann PF, Iwamoto Y, Keaveny TM, Vertebral strength changes in rheumatoid arthritis patients treated with alendronate, as assessed by finite element analysis of clinical computed tomography scans: a prospective randomized clinical trial., Arthritis Rheum 58(11):3340-3349, 2008, Arthritis Rheum 58(11):3340-3349, 2008, 2009.05.
71. Fujii M, Nakashima Y, Jingushi S, Yamamoto T, Noguchi Y, Suenaga E, Iwamoto Y., Intraarticular findings in symptomatic developmental dysplasia of the hip., J Pediatr Orthop. 2009 Jan-Feb;29(1):9-13, J Pediatr Orthop. 2009 Jan-Feb;29(1):9-13, 2009.01.
72. Matsushita A, Nakashima Y, Jingushi S, Yamamoto T, Iwamoto Y, Effects of femoral offset and head size on the safe range of motion in THA, Journal of Arthoroplasty, 2008.10.
73. Yamada H, Nakashima Y, Okazaki K, Mawatari T, Fukushi JI, Kaibara N, Hori A, Iwamoto Y, Yoshikai Y, Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis., Ann Rheum Dis 67(9):1299-1304, 2008, Ann Rheum Dis 67(9):1299-1304, 2008, 2008.09.