Kyushu University Academic Staff Educational and Research Activities Database
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Yoshihiro Matsumoto Last modified date:2018.06.22

Associate Professor / Dept. of Orthopaedic Surg. Kyushu Univ. School of Medicine
Department of Clinical Medicine
Faculty of Medical Sciences

Graduate School
Undergraduate School

Academic Degree
Field of Specialization
Orthopaedic Surgery
Research Interests
  • Basic research for bone and soft tissue tumor and spine and spinal cord disease
    keyword : Bone and soft tissue tumor, spine and spinal cord disease
Academic Activities
1. Fukushima S, Matsumoto Y, Endo M, Matsumoto Y, Fukushi JI, Matsunobu T, Kawaguchi KI, Setsu N, IIda K, Yokoyama N, Nakagawa M, Yahiro K, Oda Y, Iwamoto Y, Nakashima Y., Hypoxia-inducible Factor 1 alpha is a Poor Prognostic Factor and Potential Therapeutic Target in Malignant Peripheral Nerve Sheath Tumor. , PLOS One, 12, e0178064-e0178064, 2017.06.
2. Matsumoto Y, Harimaya K, Kawaguchi K, Hayashida M, Okada S, Doi T, Iwamoto Y., Dumbbell Scoring System: A New Method for the Differential Diagnosis of Malignant and Benign Spinal Dumbbell Tumors., Spine, 41, E1230-E1236, 2016.06.
3. Ueda T, Morioka H, Nishida Y, Kakunaga S, Tsuchiya H, Matsumoto Y, Asami Y, Inoue T, Yoneda T., Objective tumor response to denosumab in patients with giant cell tumor of bone: a multicenter phase II trial. , Ann Oncology., 26, 2149-2154, 2015.06.
4. Hatano M, Matsumoto Y, Fukushi J, Matsunobu T, Endo M, Okada S, Iura K, KamuraS, Fujiwara T, Iida K, Fujiwara Y, Nabeshima A, Yokoyama N, Fukushima S, Oda Y, Iwamoto Y., Cadherin-11 regulates the metastasis of Ewing sarcoma cells to bone. Clin Exp Metastasis., Clin Exp Metastasis, 32, 579-591, 2015.06.
5. Matsumoto Y, Matsumoto K, Harimaya K, Okada S, Doi T, Iwamoto Y., Scoliosis in patients with multiple hereditary exostoses., Eur Spine J, 24, 1568-1573, 2015.06.
6. Yoshihiro Matsumoto, Harimaya K, Hayashida M, Okada S, Iwamoto Y, Minimum five-year follow-up of selective anterior thoracolumbar or lumbar fusion for adolescent idiopathic scoliosis: an analysis of radiographic parameters relevant to the uppermost instrumented vertebra and postoperative spinal balance., 4, 933-940, 2013.07.
7. Yoshihiro Matsumoto, Katsumi Harimaya, Yukihide Iwamoto, Yoshinao Oda, Hayashida Mitsumasa, Dedifferentiated
chondrosarcoma of the cervical spine: a case report.
, World J Surg Oncol., 11, 1, 32-32, 2013.01.
8. Endo M, Yamamoto H, Setsu N, Kohashi K, Takahashi Y, Ishii T, Iida K, Matsumoto Y, Yukihide Iwamoto, Yoshinao Oda, Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect
of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath
tumors., Clin Cancer Res., 19, 2, 450-461, 2013.01.
9. Yoshihiro Matsumoto, Kazuya Yokota, Akio Sakamoto, Yukihide Iwamoto, Yoshinao Oda, Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9
cases at a single institute.
, 7, 1, 32-32, On line journal, 2012.12.
10. Yoshihiro Matsumoto, Li Y, Li X, Fukushi JI, Iwamoto Y, Impairment of
p53 acetylation by EWS-Fli1 chimeric protein in Ewing Family Tumors.
, Cancer Letter, 320, 1, 14-22, 2012.07.
11. Matsumoto Y, Harimaya K, Doi T, Kawaguchi K, Okada S, Inoguchi A, Fujiwara M, Iwamoto Y, Clinical characteristics and surgical outcome of the symptomatic ossification of ligamentum flavum at the thoracic level with combined lumbar spinal stenosis, Arch Orthop Trauma Surg, 132, 465-470, 2011.11.
12. Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y, Macrophage infiltration predicts a poor prognosis for human ewing sarcoma, Am J Pathol, 179, 1157-1170, 2011.08.
13. Matsumoto Y , Yuko Okada , Jun-ichi Fukushi , Satoshi Kamura , Toshifumi Fujiwara , Keiichiro Iida , Mihoko Koga , Shuichi Matsuda , Katsumi Harimaya , Akio Sakamoto and Yukihide Iwamoto. , Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone , Journal of Orthopaedic Surgery and Research, 5, 1, 85, 2010.10.
14. Kamura S, Matsumoto Y, Fukushi JI, Fujiwara T, Iida K, Okada Y, Iwamoto Y, Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway, Br. J. Cancer, 103, 3, 370-381, 2010.08.
15. Matsumoto Y, Matsumoto K, Irie F, Fukushi J, Stallcup WB, Yamaguchi Y, Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects. , J. Bio. Chem., 285, 25, 19227-19234, 2010.05.
16. Matsumoto Y, Harimaya K, Doi T, Maeda T, Iwamoto Y. , Outcome of osteoplastic laminotomy for excision of spinal cord tumors., J Orthop Surg. , 17, 275-279, , 2009.10.
17. Iwao K, Inatani M, Matsumoto Y, Ogata-Iwao M, Takihara Y, Irie F, Yamaguchi Y, Okinami S, Tanihara H. , Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signaling, J Clin Invest., 119, 1997-2008, 2009.05.
18. Yoshihiro Matsumoto, Fumitoshi Irie, Masaru Inatani, Marc Tessier-Lavigne, Yu Yamaguchi, Netrin-1/DCC Signaling in Commissural Axon Guidance Requires Cell-autonomous Expression of Heparan Sulfate, Journal of Neuroscience, 27: 4342-4350, 2007.04.
1. Yoshihiro Matsumoto, Iwamoto Y, Ewing Sarcoma: current biological advances and future perspectives, 8th combined meeting of orthopaedic research societies, 2013.10.
2. Yoshihiro Matsumoto, Selective Anterior Thoracolumbar or Lumbar Fusion for Adolescent Idiopathic Scoliosis: the Influence of the Selection of the Lowest Instrumented Vertebrae on Radiographic Changes, 19th International Meeting on Advanced Spine Techniques, 2012.07.