Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Toru Chikui Last modified date:2019.12.19

Associate Professor / Division of Maxillofacial Diagnostic and Surgical Sciences / Department of Dental Science / Faculty of Dental Science

1. 筑井 徹, 大賀 正浩, 北本 江梨奈, 白石 朋子, 川野 真太郎, 吉浦 敬, 吉浦 一紀, Quantification of Diffusion and Permeability of MRI in the Head and Neck Region, Journal of Radilogy and Radiation Therapy, 2014.03, Diffusion Weighted Image (DWI) has various roles such as tissue characterization, the prediction and monitoring of the response to treatment and
differentiation of recurrent tumors from post-therapeutic changes. The malignant tumors have a lower ADC compared to benign lesions. Follow-up of early response to cancer treatment is reflected in an ADC increase in the primary tumor and nodal metastases; whereas nonresponding lesions tend to reveal only
a slight increase or even a decrease in ADC during follow-up. However, there are many limitations regarding the performance of DWI in the head and neck
region, therefore, many attempts has been performed to overcome the flaws of the diffusion-weighted single-shot-echo planar imaging.
The pharmacokinetic analyses of dynamic contrast enhanced MRI (DCE-MRI) can provide physiological condition of the tissue, and Tofts and Kermode
Model has been applied to the head and neck region. Some researchers have used it for the prediction and monitoring of the tumor response to cancer therapy.
The general consensus is that the early changes of these parameters during the early phase after the treatment are useful for the interpretation of the response
to the treatment. However, the parameters reported in the literature vary considerably; therefore, it is difficult to compare the values of the parameters among research groups.
Both DWI and the pharmacokinetic analysis of the DCE-MRI have shown a wide range of potential benefits in this region, but more comparative studies with established scan techniques and the quantification of the data are required.
2. Chikui T, Obara M, Simonetti AW, Ohga M, Koga S, Kawano S, Matsuo Y, Kamintani T, Shiraishi T, Kitamoto E, Nakamura K, Yoshiura K., The Principal of Dynamic Contrast EnhancedMRI, theMethod of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region., Int J Dent, 2012.11, Many researchers have established the utility of the dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in the differential diagnosis in the head and neck region, especially in the salivary gland tumors. The subjective assessment of the pattern of the time-intensity curve (TIC) or the simple quantification of the TIC, such as the time to peak enhancement (T(peak)) and the wash-out ratio (WR), is commonly used. Although the semiquantitative evaluations described above have been widely applied, they do not provide information on the underlying pharmacokinetic analysis in tissue. The quantification of DCE-MRI is preferable; therefore, many compartment model analyses have been proposed. The Toft and Kermode (TK) model is one of the most popular compartment models, which provide information about the influx forward volume transfer constant from plasma into the extravascular-extracellular space (EES) and the fractional volume of EES per unit volume of tissue is used in many clinical studies. This paper will introduce the method of pharmacokinetic analysis and also describe the clinical application of this technique in the head and neck region..