| Teruhisa Tsuzuki | Last modified date：2013.5.18 |
Graduate School
Undergraduate School
E-Mail
Homepage
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Department of Biomedical Science, School of Medicine, Kyushu University.
[URL]
Department of Medical Biophysics and Radiation Biology, Faculty of Medical Sciences.
Phone
092-642-6141
Fax
092-642-6145
Academic Degree
Doctor of Science
Field of Specialization
Molecular Genetics, Radiation Biology
Outline Activities
Reactive oxygen species are produced through normal cellular metabolism, and formation of such radicals is further enhanced by ionizing radiation and by various chemicals. Among various classes of DNA damage induced by oxygen radicals, an oxidized form of guanine base, 8-oxoguanine seems to play a crucial role in carcinogenesis and aging. Organisms are equipped with elaborate mechanisms to counteract such deleterioous effects of 8-oxoguanine. We have been focusing on the genes encoding enzymes which involve in the prevention and repair of oxidative DNA damage. In practice, we isolate cDNA and genomic clones encoding these key enzymes, characterize the protein products and use reverse genetics to develop appropriate mouse models defective in DNA repair genes.
Research
Research Interests
Membership in Academic Society
- Molecular Mechanism for Maintenance of Genetic Information: Oxygen-induced DNA Damage and Its Repair Mechanisms
keyword : DNA damage, DNA Repair, Reactive Oxygen Species, Mutation, Tumorigenesis/Carcinogenesis, Genome Instability, Gene-Modified Mice, Gene targeting, Oxidative Stress
1992.09. - Exploiting bacteriophage genetics for high throughput functional genomics: Development of an Efficient System for Gene Targeting
keyword : Gene Targeting, Targeting Vector, Gene-Modified Mice
1996.04.
- Oxygen-induced DNA damage and Its Repair Mechanisms
- Oxygen-induced DNA damage and Its Repair Mechanisms
- Radiation induced DNA damage and its Defence Mechanism
- Experimental study on genetic interaction for cancer radiotherapy
Reports
| 1. | T. Tsuzuki, J. Piao, T. Isoda, K. Sakumi, Y. Nakabeppu, Y. Nakatsu,Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice,Health Physics- The Radiation Safety Journal,2011.03. |
| 2. | T. Tsuzuki, J. Piao, T. Isoda, K. Sakumi, Y. Nakabeppu, Y. Nakatsu,Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice,DNA Repair and Human Cancers ()Eds. S. Nishimura, L. A. Loeb, M. Masutani, H. Nakagama, T. Sekiya,Princess Takamatsu Cancer Research Fund,2010.08. |
| 3. | T. Tsuzuki, T. Isoda, J. Piao, K. Yamauchi, A. Egashira, K. Sakamoto, S. Kura, Y. Nakabeppu, Y. Nakatsu,Significance of Error-avoiding Mechanisms for Oxidative DNA Damage in Carcinogenesis,EUROBIC 9: 9th European Biological Inorganic Chemistry Conference, Editor Henryk Kozlowski, K902R9065, 7-14,International Proceedings, Medimond S. r. l., Italy,2008.09. |
| 4. | Teruhisa Tsuzuki, Yoshimichi Nakatsu, Yusaku Nakabeppu,Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis,Vol. 98, No. 4, 465-470,Cancer Science,2007.04. |
| 5. | Sekiguchi, M. and Tsuzuki, T.,Oxidative nucleotide damage: consequences and prevention.,21, 8895-8904,Oncogene,2002.12. |
Papers
| 1. | Teik-How Lim, Ryosuke Fujikane, Shiori Sano, Ryuji Sakagami, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Mutsuo Sekiguchi, and Masumi Hidaka,Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.,DNA Repair,11, 259-266 ,2012.01. |
| 2. | Tsuzuki, T., Piao, J., Isoda, T., Sakumi, K., Nakabeppu, Y., Nakatsu, Y.,Oxidative stress-induced tumorigenesis in the small intestine of various types of DNA repair-deficient mice. ［Note］,Health Physics,100, 3, 293-294 ,2011.03. |
| 3. | Komori, K., Takagi, Y., Sanada, M., Lim, T.-H., Nakatsu, Y., Tsuzuki, T., Sekiguchi, M., and Hidaka, M.,A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA,Oncogene,28, 1142-1150,2009.01. |
| 4. | Sanada M, Hidaka M, Takagi Y, Takano TY, Nakatsu Y, Tsuzuki T, Sekiguchi M.,Modes of actions of two types of anti-neoplastic drugs, dacarbazine and ACNU, to induce apoptosis.,Carcinogenesis,28, 12, 2657-2663,2007.12. |
| 5. | Sakamoto, K., Tominaga, Y., Yamauchi, K., Nakatsu, Y., Sakumi, K., Yoshiyama, K., Egashira, A., Kura, S., Yao, T., Tsuneyoshi, M., maki, H., Nakabeppu, Y. and Tsuzuki, T.,MUTYH-null mice are susceptible to spontaneous and oxidative-stress-induced intestinal tumorigenesis.,Cancer Res.,67, 14, 6599-6604,2007.07. |
| 6. | Sakumi, K., Tominaga, Y., Furuichi, M., Xu, P. Tsuzuki, T., Sekiguchi, M. and Nakabeppu, Y.,Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption.,Cancer Res.,Vol.63,No.5,63, 902-905,2003.03. |
| 7. | Egashira, A., Yamauchi, K., Yoshiyama, K., Kawate, H., Katsuki, M., Sekiguchi, M., Sugimachi, K., Maki, H. and Tsuzuki, T.,Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes.,DNA Rerair,Vol.1,No.11,1, 881-893,2002.10. |
| 8. | Tsuzuki, T., Egashira, A., Igarashi, H., Iwakuma, T., Nakatsuru, Y., Tominaga, Y., Kawate, H., Nakao, K., Nakamura, K., ide, F., Kura, S., Nakabeppu, Y., Katsuki, M., Ishikawa, T. and Sekiguchi, M.,Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase.,Proc. Natl. Acad. Sci. USA,Vol.98,No.20,98, 20, 11456-11461,2001.09. |
| 9. | Tsuzuki, T. and Rancourt, D. E.,Embryonic stem cell targeting using bacteriophage lambda vectors generated by phage-plasmid recombination.,Nucl. Acids Res.,Vol.26,No.4,26, 4, 988-993,1998.01. |
| 10. | Igarashi, H., Tsuzuki, T., Kakuma, T., Tominaga, Y. and Sekiguchi, M.,Organization and expression of the mouse MTH1 gene for preventing transversion mutation.,J. Biol. Chem.,Vol.272,No.6,272, 6, 3766-3772,1997.02. |
| 11. | Tsuzuki, T., Fujii, Y., Sakumi, K., Tominaga, Y., Nakao, K., Sekiguchi, M., Matsushiro, A., Yoshimura, Y. and Morita, T.,Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.,Proc. Natl. Acad. Sci. USA,Vol.93,No.13,93, 6236-6240,1996.06. |
| 12. | Tsuzuki, T., Sakumi, K., Shiraishi, A., Kawate, H., Igarashi, H., Iwakuma, T., Tominaga, Y., Zhang, S., Shimizu, S., Ishikawa, T., Nakamura, K., Nakao, K., Katsuki, M. and Sekiguchi, M.,Targeted disruption of the methyltransferase gene renders mice hypersensitive to alkylating carcinogens.,Carcinogenesis,17, 6, 1215-1220,1996.06. |
Presentations
| 1. | The roles of mismatch repair system in the suppression of oxidative stress-induced intestinal tumor formation in mice.［Teruhisa Tsuzuki, Jing-Shu Piao, Takuro Isoda, Yoshimichi Nakatsu］. |
| 2. | Molecular Mechanism of the Induction of Apoptosis tu Suppress Mutations and Cancer.［Masumi Hidaka, Shiori Sano, RYosuke Fujikane, Teik How Lim, Ryuji Sakagami, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Mutuso Sekiguchi］. |
| 3. | Study of the oxidative DNA Damage Repair System-deficient Mice. ［Mizuki Ohno, Kunihiko Sakumi, Ryotaro, Fukumura, Yoichi Gondo, Kenichi Taguchi, Teruhisa Tsuzuki, Yusaku Nakabeppu]. |
| 4. | 8-Oxoguanine repair system contribute to maintain stable phenotype of inbred mouse strain. ［Mizuki Ohno, Kunihiko Sakumi, Ryutaro Fukumura, Yoichi Gondo, Teruhisa Tsuzuki, Yusaku Nakabeppu]. |
| 5. | Mizuki Ohno, Kunihiko Sakumi, Teruhisa Tsuzuki, Yusaku Nakabeppu. |
| 6. | Deficiency of 8-oxoguanine repair mechanisms increases spontaneous mutation frequency in mouse germ line and consequently causes hereditary congenital abnormalities [Mizuki Ohno, Kunihiko Sakumi, Ryutaro Fukumura, Yoichi Gondo, Teruhisa Tsuzuki, Yusaku Nakabeppu]. |
- The Japanese Cancer Association
- The Japan Radiation Research Society
- The Molecular Biology Society of Japan
- The Japanese Biochemical Society
- The Japanese Environmental Mutagen Society
Educational
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