Kyushu University Academic Staff Educational and Research Activities Database
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Motohiro Nishida Last modified date:2017.06.21

Professor / Department of Translational Pharmaceutical Sciences
Department of Pharmaceutical Health Care and Sciences
Faculty of Pharmaceutical Sciences

Graduate School
Undergraduate School

Academic Degree
Field of Specialization
Outline Activities
Study on the intracellular signaling pathways regulating adaptation or maladaptation of the heart against physical stresses
Study on the regulation of cardiac redox homeostasis by sulfer circulation
Study on the pathophysiological roles of receptor-activated TRPC channels in the heart
Pharmacology, Drug Disovery and Evolution
Social activities:
presentation in scientific meeting, lecturer on demand (high school), etc.
Research Interests
  • Study on the mechanism of cardiac fibrosis
    keyword : fibrosis, nucleotide, purinergic receptor, heart
  • Role of receptor-activated TRP calcium channels in cardiovascular remodeling
    keyword : cardiovasuclar remodeling, TRP channel, calcium signal
  • Study on the regulation of cardiac senescence by reactive oxygen species
    keyword : cardiac senescence, reactive oxygen species, signaling
Academic Activities
1. Nishida M, Sunggip C, Kitajima N & Kurose H, Angiotensin: New Research, Redox regulation of angiotensin receptor signaling in the heart., NOVA Publishers (New York), 2012.03.
2. Nishida M, Ohba M, Nakaya M & Kurose H., Heart Failure: Symptoms, Causes and Treatment Options, NOVA Publishers (New York), Edited by Wright MS. 51-72頁, 2011.03.
1. Nishida M, Roles of heterotrimetric GTP-binding proteins in the progression of heart failure., J. Pharmacol. Sci., 2011.06.
2. Nishida M, Kitajima N, Saiki S, Nakaya M & Kurose H, Regulation of angiotensin II receptor signaling by cysteine modification of NF-kB., Nitric Oxide, 2011.08.
3. Nishida M, Kitajima N, Saiki S, Nakaya M & Kurose H., Regulation of angiotensin II receptor signaling by cysteine modification of NF-kB., Nitric Oxide, in press..
4. Nishida M. , Heterotrimetric G protein signaling in Heart Failure. , J. Pharmacol. Sci., in press..
5. Nishida M, Kurose H, Roles of TRP channels in the development of cardiac hypertrophy., Naunyn Schmiedebergs Arch Pharmacol. , Vol.378,395-406, 2008.07.
6. Nishida M, Hara Y, Yoshida T, Inoue R & Mori Y., TRP channels: formation of signal complex and regulation of cellular functions, Microcirculation, 13, 535-550, 2006.09.
7. Mori Y, Nishida M, Shimizu S, Ishii M, Yoshinaga T, Ino M, Sawada K & Niidome T, Mice lacking the a1B subunit (CaV 2.2) reveals a predominant role of N-type Ca2+ channels in the sympathetic regulation of circulatory system., Trends in Cardiovascular Medicine, 12, 270-275, 2002.12.
1. 西田 基宏, The purinergic P2Y6 receptor heterodimerizes with the angiotensin AT1 receptor to promote angiotensin II-induced hypertension, Science Signaling, Vol. 9, Issue 411, 2016.01.
2. Motohiro Nishida, Nakaya Michio, Hitoshi Kurose, Tajima M, Hashimoto A, GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance., Nature Communications, 4, 1532, 2013.04.
3. Motohiro Nishida, 北島直幸, Hitoshi Kurose, Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes., Mitochondrion, 12, 449-458, 2012.09.
4. Motohiro Nishida, 北島直幸, Hitoshi Kurose, Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration., Nature Chemical Biology, 8, 714-724, 2012.07.
5. Nishida M, Ogushi M, Suda R, Toyotaka M, Saiki S, Kitajima N, Nakaya M, Kim K-M, Ide T, Sato Y, Inoue K and Kurose H, Heterologous down-regulation of angiotensin type1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kB., Proc. Natl. Acad. Sci. USA., 108, 6662-6667, 2011.04.
6. Nishida M, Ogushi M, Suda R, Toyotaka M, Saiki S, Kitajima N, Nakaya M, Kim K-M, Ide T, Sato Y, Inoue K and Kurose H., Heterologous down-regulation of angiotensin type1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kB., Proceedings of National Academy of Sciences USA, 108, 6662-6667, 2011.04.
7. Kitajima N, Watanabe K, Morimoto S, Sato Y, Kiyonaka S, Hoshijima M, Ikeda Y, Nakaya M, Ide T, Mori Y, Kurose H and Nishida M., TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts., Biochemical Biophysical Research Communications, 409, 108-113, 2011.05.
8. Kinoshita H, Kuwahara K, Nishida M, Jiang Z, Rong X, Kiyonaka S, Kuwabara Y, Kurose H, Inoue R, Mori Y, Li Y, Nakagawa Y, Usami S, Fujiwara M, Yamada Y, Minami T, Ueshima K and Nakao K., Inhibition of TRPC6 channel activity contributes to the anti-hypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart., Circulation Research, in press, 2010.06.
9. Nishida M, Suda R, Tanabe S, Onohara N, Nakaya M, Kanaho Y, Sumimoto H, Sato Y and Kurose H., Pertussis toxin upregulates angiotensin type1 receptors through TLR4-mediated Rac activation., J. Biol. Chem., 285, 15268-15277, 2010.05.
10. Nishida M, Watanabe K, Sato Y, Nakaya M, Kitajima K, Ide T, Inoue R and Kurose H., Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition., J. Biol. Chem., 285, 13244-13253, 2010.05.
11. Numaga T, Nishida M, Kiyonaka S, Kato K, Katano M, Mori E, Kurosaki T, Inoue R, Hikida M, Putney JW Jr, and Mori Y., Ca2+ influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells., Journal of Cell Science, 123, 927-938, 2010.03.
12. Kiyonaka S, Kato K, Nishida M, Mio K, Numaga T, Sawaguchi Y, Yoshida T, Wakamori M, Mori E, Numata T, Ishii M, Takemoto H, Ojida A, Watanabe K, Uemura A, Kurose H, Morii T, Kobayashi T, Sato Y, Sato C, Hamachi I and Mori Y., Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound., Proc Natl Acad Sci USA. , Vol. 106, No.13, 5400-5405, 2009.03.
13. Nishida M, Sato Y, Uemura A, Narita Y, Tozaki-Saitoh H, Nakaya M, Ide T, Suzuki K, Inoue K, Nagao T & Kurose H., P2Y6 receptor-Ga12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis, The EMBO Journal, Vol27, No.23, 3104-3115, 2008.12.
14. Nishida M, Onohara N, Sato Y, Suda R, Ogushi M, Tanabe S, Inoue R, Mori Y & Kurose H., Galpha12/13-mediated upregulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through NFAT activation., The Journal of Biological Chemistry, 282, 23117-23128, 2007.08.
15. Onohara N, Nishida M, Inoue R, Kobayashi H, Sumimoto H, Sato Y, Mori Y, Nagao T & Kurose H., TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy., The EMBO Journal, 25, 5305-5316, 2006.11.
16. Nishida M, Tanabe S, Maruyama Y, Mangmool S, Urayama K, Nagamatsu Y, Takagahara S, Turner JH, Kozasa T, Kobayashi H, Sato Y, Kawanishi T, Inoue R, Nagao T, and Kurose H., Ga12/13-and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 MAPK by angiotensin receptor stimulation in rat neonatal cardiomyocytes., The Journal of Biological Chemistry, 280, 18, 280, 18434-18441, 2005.04.
17. Nishida M, Sugimoto K, Hara Y, Mori E, Morii T, Kurosaki T & Mori Y, Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCg2 in B lymphocytes., The EMBO Journal, 22, 4677-4688, 2003.09.
18. Nishida M, Schey KL, Takagahara S, Kontani K, Katada T, Urano Y, Nagano T, Nagao T & Kurose H, Activation mechanism of Gi and Go by reactive oxygen species., The Journal of Biological Chemistry, 277, 9036-9042, 2002.03.
19. Nishida M, Takagahara S, Maruyama Y, Sugimoto Y, Nagao T & Kurose H, Gbg counteracts Gaq signaling upon a1-adrenergic receptor stimulation., Biochemical and Biophysical Research Communication, 291, 995-1000, 2002.02.
20. Nishida M, Maruyama Y, Tanaka R, Kontani K, Nagao T, & Kurose H, Gai and Gao are target proteins of reactive oxygen species., Nature, 408, 492-495, 2000.12.
21. Nishida M, Urushidani T, Sakamoto K & Nagao T, l-cis Diltiazem attenuates intracellular Ca2+ overload by metabolic inhibition in guinea pig myocytes., The European Journal of Pharmacology, 385, 225-230, 1999.12.
22. Nishida M, Nagao T & Kurose H, Activation of Rac1 increases c-Jun NH2-terminal kinase activity and DNA fragmentation in a calcium-dependent manner in rat myoblast cell line H9c2., Biochemical and Biophysical Research Communication, 262, 350-354, 1999.08.
23. Nishida M, Sakamoto K, Urushidani T & Nagao T, Treatment with l-cis diltiazem before reperfusion reduces infarct size in the ischemic rabbit heart in vivo., The Journal of Pharmaceutical Sciences, 80, 319-325, 1999.07.
1. 西田 基宏, New strategies for drug development of heart failure, Medical Research Seminar in Malaysia Sabah University, 2017.01.23.
2. 西田 基宏, Myocardial early senescence mediated by mitochondria-cytoskeleton interaction, The 39th Annual Meeting of the Molecular Biology Society of Japan, 2016.12.02.
3. 西田 基宏, Regulation of cardiac oxygen remodeling via electrophilic modification of Drp1, The 89th Annual Meeting of the Japanese Biochemical Society, 2017.09.25.
4. 西田 基宏, TRPC channels in cardiovascular stress resilience, International and Interdisciplinary Symposium 2016 “Towards a New Era of Cardiovascular Research, 2016.07.11.
5. 西田 基宏, Redox regulation of G proteins in cardiac remodeling, The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, 2016.05.22.
Membership in Academic Society
  • International Society for Heart Research
  • Hydrogen sulfide suppresses H-Ras-mediated cardiac senescence after myocardial infarction via electrophilic sulfhydration
  • Roles of Heterotrimeric GTP-binding Proteins in the Progression of Heart Failure
  • ATP decreases angiotensin type 1 receptor expression through S-nitrosylation of nuclear factor κB